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Browse the failure-mode index

20,253 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

How Speaker Configuration of Recorded Media Affects Subjective Ratings for Listeners With and Without Hearing Loss.

Ricketts TA, Krivoshey R, Santos-Garrido J et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Purpose The purpose of this study was to evaluate the effects of loudspeaker configuration and relative dialogue-to-background sound levels on subjective ratings of speech understanding and sound quality of recorded media for listeners…

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Negative / Null Result ReportMedicine

Temporal Masking Assessed With Cortical Auditory Evoked Potentials.

Maynart V, Menezes P, Batista C et al. · 2026 · Ear and hearing

Abstractobjectives The purpose of this experiment was to determine the effects of sequential sounds on cortical auditory evoked potentials and to investigate temporal masking. The study tested the hypotheses that forward masking reduces…

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Negative / Null Result ReportMedicine

Examining the Factor Structure and Subgroup Invariance of the Deliberate Denial of Disordered Eating Behaviors Scale.

Howard L, Hawn S, Pitchford KD et al. · 2026 · Behavioral sciences (Basel, Switzerland)

The denial, concealment, or omission of disordered eating behaviors has received limited attention in the eating disorder literature, partly due to the lack of reliable and valid measures. This study re-examined the factor structure of the…

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Negative / Null Result ReportMedicine

Association of Prophylactic Corticosteroids with Post-Extubation Outcomes in Pediatric Cardiac Critical Care: A Retrospective Propensity-Weighted Cohort Study.

Saengsin K, Jirattikanwong N, Wongyikul P et al. · 2026 · Journal of clinical medicine

Background/Objectives : Post-extubation stridor (PES) is common in pediatric critical care and may contribute to extubation failure, particularly in children with heart disease. Prophylactic corticosteroids are frequently used before…

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Negative / Null Result ReportMedicine

Does a non-dipping heart rate profile predict adverse maternal-fetal outcomes? evidence from 24-h ambulatory monitoring in the second half of high-risk pregnancies.

Espeche W, Minetto J, Cerri G et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension

Hypertensive disorders of pregnancy are a leading cause of maternal-fetal morbidity and mortality, with preeclampsia representing a major contributor to adverse outcomes. Ambulatory blood pressure monitoring (ABPM) has improved risk…

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Negative / Null Result ReportMedicine

Clinical Evaluation of a Real-Time Wearable System for Monitoring In-Hospital Ambulatory Patients With COVID-19: Retrospective Data Study.

Vollam S, Roman C, Santos M et al. · 2026 · JMIR medical informatics

Background Many studies have evaluated the use of wearable monitoring systems to improve patient safety in hospital. Although some have demonstrated effects on intensive care admissions, there remains little evidence of impact on patient…

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Negative / Null Result Report

Physical activity during anthracycline chemotherapy: exploratory secondary analysis of a randomized trial of functional capacity, free-living activity, and ejection fraction

Appiah KN, Sharma N, Adu N et al. · 2026 · Preprint

Abstract Background: Anthracycline-based chemotherapy produces progressive functional decline and cardiotoxicity in adults with cancer. Physical activity interventions may attenuate these effects, yet evidence across multiple domains…

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Negative / Null Result Report

Colocalization Reprioritizes the Major Depressive Disorder Druggable Genome: Demotion of the Top TWAS Signal (DRD2) and Nomination of SLC12A5/FURIN/DCC by Direction-Aware, Confirmation-Gated Analysis of 635 GWAS Loci

Kang B · 2026 · Preprint

Abstract Background: Major depressive disorder (MDD) is highly polygenic, yet translating genome-wide association study (GWAS) findings into therapeutics remains challenging. Using PGC MDD2025, we integrated gene-level mapping, brain TWAS,…

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Negative / Null Result ReportMedicine

Relationships Between Estradiol Levels and Vaginal Lactobacillus Abundance Across the Menstrual Cycles in Women.

Koczur K, Blukacz M, Galbarczyk A et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Microbiota of the urogenital tract is crucial for women's reproductive and sexual health and is largely dominated by Lactobacillus strains. A reduction of these bacteria within the vaginal microbial community has been linked to…

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Negative / Null Result ReportMedicine

Voxel-wise case-control analysis of dose, linear energy transfer and symptomatic brainstem necrosis in pediatric brain tumors treated with proton therapy.

Handeland AH, Indelicato DJ, Engeseth GM et al. · 2026 · International journal of radiation oncology, biology, physics

Introduction Brainstem necrosis is a rare but serious toxicity following radiotherapy for pediatric brain tumors. In proton therapy (PT), concerns have emerged around elevated linear energy transfer (LET) and the relative biological…

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Negative / Null Result ReportMedicine

Fragmentation as a population rate-changer: A field experiment.

Nichols JD, Hines JE, Hinz RL et al. · 2026 · Ecology

Experimental and observational studies of effects of fragmentation on biodiversity and population dynamics have produced mixed results, with some reviews concluding strong evidence of negative effects and others concluding small positive…

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Negative / Null Result ReportMedicine

Prevention or relief? Voters' support for disaster policies.

Kim HH, Cragun J, DeScioli P · 2026 · Disasters

Researchers have argued that preventing disasters is more efficient than providing relief. Yet, previous scholarship has found that voters in the United States reward politicians more for relief than for prevention policies. It is unclear,…

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Negative / Null Result ReportMedicine

Educational Interventions to Improve Student Pharmacists' Empathy and Attitudes Toward Older Adults or Aging: A Scoping Review.

Gray SL, Liberman M, Onukwufor E et al. · 2026 · American journal of pharmaceutical education

Objectives Ageism remains a pervasive barrier to delivering high-quality health care to older adults. The objective of this scoping review is to describe studies on educational interventions aimed at improving the empathy and attitudes of…

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Negative / Null Result ReportMedicine

Exploring Dimensions of Posttraumatic Stress in Young Children.

Mulligan DJ, Grasso DJ, Greene CA et al. · 2026 · Research on child and adolescent psychopathology

The latent structure of posttraumatic stress symptoms (PTSS) in early childhood remains poorly understood. This study aimed to assess PTSS in young children, identify underlying latent constructs, and evaluate their construct validity.…

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