Negative / Null Result ReportOpen accessBiochemistry
Ljiljana Bošković-Rakočević, Tomo Milošević, Jelena Milivojević et al. · 2012 · Acta Scientiarum Polonorum: Hortorum Cultus
Mineral nutrition of apricot is very specific and depends on different factors such as soil fertility, soil pH, weather conditions, cultivars, rootstocks, fertilizers, age of trees etc. For these reasons, during 2008 and 2009 we evaluate nutrient status of five apricot cultivars (Vera, Aleksandar, Biljana, Harcot, Roxana) at 120 days after full bloom (DAFB) grown on acidic soil in the region of Čačak (Western Serbia). The results showed no statistically significant variations in the N, K and Ca content of apricot leaves among cultivars, as opposed to significant differences in the content of P
View details →Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Sebastian M. Christ, Markus Schettle, Annina Seiler et al. · 2021 · Clinical and Translational Radiation Oncology
Background: Radiotherapy plays an important role for symptom control in advanced stage cancer patients. Yet patients need to be carefully selected, and its use and benefits must be weighed against time spent under treatment and patient priorities in the last phase of life. In this study, we assess prevalence, indications and outcomes of radiotherapy close to death. Methods: We screened all radiotherapy treatments performed at the Department of Radiation Oncology of the University Hospital Zurich between January 2010 and December 2019 to identify those which occurred near patients’ end-of-life.
View details →Negative / Null Result ReportOpen accessSurgery
René Hage, Macé M. Schuurmans · 2022 · Transplantology
Introduction: We report on characteristics and lung function outcomes among lung transplant recipients (LTRs) after COVID-19 with infections occurring in the first year of the coronavirus pandemic prior to introduction of the vaccines. Methods: This was a retrospective study of 18 LTRs who tested positive for SARS-CoV-2 between 1 February 2020 and 1 March 2021. The mean age was 49.9 (22–68) years; 12 patients (67%) were male. Two patients died due to severe COVID-19. Results: During the study period, there were 18 lung transplant recipients with a community-acquired SARS-CoV-2 infection. In th
View details →Negative / Null Result ReportOpen accessInformation technology
Pang, Yan, Molton, James Steven, Ooi, Wei Tsang et al. · 2020 · JMIR mHealth and uHealth
BackgroundAs people living with HIV infection require lifelong treatment, nonadherence to medication will reduce their chance of maintaining viral suppression and increase the risk of developing drug resistance and HIV transmission. ObjectiveThis study aimed to evaluate the efficacy of a mobile app, Mobile Interactive Supervised Therapy (MIST), for improving adherence to oral HIV medications among HIV-infected adults in Singapore. MethodsWe conducted a two-group pilot randomized controlled trial (RCT) with a process evaluation, in which 40 HIV-infected participants with once-daily medication r
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Josef Pannee, Leslie M. Shaw, Magdalena Korecka et al. · 2021 · Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Abstract Introduction Blood‐based assays to measure brain amyloid beta (Aβ) deposition are an attractive alternative to the cerebrospinal fluid (CSF)–based assays currently used in clinical settings. In this study, we examined different blood‐based assays to measure Aβ and how they compare among centers and assays. Methods Aliquots from 81 plasma samples were distributed to 10 participating centers. Seven immunological assays and four mass‐spectrometric methods were used to measure plasma Aβ concentrations. Results Correlations were weak for Aβ42 while Aβ40 correlations were stronger. The rati
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Gulsen Ozen, Michael O'Rorke, Paul Romitti et al. · 2026 · ACR Open Rheumatology
Objective The aim of this study was to develop and validate International Classification of Diseases (ICD) code–based algorithms for identifying systemic sclerosis (SSc) cases within electronic health record (EHR) data and to evaluate algorithm performance. Methods We identified patients with at least one ICD, Ninth Revision (ICD‐9)/ICD‐10 code for SSc in a large multicenter EHR dataset (TriNetX Research Network). A random sample of patients underwent detailed medical record review to confirm SSc diagnosis (gold standard). All ICD‐9/10 codes assigned during inpatient or outpatient encounters a
