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Browse the failure-mode index

19,854 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

High-flow nasal cannula improves pulmonary gas exchange during endoscopic retrograde cholangiopancreatography: A single-center randomized controlled trial.

Martínez-Ocón J, Pérez M, Calvo A et al. · 2026 · Journal of clinical anesthesia

Background Sedation during endoscopic retrograde cholangiopancreatography procedures (ERCP) increases the risk of hypoxemia and the need for respiratory support in high-risk patients. High flow nasal cannula (HFNC) provides humidified gas…

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Negative / Null Result Report

Effectiveness of an mHealth Exercise Program on Fall Incidence, Fall Risk, and Fear of Falling in Nursing Home Residents: The Cluster Randomized Controlled BeSt Age Trial

Diener J, Krafft J, Rayling S et al. · 2025 · Preprint

The global rise in nursing home (NH) populations presents substantial challenges, as residents frequently experience physical and cognitive decline, low physical activity, and high fall risk. This study evaluated the effectiveness of the…

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Negative / Null Result Report

Dexamethasone as an Adjuvant to Erector Spinae Plane Block in Cardiac Surgery: A Randomized Controlled Trial on Postoperative Recovery and Pain chronification

Linares LAR, Martinez RCR, Carvalho VH et al. · 2026 · Preprint

Abstract Background and Objectives: Pain control after cardiac surgery remains suboptimal, and concerns about neuraxial techniques under anticoagulation limit the use of thoracic epidurals. The erector spinae plane (ESP) block offers a…

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Negative / Null Result ReportMedicine

Use of Virtual Reality for Pain Relief During Cervical Conization Under Local Anesthesia: A Randomized Controlled Trial.

Michaan N, Michaan N, Laskov I et al. · 2026 · Journal of lower genital tract disease

Objectives Cervical conization (loop electrosurgical excision procedure) under local anesthesia is often associated with anxiety and procedural pain. Virtual reality (VR) glasses may enhance patient experience and reduce discomfort during…

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Negative / Null Result ReportOpen accessMedicine

Experience over tools: does the use of magnifying loupes reduce the incidence of transient postoperative hypocalcemia after total thyroidectomy with central neck dissection? - a single-centre prospective randomized study.

Sielski W, Osęka T, Antolak A et al. · 2026 · Frontiers in endocrinology

Background Parathyroid preservation during total thyroidectomy with central neck dissection in papillary thyroid carcinoma remains challenging due to the glands' delicate vascular anatomy and risk of inadvertent devascularization or…

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Negative / Null Result ReportMedicine

Hyaluronidase activity of Indian ornamental tarantula (Poecilotheria regalis) venom is significantly reduced by commercial Latrodectus mactans and American scorpion antivenoms

García-García M, Mosqueda J, Escobar Cabrera JE et al. · 2025 · Toxicon

A recent clinical case involving a Poecilotheria regalis bite was treated with Mexican L. mactans antivenom (Aracmyn Plus, Silanes, Mexico), resulting in the improvement of some of the symptoms. This could be attributed to cross-reactivity…

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Negative / Null Result ReportMedicine

Artificial intelligence reliability in implant dentistry: A comparative analysis of clinical accuracy and hallucination patterns across multiple language models.

Hooshiar MH · 2026 · The Journal of prosthetic dentistry

Statement of problem Artificial intelligence (AI) language models have been increasingly used for clinical decision-making in implant dentistry and for scholarly writing. Yet, their reliability, fabrication rates, and comparative…

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Negative / Null Result ReportMedicine

Reducing Artifact Preprocessing in Heart Rate Variability-Based Personalized Psychosis Prediction Using Adaptive Long Short-Term Memory Models.

Tsakmaki PV, Tasoulis S, Georgakopoulos SV et al. · 2025 · International journal of neural systems

This research looks at the use of long-short-term memory (LSTM) networks to predict psychosis, in patients within the schizophrenia spectrum, based on Heart Rate Variability (HRV) data acquired from wearable devices. Our primary objective…

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Negative / Null Result ReportMedicine

Optimized Autologous Serum and Activated Leukocyte-Poor Platelet-Rich Plasma Eye Drops Production Protocol: Effect of Fasting, Filtering, and Complement Inactivation on the Concentration of Growth Factors and Lipids.

Sanak F, Iselin K, Kaufmann C et al. · 2026 · Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

Purpose To analyze the effect of fasting on volume, growth factor, and lipid concentration in eye drops derived from autologous serum (AS) and leukocyte-poor platelet-rich plasma (LP-PRP). To assess changes in protein and growth factor…

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Negative / Null Result ReportMedicine

Reducing inappropriate vitamin D testing: an analysis of three sequential diagnostic stewardship interventions and the carbon footprint implications.

