e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

19,847 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Core Temperature Estimation Using Wearable Earbud-Type Thermometer and Machine Learning During Light-Intensity Cycling Under Varying Indoor Ambient Temperatures.

Fujii N, Katagiri A, Nakagome K et al. · 2026 · Scandinavian journal of medicine & science in sports

Continuous monitoring of core temperature is crucial for optimizing exercise performance, promoting health, and ensuring safety. Here, we evaluated the validity of a machine learning-based earbud-type core temperature sensor during…

View details →
Negative / Null Result ReportMedicine

Development and validation of the OMERACT juvenile idiopathic arthritis MRI- sacroiliac joint score (OMERACT JAMRIS-SIJ): Phase 3.

Maksymowych WP, Weiss PF, Francavilla ML et al. · 2026 · Seminars in arthritis and rheumatism

Objective The OMERACT JAMRIS working group has defined a spectrum of MRI lesions in the sacroiliac joint (SIJ) in pediatric cases with spondyloarthritis (SpA) that match domains for inflammation and structural damage. We aimed to assess…

View details →
Negative / Null Result Report

Progressive Strength Training Counteracts Frailty but Does not Improve Short-Term Autonomic Compensatory Responses During Active Standing Orthostatic Stress

Gama de Matos D, de Santana JL, Aidar FJ et al. · 2025 · Preprint

Background: Frailty is a multifactorial condition that significantly impacts older adults health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…

View details →
Negative / Null Result ReportMedicine

Impact of Probiotic-Adjunctive Vonoprazan-Amoxicillin Dual Therapy on Gut Microbiota and Clinical Symptoms in Helicobacter pylori Eradication.

Yang Y, Lan C, Jiang Z · 2026 · Tissue engineering and regenerative medicine

Background This study evaluates the impact of Bacillus subtilis dual-strain enteric-coated capsules combined with vonoprazan-amoxicillin (VA) therapy on Helicobacter pylori (Hp) eradication rates, gastrointestinal symptoms, adverse events…

View details →
Negative / Null Result ReportMedicine

In Vivo Evaluation of Preconditioned Adipose-Derived Stromal Cells Reveals Limited Impact on Vascular and ECM Remodeling in Polymer Scaffolds.

Pinheiro-Machado E, Kuiper T, Huurman RH et al. · 2026 · Journal of biomedical materials research. Part B, Applied biomaterials

Polymer scaffolds are a promising platform for the transplantation of insulin-producing cells in Type 1 Diabetes. While vascularization has been a primary focus due to its role in oxygen and nutrient delivery, the interplay between blood…

View details →
Negative / Null Result ReportMedicine

The Impact of Blood Pressure Targets on Hemodynamics in Patients With Cardiogenic shock Caused by Infarction-Related Out-of-Hospital Cardiac Arrest: A Substudy of the BOX-trial.

Ten Berg S, Beske RP, Grand J et al. · 2026 · European heart journal. Acute cardiovascular care

Background Noradrenaline is frequently used to increase mean arterial pressure (MAP) in patients with cardiogenic shock caused by infarction-related out-of-hospital cardiac arrest (OHCA-AMICS). This Blood pressure and Oxygenation-Targets…

View details →
Negative / Null Result Report

Contrasting the classic effect of reward on attentional priority maps: Behavioral evidence for an attentional gating of spatially-specific reward signals

Beffara B, Hadj-Bouziane F, Ben Hamed S et al. · 2026 · Preprint

The control of selective visuo-spatial attention is known to rely on multiple signals, including reward. While most attention control signals are well acknowledged to interact with each other, the case of reward has led to mixed findings…

View details →
Negative / Null Result ReportMedicine

No Effect of a Single Session of Anodal Transcranial Direct Current Stimulation on Exercise-Induced Hypoalgesia in Knee Osteoarthritis: A Randomized Cross-Over Trial.

Toomey D, Lewis G, Rashid U et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

Background Exercise induces short-term pain relief (exercise-induced hypoalgesia, EIH), but this response is often blunted in people with knee osteoarthritis (OA). Transcranial direct current stimulation (tDCS) has been proposed as a…

View details →
Negative / Null Result Report

Contrasting the classic effect of reward on attentional priority maps: Behavioral evidence for an attentional gating of spatially-specific reward signals

Beffara B, Hadj-Bouziane F, Ben Hamed S et al. · 2026 · Preprint

The control of selective visuo-spatial attention is known to rely on multiple signals, including reward. While most attention control signals are well acknowledged to interact with each other, the case of reward has led to mixed findings…

View details →
Negative / Null Result ReportMedicine

Therapeutic and Prophylactic Effects of the Surfactant Protein D Mimetic CGSPS18 Against Schistosoma mansoni in Biomphalaria alexandrina and Mice.

El-Karim RMG, Ali REM, Habib MR et al. · 2026 · Acta parasitologica

Bachground Schistosomiasis remains difficult to control due to persistent transmission via freshwater snails and reliance on praziquantel (PZQ) as the primary treatment. Novel adjunctive strategies targeting multiple stages of the parasite…

View details →
Negative / Null Result Report

Comparative Evaluation of Non-HDL Cholesterol and the Triglyceride-Glucose Index for Predicting Acute Myocardial Infarction Risk in a Nepalese Hospital Population: A Cross-Sectional Study

Gupta BK, Pandey R, Thapa N et al. · 2026 · Preprint

Abstract Background Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, with South Asian populations facing a disproportionately high burden. In Nepal, the incidence of MI has been rising, and recent…

View details →
Negative / Null Result ReportMedicine

Can transcranial Direct Current Stimulation enhance the efficacy of a rehabilitative intervention for the treatment of Freezing of Gait in Parkinson's disease? A double-blind, randomized controlled study.

Madrid J, Batzianouli E, Rutz D et al. · 2026 · Journal of Parkinson's disease

BackgroundFreezing of gait (FOG) in Parkinson's disease (PD) is a major cause of disability and falls and often responds incompletely to conventional therapy. Rehabilitative interventions including cognitive strategies and sensory cueing…

View details →
Negative / Null Result ReportMedicine

A Combinatorial Strategy for Peripheral Nerve Repair Utilizing 3D-Printed Collagen Nerve Guidance Conduits and Photobiomodulation Therapy: A Pilot Study in a Rat Sciatic Nerve Transection Model.

Fellin CR, Steiner RC, Buchen JT et al. · 2026 · Photobiomodulation, photomedicine, and laser surgery

Background Nerve guidance conduits (NGCs) are a clinically approved option for peripheral nerve repair but remain ineffective compared with autograft "gold standard" treatment options. A combinatorial approach to conduit-based peripheral…

View details →
Negative / Null Result ReportMedicine

Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo.

Broadley D, Le Riche A, Yu Y et al. · 2026 · International journal of molecular sciences

Androgen receptor (AR) signaling plays a key role in male pattern baldness. We investigated whether targeting Dickkopf 1 ( DKK1 ) and Secreted frizzled-related protein 1 ( SFRP1 ), two AR-regulated genes, offers a novel therapeutic…

View details →