20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Komarow HD, Wang J, Eisch R et al. · 2025 · The journal of allergy and clinical immunology. Global
Background Indolent systemic mastocytosis is a clonal mast cell disease that results in an increase in mast cells in the skin, bone marrow, and other organ systems. IL-6 has been shown to promote mast cell maturation, proliferation, and…
View details →Guo JY, Lin HY · 2023 · Chinese journal of traumatology = Zhonghua chuang shang za zhi
The Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin (SCARLET) trial has many defects, and thus cannot be the terminator of recombinant thrombomodulin (rTM). On the contrary, it provides sufficient evidence for further research.…
View details →de Ruiter MB, Groot PFC, Deprez S et al. · 2023 · Neuro-oncology
Background Reducing radiation dose to the hippocampus with hippocampal avoidance prophylactic cranial irradiation (HA-PCI) is proposed to prevent cognitive decline. It has, however, not been investigated whether hippocampal atrophy is…
View details →Abrams D, Montesi SB, Moore SKL et al. · 2020 · Critical care medicine
Objectives Recurring issues in clinical trial design may bias results toward the null, yielding findings inconclusive for treatment effects. This study evaluated for powering bias among high-impact critical care trials and the associated…
View details →Stockton S, Catalano P, Cohen SJ et al. · 2023 · The oncologist
Background Patients with advanced esophageal cancer carry poor prognoses; limited data exist to guide second-line therapy in the metastatic setting. Paclitaxel has been used yet is associated with limited efficacy. There is preclinical…
View details →Gandhy SU, Karzai FH, Bilusic M et al. · 2024 · European urology oncology
Background The emergence of positron emission tomography (PET) in prostate cancer is impacting clinical practice, but little is known about PET imaging as a tool to determine treatment failure in metastatic castration-resistant prostate…
View details →Gagnon J, Quansah JE, Saleh G et al. · 2022 · Psychopathology
Introduction Splitting, as a defense mechanism in Kernberg's theory, plays a significant role in the development and maintenance of polarized and oscillating representations of self/other characteristics of borderline personality disorder…
View details →Imamura Y, Kiyota N, Tahara M et al. · 2024 · Cancer medicine
Background In a randomized phase II/III trial (JCOG1008), weekly cisplatin (40 mg/m 2 ) was non-inferior to 3-weekly cisplatin (100 mg/m 2 ) for postoperative high-risk head and neck cancer. We investigated how acute kidney injury (AKI), a…
View details →Wüst LN, Cajochen C, Lasauskaite R · 2025 · Neurobiology of sleep and circadian rhythms
A chronotype is defined as a preference for certain behaviours (e.g., sleep and wake) to occur at specific times of day. It is therefore also temporally linked with cognitive performance across the day. In an exploratory analysis, we…
View details →Metsch LR, Feaster DJ, Gooden LK et al. · 2025 · Open forum infectious diseases
Background People with HIV (PWH) who use cocaine are less likely to achieve virologic suppression ( Methods Project RETAIN recruited 360 cocaine-using PWH who were not virologically suppressed in Miami, FL, and Atlanta, GA. Patients were…
View details →Ackermans N, Taylor C, Tam R et al. · 2019 · Multiple sclerosis journal - experimental, translational and clinical
Objective The objective of this paper is to evaluate potential dose-dependent adverse effects of gadolinium-based contrast agents (GBCAs) on MS progression. Methods Outcomes from a cohort of 612 secondary progressive MS (SPMS) patients,…
View details →Domsic RT, Gao S, Laffoon M et al. · 2021 · Rheumatology (Oxford, England)
Objectives Clinical trials in early diffuse cutaneous systemic sclerosis (SSc) using the modified Rodnan skin score (mRSS) as the primary outcome measure have most often been negative. We wanted to assess how the definition of disease…
View details →Kremer L, Bus JD, Webb LE et al. · 2021 · Scientific reports
Affective states can be inferred from responses to ambiguous and threatening stimuli, using Judgement Bias Tasks (JBTs) and Attention Bias Tasks (ABTs). We investigated the separate and interactive effects of personality and housing…
View details →Mason MG, Richardson EJ, Giarrusso C et al. · 2025 · Journal of the experimental analysis of behavior
This experiment explored a rodent model of functional class formation by assessing the transfer of a novel discriminative function across class members. Following simple successive discrimination reversal training and consistently strong…
View details →Chamberlain DB, Chamberlain JM · 2017 · Annals of emergency medicine
