20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Liu X, Wang Y, Medina AA et al. · 2026 · Pharmacological research
Gut-liver axis disturbance is the unifying pathogenesis of cholestatic liver diseases. The purpose of this study was to explore the underlying mechanisms of the probiotic Lactobacillus amylovorus (LA) and its secreted extracellular…
View details →Sohal P, Gupta K, Kaushal S et al. · 2025 · Preprint
ABSTRACT Objective Acute isoniazid toxicity causes refractory seizures due to pyridoxine deficiency-mediated gamma-aminobutyric acid depletion. While pyridoxine is the established antidote, its limited availability in emergency settings…
View details →Huchthausen C, Shi M, Sousa GL et al. · 2025 · Preprint
Abstract Radiomics-based machine learning models have the potential to detect lung cancer at inception from CT scans and transform patient outcomes. Low malignancy rates in early-development pulmonary nodules (PNs) and variable image…
View details →Timimi S · 2025 · Child and adolescent mental health
Because definitions of mental disorder are inescapably subjective, they can be continuously expanded in response to commercial, guild and social interests and pressures. In this article, I argue that this has resulted in young people…
View details →Moncheaux A, Guimond A, Spiegelhalter C et al. · 2025 · Preprint
ABSTRACT Background Mutations in CAV3 , encoding caveolin-3, cause caveolinopathies, rare genetic disorders affecting both skeletal and cardiac muscle. Caveolin-3 contributes to T-tubule formation and excitation-contraction coupling. BIN1…
View details →Fujii T, Nogami Y, Seo T · 2026 · BMJ open
Objectives Cognitive behavioural therapy (CBT) is recommended as a first-line treatment for depression and anxiety disorders, but its utilisation under Japan's national health insurance remains poorly understood. This study aimed to…
View details →Ead AS, Wirkus J, Machuca J et al. · 2026 · The Journal of nutrition
Background Pancreatic ductal adenocarcinoma is a deadly cancer linked to obesity. Adipose tissue contributes to tumor progression by promoting inflammation and supplying lipids and cytokines that support cancer growth. Although omega-6…
View details →Mudupula Vemula SS, Adhikari S, Motkur S et al. · 2026 · Cureus
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction, with high untreated mortality that can…
View details →Alpat SE, Kaya B, Nakkaş HG et al. · 2026 · Burns : journal of the International Society for Burn Injuries
Objective Despite notable advancements in burn care, morbidity and mortality remain high, with progressive tissue loss typically occurring in the first 48 h post-injury. While microneedling and topical retinyl palmitate are recognized for…
View details →Uyanık G, Yüksel M, Abay M et al. · 2026 · Animal reproduction science
This study aimed to evaluate the effects of TAK-683 administered to suckling goats in lactational anestrus on the 4th day (D4) after mating on luteal function, serum progesterone (P₄) levels, and reproductive performance. Forty-five Aleppo…
View details →Gardner JD, Triadafilopoulos G · 2026 · Digestive diseases and sciences
Purpose For unclear reasons, up to 50% of subjects with gastroesophageal reflux disease have an inadequate symptomatic response to treatment with a proton pump inhibitor. Our primary objective was to examine esophageal acid in subjects who…
View details →Huang Y, Chen Q, Chen R et al. · 2025 · BMC gastroenterology
OBJECTIVE: To explore disease severity thresholds beyond which endoscopic intervention fails to reduce mortality in the context of renal insufficiency and upper gastrointestinal bleeding (UGIB), and to develop predictive models for…
View details →Lee KA, Kim YH, Kim HS · 2026 · Clinical rheumatology
Objectives To evaluate the diagnostic concordance between salivary gland ultrasound (SGUS) and minor salivary gland biopsy (MSGB) in suspected primary Sjögren disease (SjD), and to assess the added value of Doppler ultrasound and extended…
View details →Schmidt US, Van Rickstal R, Van Goethem V et al. · 2026 · Palliative medicine
Background Supporting psychoeducational functioning for advanced cancer patients and informal caregivers (dyads) can be challenging. Self-managed digital interventions offer a possible cost-effective alternative but often face low…
View details →de Freitas ALS, Guth G, Araújo ALD et al. · 2026 · Archives of oral biology
Objective To investigate the temporal evolution and predictive value of individual histopathological features of oral epithelial dysplasia (OED) during carcinogenesis, and to evaluate the diagnostic utility of optical fluorescence imaging…
View details →Barham E, Khan M, Del-Cristo M et al. · 2026 · Cureus
