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Browse the failure-mode index

20,253 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The impact of clinical presentation on one-year major adverse cardiac events in patients with angiographically defined moderate to severe calcified coronary artery disease.

Mkrtchjan A, Ntantou E, Siskos AA et al. · 2026 · The Journal of invasive cardiology

Objectives The authors aimed to investigate the impact of clinical presentation on 1-year major adverse cardiac events (MACE) in patients with angiographically defined moderate or severe calcified coronary artery disease. Methods The…

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Negative / Null Result ReportMedicine

In neonates, how effective is lung ultrasonography in directing chest physiotherapy intervention when compared to the combination of chest x-ray and auscultation?

Hough J, Gouveia M, Steele M et al. · 2026 · Physiotherapy

Objective Evaluate the impact of lung ultrasound (LUS) compared to current chest physiotherapy (CPT) outcome measures on clinical decision-making in the Neonatal Intensive Care Unit (NICU). Design and setting Single-centre prospective…

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Negative / Null Result ReportOpen accessMedicine

Effect of cold atmospheric pressure plasma on wettability of implant prosthetic materials: an in-vitro study.

Bayadse M, Grander L, Steiner L et al. · 2026 · International journal of implant dentistry

Purpose Surface wettability is a key factor in bonding of dental materials. The aim of the present study was to investigate the influence of different exposure times of cold atmospheric pressure plasma at constant power on the surface…

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Negative / Null Result ReportMedicine

Peri-Implant Reconstruction With Autogenous Bone and Electrolytic Therapy: A Randomized Controlled Clinical Trial.

Puisys A, Akhondi S, Vindasiute-Narbute E et al. · 2026 · Clinical implant dentistry and related research

Objectives To evaluate the efficacy of peri-implant reconstructive therapy using autogenous tuberosity bone grafts, with or without adjunctive electrolytic therapy, as part of surgical treatment for peri-implantitis. Methods This…

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Negative / Null Result ReportMedicine

Evaluation of an Immune-guided Prevention Strategy Against CMV Among Intermediate-risk Kidney Transplant Recipients: A Quasi-experimental Study.

Caso JM, Fernández-Ruiz M, González E et al. · 2026 · Transplantation

Background Observational studies have shown that kidney transplant (KT) recipients who are cytomegalovirus (CMV)-seropositive (R+) but lack effective CMV-specific cell-mediated immunity (CMV-CMI) are at increased risk of CMV infection.…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the role of high-dose intravenous thiamine supplementation for lactate clearance in patients with cirrhosis and sepsis.

Ali R, Yazdi A, Collins K et al. · 2026 · International journal of critical illness and injury science

Background Thiamine is a vitamin that plays a role in lactate clearance. Patients with sepsis may present with elevated lactate, and also in cirrhosis, as lactate is hepatically metabolized. Prior studies showed mixed results regarding the…

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Negative / Null Result ReportMedicine

Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy (MIP) for Primary Hyperparathyroidism With Concordant Localisation.

Chew BMH, Lim SSA, Gan TRX et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Objective There is increasing use of intraoperative parathyroid hormone (ioPTH) in minimally invasive parathyroidectomy (MIP). While ioPTH has improved cure rate, there is little evidence to suggest effectiveness in primary…

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Negative / Null Result ReportMedicine

Impact of eravacycline on fibrinogen.

Stevenson E, Ponder M, Daniels L et al. · 2026 · The Journal of antimicrobial chemotherapy

Objectives While tigecycline has been associated with hypofibrinogenaemia, limited data with eravacycline suggest this may also occur with this agent. However, the incidence and clinical significance of this finding are not well defined.…

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Negative / Null Result ReportMedicine

There Is No Clinical and Radiological Difference between Suspensory and Cortical Button Fixation at the Treatment of Medial Meniscus Posterior Root Tear.

Sarikaya G, Paksoy AE, Karaşahin Ö et al. · 2026 · Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Purpose of the study The purpose of this prospective study was to compare the two surgical techniques; (Transosseous Fixation with the Suspensory Fixation System technique and Pull Out Suture Repair) for clinical and radiologic scores and…

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Negative / Null Result ReportMedicine

Vasopressors or Fluids in Early Septic Shock.

Peake SL, Macdonald SPJ, Howe BD et al. · 2026 · The New England journal of medicine

Background The optimal approach to early resuscitation in septic shock is unknown. Equipoise exists between the use of larger volumes of intravenous fluids to restore perfusion and the use of early vasopressor therapy along with smaller…

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Negative / Null Result ReportMedicine

The Cost-Utility of a Workplace Mental Health Program for Employees with Common Mental Disorders (FRIAA Project).

Mulfinger N, Waldmann T, Herold R et al. · 2026 · The journal of mental health policy and economics

Background Common mental disorders (CMDs) are a leading cause of sickness absence and early retirement due to health problems. Early identification and treatment of CMDs may have a positive impact on prognosis and associated economic…

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Negative / Null Result ReportMedicine

Contribution of oilseed waste on the development of the edible insect species Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae): From trash to cash.

Baliota GV, Rumbos CI, Athanassiou CG · 2026 · The Science of the total environment

The lesser mealworm, Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae), has attracted considerable commercial interest as an authorized insect species for use as food and feed, thanks to many important features that enable its…

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