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20,240 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Urolithin A improves motility, antioxidant defense, and mitochondrial function of chilled canine spermatozoa during 72-h liquid storage.

Mirzaei R, Soleimanzadeh A, Asri-Rezaei S · 2026 · Scientific reports

Dog semen conservation at cold temperatures (5 °C) is a valuable reproductive management tool, but it is bedeviled by issues of oxidative stress and mitochondrial damage that reduce sperm quality and viability. Urolithin A (UA), a natural…

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Negative / Null Result Report

Enhancing Port Performance through Digital Transformation: The Role of Networking Capability and Organizational transformation in Indonesian Container Ports

Pramitra B, Al Musadieq M, Afrianty TW et al. · 2026 · Preprint

Although digital transformation in port management has been widely discussed, previous studies have not extensively examined how organizational capabilities translate into performance through digital adoption at ports. This study addresses…

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Negative / Null Result ReportMedicine

[Effects of repeated controlled ovarian stimulation on the expression of aerobic glycolysis-related enzymes at various stages of early embryo development in mice].

Shen LL, Shi BB, Xiong WY et al. · 2026 · Sheng li xue bao : [Acta physiologica Sinica]

This study aims to investigate whether the reduction in early embryonic development due to repeated controlled ovarian stimulation (COS) is associated with the expression levels of enzymes related to aerobic glycolysis. A repeated COS…

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Negative / Null Result ReportOpen accessMedicine

A Standardized Onion Peel-Derived Bioactive Ingredient Attenuates Palmitate-Induced Steatosis and Oxidative Stress by Modulating Mitochondrial Dynamics and Autophagy in HepG2 Cells.

Di Gregorio I, Migliaccio V, D'Elia M et al. · 2026 · Antioxidants (Basel, Switzerland)

Onion peel represents a valuable food by-product rich in bioactive phenolic compounds. Building on previous phytochemical investigations, an onion peel extract from the Rossa di Tropea variety was developed as a standardized bioactive…

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Negative / Null Result ReportMedicine

The effect of sesame, canola, and sesame-canola oils on oxidative stress markers in patients with type 2 diabetes: A three-way randomized crossover clinical trial.

Moghtaderi F, Zimorovat A, Raeisi-Dehkordi H et al. · 2026 · Nutrition and health

BackgroundOxidative stress plays a critical role in the pathogenesis of chronic diseases. Canola oil (CO) and sesame oil (SO), due to their antioxidant constituents, may differentially influence oxidative stress biomarkers.AimThis study…

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Negative / Null Result ReportMedicine

Depression and cognition: is there a bidirectional relationship?

Glei DA, Weinstein M · 2026 · Aging & mental health

Objectives The association between depression and cognition is well-established, but there is uncertainty regarding the direction of causation. We evaluated the relationship between depression and poor cognition in both directions. Method…

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Negative / Null Result ReportMedicine

Beyond Conventional Care: The use of Alternative Medicine by Head and Neck Cancer Patients in Pakistan - A Retrospective study.

Akhtar, Ghaloo, Pasha et al. · 2026 · JPMA. The Journal of the Pakistan Medical Association

To investigate the prevalence, utilisation and association of diagnostic delay, tumour stage and recurrence with alternative medicine among head and neck cancer patients having undergone surgical resection. The retrospective,…

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Negative / Null Result ReportOpen accessTechnology

Effects of Allicin Supplementation on the Mechanical and Viscoelastic Properties of the Tibia in Bovans Brown Hens

Anna Skic, Zbigniew Stropek, Kamil Drabik et al. · 2026 · Applied Sciences

Bone tissue exhibits viscoelastic behavior, and stress relaxation analysis provides valuable insight into its time-dependent mechanical performance. This study aimed to evaluate the effects of allicin supplementation on the mechanical and viscoelastic properties of tibial bone in Bovans Brown laying hens. Tibiae of 68-week-old hens were subjected to three-point bending tests to determine quasi-static mechanical properties, as well as stress relaxation tests conducted at three deformation velocities (0.1, 1, and 10 mm/s). Stress relaxation behavior was described using a five-parameter generaliz

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Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

