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20,240 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

A Comparative Study on the Effects of Spherical and Aspheric Orthokeratology Lenses on Myopia Control and Ocular Surface Health in Adolescents: A Retrospective Cohort Study Based on Propensity Score Matching

Cai¹ J, Lan² G, Lin² Y et al. · 2026 · Preprint

Abstract Purpose To compare the 1-year efficacy of spherical versus aspheric base curve orthokeratology (OK) lenses in controlling axial length (AL) elongation in myopic adolescents, and to explore differences in their impact on tear film…

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Negative / Null Result ReportOpen accessMedicine

Does Combined Intravenous and Topical Tranexamic Acid Offer Additional Benefit Compared With Intravenous or Topical Alone in Open Elbow Arthrolysis-A Pilot Randomized Controlled Trial.

Chen C, Zhang J, Hua K et al. · 2026 · Orthopaedic surgery

Purposes Open elbow arthrolysis (OEA) is a common method for treating post-traumatic elbow stiffness, which may lead to severe bleeding when resecting heterotopic ossification (HO) and fibrous scar tissue. The purpose of this study is to…

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Negative / Null Result ReportMedicine

The influence of lesion type and lesion location on the prediction of language laterality in patients with cerebral vascular malformations using functional MRI.

Rossmann J, Hense K, Knott M et al. · 2026 · Journal of neurosurgery

Objective Predicting language lateralization using functional MRI (fMRI) in patients with cerebral vascular malformations close to language areas is essential for treatment decision-making and patient outcomes. Functional MRI-based…

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Negative / Null Result ReportOpen accessMedicine

Comparable improvements in selective, but not sustained, attention in response to a multi-ingredient nootropic formulation when compared with caffeine.

Hearris MA, Langan-Evans C, Foo WL et al. · 2026 · European journal of nutrition

PURPOSE: The ergogenic effects of caffeine on cognitive performance are largely restricted to improved alertness and enhanced attention and do not typically extend to other cognitive domains. In contrast, plant extracts and phytochemicals…

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Negative / Null Result ReportMedicine

Retrospective Analysis of Dronedarone Versus Amiodarone on Outcomes Following Radiofrequency Ablation for Atrial Fibrillation.

Shi Y, Shi X, Li H et al. · 2026 · British journal of hospital medicine (London, England : 2005)

Aims/background Pharmacological therapy can enhance the therapeutic efficacy of radiofrequency ablation (RFA) for atrial fibrillation (AF) and reduce the risk of recurrence. Dronedarone and amiodarone are two commonly prescribed adjuvant…

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Negative / Null Result ReportMedicine

Similar water uptake depths in lianas and trees, but divergent functional trait coordination across organs in a seasonally dry tropical forest in Cambodia.

Hiiragi K, Sopheak T, Sophors C et al. · 2026 · Tree physiology

Although previous studies have suggested that lianas exhibit superior growth compared with trees during dry seasons, their strategies for acquiring water remain poorly understood. This study investigated the water uptake depth and…

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Negative / Null Result ReportOpen accessMedicine

Impact of Junior Physicians' Resignation on Palliative Sedation Practices: A Retrospective Single-Center Study in South Korea.

Hong M, Lee SW, Jung M · 2026 · Journal of hospice and palliative care

Purpose This study aimed to evaluate changes in the proportion of patients receiving palliative sedation (PS) before and after the mass resignation of junior physicians in South Korea. Methods This single-center retrospective chart review…

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Negative / Null Result ReportOpen accessMedicine

Mitigation of salinity stress in Mentha piperita L. through foliar application of chitosan-salicylic acid encapsulated ZnO nanoparticles.

Al-Obaidi MHR, Mehrabani LV, Hassanpouraghdam MB et al. · 2026 · Scientific reports

Salinity stress harms plant growth and physiological characteristics. To investigate the effect of NaCl salinity stress (without salinity stress and 100 mM salinity) and foliar spray with: control (distilled water), zinc oxide…

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Negative / Null Result ReportMedicine

Factors Associated With Surgical Outcomes in Medial Orbital Wall Fracture Reconstruction With Absorbable Plates.

Li B · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Preoperative imaging factors associated with absorbable plate reconstruction outcomes for medial orbital wall fractures are not well-established. The role of muscle cone integrity on computed tomography (CT) has not been…

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Negative / Null Result ReportOpen accessMedicine

The effect of <i>Lactiplantibacillus plantarum</i> probiotic supplement on rainbow trout challenged with <i>Aeromonas salmonicida</i>.

