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19,871 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

M. Oksman, H. Iivonen, E. Hogyes et al. · 2006 · Neurobiology of Disease

The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3–4 months beginning at a young adult age (6 months). Hippocampal Aβ levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Aβ levels comp

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Negative / Null Result ReportOpen accessMedicine

The efficacy of a range of hygiene measures for boot cleaning to protect natural vegetation from Phytophthora cinnamomi

Edward C. Y. Liew, Maureen Phelan, Keith L. McDougall · 2023 · Scientific Reports

Abstract Phytophthora cinnamomi is an oomycete found in the soil and capable of invading the roots of a wide range of host plants globally, potentially killing them and affecting the ecosystems they inhabit. This pathogen is often inadvertently dispersed in natural vegetation on the footwear of humans. A range of equipment is often provided or recommended to be carried for cleaning footwear in places where P. cinnamomi poses a threat to biodiversity. These are typically a brush for mechanically removing soil and/or a disinfectant for killing the pathogen. Despite their widespread use, to our k

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Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

LY2495655, an antimyostatin antibody, in pancreatic cancer: a randomized, phase 2 trial

Talia Golan, Ravit Geva, Donald Richards et al. · 2018 · Journal of Cachexia, Sarcopenia and Muscle

Abstract Background Cachexia is a formidable clinical challenge in pancreatic cancer. We assessed LY2495655 (antimyostatin antibody) plus standard‐of‐care chemotherapy in pancreatic cancer using cachexia status as a stratifier. Methods In this randomized, phase 2 trial, patients with stage II–IV pancreatic cancer were randomized to 300 mg LY2495655, 100 mg LY2495655, or placebo, plus physician‐choice chemotherapy from a prespecified list of standard‐of‐care regimens for first and later lines of care. Investigational treatment was continued during second‐line treatment. The primary endpoint was

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Negative / Null Result ReportMedicine

Outcomes of transanal total mesorectal excision with ultra-low anterior resection: A single institute propensity-matched cohort study.

Kute, Fujino, Centauri et al. · 2026 · Experimental and therapeutic medicine

Ultra-low anterior resection (ULAR) and total mesorectal excision (TME) are sphincter-preserving treatments for low rectal cancer. However, these techniques face challenges in patients with a narrow pelvis, particularly those with a high…

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Negative / Null Result ReportOpen accessMedicine

Failure of bumetanide to improve outcome after intracerebral hemorrhage in rat.

Cassandra M Wilkinson, Brittany A Fedor, Jasmine R Aziz et al. · 2019 · PLoS ONE

After intracerebral hemorrhage (ICH), brain edema commonly occurs and can cause death. Along with edema, there are significant alterations in the concentrations of key ions such as sodium, potassium, and chloride, which are essential to brain function. NKCC1, a cation-chloride cotransporter, is upregulated after brain damage, such as traumatic injury and ischemic stroke. NKCC1 brings sodium and chloride into the cell, possibly worsening ion dyshomeostasis. Bumetanide, a specific NKCC1 antagonist, blocks the transport of chloride into cells, and thus should attenuate the increases in chloride,

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Negative / Null Result ReportOpen accessPsychiatry

H-coil repetitive transcranial magnetic stimulation does not improve executive function in patients with chronic peripheral neuropathic pain: a randomized sham-controlled crossover study

Nadine Farnes, Nadine Farnes, Henrik B. Jacobsen et al. · 2024 · Frontiers in Psychiatry

IntroductionDeep rTMS is an increasingly popular noninvasive brain stimulation technique which has shown promise for treating cognitive impairments. However, few studies have investigated the cognitive effects it could exert in patients with chronic peripheral neuropathic pain. Therefore, we aimed to assess the effects of deep rTMS on executive functioning in patients with peripheral neuropathic pain, in a randomized, double-blind crossover trial.MethodsIn total, 17 patients were randomly assigned to receive both active and sham deep H-coil rTMS targeting the primary motor cortex. Each treatme

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Negative / Null Result Report

Statistically significant improvement in hemophilia A control: a retrospective analysis of the effectiveness and safety of emicizumab in children with severe and inhibitor forms of hemophilia A

V. Yu. Petrov, I. N. Lavrentyeva, V. V. Vdovin et al. · 2024 · Pediatric Hematology/Oncology and Immunopathology

Hemophilia A presents a serious problem, especially in its severe and inhibitor forms, leading to severe bleeding and complications. The importance of studying the effectiveness and safety of new treatment approaches, particularly…

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Negative / Null Result Report

Can education quality be statistically measured?

