e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

84 real negative results, null findings, and replication failures · Abandoned Hypothesis. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Abandoned HypothesisMedicine

Iridology: Biological plausibility, clinical evidence, and implications for ophthalmic practice : A position paper of the Associazione Pazienti Malattie Oculari (APMO).

Iuliano L, Veritti D, Lanzetta P · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Iridology is an alternative diagnostic practice that claims to identify systemic diseases and organ dysfunction through visual inspection of iris features, including pigmentation patterns, crypts, furrows, and discolorations. Despite its…

View details →
Abandoned HypothesisOpen accessMedicine

Intrawound vancomycin powder in orthopaedic surgery after the VPIP trial: a critical reappraisal of efficacy, dosing, application plane, and antimicrobial stewardship.

Werneburg F, Zeh A, Gutteck N et al. · 2026 · Journal of bone and joint infection

Topical intrawound vancomycin powder has been widely adopted in orthopaedic surgery as an adjunct for the prevention of surgical site infection (SSI) and periprosthetic joint infection (PJI). Retrospective cohorts and derived meta-analyses…

View details →
Abandoned HypothesisMedicine

Hermann J. Muller's research swan song: His long-term radiation dose-rate mutation investigations yielded no research publications, leaving questions of scientific misconduct.

Calabrese EJ · 2026 · Chemico-biological interactions

This paper evaluates the final major research effort of Hermann J. Muller, Nobel Laureate, to assess whether radiation displays a dose-rate process for radiation-induced germ cell mutation. Muller tried to extend the dose-rate findings of…

View details →
Abandoned HypothesisOpen accessMedicine

Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors.

Ghosh AK, Bhattacharjee A, Jayashankar U et al. · 2026 · Organic & biomolecular chemistry

We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective…

View details →
Abandoned HypothesisMedicine

Two New Pyrrole Alkaloids From Lanmaoa asiatica.

Li, Hou, Li et al. · 2026 · Chemistry & biodiversity

Two new pyrrole alkaloids, asiaticain A (1) and asiaticain B (2), two aromatic compounds 3-4, and one steroid 5 were isolated from Lanmaoa asiatica. The structural elucidation of the isolated compounds was determined by using NMR, MS, IR,…

View details →
Abandoned HypothesisOpen access

On the Singularity at Light Velocity

Nishida, Akira, 西田, 晃 · 2013

The Michelson-Morley experiment failed to detect evidence for the wind of luminiferous aether. However, the fact that light propagates without affecting aether wind on the rotating earth means that the medium is also rotating with us. For…

View details →
Abandoned HypothesisOpen accessPhilosophy (General)

A Study of the Possibility of a Science Associated with a Specific Worldview

Mostafa Taqavi · 2019 · Journal of Philosophical Investigations

There are two main sections in this paper. First, we will show that some of the chief 20th-century theories of science either have failed to demonstrate that value judgments do not influence the context of consolidation and determination of science or have accepted the role of value judgments in the context of consolidation and determination of science and theorized accordingly. For this purpose, the ideas of logical positivists, Willard Quine, Karl Popper, Thomas Kuhn, Imre Lakatos, Paul Feyerabend, and Roy Bhaskar on science are briefly reviewed. Finally, the validity of the following statem

View details →
Abandoned HypothesisOpen accessImmunologic diseases. Allergy

The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments

John P. Veluchamy, John P. Veluchamy, Nina Kok et al. · 2017 · Frontiers in Immunology

Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely explored in cancer immunotherapy. Early studies from autologous NK cells have failed to demonstrate significant clinical benefit. In this review, the clinical benefits of adoptively transferred allogeneic NK cells in a transplant and non-transplant setting are compared and discussed in the context of re

View details →
Abandoned Hypothesis

Before We Can Find a Model, We Must Forget about Perfection

Dimiter Dobrev · 2022 · Serdica Journal of Computing

With Reinforcement Learning we assume that a model of the world does exist. We assume furthermore that the model in question is perfect (i.e. it describes the world completely and unambiguously). This article will demonstrate that it does…

View details →
Abandoned Hypothesis

The Failed Reader: Keats’s “Brain-Sick” Endymion

Jo-Anne Cappeluti · 2012 · Philosophy and Literature

John Keats’s subject in Endymion is the imagination operating on the failed reader: the neutral or adolescent intellect that ultimately denies the transcendence it experiences; failing to mature, willfully remaining adolescent. Keats’s…

View details →
Abandoned Hypothesis

Did Copyright Fail Music Artists?

Rachel Landy · 2025 · SSRN Electronic Journal

Music soundtracks our lives, supports over two million domestic jobs annually, and is being listened to more than ever before. The record industry is thriving, having made over $17 billion in 2024. Yet, many professional artists…

View details →
Abandoned HypothesisOpen accessPhysics

Modelling the Astronomical Silicate Features: I. On the Spectrum Subtraction Method

Aigen Li, J. Mayo Greenberg, Gang Zhao · 2002 · arXiv

The {\it assumption of additive absorptivity} by different components in compound particles is a widely used method applied in the literature to the analysis of the chemical and structural properties of astronomical (circumstellar, interstellar, protostellar, and cometary) silicates as well as other materials. The errors intrinsic in this additivity assumption, which, in application to astronomical spectra, amounts in some case to {\it spectrum subtraction} have not always been adequately considered in previous works on silicate mineralogy. The failings in the ``{\it spectrum subtraction metho

View details →