View details →Negative / Null Result ReportOpen accessAnimal culture
G. Martemucci, A. G. D'Alessandro · 2010 · Italian Journal of Animal Science
Two experiments were carried out in Martina Franca asses in order to study milk yield and udder healthy conditions in relation to daily milking number and frequency. Experiment I - A total of 15 asses were subdivided into three groups (N.5) corresponding to: one milking per day, after a 3 hour interval from foal separation by dams (Group A); three milkings per day with 3 hour frequency (Group B); three milkings per day with 2 hour frequency (Group 3M). Experiment II - Evaluation was made of the effect of a schedule of 6 milkings per day with frequency of 2 hours on milk yield (Group 6M; N. 5),
View details →Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Myrthe E. Sonneveld, Myrthe E. Sonneveld, Carolien A. M. Koeleman et al. · 2018 · Frontiers in Immunology
After albumin, immunoglobulin G (IgG) are the most abundant proteins in human serum, with IgG1 and IgG3 being the most abundant subclasses directed against protein antigens. The quality of the IgG-Fc-glycosylation has important functional consequences, which have been found to be skewed toward low fucosylation in some antigen-specific immune responses. This increases the affinity to IgG1-Fc-receptor (FcγR)IIIa/b and thereby directly affects downstream effector functions and disease severity. To date, antigen-specific IgG-glycosylation have not been analyzed for IgG3. Here, we analyzed 30 pregn
View details →Negative / Null Result ReportOpen accessChemical technology
Caterina Pagnini, Giacomo Sampietro, Gaia Santini et al. · 2023 · Foods
Microalgae, because of their high nutritional value and bioactive molecule content, are interesting candidates for functional foods, including fermented foods, in which the beneficial effects of probiotic bacteria combine with those of biomolecules lying in microalgal biomass. The aim of this work was to evaluate the potential of Tisochrysis lutea F&M-M36 as a substrate for Lactiplantibacillus plantarum ATCC 8014 and to verify fermentation effects on functionality. Bacterium selection among three lactobacilli was based on growth and resistance to in vitro digestion. Microalgal raw biomass and
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Maysa S. Campos, José B. Volpon, João Paulo B. Ximenez et al. · 2022 · Frontiers in Endocrinology
ObjectiveTo investigate the effects of vibration therapy on fracture healing in diabetic and non-diabetic rats.Methods148 rats underwent fracture surgery and were assigned to four groups: (1) SHAM: weight-matched non-diabetic rats, (2) SHAM+VT: non-diabetic rats treated with vibration therapy (VT), (3) DM: diabetic rats, and (4) DM+VT: diabetic rats treated with VT. Thirty days after diabetes induction with streptozotocin, animals underwent bone fracture, followed by surgical stabilization. Three days after bone fracture, rats began VT. Bone healing was assessed on days 14 and 28 post-fracture
View details →Negative / Null Result ReportMedicine
Xu, Wu, Liu et al. · 2026 · Annals of hematology
In adult patients with early-stage follicular lymphoma (FL), age-related differences in the risk of non-lymphoma-related death (LRD) during the follow-up period after treatment are unclear. We aimed to investigate the interactive effects…
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Ce Zhou, You Zhou, Niannian Shuai et al. · 2024 · Frontiers in Cardiovascular Medicine
Background and aimEstimated glomerular filtration rate (eGFR) is a key indicator of kidney function and is associated with numerous health conditions. This study examines the association between eGFR and cardiovascular disease (CVD) risk in a representative cohort of the US adult population.MethodsA cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. The study included 31,020 participants aged 20 years and older. The eGFR estimates were calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD
View details →Negative / Null Result ReportOpen accessMedicine
Lijing Ma, Heng Su, Yan Wang et al. · 2020 · European Journal of Inflammation
