Negative / Null Result ReportOpen accessMedicine
Patricia Baxter, Jack M. Su, Arzu Onar‐Thomas et al. · 2020 · Neuro-Oncology
BACKGROUND: A Pediatric Brain Tumor Consortium (PBTC) phase I/II trial of veliparib and radiation followed by veliparib and temozolomide (TMZ) was conducted in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). The…
View details →Negative / Null Result ReportOpen accessMedicine
William W. Ho, Igor L. Gomes‐Santos, Shuichi Aoki et al. · 2021 · Proceedings of the National Academy of Sciences
Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC). Mismatch repair-proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are unresponsive to immune checkpoint blockade (ICB) therapy. Here…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Eric J. Pedersen, William H.B. McAuliffe, Michael E. McCullough · 2018 · Journal of Experimental Psychology General
Many social scientists believe humans possess an evolved motivation to punish violations of norms-including norm violations that do not harm them directly. However, most empirical evidence for so-called altruistic punishment comes from…
View details →Negative / Null Result ReportPsychology
Uzma S. Rehman, Erick Janssen, Sarah K. Newhouse et al. · 2011 · Journal of Sex & Marital Therapy
The way couples communicate during conflict discussions has been found to be a reliable predictor of marital satisfaction. However, in previous research, there has been little experimental control over the selection of topics. The present…
View details →Negative / Null Result ReportMedicine
Mark A. Hyde, Michael L. Hadley, Payam Tristani‐Firouzi et al. · 2012 · Archives of Dermatology
OBJECTIVE: To determine if the complete response rates of lentigo maligna (LM) to imiquimod, 5%, cream can be improved by the addition of a topical retinoid. DESIGN: Prospective randomized study of patients treated with imiquimod alone vs…
View details →Negative / Null Result ReportOpen accessMedicine
Allon N. Friedman, Mary Chambers, Lisa M. Kamendulis et al. · 2013 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Obesity precedes and is strongly linked to the development of type 2 diabetic nephropathy in most patients, yet little is known about the effects of weight reduction on this disease. This study aimed to establish…
View details →Negative / Null Result Report
Nativ Omri, Malshy Kamil, Kastin Alexander et al. · 2020 · The Prostate
Abstract Background The early diagnosis of prostate cancer (PCa) is mainly based on prostate‐specific antigen (PSA) blood levels and digital rectal examination. However, this approach may result in a high rate of negative biopsies and…
View details →Negative / Null Result ReportOpen accessPsychology
Lara M. Wierenga, Marieke Bos, Fabienne van Rossenberg et al. · 2019 · Journal of Cognitive Neuroscience
Although male brains have consistently reported to be 8-10% larger than female brains, it remains not well understood whether there are differences between sexes (average or variance) in developmental trajectories. Furthermore, if sex…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Hakan Gündüz · 2021 · Financial Innovation
Abstract In this study, the hourly directions of eight banking stocks in Borsa Istanbul were predicted using linear-based, deep-learning (LSTM) and ensemble learning (LightGBM) models. These models were trained with four different feature sets and their performances were evaluated in terms of accuracy and F-measure metrics. While the first experiments directly used the own stock features as the model inputs, the second experiments utilized reduced stock features through Variational AutoEncoders (VAE). In the last experiments, in order to grasp the effects of the other banking stocks on individ
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Amy C. Graham, Kimberly M. Hilmer, Julianne Zickovich et al. · 2013 · The Journal of Immunology
Influenza A virus (IAV) is a major respiratory pathogen of both humans and animals. The lung is protected from pathogens by alveolar epithelial cells, tissue-resident alveolar macrophages, dendritic cells, and mast cells. The role of…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Harold Bae, Paola Sebastiani, Jenny X. Sun et al. · 2013 · Frontiers in Genetics
Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p < 10(-8)) and replicated in a
View details →Negative / Null Result ReportOpen accessSocial Sciences
Sunhee Park, David J. Hendry · 2015 · American Journal of Political Science
An underlying assumption of proportional hazards models is that the effect of a change in a covariate on the hazard rate of event occurrence is constant over time. For scholars using the Cox model, a Schoenfeld residual‐based test has…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Federico C. F. Calboli, Federica Tozzi, N. W. Galwey et al. · 2010 · PLoS ONE
Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire. After Quality Control, we analysed 430,000 autosomal SNPs together with an additional 1.2 million SNPs imputed with high quality from the Hap Map CEU samples. We found a very small effect of popu
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Haftu Etsay, Teklay Negash, Metkel Aregay · 2019 · Ecological Processes
Sustainable land management is considered as one of the useful approaches to combat the threat of various forms of land degradation in Ethiopia. Despite this, there is scant information regarding households’ decision towards the implementation of sustainable land management practices. This paper, therefore, looks into the determinants for the continued use and choice of the sustainable land management practices by smallholder farmers and its productivity effect in three randomly chosen districts in Tigrai region, Ethiopia. The study uses data from household survey and key informant interviews.