A Pilot Study on the Impact of Cranberry and Ascorbic Acid Supplementation on the Urinary Microbiome of Healthy Women: A Randomized Controlled Trial

Alina Nussbaumer-Pröll, Bela Hausmann, Maria Weber et al. · 2025 · Antibiotics

Background : The collection of microorganisms that colonize the human genital and urinary tract is referred to as the genitourinary microbiome. Urinary tract infections (UTIs), which predominantly affect women, are linked to alterations in the genitourinary microbiome. Cranberries ( Vaccinium oxycoccos ), rich in proanthocyanidins, and ascorbic acid (vitamin C), known for their urinary acidification properties, are commonly used for UTI prevention. However, their effects on the genitourinary microbiome remain inadequately characterized. This pilot study assesses the genitourinary microbiome co

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Negative / Null Result ReportOpen accessAgriculture

Comparative study on quality parameters of dry-cured beaver (Castor fiber) and nutria (Myocastor coypus) sausages

Jan Slováček, Šárka Nedomová, Markéta Janík Piechowiczová et al. · 2024 · Czech Journal of Food Sciences

The aim of the study was to define and compare the quality properties of dry-cured heat-treated meat products from the meat of free-living semi-aquatic wildlife species. Eurasian beaver (Castor fiber) and nutria (Myocastor coypus) are wild animals whose presence in the countryside is regulated in the Czech Republic. Basic chemical, microbiological, sensory analyses, and instrumental measurements of the colour and texture of dry-cured sausages (pork, as a control group with 51% lean pork and experimental groups with 51% lean beaver and nutria meat in fresh state) were performed. There were no s

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Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Frequency of MYD88 L256P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasm

Raja Shekhar, Shano Naseem, Jogeshwar Binota et al. · 2021 · Hematology/Oncology and Stem Cell Therapy

Objective/background: B-cell neoplasms are clonal tumors of B cells at various stages of maturation, including diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic lymphoma (CLL), Burkitt lymphoma (BL), lymphoplasmacytic lymphoma (LPL)/Waldenström’s macroglob- ulinemia (WM), splenic marginal zone lymphoma (SMZL), nodal marginal zone lymphoma (NMZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and hairy cell leukemia (HCL). In this study, we analyzed the frequency of MYD88 L265P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasms. Methods:

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Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs

Validation of a pulmonary embolism risk assessment model in gynecological inpatients

Zhen-Yi Jin, Chun-Min Li, Hong Qu et al. · 2024 · Thrombosis Journal

Abstract Objective To compare the predictive efficacy of the PADUA and Caprini models for pulmonary embolism (PE) in gynecological inpatients, analyze the risk factors for PE, and validate whether both models can effectively predict mortality rates. Methods A total of 355 gynecological inpatients who underwent computed tomography pulmonary angiography (CTPA) were included in the retrospective analysis. The comparative assessment of the predictive capabilities for PE between the PADUA and Caprini was carried out using receiver operating characteristic (ROC) curves. Logistic regression analysis

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Negative / Null Result ReportOpen accessAstrophysics

Systematics in the Cepheid and TRGB Distance Scales: Metallicity Sensitivity of the Wesenheit Leavitt Law

Barry F. Madore, Wendy L. Freedman · 2024 · The Astrophysical Journal

Using an updated and significantly augmented sample of Cepheid and tip of the red giant branch (TRGB) distances to 28 nearby spiral and irregular galaxies, covering a wide range of metallicities, we have searched for evidence of a correlation of the zero-point of the Cepheid period–luminosity relation with H ii region (gas-phase) metallicities. Our analysis, for the 21 galaxies closer than 12.5 Mpc, results in the following conclusions: (1) The zero-points of the Cepheid and TRGB distance scales are in remarkably good agreement, with the mean offset in the zero-points of the most nearby distan

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Negative / Null Result ReportOpen accessOphthalmology

Comparison of 12-month therapeutic effect of conbercept and ranibizumab for diabetic macular edema: a real-life clinical practice study