Variants of the interleukin-1β (IL-1β) gene have been associated with type 2 diabetes (T2D) and coronary artery diseases (CAD). However, association of IL-1β polymorphisms with diabetic patients having CAD clinical manifestation has not been studied yet. In this study, we aim to decipher the role of IL-1β common promoter variants with susceptibility/resistance to development of CAD in T2D patients. T2D patients with (n = 134) or without CAD (n = 533) were enrolled. A total of 513 essentially healthy individuals from the same population were included in this study as control. Plasma levels of I
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Keyi Wu, Huamin Liu, Jiazhen Zheng et al. · 2022 · Frontiers in Aging Neuroscience
Background: Diabetes mellitus (DM) is a recognised risk factor for cognitive dysfunction. The purpose of this study was to explore the relationship between active treatment for DM and cognitive function in middle-aged (< 60 years) and older adults (≥60 years), respectively.Methods: A total of 13,691 participants (58.55 ± 9.64 years, 47.40% of men) from the Chinese Health and Retirement Longitudinal Study (CHARLS) were included. The participants were classified into three groups according to whether or not they have diabetes and to their diabetes treatment status: diabetes-free, treated-diabete
View details →Negative / Null Result ReportOpen accessPediatrics
Mohamad A. Alanbari, Mohamad A. Alanbari, Hebah M. Hamdan et al. · 2024 · Frontiers in Pediatrics
Background/AimManaging young children with negative behaviors can be challenging in dental settings. Moderate sedation (MS) is often used as a treatment option for such children. However, children's behavior during MS may vary depending on several variables. These variables include parental factors, such as parental anxiety, coping strategies, and pain catastrophizing. However, this area, particularly in Saudi Arabia, remains underexplored. Therefore, this study aimed to assess the association among parental anxiety, coping style, pain catastrophizing, and children's behavior during MS among S
View details →Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Yanhua Liu, Shunping Ma, Xuemin Huang et al. · 2023 · Frontiers in Nutrition
BackgroundMany studies have suggested that the serum concentrations of vitamin A (VA) and vitamin E (VE) influence preeclampsia (PE) risk in pregnant women. However, few studies have assessed whether dietary intake and serum concentrations of VA and VE are correlated with PE risk.MethodsA 1:1 matched case-control study was conducted to explore the association between the dietary intake and serum concentrations of VA and VE and the risk of PE in pregnant Chinese women. A total of 440 pregnant women with PE and 440 control pregnant women were included in the study. Dietary information was obtain
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Chaoqun Feng, Junjie Yao, Yizhou Xie et al. · 2024 · BMC Public Health
Abstract Background Low back pain is the leading cause of productivity loss, imposes a significant economic burden on the patients and society. Oxidative stress is considered a critical factor in the complex pathophysiological process and pathogenic mechanism of low back pain. Adjustment dietary pattern can effectively increase antioxidant biomarkers levels within the body to reduce oxidative stress. The composite dietary antioxidant index (CDAI) serves a reliable scoring system for quantifying the potential dietary antioxidant capacity of daily diets. Objective We aim to investigate the poten
View details →Negative / Null Result ReportMedicine
Beri, Patil, Sharma et al. · 2026 · Journal of glaucoma
Aqueous humor outflow (AHO) is significantly lower in primary angle closure glaucoma (PACG) compared to primary open angle glaucoma (POAG). To quantitatively compare circumferential,perilimbal aqueous humor outflow(AHO) pathways in…
View details →Negative / Null Result ReportOpen accessPediatrics
Uchenna Modestus Nnaji, Christian Chukwukere Ogoke, Henrietta Uche Okafor et al. · 2020 · International Journal of Pediatrics