View details →Negative / Null Result ReportOpen accessMedicine
Elisa Maria Stroppa, Ilaria Toscani, Chiara Citterio et al. · 2020 · Future Oncology
Background: We describe cancer patients with coronavirus disease-2019 (COVID-19) infection treated at the Piacenza’s general hospital (north Italy). Materials & methods: 25 cancer patients infected by COVID-19 admitted at the Piacenza’s…
View details →Negative / Null Result ReportOpen accessMedicine
Xuling Lin, M. Lee, Olivia Buck et al. · 2016 · American Journal of Neuroradiology
BACKGROUND AND PURPOSE: Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging modalities do not effectively differentiate them. We aimed to examine the use of DWI and T1-weighted dynamic contrast-enhanced–MR imaging as potential discriminative tools. MATERIALS AND METHODS: We retrospectively reviewed 18 patients with primary CNS lymphoma and 36 matched patients with glioblastoma with pretreatment DWI and dynamic contrast-enhanced–MR imaging. VOIs were drawn around the tumor on contrast-enhan
View details →Negative / Null Result ReportMedicine
Caner Süsal, Dániel Wettstein, Bernd Döhler et al. · 2015 · Transplantation
BACKGROUND: The association of donor-specific HLA antibodies (DSA) with kidney graft failure has been addressed previously; however, the majority of studies were based on small numbers of patients with graft failure. METHODS: We…
View details →Negative / Null Result ReportOpen accessMedicine
David Hodgson, Richard Pebody, Jasmina Panovska‐Griffiths et al. · 2020 · BMC Medicine
BACKGROUND: With a suite of promising new RSV prophylactics on the horizon, including long-acting monoclonal antibodies and new vaccines, it is likely that one or more of these will replace the current monoclonal Palivizumab programme. However, choosing the optimal intervention programme will require balancing the costs of the programmes with the health benefits accrued. METHODS: To compare the next generation of RSV prophylactics, we integrated a novel transmission model with an economic analysis. We estimated key epidemiological parameters by calibrating the model to 7 years of historical ep
View details →Negative / Null Result ReportOpen accessMedicine
Martin D. Hoffman, Julie L. Ingwerson, Ian R. Rogers et al. · 2012 · Wilderness and Environmental Medicine
OBJECTIVE: Very high blood creatine kinase (CK) concentrations have been observed among recent finishers of the 161-km Western States Endurance Run (WSER), and it has been suggested that there is a link between rhabdomyolysis and…
View details →Negative / Null Result Report
Jeffrey Jensen Arnett · 2013 · Emerging Adulthood
This article addresses the question of whether today’s emerging adults are excessively “narcissistic” as claimed by Jean Twenge and others. The answer is a decisive “no.” There is no persuasive evidence that scores on the Narcissistic…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Qilong Lu, Sebahattin Çirak, Terence A. Partridge · 2014 · Molecular Therapy — Nucleic Acids
On 20 September 2013, GlaxoSmithKline (GSK) and Prosensa announced that GSK's Phase III clinical trial (NCT01254019) of Drisapersen, an exon skipping drug for Duchenne muscular dystrophy (DMD), failed to meet the primary endpoint of a…
View details →Negative / Null Result ReportOpen accessMedicine
Raffaele Garofalo, Brody A. Flanagin, Alessandro Castagna et al. · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Complex proximal humeral fractures are very difficult to treat particularly in patients older than 65 years with an osteoporotic bone and tuberosities compromised. The goal of this paper is to evaluate radiological outcomes at mid-term follow-up of proximal humerus fractures treated with reverse shoulder arthroplasty using a dedicated fracture stem. MATERIALS AND METHODS: The study population included 98 patients who underwent reverse shoulder with a dedicated fracture stem for an acute proximal humerus fracture; 87/98 patients were available for analysis. There were 62 female and
