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Browse the failure-mode index

20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Antileishmanial Activity of Oseltamivir and Acyclovir: Modulation of Macrophage Phagocytosis and Cytotoxicity Assessment.

Lima Neta PP, Leal PPMS, Passos VHAA et al. · 2025 · Anais da Academia Brasileira de Ciencias

Leishmaniasis is a group of diseases caused by protozoa of the genus Leishmania . Current treatments exhibit high toxicity, high costs, and parasite resistance. Consequently, the search for new drugs is of utmost importance, and drug…

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Negative / Null Result ReportMedicine

Comparative Analysis of Intrathecal Lidocaine Combined With Guanfacine or Dexmedetomidine on Nociceptive and Motor Blockade in Rats.

Chou AK, Chiu CC, Chen YW et al. · 2025 · Fundamental & clinical pharmacology

The aim of this study was to examine the effects of intrathecal lidocaine combined with guanfacine or dexmedetomidine on nociceptive and motor blockade, in comparison to clonidine. Using a rat model of intrathecal injection, we evaluated…

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Negative / Null Result ReportMedicine

Investigating the role of ketogenic diet and high-dose vitamin C in modulating doxorubicin toxicity in a murine breast cancer model

Al-Jada DN, Takruri HR, Talib WH et al. · 2025 · Biochemical and Biophysical Research Communications

In this study, we investigated the effectiveness of combining the ketogenic diet (KD) with high-dose vitamin C (VitC) as adjuvant nutritional therapy to mitigate doxorubicin (DOX) toxicity, with a focus on cardiotoxicity, while enhancing…

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Negative / Null Result ReportMedicine

Reevaluating diagnostic confidence: the impact of delayed excretory phase imaging in CT urography on detecting renal and urinary tract abnormalities.

Firoozeh N, Park SY, Basavalingu D et al. · 2026 · Abdominal radiology (New York)

Objective To assess the diagnostic value of the delayed excretory phase in computed tomography urography (CTU) for detecting renal and urinary tract abnormalities and its impact on readers' confidence in patients with hematuria, given…

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Negative / Null Result ReportMedicine

Commercial cytokine assay on equine cerebrospinal fluid does not distinguish equine degenerative myeloencephalopathy from cervical vertebral stenotic myelopathy.

Payette F, Kulp JC, Graves A et al. · 2025 · American journal of veterinary research

Objective To measure and compare CSF cytokine concentrations among horses with equine neuroaxonal dystrophy (eNAD)/equine degenerative myeloencephalopathy (EDM), horses with cervical vertebral stenotic myelopathy (CVSM), and control horses…

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Negative / Null Result ReportMedicine

Moderate intermittent hypoxic conditioning to enhance cerebrovascular function in the elderly: a randomized controlled trial.

Randy H, Perrin TP, Ghaith A et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology

Aging is associated with cerebrovascular impairment, increasing the risk for neurovascular and degenerative diseases. Intermittent hypoxic conditioning (IHC) has been proposed as a valuable strategy to enhance vascular health. However, its…

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Negative / Null Result ReportMedicine

Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-term Mortality.

Bonsu KO, Young SW, Lee T et al. · 2025 · Seminars in thrombosis and hemostasis

Acute pulmonary embolism (PE) is potentially life-threatening, with up to 15% risk of death. We compared four risk stratification models to identify outpatients at risk of mortality up to 90 days post acute PE. A retrospective cohort study…

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Negative / Null Result ReportMedicine

Effects of passive information dissemination on human papillomavirus vaccination attitudes and knowledge among pharmacy visitors: A cluster randomized controlled trial.

Wakui N, Kawakubo S, Harayama M et al. · 2025 · Journal of the American Pharmacists Association : JAPhA

Background In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible health care facilities, often serve as sources of health information. However,…

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Negative / Null Result ReportOpen accessMedicine

Subacromial bursa augmentation in arthroscopic rotator cuff repair: Clinical and doppler ultrasound assessment-A preliminary study.

Freislederer F, Dimitriu M, Endell D et al. · 2026 · Journal of experimental orthopaedics

Purpose To determine whether augmentation with the subacromial bursa influences postoperative tendon healing, particularly regarding morphology and vascularity, after arthroscopic rotator cuff repair. Methods In this prospective…

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Negative / Null Result ReportMedicine

Entomopathogenic Nematodes Induce Metabolic Reallocation in Maize Roots Without Altering the Performance of Two Root Herbivores, Diabrotica virgifera and Diabrotica balteata.

