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19,786 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessSocial Sciences

Firm efficiency, foreign ownership and CEO gender in corrupt environments

Jan Hanousek, Anastasiya Shamshur, Jiří Trešl · 2017 · Journal of Corporate Finance

We study the effects of corruption on firm efficiency using a unique dataset of private firms from 14 Central and Eastern European countries from 2000 to 2013. We find that an environment characterized by a high level of corruption has an adverse effect on firm efficiency. This effect is stronger for firms with a lower propensity to behave corruptly, such as foreign-controlled firms and firms managed by female CEOs, while local firms and firms with male CEOs are not disadvantaged. We also find that an environment characterized by considerable heterogeneity in the perception of corruption is as

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Negative / Null Result Report

Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology

Cyrus Kholdani, Wassim H. Fares, Vahid Mohsenin · 2015 · Pulmonary Circulation

The development of pulmonary hypertension is a poor prognostic sign in patients with obstructive sleep apnea (OSA) and affects both mortality and quality of life. Although pulmonary hypertension in OSA is traditionally viewed as a result…

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Negative / Null Result ReportOpen accessMedicine

Blood Biomarkers in Moderate-To-Severe Traumatic Brain Injury: Potential Utility of a Multi-Marker Approach in Characterizing Outcome

Alex P. Di Battista, John E. Buonora, Shawn G. Rhind et al. · 2015 · Frontiers in Neurology

BACKGROUND: Blood biomarkers are valuable tools for elucidating complex cellular and molecular mechanisms underlying traumatic brain injury (TBI). Profiling distinct classes of biomarkers could aid in the identification and characterization of initial injury and secondary pathological processes. This study characterized the prognostic performance of a recently developed multi-marker panel of circulating biomarkers that reflect specific pathogenic mechanisms including neuroinflammation, oxidative damage, and neuroregeneration, in moderate-to-severe TBI patients. MATERIALS AND METHODS: Periphera

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Do Neonatal Mouse Hearts Regenerate following Heart Apex Resection?

Ditte Caroline Andersen, Suganya Ganesalingam, Charlotte Harken Jensen et al. · 2014 · Stem Cell Reports

The mammalian heart has generally been considered nonregenerative, but recent progress suggests that neonatal mouse hearts have a genuine capacity to regenerate following apex resection (AR). However, in this study, we performed AR or sham…

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Negative / Null Result ReportEnvironmental Science

Patterns of tree species composition across tropical African forests

Adeline Fayolle, Michael Swaine, Jean‐François Bastin et al. · 2014 · Journal of Biogeography

Abstract Aim In this study we identified large‐scale variation in tree species composition across tropical African forests and determined the underlying environmental and historical factors. Location Tropical forests from Senegal to…

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Negative / Null Result ReportOpen accessMedicine

Inhalation aromatherapy in children and adolescents undergoing stem cell infusion: results of a placebo‐controlled double‐blind trial

Deborah H. Ndao, Elena J. Ladas, Bin Cheng et al. · 2010 · Psycho-Oncology

OBJECTIVE: Though often lifesaving, stem cell transplantation (SCT) is a period of great distress for both child and parent. METHODS: We conducted a double-blind, placebo-controlled randomized study evaluating the effect of the respiratory…

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Negative / Null Result ReportOpen accessDecision Sciences

Publication Bias in Antipsychotic Trials: An Analysis of Efficacy Comparing the Published Literature to the US Food and Drug Administration Database

Erick H. Turner, Daniel Knoepflmacher, Lee Shapley · 2012 · PLoS Medicine

BACKGROUND: Publication bias compromises the validity of evidence-based medicine, yet a growing body of research shows that this problem is widespread. Efficacy data from drug regulatory agencies, e.g., the US Food and Drug Administration (FDA), can serve as a benchmark or control against which data in journal articles can be checked. Thus one may determine whether publication bias is present and quantify the extent to which it inflates apparent drug efficacy. METHODS AND FINDINGS: FDA Drug Approval Packages for eight second-generation antipsychotics-aripiprazole, iloperidone, olanzapine, pali

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Negative / Null Result ReportMedicine

Fear of recurrence in long-term cancer survivors—Do cancer type, sex, time since diagnosis, and social support matter?

