Negative / Null Result ReportMedicine
Bhardwaj A, Saili A, Yadav DK et al. · 2025 · Journal of neonatal-perinatal medicine
BackgroundThe prolonged ductal patency in preterm newborns despite being associated with short- and long-term morbidities has failed to show significant improvement in the long-term outcome with routine ductal treatment. Echocardiography…
View details →Negative / Null Result ReportMedicine
Van Gent JM, Clements TW, Gurney JM et al. · 2025 · The journal of trauma and acute care surgery
Background Empiric cryoprecipitate administration has recently failed to show survival benefit in hemorrhaging trauma patients. However, a recent Trauma Quality Improvement Program query suggested a survival benefit in massive transfusions…
View details →Negative / Null Result ReportMedicine
Sant VR, Zhou H, Zhou MM et al. · 2025 · The Journal of clinical endocrinology and metabolism
Context Primary hyperparathyroidism (PHPT) has initially been implicated in adverse maternal and neonatal outcomes, while subsequent population studies have failed to show an association. Objective This work aimed to compare maternal,…
View details →Negative / Null Result Report
Perdue MV, Geeraert BL, Manning KY et al. · 2024 · Preprint
Numerous studies have linked reading ability to white matter microstructure using diffusion tensor imaging, but recent large studies have failed to show consistency. Fiber-specific diffusion-weighted magnetic resonance imaging (dMRI)…
View details →Negative / Null Result ReportMedicine
Wang X, Men C, Shan S et al. · 2025 · Gene
Chemoresistance is a considerable challenge for gastric cancer (GC), and the combination of cisplatin (DDP) and anti-EGFR therapy failed to show remarkable benefit. So other targets in EGFR-overexpressed and DDP-resistant GC need to be…
View details →Negative / Null Result ReportMedicine
Drieghe B, De Buyzere M, Bové T et al. · 2024 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Randomized clinical trials failed to show additional benefit of renal artery stenting on top of medical therapy. Instead of writing an obituary on renal artery stenting, we try to explain these disappointing results. A transstenotic…
View details →Negative / Null Result Report
Davani SZ, Pazooki D, Kamalzadeh N · 2024 · Preprint
41-year-old male with no significant past medical history presented as an outpatient with atypical chest pain and had positive nuclear stress test. The patient subsequently underwent left heart catheterization, which revealed a fistula…
View details →Negative / Null Result ReportMedicine
Morimoto J, Satogami K, Naraoka T et al. · 2024 · International heart journal
Deficiency of vitamin B 1 (VB1), an essential micronutrient, causes heart failure (HF). A recent randomized controlled trial failed to show any improvement in HF prognosis after short-term VB1 supplementation. In the current study, we…
View details →Negative / Null Result ReportMedicine
Canning C, McCormack T, Clifford E et al. · 2024 · The British journal of developmental psychology
Previous studies have failed to show an effect of episodic future thinking (EFT) on children's delay of gratification (DoG), contrasting strikingly with adult findings. Recent findings from a sample of 8-11-year-old children by Canning et…
View details →Negative / Null Result ReportMedicine
Danahay H, McCarthy C, Schofield T et al. · 2025 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Inhibiting ENaC in the airways of people with cystic fibrosis (pwCF) is hypothesized to enhance mucociliary clearance (MCC) and provide clinical benefit. Historically, inhaled ENaC blockers have failed to show benefit in pwCF…
View details →Negative / Null Result ReportMedicine
Cornell CA, Norman KA, Griffiths TL et al. · 2024 · Psychological science
We often use cues from our environment when we get stuck searching our memories, but prior research has failed to show benefits of cuing with other, randomly selected list items during memory search. What accounts for this discrepancy? We…
View details →Negative / Null Result ReportMedicine
Wan H, Myerson J, Green L et al. · 2025 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Previous studies failed to find age-related differences in the discounting of delayed, monetary losses, potentially due to their failure to examine the effects of income and their use of relatively small loss amounts.…
View details →Negative / Null Result ReportOpen accessMedicine
Gibb RD, Brum JM, Sloan KJ et al. · 2025 · Journal of travel medicine
What can be concluded from a clinical trial that spanned 5 years yet failed to achieve target enrollment, generated flat results that contradict the existing body of knowledge and has a primary efficacy endpoint confounded by a…
View details →Negative / Null Result ReportMedicine
Chevalley S, Wängberg V, Åhlén M et al. · 2024 · The Journal of hand surgery
Purpose There is no consensus on the optimal postoperative rehabilitation program following flexor tendon repair. Some studies suggest a faster recovery after active mobilization, whereas other studies have failed to find any differences…
View details →Negative / Null Result Report
Cassario A, Brandt MJ · 2024 · Preprint