Background. Sickle cell nephropathy (SCN) is a serious complication of sickle cell anaemia (SCA) with asymptomatic onset in childhood and possible progression to chronic kidney disease (CKD). In Southeast Nigeria, few studies have evaluated renal function in paediatric SCA patients for early detection of renal impairment and early intervention to reduce morbidity and mortality. Therefore, this study evaluated the renal function of paediatric SCA patients in a steady state based on glomerular filtration rate and urinalysis findings (proteinuria and haematuria). Methods. A cross-sectional study
View details →Negative / Null Result ReportMedicine
Ginesin, Barsheshet-Karif, Mayer et al. · 2026 · Dentistry journal
Background : Peri-implantitis is a prevalent inflammatory condition leading to progressive bone loss around dental implants. In vivo studies widely use murine peri-implantitis models. Micro-computed tomography (micro-CT) is the gold…
View details →Negative / Null Result ReportMedicine
Pinho, Novais, Gonçalves · 2026 · Dentistry journal
Background : Interceptive orthodontic treatment during mixed dentition aims to reduce malocclusion complexity and improve occlusal development. Although Invisalign ® First was introduced for Phase I therapy in growing patients,…
View details →Negative / Null Result ReportMedicine
Izbassarova, Imangaliyeva, Bakhshinyan et al. · 2026 · Audiology research
Background/Objectives: Hearing loss is a leading cause of disability worldwide, with speech perception representing a key functional outcome of auditory rehabilitation. While hearing aids improve audibility, outcomes vary substantially…
View details →Negative / Null Result ReportMedicine
Sucato, Serra, Buttà et al. · 2026 · Microbiology spectrum
Human papillomavirus (HPV) represents the most prevalent sexually transmitted infection worldwide, often presenting as asymptomatic or subclinical in males. There is still uncertainty about the most suitable biological specimen for an…
View details →Negative / Null Result ReportMedicine
Yang · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research
Atypical meningiomas have higher recurrence and mortality than benign variants, and age may influence treatment decisions and outcomes. We evaluated associations between age, treatment modality, and survival in patients with atypical…
View details →Negative / Null Result ReportMedicine
Matsubara, Pletschacher, Schaeffer et al. · 2026 · Cardiology in the young
In hypoplastic left heart syndrome with aortic atresia, the non-functional left ventricle may influence right ventricular performance. We evaluated serial changes in tricuspid and mitral valve diameters after the Norwood procedure and…
View details →Negative / Null Result ReportMedicine
Zhang, Li, Ma et al. · 2026 · Brain research bulletin
This study used event-related potentials (ERPs), time-frequency analysis, and multivariate pattern analysis (MVPA) to investigate how hypnosis modulates visual and auditory processing. Twenty-two highly hypnotizable participants performed…
View details →Negative / Null Result ReportMedicine
Wali, Abbara, Ekhelikar et al. · 2026 · Postgraduate medical journal
Diastolic dysfunction is an important early indicator of heart failure (HF) with preserved ejection fraction (HFpEF). Type 2 diabetes mellitus (T2DM) may contribute to HFpEF, as it is associated with an increased risk of hospitalization…
View details →Negative / Null Result ReportMedicine
Elganzory, Baraka, Elkholy et al. · 2026 · La Clinica terapeutica
Helicobacter pylori infection affects nearly half of the global population and is a major cause of peptic ulcer disease and gastric cancer. Increasing antibiotic resistance, particularly to clarithromycin, has reduced the efficacy of…
View details →Negative / Null Result ReportMedicine
Kilinc, Günaydin, Demirtas et al. · 2026 · Revista da Associacao Medica Brasileira (1992)
The success of anterior cruciate ligament reconstruction depends on anatomical tunnel placement. The aim of this was to compare the effects of 30° and 70° arthroscopes on femoral and tibial tunnel positioning and their…
View details →Negative / Null Result ReportMedicine
Nishimura, Oyama, Hasegawa et al. · 2026 · The Journal of dermatology
Psoriasis is a chronic, immune-mediated inflammatory disease with heterogeneous manifestations. Reliable biomarkers reflecting disease severity and treatment response remain limited. Glycans-carbohydrate structures attached to proteins and…
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