Yule Xu, Ao Rong, Wei Xu et al. · 2017 · BMC Ophthalmology

Abstract Background To compare the efficacy of intravitreal conbercept and ranibizumab in the treatment of diabetic macular edema (DME) in a real-life clinical practice. Methods This was a retrospective study. Among 62 Chinese patients with DME, 32 patients (36 eyes) received intravitreal conbercept (IVC) injections and 30 patients (32 eyes) received intravitreal ranibizumab (IVR) injections, once a month for 3 months followed by as needed therapy. All participants had at least 12 months of follow-up. We compared the changes in best-corrected visual acuity (BCVA) letter score and central retin

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Negative / Null Result ReportOpen accessLanguage and Literature

Young People's Attitudes Toward the Causes of Drug Abuse and Its Effects on the Family and Society

khawla Alobeidli, Mohammed AL Hourani · 2026 · مجلة الآداب

This study aimed to identify young people's attitudes toward the causes of drug use and its effects on the family and society. Data were collected through a questionnaire distributed to a sample of 143 students at the University of Sharjah. The results showed that less than half of the participants (42.0%) believed that a weak religious conscience is a reason for drug use, while nearly half (41.3%) agreed that bad company is one of the individual factors leading to drug use. Additionally, 30.8% of the participants were uncertain whether traveling for recreation contributes to drug use. The qua

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Negative / Null Result ReportOpen accessGynecology and obstetrics

Sleep hygiene education during prenatal care visits: A quasi–experimental study

Sepideh Mashayekh-Amiri, Fatemeh Bakouei, Sedighe Esmaeilzadeh et al. · 2019 · Caspian Journal of Reproductive Medicine

Background: The effect of individual sleep hygiene education on sleep quality components remains largely unknown during pregnancy. This study aimed to assess the effect of a short-term sleep hygiene education during prenatal care visits on pregnant women with poor sleep quality. Methods: A quasi-experimental study, designed as a pre- and post-test with a single group, was conducted on 32 pregnant woman with poor sleep quality. All the participants completed the Beck Depression Inventory (BDI), Perceived Stress Scale (PSS), and Pittsburgh Sleep Quality Index (PSQI). The women with good sleep qu

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Negative / Null Result ReportOpen accessDentistry

Sealing ability of a new calcium silicate based material as a dentin substitute in class II sandwich restorations: An in vitro study

Raji Viola Solomon, Parupalli Karunakar, Deepthi Sarvani Grandhala et al. · 2014 · Journal of Oral Research and Review

Background: Class ll sandwich restorations are routinely performed where conventional Glass ionomer cement (GIC) or Resin-modified GIC (RMGIC) is used as a base or dentin substitute and a light curing composite resin restorative material is used as an enamel substitute. Various authors have evaluated the microleakage of composite resin restorations where glass ionomer cement has been used as a base in class II sandwich restorations, but a literature survey reveals limited studies on the microleakage analysis of similar restorations with biodentine as a dentin substitute, as an alternative to g

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Negative / Null Result ReportOpen accessEducation

The degree of enhancing the values of integrity among the female secondary school students from the point of view of the female teachers in Jeddah Governorate

Amaal Abdulrahman Al-Awydi, Prof. Olfat Abdulaziz Al-Ashi · 2026 · مجلة بحوث التعليم والإبتكار

The study aimed to identify integrity values among secondary school students from the perspective of their teachers. A descriptive survey methodology was used, employing a general data form and an integrity values scale. The study sample (367) is a secondary school teacher in Jeddah Governorate. Results. The overall degree of integrity values promotion across its various dimensions among the study sample, from the teachers' perspective, was high. The dimensions of integrity values promotion were ranked as follows: first, justice; second, dedication to work; and third, honesty—all with high sco

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Negative / Null Result ReportOpen accessMedicine

Efficacy and Safety of Penile Girth Enhancement Using Hyaluronic Acid Filler and the Clinical Impact on Ejaculation: A Multi-Center, Patient/ Evaluator-Blinded, Randomized Active-Controlled Trial

Sun Tae Ahn, Ji Sung Shim, Woong Jin Bae et al. · 2022 · The World Journal of Men's Health

Purpose: We aimed to evaluate the efficacy and safety of penile girth enhancement (PGE) using hyaluronic acid (HA) filler with different physical properties from previous studies. Additionally, we evaluated the clinical impact on ejaculation after PGE. Materials and Methods: This was a prospective, patient/evaluator-blinded, randomized, active-controlled, multicenter trial. Patients recruited between December 2017 and March 2018 were randomly assigned to the HA filler or control group (polylactic acid [PLA] filler). Penile girth, satisfaction level, Premature Ejaculation Profile (PEP), and sel