View details →Negative / Null Result ReportBusiness, Management and Accounting
Ralph Kober, Thanesvary Subraamanniam, John Watson · 2011 · Accounting and Finance
Abstract This paper examines whether the management accounting practice of total quality management (TQM) positively impacts on the financial performance of small and medium enterprises (SMEs). While research has investigated the impact of…
View details →Negative / Null Result ReportOpen accessMedicine
Yan Xu, Sam Schulman, Dar Dowlatshahi et al. · 2017 · CHEST Journal
BackgroundDirect oral anticoagulants (DOACs) have expanded the armamentarium for antithrombotic therapy. Although DOAC-related major bleeding was associated with favorable outcomes compared with warfarin in clinical trials, warfarin…
View details →Negative / Null Result ReportOpen accessNursing
Theresa J. Ochoa, Jaime Zegarra, Luis Cam et al. · 2014 · The Pediatric Infectious Disease Journal
BACKGROUND: Lactoferrin (LF) is a broad-spectrum antimicrobial and immunomodulatory milk glycoprotein. OBJECTIVE: To determine the effect of bovine LF on the prevention of the first episode of late-onset sepsis in Peruvian infants.…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Roanna George, Stuart J. Moat · 2015 · Clinical Chemistry
BACKGROUND: The analysis of dried blood spots has been used routinely for newborn screening since the early 1970s, and the number of disorders screened has expanded substantially in recent years. However, there is a lack of evidence…
View details →Negative / Null Result ReportOpen accessMedicine
Azra Fatima, Shao Kaifeng, Sven Dittmann et al. · 2013 · PLoS ONE
Long QT syndromes (LQTS) are heritable diseases characterized by prolongation of the QT interval on an electrocardiogram, which often leads to syncope and sudden cardiac death. Here we report the generation of induced pluripotent stems (iPS) cells from two patients with LQTS type 3 carrying a different point mutation in a sodium channel Nav1.5 (p.V240M and p.R535Q) and functional characterization of cardiomyocytes (CM) derived from them. The iPS cells exhibited all characteristic properties of pluripotent stem cells, maintained the disease-specific mutation and readily differentiated to CM. Th
View details →Negative / Null Result ReportOpen accessMedicine
Martin Michaelis, Bishr Agha, Florian Rothweiler et al. · 2015 · Scientific Reports
Flubendazole was shown to exert anti-leukaemia and anti-myeloma activity through inhibition of microtubule function. Here, flubendazole was tested for its effects on the viability of in total 461 cancer cell lines. Neuroblastoma was identified as highly flubendazole-sensitive cancer entity in a screen of 321 cell lines from 26 cancer entities. Flubendazole also reduced the viability of five primary neuroblastoma samples in nanomolar concentrations thought to be achievable in humans and inhibited vessel formation and neuroblastoma tumour growth in the chick chorioallantoic membrane assay. Resis
View details →Negative / Null Result ReportMedicine
A. Sertaç Batıoğlu, Uğraş Şahin, Beril Gürlek et al. · 2011 · Gynecological Endocrinology
The aim of the study was to evaluate the efficacy of melatonin administration on oocyte quality in women underwent in vitro fertilization (IVF) cycles. Eighty-five women undergoing IVF cycles were randomized in two groups during IVF-embryo…
View details →Negative / Null Result ReportBusiness, Management and Accounting
Denton Collins, William R. Pasewark, Mark E. Riley · 2012 · Accounting Horizons
SYNOPSIS: This archival study addresses whether the presence or absence of “bright lines” in a lease accounting standard influences the classification of leases as capital or operating. To the best of our knowledge, our study is the first…
View details →