Study objective We demonstrate the application of a Bayesian approach to a recent negative clinical trial result. A Bayesian analysis of such a trial can provide a more useful interpretation of results and can incorporate previous…
View details →Yurttas C, Horvath P, Fischer I et al. · 2024 · Journal of clinical medicine
(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This…
View details →Puvvada SD, Guillén-Rodríguez JM, Rivera XI et al. · 2017 · Oncology
Objective Aggressive lymphomas (aNHL) including diffuse large B-cell lymphoma (DLBCL) have poor outcomes in relapsed refractory patients. Prior studies have demonstrated that loss of major histocompatibility complex class II (MHCII)…
View details →Bajwa MS, Jackson R, Dhanda J et al. · 2023 · Cancers
Objectives High-quality randomised controlled trials (RCT) to support the use of Fibrin Sealants (FS) in neck dissection (ND) are lacking. The DEFeND trial assessed critical pilot/feasibility questions and signals from clinical outcomes to…
View details →Howland RH · 2015 · Journal of psychosocial nursing and mental health services
Seven topics previously described in this column are revisited. The use of quantitative electroencephalography has been shown in a prospective study to be effective for predicting antidepressant treatment response. A novel antidepressant…
View details →Ford KL, Sawyer MB, Ghosh S et al. · 2024 · ESMO open
Background Low muscle mass (MM) predicts unfavorable outcomes in cancer. Protein intake supports muscle health, but oncologic recommendations are not well characterized. The objectives of this study were to evaluate the feasibility of…
View details →Wulff KC, Miller FG, Pearson SD · 2011 · Health affairs (Project Hope)
To attain the anticipated benefits of increased investments in comparative effectiveness research, the results must translate into improved medical practice and policy. In this article we present an analysis of a case study of percutaneous…
View details →Komiya T, Huang CH · 2018 · Frontiers in oncology
Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers. Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a…
View details →Ponizovsky AM, Rosca P, Aronovich E et al. · 2015 · Journal of substance abuse treatment
Background Limited clinical trials and case-reports yielded conflicting results regarding the efficacy of baclofen (a GABAB agonist) in the treatment of alcohol dependence. The aim of this study was to test the efficacy and tolerability of…
View details →Park L, Furey M, Nugent AC et al. · 2019 · The international journal of neuropsychopharmacology
Background This randomized, placebo-controlled, crossover trial examined the antidepressant efficacy of the muscarinic antagonist scopolamine in major depressive disorder subjects with more severe and refractory forms of major depressive…
View details →Wu CC, Wolfe JM · 2022 · Vision research
During a visual search for a target among distractors, observers do not fixate every location in the search array. Rather processing is thought to occur within a Functional Visual Field (FVF) surrounding each fixation. We argue that there…
View details →Pramhas S, Thalhammer T, Terner S et al. · 2023 · The Lancet regional health. Europe
Background Painful knee osteoarthritis (KOA) is common, pharmacological treatment, however, is often hampered by limited tolerability. Cannabidiol, which preclinically showed anti-inflammatory, analgesic activity, could supplement…
View details →Galata Z, Limoncu O, Tunakan Dalgıc C et al. · 2026 · Allergy and asthma proceedings
Introduction: Local anesthetics (LAs) are commonly used to provide regional insensitivity in dentistry, minor surgical procedures, and general anesthesia but may rarely cause allergic reactions. Methods: The file data of 101 patients who…
View details →Staley I · 2026 · Preprint
Quantum-like models of cognition account for order effects, conjunction and disjunction fallacies, and contextuality in human decision data using the Hilbert-space formalism without claiming literal quantum processes in the brain. Two…
View details →Horita V, Yuan L · 2026 · Preprint
Commercial inoculants based on associative diazotrophs and methylotrophic bacteria, and bios-timulant programs, are marketed for broad use in cereal and fiber production, yet most field deployment occurs over already adequate mineral…
View details →Laird G, Calinger-Yoak A, Zhang Q · 2026 · EcoHealth
Wild Eastern Gray Squirrels (Sciurus carolinensis) rehabilitated at a Midwestern facility, the Ohio Wildlife Center, were experiencing an increased mortality rate due to unknown respiratory illness in 2022-2023. A qPCR test was developed…
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