Ekaterina Bagrova, Sergei Kruchinin · 2021 · SHS Web of Conferences

Currently there are many theories about quality education. The paper presents some of them. It also includes some points of Deming’s philosophy and statistical indicators implemented to determine lecturers’ achievements in Russian higher…

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Negative / Null Result Report

P-B02 Does the length of alimentary limb make a significant difference in the weight loss in Roux en y gastric bypass patients?

Mayank Bhandari, Sabyasachi Chowdhary, Milind Rao et al. · 2021 · British Journal of Surgery

Abstract Background Roux en Y gastric bypass (RYGB) surgery for morbid obesity is considered as gold standard, but there can be a difference in the length of alimentary and biliopancreatic limb to achieve optimum weight loss. Till now…

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Negative / Null Result Report

Knowledge of General Practitioner Doctors and Midwives Who Has and Has Not Attended Neonatal Resuscitation Course Has No Significant Difference

Vincent Geraldus Enoch Lusida, Bambang Puijo Semedi, Bambang Herwanto · 2020 · Indonesian Journal of Anesthesiology and Reanimation

Introduction: Infant death is most prominent in the neonatal period. The success of neonatal resuscitation practice has many contributing factors. One of which is the health workers’ knowledge of the Neonatal Resuscitation Program (NRP)…

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Negative / Null Result Report

Thus far there are no statistically significant differences between various apolipoprotein E genotypes in the cluster of seven responsiveness to a flaxseed oil supplement in persons with type 2 diabetes

Douglas E. Barre, Kazimiera A. Mizier-Barre, Odette Griscti · 2025 · Endocrine Regulations

Abstract Objective. The objective of the present study was to determine if there would be statistically significant differences among apolipoprotein E genotypes in the responsiveness of members of a cluster of seven measures in persons…

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Negative / Null Result Report

Revelation of Significant Fake Rhetorical in Wrapping Bygone Utilizing Significant Learning Procedures

N. Pughazendi, T. S. Suganya, Soorya S. et al. · 2023 · International Journal on Recent and Innovation Trends in Computing and Communication

The developing computation control has made the profound learning calculations so powerful that making an unclear human synthesized video famously called a profound fake has got to be exceptionally straightforward. Scenarios where these…

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Negative / Null Result Report

Statistically Stable Verb-Noun Combinations in Russian Chronicals

R. A. Vernyaeva, S. R. Zaynullina · 2020 · Intellekt. Sist. Proizv.

В работе представлено количественно-статистическое исследование языковых единиц древнейших русских летописей. Инструментом для получения необходимых выборок стал модуль n-грамм ИАС «Манускрипт», позволяющий выявить текстовые сочетания с…

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Negative / Null Result Report

Dysregulation of LYN Gene Expression in Melanoma Patients: A Statistically Significant Association with Clinical Outcomes

Maryam Khalid, Sadia Tameez Ud Din, Mumtaz Hussain et al. · 2025 · South Eastern European Journal of Public Health

Skin cancer accounts for one-third of all diagnosed cancers, with 132,000 new cases of melanoma detected each year (1). By 2040, the melanoma burden is projected to reach 510,000 new cases (a 50% increase) and 96,000 deaths (a 68%…

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Negative / Null Result ReportOpen accessMedicine

Study preregistration: an early example and analysis.

Wiseman R, Watt C · 2026 · PeerJ

Preregistration is commonly seen as an effective way of reducing questionable research practices within psychology. This procedure happens prior to data collection/analysis and usually involves either sending in a research plan to a study…

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Negative / Null Result Report

Can We Still Find an Ideal Memristor?

Frank Zhigang Wang · 2024 · Magnetism

In 1971, Chua defined an ideal memristor that links magnetic flux φ and electric charge q. In a magnetic lump with a current-carrying conductor, we found that the direct interaction between physical magnetic flux φ and physical electric…

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Negative / Null Result Report

Are There Statistically Impenetrable Contexts?

Kent Olson · 2022 · International Journal of Science and Research Methodology

Bayesians claim that reason is conducted according to the axioms of probability. In addition, to this, they claim that Bayesian methodology gives us an account of the scientific method―an account that describes the actual practice of…

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Negative / Null Result Report

This study examined belief, concern, and practice of the in-service postgraduate science teachers towards solid waste management and recycle (SWMR) in one of the colleges of education in Bhutan. A structured online survey questionnaire was administered to 39 first-year in-service science teachers out of which 22 (13 male and 9 female) responded. The data were subjected to descriptive statistics su

Sherab Jatsho1, Sonam Dhendup · 2021 · Contemporary Education and Teaching Research

This study examined belief, concern, and practice of the in-service postgraduate science teachers towards solid waste management and recycle (SWMR) in one of the colleges of education in Bhutan. A structured online survey questionnaire was…

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