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Browse the failure-mode index

19,885 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The Efficacy of 5% Propolis Gel in the Treatment of Primary Herpetic Gingivostomatitis in Children and Its Effect on Salivary IFN-γ Levels: A Parallel Randomized Controlled Pilot Trial.

Shalaby R, Sadek GEM, Gamil Y et al. · 2026 · European journal of dentistry

Objectives This pilot trial was designed to investigate the efficacy of propolis-based gel in the treatment of primary herpetic gingivostomatitis in children and assessed salivary IFN-γ levels before and after treatment to reflect the…

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Negative / Null Result ReportMedicine

Comparison of Knee Extensor Mechanism, Function, and Flexion Range of Motion Between Obese and Nonobese Patients After Simultaneous Bilateral Total Knee Arthroplasty: A Retrospective Follow-up Study.

Bakırhan S, Şahinoğlu E, Ünver B et al. · 2026 · The journal of knee surgery

Abstract Conflicting findings exist regarding the association between obesity and functionality after total knee arthroplasty (TKA). We aimed to compare knee extensor mechanism function, knee function, and knee flexion range of motion…

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Negative / Null Result ReportOpen accessMedicine

Health Storylines Mobile Application and Self-management among Chronically Ill Patients: A Quasi-experimental Research Design.

Moreno-Lacalle RC, Agbayani KPG, Alog JR et al. · 2026 · Acta medica Philippina

Background Self-management is crucial for individuals with chronic illnesses. While mobile applications (mAPPs) have emerged to support diverse health needs, evidence regarding their efficacy for self-management among chronically ill…

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Negative / Null Result ReportOpen accessMedicine

Impact of Post-Curing Exposure Time on the Dimensional Fidelity of 3D-Printed Provisional Crowns: A Root Mean Square (RMS) Evaluation.

Anghel MA, Mitruț I, Ionescu M et al. · 2026 · Journal of functional biomaterials

Background Dimensional stability during post-curing exposure time is critical for the clinical success of 3D-printed restorations. This study evaluates how different post-curing protocols affect the accuracy of provisional crowns. Methods…

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Negative / Null Result ReportOpen accessMedicine

Impact of a structured case report on self-reported responses to simulated emergency scenarios: a randomized survey-based study.

Porschen C, Hellenthal KEM, Zarbock A et al. · 2026 · Scientific reports

Case reports are a long-standing component of medical research, but their association with self-reported responses to simulated clinical scenarios remains underexplored. This study investigated whether exposure to a structured case report…

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Negative / Null Result ReportOpen accessMedicine

Subcutaneous Tranexamic Acid Achieves Comparable Serum Concentrations to Intramuscular Administration During Haemorrhagic Shock in a Swine Model.

Lynghaug T, Fuskevåg OM, Storm BS et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Tranexamic acid is an antifibrinolytic agent reducing mortality when administered to trauma patients with haemorrhagic shock. This mortality reduction is time sensitive. Increased intramuscular dose administration has proven an…

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Negative / Null Result ReportOpen accessMedicine

Impact of tumor budding on recurrence risk prediction in stage I-III colorectal cancer: a Swedish cohort study.

Barot S, Andersson-Franko M, Ghazi S et al. · 2026 · American journal of clinical pathology

Objectives Tumor budding is an emerging micromorphologic predictor of recurrence in localized colorectal cancer (CRC). Whether its addition to established CRC recurrence risk factors routinely assessed in clinical practice improves…

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Negative / Null Result ReportMedicine

Feasibility of Individualized Homoeopathic Treatment in Temporomandibular Joint Dysfunction: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial.

Bhattacharjee B, Ghosh S, Basu N et al. · 2026 · Journal of integrative and complementary medicine

Objectives To assess the feasibility of conducting a randomized controlled trial and to explore preliminary effects of individualized homoeopathic medicines (IHMs) compared with placebo in patients with temporomandibular joint dysfunction…

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Negative / Null Result Report

The Inflation Reduction Act’s Impact Upon Late-Stage R&D

Bowen HP, O’Loughlin G, Schleicher C et al. · 2026 · Preprint

Background The impact of the Inflation Reduction Act (IRA) upon late-stage developments has been assumed to be limited. The Congressional Budget Office’s IRA analysis excluded post-approval innovation, potentially overlooking substantial…

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Negative / Null Result ReportMedicine

Association between short-term air pollution exposure and the risk of fatal recurrence within 1 year in patients with first-episode acute hemorrhagic stroke: a time-stratified case-crossover study.