Lena Koch‐Gallenkamp, Heike Bertram, Andrea Eberle et al. · 2016 · Health Psychology

OBJECTIVE: Fear of recurrence (FoR) is among the most important concerns for cancer survivors. Studies on potentially influencing variables, like time since diagnosis, cancer type, and sex, have yielded heterogeneous results. Also social…

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Negative / Null Result ReportBusiness, Management and Accounting

Effects of vice‐principals' psychological empowerment on job satisfaction and burnout

Carsten C. Schermuly, René A. Schermuly, Bertolt Meyer · 2011 · International Journal of Educational Management

Purpose This paper aims to investigate the relationship between psychological empowerment, job satisfaction, and burnout among vice‐principals (VPs) in primary schools. Design/methodology/approach A total of 103 VPs at 103 different…

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Negative / Null Result ReportEngineering

Effective and Noneffective Recombination Center Defects in Cu2ZnSnS4: Significant Difference in Carrier Capture Cross Sections

Jiqiang Li, Zhen‐Kun Yuan, Shiyou Chen et al. · 2019 · Chemistry of Materials

By combining the electron–phonon coupling effect and the static coupling formalism, we calculate, through the first-principles methods, the carrier capture cross sections of the three possible nonradiative recombination center (NRRC)…

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Negative / Null Result ReportOpen accessSocial Sciences

The heart trumps the head: Desirability bias in political belief revision.

Ben M Tappin, Leslie van der Leer, Ryan McKay · 2017 · Journal of Experimental Psychology General

Understanding how individuals revise their political beliefs has important implications for society. In a preregistered study (N = 900), we experimentally separated the predictions of 2 leading theories of human belief revision-desirability bias and confirmation bias-in the context of the 2016 U.S. presidential election. Participants indicated who they desired to win, and who they believed would win, the election. Following confrontation with evidence that was either consistent or inconsistent with their desires or beliefs, they again indicated who they believed would win. We observed a robust

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Negative / Null Result ReportOpen accessMedicine

FTO and MC4R Gene Variants Are Associated with Obesity in Polycystic Ovary Syndrome

Kathryn G. Ewens, Michelle R. Jones, Wendy Ankener et al. · 2011 · PLoS ONE

Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in women. It is also associated with metabolic disturbances that place women at increased risk for obesity and type 2 diabetes. There is strong evidence for familial clustering of PCOS and a genetic predisposition. However, the gene(s) responsible for the PCOS phenotypes have not been elucidated. This two-phase family-based and case-control genetic study was designed to address the question of whether SNPs identified as susceptibility loci for obesity in genome-wide association studies (GWAS) are also associated w

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Negative / Null Result ReportMedicine

Remote Ischemic Preconditioning for Cerebral and Cardiac Protection During Carotid Endarterectomy: Results From a Pilot Randomized Clinical Trial

Stewart R. Walsh, S.A.R. Nouraei, Tjun Yip Tang et al. · 2010 · Vascular and Endovascular Surgery

Remote ischemic preconditioning (RIPC) is a physiological mechanism whereby brief ischemia-reperfusion episodes attenuate damage by subsequent prolonged ischemic insults. It reduces myocardial injury following cardiac and aortic aneurysm…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genome‐wide analysis of adolescent psychotic‐like experiences shows genetic overlap with psychiatric disorders

Oliver Pain, Frank Dudbridge, Alastair G. Cardno et al. · 2018 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics

This study aimed to test for overlap in genetic influences between psychotic-like experience traits shown by adolescents in the community, and clinically-recognized psychiatric disorders in adulthood, specifically schizophrenia, bipolar disorder, and major depression. The full spectra of psychotic-like experience domains, both in terms of their severity and type (positive, cognitive, and negative), were assessed using self- and parent-ratings in three European community samples aged 15-19 years (Final N incl. siblings = 6,297-10,098). A mega-genome-wide association study (mega-GWAS) for each p

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Negative / Null Result ReportNursing

Human Milk Versus Formula Feeding Among Preterm Infants: Short-Term Outcomes

Ayala Maayan‐Metzger, Shirli Avivi, Irit Schushan‐Eisen et al. · 2011 · American Journal of Perinatology

We evaluated short-term neonatal outcomes among preterm infants according to type of feeding administered (human milk or formula). Retrospective data were collected on 400 preterm infants at gestational age ≤32 weeks. Groups were chosen…

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Negative / Null Result ReportBusiness, Management and Accounting

The impact of board and audit committee characteristics on corporate social responsibility: evidence from the Iranian stock exchange

Shaban Mohammadi, Hadi Saeidi, Nader Naghshbandi · 2020 · International Journal of Productivity and Performance Management

Purpose The purpose of this study is to investigate the effect of board and audit committee characteristics on corporate social responsibility (CSR) in Iranian companies listed in stock exchanges. Design/methodology/approach This is a…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn’s disease: report of the OPERA study

William J. Sandborn, Scott D. Lee, Dino Tarabar et al. · 2017 · Gut

Objective This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion…

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Negative / Null Result ReportOpen accessMedicine

Riociguat in patients with early diffuse cutaneous systemic sclerosis (RISE-SSc): randomised, double-blind, placebo-controlled multicentre trial

Dinesh Khanna, Yannick Allanore, Christopher P. Denton et al. · 2020 · Annals of the Rheumatic Diseases