Mikulikova I, Lepkova Z, Bandouchova H et al. · 2026 · Veterinarni medicina

Two probiotic ( Lactiplantibacillus plantarum ) supplementation strategies (continuous and cyclic) were evaluated for their ability to enhance resistance of rainbow trout ( Oncorhynchus mykiss ) to Aeromonas salmonicida infection. Neither…

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Negative / Null Result ReportMedicine

[Efficacy of photodynamic therapy in extrahepatic cholangiocarcinoma].

Chen C, Liu HC, Wang RF et al. · 2026 · Zhonghua wai ke za zhi [Chinese journal of surgery]

Objective: To investigate the safety and efficacy of photodynamic therapy(PDT) combined with biliary stent implantation in the treatment of extrahepatic cholangiocarcinoma. Methods: A retrospective cohort analysis was conducted based on…

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Negative / Null Result ReportOpen accessMedicine

Finite element analysis of the pedicle screw in lumbar transpedicular dynamic stabilization that penetrates the lateral cortex of the vertebral pedicle.

Zhao C, Zhang M, Li P et al. · 2026 · BMC musculoskeletal disorders

BACKGROUND: The mechanical stability of lumbar transpedicular dynamic stabilization (LTDS) was determined by simulating the degree to which the pedicle screws penetrated the lateral pedicle cortex. METHODS: A finite element model of the…

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Negative / Null Result ReportMedicine

Preoperative radiotherapy negatively affects early hypertrophy but has no effect on graft survival and union in patients treated with vascularized fibular grafts for bone tumors.

Bayram S, Atasoy İT, Salduz A et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Preoperative radiotherapy may impair bone healing and remodeling after wide resection and reconstruction using vascularized fibular grafts for bone tumors. This study evaluated whether preoperative radiotherapy affected union,…

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Negative / Null Result ReportOpen accessMedicine

Axial Length Asymmetry in Patients with Unilateral Retinal Detachment.

Wang H, Loke JY, Chan WO et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives: Increased axial length is a major risk factor for retinal detachment. This study explored whether, in individuals presenting with unilateral disease, the longer eye was more likely to have rhegmatogenous disease.…

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Negative / Null Result ReportOpen accessMedicine

Dexmedetomidine and Apigenin Combination Mitigates Memory Deficits Caused by Microglial Activation and Hippocampal Neurogenesis Impairment in Methotrexate-Induced Chemo-Brain in Rats.

Yousef EM, Eldemerdash OM, Senousy MA et al. · 2026 · Neural plasticity

Dexmedetomidine (Dex), an α2-adrenergic receptor agonist, and apigenin (Api), a naturally occurring bioflavonoid, have recently shown neuroprotective effects in experimental models of methotrexate (MTX)-induced neurotoxicity; however, the…

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Negative / Null Result ReportOpen accessMedicine

Can Lactate Values Predict Postoperative Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery? A Prospective Observational Study.

Temiztürk Z, Beyazal OF, Topçu AC et al. · 2026 · Brazilian journal of cardiovascular surgery

Introduction The aim of our study is to investigate the relationship and predictive significance of routinely measured serum lactate values with postoperative atrial fibrillation (POAF) in patients following isolated coronary artery bypass…

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Negative / Null Result ReportMedicine

Computed tomography based distal femoral morphology and comparative multi-implant total knee replacement fit analysis in a South East London population.

Eveson TE, Davis TP, Tindall AJ · 2026 · Journal of orthopaedics

Background Accurate medio-lateral sizing of the distal femur during total knee replacement (TKR) is essential to optimise implant fit and avoid over- or under-hang, which have been associated with suboptimal outcomes. National guidance…

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Negative / Null Result ReportOpen accessMedicine

Survival Benefit of Adjuvant Radiotherapy After Surgery in Patients With T1-2N1M0 Hypopharyngeal Squamous Cell Carcinoma: A Dual-Cohort Analysis of SEER and Institutional Data.

Hu Z, Ma R, Wen Y et al. · 2026 · Cancer medicine

Background The optimal therapeutic strategy for patients with T2-3N0-3 M0 or T1N1-3 M0 hypopharyngeal squamous cell carcinoma (HPSCC) and the use of postoperative radiotherapy with or without systemic therapy for patients with T1-2N1M0…

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Negative / Null Result ReportOpen accessMedicine

Effect of diode laser biostimulation on implant stability, post-surgical inflammation, and bone healing in immediate implant in the maxillary premolars. A randomized double-blind trial.

Kassem BA, Osman SM, El-Mahallawy Y · 2026 · Clinical oral investigations

INTRODUCTION: The stimulatory effects of laser Biostimulation on immediate implant clinical wound healing and radiographic bone quality analysis is with insufficient evidence. AIM: To evaluate the effect of low-level diode laser as a…

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