Chylothorax, a rare complication of hepatic cirrhosis, is often under-recognized in the absence of ascites or other classical signs of portal hypertension. The diagnosis can be challenging due to its infrequent presentation, which…
View details →Lee KK, Lin YN · 2026 · Cureus
Non-purulent skin and soft tissue infections (NP-SSTIs) are commonly managed with antibiotic therapy; however, a subset of patients demonstrate inadequate clinical response and develop refractory disease. At present, no standardized…
View details →Dirisala A, Uchida S, Toh K et al. · 2025 · Journal of Controlled Release
Polycation-based mRNA delivery systems have an issue with mRNA integrity in the physiological milieu, particularly in blood compartments, despite their vast potential in mRNA therapeutics. Without comprehensive mechanistic analyses, design…
View details →Pouplard C, Charuel N, Archer E et al. · 2026 · International journal of laboratory hematology
Background Immunoassays detecting anti-PF4/H antibodies must be sensitive to exclude heparin-induced thrombocytopenia (HIT), and optical density (OD) values are useful for confirming HIT, but no calibration is currently available.…
View details →Biswas B, van Bergen E, Vaello T et al. · 2025 · Preprint
Plants and herbivorous insects are engaged in long-term coevolutionary arms races, where gains in novel plant defences and corresponding adaptations in herbivores may drive evolutionary change. One such recent innovation is the gain of…
View details →Kaur J, Yogesvaran R, Mohd Khialdin S et al. · 2025 · Cureus
A 72-year-old male patient with multiple comorbidities was under our follow-up for bilateral advanced pseudoexfoliative glaucoma with uncontrolled intraocular pressure (IOP) despite maximum medical therapy. He had previously received…
View details →Benamou A, El Moudane A, Barki A · 2026 · Cureus
Intravesical instillation of Bacillus Calmette-Guérin (BCG) is the standard adjuvant treatment for non-muscle-invasive bladder cancer. Although highly effective, BCG therapy may be associated with rare but potentially severe systemic…
View details →Hackett GI · 2025 · The world journal of men's health
TRAVERSE (TheRapy for Assessment of long-term Vascular events and Efficacy ResponSE in hypogonadal men) is multicentre randomized, double-blind, placebo-controlled, noninferiority trial of testosterone therapy, enrolling 5,246 men 45 to 80…
View details →El Housheimi A, Tato Varela S, Kuhn WC · 2026 · Oncology research and treatment
Background Ovarian cancer (OC) accounts for the most cancer deaths in women worldwide, despite it being the 8th most common one. Almost two-thirds or OC cases present in advanced stages (III/IV) and will require maintenance therapy lasting…
View details →Mano T · 2025 · Clinical medicine insights. Case reports
Cervical traction therapy is commonly used for cervical spondylosis; however, complications, such as subdural hematomas can occur. Possible mechanisms include cerebrospinal fluid (CSF) leakage and bridging vein damage. A 51-year-old…
View details →Serour MH, Mohammad H, Aziza O et al. · 2026 · Journal of surgical case reports
Chronic diabetic foot ulcers remain a major clinical challenge, particularly when complicated by tendon exposure and failure to respond to standard care. We report a 47-year-old male with Type II diabetes mellitus with a history of smoking…
View details →Kankotia S, Park S, Thomas J · 2025 · Current opinion in oncology
Purpose of review Relapsed or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a deadly disease that historically was treated with palliative chemotherapy-based regimens. Since 2019, immunotherapy-based regimens have become…
View details →Glauser G, Kvint S, Ramayya AG et al. · 2025 · Neurosurgery practice
Background and objectives The purpose of the present work was to review our series of patients with far lateral disk herniations treated by the intertransverse approach. Methods Patients undergoing intertransverse approach to treat…
View details →Childs H, Zhou P, Donald BR · 2025 · Preprint
Due to their favorable therapeutic properties, including improved stability, bioavailability, and membrane permeability, D-peptides that bind biological L-proteins represent an important class of systems in computational drug design. A…
View details →Simeonova L, Leseva M, Stoyanov K et al. · 2025 · Biochimica et biophysica acta. Molecular basis of disease
Sirtuin 1 (Sirt1), a class III histone deacetylase, is a key regulator of gene expression in various immune cell types, including neutrophils, during infection and acute inflammation. Herein, we studied the effect of the Sirt1 activator…
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