Recent attempts to establish the veracity of the conservative shift hypothesis have failed to find supportive evidence. Instead, this work yields inconsistent results and reveals considerable individual differences in ideological responses…
View details →Negative / Null Result ReportMedicine
Madill-Thomsen KS, Gauthier PT, Abouljoud M et al. · 2025 · Transplantation
Background Initial analysis of liver transplant biopsies in the INTERLIVER study ( ClinicalTrials.gov ; unique identifier NCT03193151) using rejection-associated transcripts failed to find an antibody-mediated rejection state (ie, rich in…
View details →Negative / Null Result ReportMedicine
Stone BM, Hammersley JJ, Rabinovich NE et al. · 2024 · Experimental and clinical psychopharmacology
In contrast to overnight deprivation versus satiety studies, a small number of placebo-controlled studies have failed to find that nicotine administration reduces attentional bias (AB) to smoking cues. To assess the reliability of this…
View details →Negative / Null Result Report
Liu R, Cheng W · 2023 · Preprint
Background Previous observational studies in patients with diabetes have examined the relationship between insulin resistance (IR) and cognitive outcomes and failed to find that IR is associated with cognitive function. And the…
View details →Negative / Null Result ReportOpen accessMedicine
Catling FJR, Nagendran M, Festor P et al. · 2024 · Critical care explorations
Large randomized trials in sepsis have generally failed to find effective novel treatments. This is increasingly attributed to patient heterogeneity, including heterogeneous cardiovascular changes in septic shock. We discuss the potential…
View details →Negative / Null Result ReportOpen accessMedicine
Saki F, Shams M, Dastghaib S et al. · 2023 · BioMed research international
Background Recent researches have failed to uncover a clear explanation for proton pump inhibitors' bone-loss effects. In light of pantoprazole's effects on gastrin secretion, the goal of this study was to see if it caused bone loss…
View details →Negative / Null Result ReportMedicine
Platts CR, Groh AM, Runze J et al. · 2026 · Attachment & human development
Initial molecular genetic studies identified specific genes that contribute to variation in associations between maternal sensitivity and infant attachment, but these findings from small samples failed to replicate in larger-sample…
View details →Negative / Null Result ReportMedicine
Kong SH · 2026 · Endocrinology and metabolism (Seoul, Korea)
For decades, vitamin D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with…
View details →Negative / Null Result ReportMedicine
Salwei M, Tang LA, Vogus TJ et al. · 2026 · Health care management review
Background Health care organizations have failed to replicate the performance of high-reliability organizations (HROs), systems that operate nearly error-free despite inherently complex, interdependent, and time-pressured environments.…
View details →Negative / Null Result ReportMedicine
Zhang X, Gunderson EA · 2025 · Developmental psychology
Spatial skills in early childhood are key predictors of mathematical achievement. Previous studies have found that training mental rotation can transfer to arithmetic skills; however, some studies have failed to replicate this transfer…
View details →Negative / Null Result Report
Boyce V, Mathur MB, Frank MC · 2023 · Preprint
Cumulative scientific progress requires empirical results that are robust enough to support theory construction and extension. Yet in psychology, some prominent findings have failed to replicate, and large-scale studies suggest…
View details →Negative / Null Result Report
Pitz V, Makarious M, Bandrés-Ciga S et al. · 2023 · Preprint
Abstract Objective Although many rare variants have been reportedly associated with Parkinson’s disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants.…
View details →Negative / Null Result Report
Chang J, Pais GM, Marianski S et al. · 2023 · Preprint
Recent clinical studies have reported additive nephrotoxicity with the combination of vancomycin and piperacillin-tazobactam. However, preclinical models have failed to replicate this finding. This study assessed differences in…
View details →Negative / Null Result ReportMedicine
Odintsova VV, van Dongen J, van Beijsterveldt CEM et al. · 2023 · Twin research and human genetics : the official journal of the International Society for Twin Studies
In studies of singletons, a range of early-life characteristics have been reported to be associated with handedness, but some of these associations have failed to replicate. We examined associations between 23 early life characteristics…
View details →Negative / Null Result ReportMedicine
Legendre M, Sabourin S, Bégin C · 2022 · Eating and weight disorders : EWD
Purpose A higher risk of food addiction (FA) in individuals reporting childhood sexual abuse (CSA) has been well demonstrated with community samples, but studies including clinical samples failed to replicate this relation. This study…
View details →Negative / Null Result ReportMedicine
Zhang J, Whitehurst LN, Mednick SC · 2022 · Neurobiology of learning and memory
Prior studies suggest a role for sleep in memory consolidation, with specific contributions from slow oscillations and sleep spindles (Rasch & Born, 2013). However, recent studies failed to replicate sleep's superiority over wake in…
View details →