Gu X, Liu J, Wang H et al. · 2026 · Frontiers in public health

Objective To analyze the association between short-term exposure to air pollutants and the risk of fatal recurrence within 1 year in patients with first-episode acute hemorrhagic stroke, to provide scientific basis for health management…

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Negative / Null Result ReportOpen accessMedicine

Associations between fat distribution and obstructive sleep apnea severity among individuals with type 2 diabetes: an MRI-based study.

Ahtola K, Ulander M, Agholme J et al. · 2026 · Scientific reports

Obstructive Sleep Apnea (OSA) affects 1 billion people globally, with a male-to-female ratio of 2:1. While obesity is a major risk factor, sex differences in fat distribution may influence OSA risk. This study examined the relationship…

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Negative / Null Result ReportMedicine

Knowledge, attitudes, and practices of occupational health and safety measures among nurses at Bolgatanga Regional Hospital of Ghana.

Ti-Enkawol Nachinab G, Alem JN, Coffie GB · 2026 · BMC health services research

Introduction Occupational health and safety are major concerns for health workers worldwide. Nurses working in resource-constrained areas are at higher risk of occupational hazards. The purpose of the study was to assess the knowledge,…

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Negative / Null Result ReportMedicine

Proximal femoral bionic nail is associated with lower postoperative complication risk and better early functional recovery in older patients with intertrochanteric fractures: a retrospective cohort study.

Luo X, Ma N, Yang Y et al. · 2026 · BMC surgery

Objective Proximal femoral bionic nail (PFBN) represents a novel biomechanical design for the internal fixation of intertrochanteric fractures in older adults. However, comparative real-world evidence between PFBN and the conventional…

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Negative / Null Result ReportMedicine

Role of Prenatal Ultrasound and Fetal MRI in Diagnosing Congenital Anomalies of the Kidney and Urinary Tract: A Comparative Diagnostic Study.

Thompson GE, Wesemann LB, Ogundipe EA et al. · 2026 · Fetal diagnosis and therapy

Prenatal diagnoses of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are critical for counseling families about potential postnatal outcomes. While ultrasound (US) remains the gold standard for prenatal diagnosis of CAKUT,…

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Negative / Null Result ReportMedicine

Comparative efficacy of intraoperative wound irrigation with aqueous chlorhexidine versus normal saline to prevent surgical site infections: a double-blind randomized controlled trial.

Kultanaruangnonth M, Chatrung L, Tansawet A et al. · 2026 · World journal of emergency surgery : WJES

Background Surgical site infections (SSIs) remain a major concern after abdominal surgery, with incidences of 15-22%. Intraoperative wound irrigation (IOWI) before closure is routinely performed to reduce bacterial contamination, but the…

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Negative / Null Result ReportMedicine

[Comparative analysis of the efficacy between endoscopic submucosal dissection combined with low-dose radiotherapy and direct surgical resection for T1a-MM/T1b-SM stage esophageal squamous cell carcinoma].

Geng YQ, Ding Y, Fu CG et al. · 2026 · Zhonghua yi xue za zhi

Objective: To compare the efficacy between endoscopic submucosal dissection (ESD) combined with low-dose radiotherapy and direct surgical resection in patients with T1a-MM/T1b-SM stage esophageal squamous cell carcinoma. Methods: A…

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Negative / Null Result ReportOpen accessMedicine

Resuscitative endovascular occlusion of the aorta restores cerebral metabolic markers of ischaemia induced by haemorrhagic shock.

Bader SE, Magnuson A, Brorsson C et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Background Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used as an adjunct in haemorrhagic shock (HS) to restore proximal perfusion. Its cerebral metabolic effects during haemorrhagic shock, particularly in the…

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