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Negative / Null Result ReportOpen accessOrthopedic surgery

Measurement of midshaft clavicle vertical displacement is not influenced by radiographic projection

Paul Hoogervorst, MD, Aman Chopra, Zachary M. Working et al. · 2020 · JSES International

Background: Measured shortening of midshaft clavicle fracture fragments is known to be influenced by multiple factors. The influence of radiographic projection on vertical displacement is unclear. The aims of this study were (1) to quantify the difference in measurements of vertical displacement in an absolute, relative, and categorical manner between 5 different projections; (2) to quantify the differences in interobserver and intraobserver agreement using a standardized method for measuring vertical displacement; and (3) to assess the association between categorical and continuous descriptio

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Negative / Null Result ReportOpen accessMedicine

The importance of procalcitonin in early diagnosis of sepsis

Funda Yetkin, Sibel Altunisik Toplu · 2017 · Medicine Science

Despite the advances and a wide range of studies conducted, sepsis is one of the most frequent causes of death in patients with critical health condition. Early diagnosis, rapid and effective treatment are extremely important. Use of procalcitonin (PCT) for this purpose has become widespread and notable recently. Procalcitonin is an important test as “point-of-care testing (POCT)” just like C-reactive protein (CRP). Procalcitonin is the prohormone of calcitonin. It is released from the parenchymal cells of the liver, kidneys and muscles, and in response to bacterial toxins, it is released from

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Negative / Null Result ReportOpen accessGeriatrics

Clinical Features of CINin ChineseVery Elderly Patients Undergoing Coronary Angiography Procedure With Hydration Treatment: A Three-Center, Prospective Study

Liwen Bao, Jun Bo, Bo Jin et al. · 2018 · International Journal of Gerontology

Summary: Background: To assess the morbidity and risk factors of contrast induced nephropathy (CIN) in Chinese very elderly patients. Methods: The very elderly patients whose age ≥75 year-old, from North Huashan Hospital, South Renji Hospital and Tongren Hospital, underwent coronary angiography or percutaneous coronary intervention, were included in this study. All of these patients were treated by hydration, those who developed contrast-induced nephropathy were divided into CIN group and the others were divided into non-CIN group. The baseline information was evaluated and serum creatinine wa

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Negative / Null Result ReportOpen accessMedicine

Blue®m gel vs hyaluronic acid gel in wound healing and pain control following functional crown lengthening: a randomized controlled trial

Riddhi Vyas, Santhosh Kumar, C M Manasa · 2026 · Saudi Dental Journal

Abstract Periodontal wound dressings have advanced from passive protectants to bioactive agents. This study compared the efficacy of Blue®m gel and a hyaluronic acid (HA) gel in promoting wound healing and controlling postoperative pain after functional crown lengthening surgery. A prospective, randomized, patient and outcome assessor-blinded study was conducted on 40 systemically healthy patients (aged 20–60 years) requiring crown lengthening of posterior teeth. Participants were divided into two groups: Blue®m gel (Group A) and custom-formulated HA gel (Group B). Both gels were applied to th

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Negative / Null Result ReportOpen accessBiology (General)

Evaluation of the efficacy of N-Acetylcysteine combined with standard quadruple therapy versus standard quadruple therapy alone for Helicobacter pylori eradication

Farahnaz Joukar, Sara Manafi Afkham, Afshin Shafaghi et al. · 2023 · Journal of Current Biomedical Reports

N-acetyl cysteine (NAC) has recently been proposed as an adjunctive therapy for the eradication of Helicobacter pylori infection due to its mucolytic, antioxidant, and antimicrobial properties. This study aimed to evaluate the efficacy of adding NAC to the standard 4-drug regimen consisting of amoxicillin, clarithromycin, pantoprazole, and bismuth subcitrate. In this double-blind, randomized clinical trial, 92 patients with confirmed H. pylori infection were randomly assigned to either the intervention group or the control group (46 patients each) using a randomized block design. All patients

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