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19,854 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Outcomes of Patients With Mitral Stenosis With Prior Percutaneous Mitral Commissurotomy Undergoing Mitral Valve Surgery.

Ruangsubvilai N, Au-Yeung K, Wongbuddha C et al. · 2026 · The American journal of cardiology

Limited data exist on outcomes for patients with mitral stenosis (MS) who have previously undergone percutaneous mitral commissurotomy (PMC) and later require surgical mitral valve replacement (MVR). This study evaluates the impact of…

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Negative / Null Result ReportMedicine

Good enough assessment: A comparison of brief screener and detailed interview assessments of borderline personality disorder symptoms in a clinical research setting.

Furtado Fernandes L, Davis MT, Luo W et al. · 2026 · Personality disorders

Structured clinical interviews are the gold standard for identifying borderline personality disorder (BPD) in research. No self-report instrument has been validated as a replacement tool for BPD diagnosis. However, clinical interviews can…

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Negative / Null Result ReportMedicine

Does Resident Involvement Affect Clinical Outcomes and Postoperative Complication Rates in Orthopaedic Sports Medicine Surgery?

Stokes DJ, Cram TR, Pasic N et al. · 2026 · The American journal of sports medicine

Background The "July effect" suggests increased patient morbidity and mortality during the early academic year due to new resident involvement. Evidence specific to orthopaedic sports medicine is limited. Purpose To evaluate the effect of…

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Negative / Null Result ReportMedicine

Effect of clarithromycin versus placebo on risk of atrial fibrillation.

Jensen GB, Olsen MH, Jensen MT et al. · 2026 · Danish medical journal

Introduction The CLARICOR randomised trial of clarithromycin versus placebo in patients with stable ischaemic heart disease found increased all-cause and cardiovascular mortality after a brief clarithromycin regimen, suggesting a possible…

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Negative / Null Result ReportMedicine

Rates of Arthrofibrosis in Adolescent Patients After ACL Reconstruction Using Hamstring Autograft With or Without Lateral Extra-articular Tenodesis.

DeFrancesco CJ, Cavendish E, Kocher MS · 2026 · The American journal of sports medicine

Background Lateral extra-articular tenodesis (LET) can reduce the risk of graft failure after anterior cruciate ligament (ACL) reconstruction in adolescents and young adults. It is unclear whether the use of this procedure increases risks…

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Negative / Null Result ReportMedicine

Surgical complications after therapeutic lymph node dissection in stage III-IV melanoma: impact of neoadjuvant immunotherapy.

Lytchiér JVC, Okur MI, Rutkowski W et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Neoadjuvant immune checkpoint inhibitors (ICI) have recently entered clinical practice in management of melanoma, yet its impact on surgical outcomes remains unclear. This study evaluated the influence of neoadjuvant ICI on…

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Negative / Null Result ReportMedicine

Obstructive sleep apnea increases recurrent cardiovascular event risk in younger but not older patients with acute coronary syndrome: a prospective cohort study.

Gong W, Chen X, Zhao W et al. · 2026 · Sleep medicine

Background Obstructive sleep apnea (OSA) and age are strongly associated with recurrent events following acute coronary syndrome (ACS), but their interaction is unclear. This study was designed to evaluate the age-dependent impact of OSA…

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Negative / Null Result ReportMedicine

Caffeine Supplementation Increases Muscle Strength, but Not Endurance, While Both Caffeine and Its Expectation Elevate Blood Lactate: A Balanced-Placebo Design Study.

Soares EMKVK, da Cruz CJG, Ives SJ et al. · 2026 · Nutrients

Objectives : To determine whether caffeine supplementation and its expectancy influence muscle strength (ST) and muscle endurance (ME) using a balanced-placebo design. Methods: Using a randomized, double-blind, balanced-placebo design,…

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Negative / Null Result ReportMedicine

Do Respiratory Viruses Cause Leaky Gut Syndrome?

Karataş ŞN, Çağan E, Demirören K et al. · 2025 · Turkish archives of pediatrics

Objective Increased intestinal permeability is associated with the development of allergic and autoinflammatory diseases. Zonulin is a key physiological regulator of tight junctions in the intestinal epithelium. Thymus-expressed chemokine…

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Negative / Null Result ReportMedicine

Clinical utility of post-GnRH agonist trigger serum hormonal testing and effect on the incidence of empty follicle syndrome: a single-center retrospective cohort study.

Kloosterman R, Dinh T, Michaeli J · 2026 · Journal of assisted reproduction and genetics

Purpose The purpose of this study is to assess whether discontinuing routine serum hormone testing following gonadotropin-releasing hormone (GnRH) agonist trigger affects the incidence of empty follicle syndrome (EFS) and embryological…

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Negative / Null Result Report

Effect of insect exclusion screens on insect pests in high tunnels

Quesada CR, Batson C, Holaskova I et al. · 2025 · Preprint

Abstract High tunnels can use insect exclusion screens as a mechanical pest control method within integrated pest management (IPM) programs. The impact of insect screens was evaluated on several tomato pests in commercial high tunnels. The…

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Negative / Null Result ReportMedicine

Immune Checkpoint Inhibitors Did Not Exacerbate Autoimmune Rheumatic Disease Activity in Patients With Cancer.

Tsai PH, Hsieh CI, Kuo YC et al. · 2026 · Journal of the National Comprehensive Cancer Network : JNCCN

Background The safety of immune checkpoint inhibitors (ICIs) in patients with cancer and preexisting or acquired autoimmune rheumatic diseases (ARDs) remains unclear. This study aimed to evaluate the safety of ICIs in patients with cancer…

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Negative / Null Result ReportMedicine

Evaluation of a web-based self-monitoring application (MyRA) to empower people with rheumatoid arthritis in daily life.

Hochstenbach LMJ, Verbeek JGE, Brokken-Peters MBJ et al. · 2026 · Rheumatology (Oxford, England)

Objectives To evaluate MyRA, a web-based self-monitoring application for RA, on patient empowerment, usability and perceived usefulness. Methods MyRA was co-developed with patients and used at their own discretion during a 4-month…

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Negative / Null Result ReportMedicine

[Deep learning-based assessment of periodontal ligament area changes in maxillary central incisors under different orthodontic regimens using cone beam CT images].

Li RQ, Su S, Zhan LP et al. · 2026 · Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

Objective: To investigate the differences in the changes of periodontal ligament area (PDLA) and related clinical indicators before and after maxillary central incisor movement under different orthodontic treatment regimens. Methods: This…

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