Hughes C, Myers MA, Tickell-Painter M et al. · 2026 · Clinical biochemistry

Introduction The climate crisis is a health crisis, and healthcare contributes to this via consumption of resources, the release of greenhouse gases, and the generation of waste. Pathology testing underpins most healthcare, and the vast…

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Negative / Null Result ReportMedicine

West Nile Virus-Neutralizing Plasma for West Nile Virus Disease.

Regev-Yochay G, Barda N, Shusterman Y et al. · 2026 · NEJM evidence

Background In 2024, Israel faced a major West Nile virus (WNV) disease outbreak. We aimed to evaluate the efficacy and safety of WNV-neutralizing plasma for hospitalized patients with WNV disease. Methods We conducted a randomized,…

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Negative / Null Result ReportMedicine

Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope: A Randomized Sham-Controlled Trial.

Tavolinejad H, Bozorgi A, Emkanjoo Z et al. · 2025 · Journal of the American College of Cardiology

Background Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear.…

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Negative / Null Result ReportMedicine

Effects of routine invasive management on reinfarction risk in older adults with frailty and non-ST-segment elevation myocardial infarction: a subanalysis of a randomised clinical trial.

Sanchis J, Bueno H, Martí Sánchez D et al. · 2025 · Heart (British Cardiac Society)

Background Clinical trials and meta-analyses indicate a reduced reinfarction risk with invasive management in older patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study investigated whether similar benefits…

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Negative / Null Result Report

Heavy gravity combined with light gravity local anesthetic in subarachnoid anesthesia for cesarean section did not reduce the incidence of intraoperative hypotension in maternal women: a prospective cohort study

Qiao W, Liu L, Zhang X et al. · 2024 · Preprint

Abstract Background Subarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia. However, subarachnoid anesthesia is prone to cause a high…

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Negative / Null Result ReportOpen accessMedicine

Virtual Nursing for the Care of Hospitalized Patients.

Muir KJ, Maye A, McHugh MD et al. · 2025 · JAMA network open

Importance It is unknown if virtual nursing (VN) enhances care quality or improves the workload of bedside nurses in hospitals. Objective To describe what services VNs provide to patients and nurses in hospitals; to evaluate whether the…

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Negative / Null Result ReportMedicine

Managing visceral leishmaniasis-associated hemophagocytic lymphohistiocytosis in pediatric patients: Clinical insights and treatment strategies.

Zhang J, Suo T, Cheng Y et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis (VL-HLH) is a severe and often fatal condition marked by systemic inflammation and immune dysfunction. In this retrospective cohort study at Shanxi Children's…

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Negative / Null Result ReportMedicine

Extended use of point-of-care technology by acute community nurses during in-home assessment of older adults with potential acute respiratory conditions: a parallel-group, open-label, randomised controlled trial.

Smedemark SA, Jarbøl DE, Laursen CB et al. · 2026 · The lancet. Healthy longevity

Background Diagnosing acute respiratory conditions in adults older than 65 years is challenging due to age-related physiological changes, which increase diagnostic complexity and the risk of hospital admission. We investigated whether…

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Negative / Null Result ReportOpen accessMedicine

C4/5 Facetectomy Is Associated With Improved Recovery of C5 Palsy in Severe Foraminal Stenosis After Posterior Cervical Decompression and Fusion.

Nakamura Y, Murata S, Yabe T et al. · 2026 · Cureus

Introduction C5 palsy is a disabling complication after posterior cervical decompression and fusion (PCDF). Whether C4/5 facetectomy reduces the incidence or improves the outcomes of C5 palsy remains uncertain. Therefore, this study aimed…

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Negative / Null Result ReportMedicine

Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.

Perez-Valero I, Corona Mata D, Crussells Canales MJ et al. · 2026 · International journal of antimicrobial agents

Objective To evaluate if switching from dolutegravir/lamivudine (DTG/3TC) to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) improves neuropsychiatric tolerability in suppressed adults with stable neuropsychiatric…

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Negative / Null Result ReportMedicine

Prophylactic Subcutaneous Heparin Is Not Associated With Increased Rates of Hematoma, Pulmonary Embolism, or Deep Vein Thrombosis Following Lumbar Fusion: A Multi-Institutional, Propensity Score-Matched Analysis of 3106 Patients.

Crawford AM, Striano BM, Schoenfeld AJ et al. · 2026 · Spine

Study design Retrospective multicenter cohort study. Objective To compare the safety and efficacy of venous thromboembolism prophylaxis (VTE) strategies between two high-volume spine centers with distinct protocols. Summary of background…

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