OBJECTIVES: Riociguat is approved for pulmonary arterial hypertension and has antiproliferative, anti-inflammatory and antifibrotic effects in animal models of tissue fibrosis. We evaluated the efficacy and safety of riociguat in patients with early diffuse cutaneous systemic sclerosis (dcSSc) at high risk of skin fibrosis progression. METHODS: In this randomised, double-blind, placebo-controlled, phase IIb trial, adults with dcSSc of <18 months' duration and a modified Rodnan skin score (mRSS) 10-22 units received riociguat 0.5 mg to 2.5 mg orally three times daily (n=60) or placebo (n=61). T

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Negative / Null Result ReportOpen accessMedicine

SKYSCRAPER-02: Tiragolumab in Combination With Atezolizumab Plus Chemotherapy in Untreated Extensive-Stage Small-Cell Lung Cancer

Charles M. Rudin, Stephen V. Liu, Ross A. Soo et al. · 2023 · Journal of Clinical Oncology

PURPOSE The phase III SKYSCRAPER-02 study determined whether the benefits of atezolizumab plus carboplatin and etoposide (CE) could be enhanced by the addition of tiragolumab in untreated extensive-stage small-cell lung cancer (ES-SCLC).…

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Negative / Null Result ReportMedicine

Long‐Term Outcome After Arthroscopic Repair of Type II SLAP Lesions: Results According to Age and Workers' Compensation Status

Patrick J. Denard, Alexandre Lädermann, Stephen S. Burkhart · 2012 · Arthroscopy The Journal of Arthroscopic and Related Surgery

PURPOSE: The purpose of this study was to determine the long-term functional outcome of anatomic arthroscopic repair of type II SLAP lesions with suture anchors. METHODS: We examined all arthroscopic repairs of isolated type II SLAP…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Single nucleotide polymorphisms associated with non-contact soft tissue injuries in elite professional soccer players: influence on degree of injury and recovery time

Ricard Pruna, Rosa Artells, Jordi Ribas et al. · 2013 · BMC Musculoskeletal Disorders

BACKGROUND: The biological mechanisms involved in non-contact musculoskeletal soft tissue injuries (NCMSTI) are poorly understood. Genetic risk factors may be associated with susceptibility to injuries, and may exert marked influence on recovery times. METHODS: Data on type and degree of injury and recovery time were collected in 73 male professional soccer players (43 White, 11 Black Africans and 19 Hispanics) who suffered total of 242 injuries (203 muscle, 24 ligament, and 15 tendon injuries). One single nucleotide polymorphism (SNPs) in the following genes were analyzed: Elastin (ELN); Titi

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Negative / Null Result ReportMedicine

CSF chitinase proteins in amyotrophic lateral sclerosis

Alexander G. Thompson, Elizabeth Gray, Alexander Bampton et al. · 2019 · Journal of Neurology Neurosurgery & Psychiatry

Objective To evaluate the classifier performance, clinical and biochemical correlations of cerebrospinal fluid (CSF) levels of the chitinase proteins Chitotriosidase-1 (CHIT1), Chitinase-3-like protein 1 (CHI3L1) and Chitinase-3-like…

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Negative / Null Result ReportOpen accessNeuroscience

A Network Convergence Zone in the Hippocampus

Bratislav Mišić, Joaquín Goñi, Richard F. Betzel et al. · 2014 · PLoS Computational Biology

The hippocampal formation is a key structure for memory function in the brain. The functional anatomy of the brain suggests that the hippocampus may be a convergence zone, as it receives polysensory input from distributed association areas throughout the neocortex. However, recent quantitative graph-theoretic analyses of the static large-scale connectome have failed to demonstrate the centrality of the hippocampus; in the context of the whole brain, the hippocampus is not among the most connected or reachable nodes. Here we show that when communication dynamics are taken into account, the hipp

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Negative / Null Result ReportOpen accessPhysics and Astronomy

Limit on the production of a new vector boson in e + e − → Uγ, U → π + π − with the KLOE experiment

A. Anastasi, D. Babusci, G. Bencivenni et al. · 2016 · Physics Letters B

The recent interest in a light gauge boson in the framework of an extra U(1) symmetry motivates searches in the mass range below 1 GeV. We present a search for such a particle, the dark photon, in e + e - U, U + -based on 28 million e + e - + - events collected at DA NE by the KLOE experiment. The + -production by initial-state radiation compensates for a loss of sensitivity of previous KLOE U e + e -, + -searches due to the small branching ratios in the - resonance region. We found no evidence for a signal and set a limit at 90% CL on the mixing strength between the photon and the

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Negative / Null Result ReportOpen accessPsychology

Does placing children in foster care increase their adult criminality?

Matthew J. Lindquist, Torsten Santavirta · 2014 · Labour Economics

We evaluate the association between foster care placement during childhood and adult criminality. In contrast to previous studies, we allow associations to vary by gender and age at initial placement. We find that foster care predicts…

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