Verdecia-Mogena AM, Himmighofen PA, Mateo P et al. · 2025 · Plant, cell & environment

Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore…

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Negative / Null Result ReportOpen accessMedicine

The Impact on Audience Engagement of Coordinating a Public Health Campaign on Antimicrobial Resistance Through a Network of Health Content Creators: Longitudinal Observational Study.

Chen F, Cooper J, Acharya A et al. · 2026 · JMIR public health and surveillance

Background Antimicrobial resistance (AMR) is a significant global health threat. Several public health campaigns aimed to raise AMR awareness and inspire related behavioral changes have been delivered in a time-specific, coordinated…

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Negative / Null Result ReportMedicine

The Acute Effects of Caffeine and Normobaric Hypoxia on Cardiorespiratory Exercise Responses in Healthy Adults: A Randomized Controlled Trial.

Narang BJ, Štritof A, Debevec T · 2025 · International journal of sport nutrition and exercise metabolism

The ergogenic effects of caffeine for endurance performance at sea level are well established. However, whether caffeine enhances exercise capacity or modulates cardiorespiratory responses in hypoxia remains unclear. Twenty-nine healthy,…

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Negative / Null Result ReportMedicine

PcrV in an intranasal adjuvanted tobacco mosaic virus conjugate vaccine mediates protection from Pseudomonas aeruginosa via an early Th1/Th17 skewed localized and systemic immune response.

Katseff AS, Toumanios C, Barahim E et al. · 2025 · Vaccine

Multi-drug-resistant Pseudomonas aeruginosa (PA) infections are a growing problem for at-risk populations, causing thousands of deaths per year, and novel therapies to treat or prevent severe PA infection are desperately needed. We…

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Negative / Null Result ReportMedicine

Preimplantation genetic testing for aneuploidy mosaicism reporting lacks clinical predictive value for live birth in a multisite, double-blinded study with independent validation.

Gill P, Tao X, Zhan Y et al. · 2026 · American journal of obstetrics and gynecology

Background Preimplantation genetic testing for aneuploidy is used to improve in vitro fertilization outcomes by identifying embryos with lethal chromosomal abnormalities that impair development or lead to pregnancy loss. The adoption of…

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Negative / Null Result ReportMedicine

Perceptual, Thermoregulatory, and Performance Effects of Menthol Gel Application in Trained Triathletes Exercising in Hot Conditions.

Barwood M, Barwood H, Davis D et al. · 2025 · International journal of sports physiology and performance

Purpose Topical menthol application improves thermal perception and enhances performance but reduces sweat production in hot environments. In the aquatic environment, where sweat evaporation is of limited thermoregulatory benefit (ie,…

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Negative / Null Result ReportMedicine

Reduction of Enteric Pathogens in Bottled Water Using Residual Ozone.

Schwaner WR, Kumar S, Thippareddi H · 2025 · Journal of food protection

Ozone is an effective and safe disinfectant used globally in the bottled water industry. Ozone infusion at a high level helps maintain a residual level (0.1-0.4 mg/L) at the time of bottling, thus can ensure 4 log microbial reductions.…

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Negative / Null Result ReportOpen accessMedicine

Evaluating Dermal Bioactivity of Metal Additive Manufacturing Powders Using Human <i>In Vitro</i> and <i>Ex Vivo</i> Skin Models.

Persson A, Łyczyńska Z, Shahata M et al. · 2026 · Chemical research in toxicology

Metal additive manufacturing (AM) relies on alloy feedstock powders that may come into contact with the workers' skin during handling, yet skin-relevant data on metal release and biological reactivity remain limited. Here, we assessed the…

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Negative / Null Result ReportMedicine

Design and optimization of an automatic deep learning-based cerebral reperfusion scoring (TICI) using thrombus localization.

Folcher A, Piters J, Wallach D et al. · 2025 · Journal of neuroradiology = Journal de neuroradiologie

Background The Thrombolysis in Cerebral Infarction (TICI) scale is widely used to assess angiographic outcomes of mechanical thrombectomy despite significant variability. Our objective was to create and optimize an artificial intelligence…

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Negative / Null Result ReportMedicine

A single session of whole-body vibration did not affect cardiovascular autonomic recovery after a high intensity exercise in horses

Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science

Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic reactivity during…

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Negative / Null Result ReportOpen accessMedicine

Trained immunity agonists given to neonatal mice fail to protect against leptospiral infection in adulthood and may cause adverse effects.

Fernandez M, Vernel-Pauillac F, Pezier T et al. · 2026 · Innate immunity

Background and ObjectivesTrained immunity (TI) refers to a non-specific, long-lasting protective immune response that occurs following initial stimulation of the immune system and thought to be largely mediated by functional reprogramming…

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