20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mourikes VE, Lee C, Oladosu JI et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
Imidacloprid (IMI) is an insect-selective synthetic nicotine derivative used in commercial agricultural systems, home gardening, and veterinary pharmaceuticals. People are exposed to IMI through consumption of contaminated food and water…
View details →Fujita E, Hadano J, Hashimoto J et al. · 2026 · Behavioural brain research
Neural circuit formation through synaptogenesis plays a crucial role in learning, memory, and the recovery of neural function following brain dysfunction. We previously reported that administering the low-dose cardiac glycoside digoxin,…
View details →Lin CJ, Bosco AA, Alves LI et al. · 2026 · Scientific reports
Long-COVID-19 presentation has not been evaluated with proper depth in patients with diabetes (DM). This retrospective study evaluated 870 patients (320 DM, 550 non-DM) followed for up to 7.1 months post-hospitalization. Acute myocardial…
View details →Vincová A, Šantová K, Jaššo M et al. · 2026 · Journal of dairy science
The objective of this study was to evaluate the effect of citrus fiber (1% wt/wt) on the physicochemical, rheological, textural, tribological, and sensory properties of quark cheese spreads with different fat content (10%, 15%, and 20%…
View details →Pottorf TS, Lane EL, Haley-Johnson Z et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
Spinal cord ventral horn microglia proliferate after nerve injuries and migrate toward cell bodies of injured motoneurons (MNs) enwrapping them. The significance of this microglia reaction has remained unclear. Moreover, some injured MNs…
View details →Scioli MV, Sosa E, Barale J et al. · 2026 · Veterinary immunology and immunopathology
Bovine genital campylobacteriosis (BGC) remains a major cause of reproductive failure in beef cattle systems. This study evaluated the persistence of Campylobacter fetus subsp. venerealis (Cfv) and associated lesions in the reproductive…
View details →Ormes JA, Smrcka AV, Jutkiewicz EM · 2026 · Molecular pharmacology
The clinical utility of μ-opioid receptor (MOR) agonists is limited by side effects and tolerance. G protein βγ subunits (Gβγ) are critical mediators of MOR signaling that not only drive anticonception but also regulate phospholipase C and…
View details →Sigaard JVA, Spindler H, Joensen EDR et al. · 2026 · Journal of palliative medicine
Background An estimated 4.4 million people in Europe require palliative care annually, a number expected to rise with population aging. Telepalliative care (TPC) has been practiced in various settings over the past two decades. The Telepal…
View details →AhmadQaderi F, Pazouki A, Pishgahroudsari M et al. · 2026 · Obesity surgery
BACKGROUND: Metabolic-bariatric surgery (MBS) is recognized as the most effective long-term intervention for obesity and its associated conditions, including type 2 diabetes mellitus (T2DM) One-anastomosis gastric bypass (OAGB), the third…
View details →Del-Ángel-Monroy S, Rodríguez-Márquez A, Orozco-Suárez S et al. · 2026 · Basic & clinical pharmacology & toxicology
Vascular relaxation induced by 5-HT 2B receptor is thought to be mediated by stimulation of endothelial nitric oxide synthase (eNOS), but this assumption still requires investigation. To investigate potential mechanisms, BW723C86 (5-HT 2B…
View details →Torres-Huerta A, Ruley-Haase K, Boger-May A et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
The cause of inflammatory bowel disease (IBD) is not known, but both innate and adaptive immunity contribute to IBD pathogenesis. To better understand the contributions of innate immunity to IBD, we have generated a mouse model of IBD that…
View details →Aragone L, Burbano P, Cameron A et al. · 2026 · Annals of surgical treatment and research
Purpose A Suffocating Neck Hematoma (Snh) Is A Rare But Potentially Fatal Surgical Complication Of Thyroidectomy. In An Effort To Reduce Its Incidence, Many Surgeons Opt For The Selective Use Of Drains. However, There Are No Studies…
View details →Szlufik S, Duszyńska-Wąs K, Koźmińska A et al. · 2026 · Neurologia i neurochirurgia polska
Introduction Bilateral subthalamic nucleus deep brain stimulation (DBS STN) is a very effective surgical method of treating motor symptoms in Parkinson's disease (PD) patients. The long-term cognitive outcome after the surgery is still…
View details →Lagacé JC, St-Martin P, Avino M et al. · 2026 · Experimental physiology
Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals…
View details →Stadie N, Heinzer R, Marques-Vidal P · 2026 · European journal of nutrition
PURPOSE: Many individuals turn to supplements like magnesium, believing them to offer a natural way to improve sleep quality. Yet, research on magnesium’s effects has produced inconsistent results. We assessed the relationships between…
View details →Thomas S, Ben-Davies R, Cetinkaya-Fisgin A et al. · 2026 · Journal of the peripheral nervous system : JPNS
Background and aims Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD + ) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD + levels are associated with axonal…
View details →Battistelli LS, Moraes RM, Santos YC et al. · 2026 · Journal of periodontology
Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro-inflammatory environment which may exacerbate tissue damage.…
View details →Spormann S, Lebre M, Moutinho-Pereira J et al. · 2026 · Journal of plant physiology
Wild tomato species (WTS) have long been attracting the attention of plant researchers due to their ability to tolerate harsh environmental conditions in their natural habitats. In this context, their use in grafting procedures, where they…
View details →Espelta JM, Viana‐Soto A, Molowny‐Horas R et al. · 2026 · Journal of Applied Ecology.
While disturbances are essential for biodiversity, their escalation driven by climate change may threaten forest ecosystems. Contrasting approaches to adapt forests to disturbances-intensifying management versus encouraging natural…
View details →Ruocco-Vetucci V, Chaves RAC, Ballan ACF et al. · 2026 · General dentistry
Considering that osteonecrosis of the jaw may be due to the antiangiogenic effect of bisphosphonates and that leukocyte- and platelet-rich fibrin (L-PRF) releases proangiogenic factors, this study hypothesized that L-PRF could prevent…
View details →Al-Haddad C, Kobeissi H, Wehbi Z et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
Purpose To assess the driving performance and visual attention of amblyopic drivers using a driving simulator integrated with eye tracking technology in an urban setting. Methods A total of 30 participants were enrolled: 14 amblyopic…
View details →Cao X, Francisco CO, TaghiBeyglou B et al. · 2026 · Sleep & breathing = Schlaf & Atmung
PURPOSE: The recumbent posture during sleep increases small airway narrowing and nocturnal asthma despite optimal asthma treatment. Fluid accumulation in the chest can narrow the airway lumen, contributing to small airway narrowing. We…
View details →Lu X, Han Y, Song J et al. · 2025 · Frontiers in endocrinology
Background Recent studies have focused on investigating the role of cellular senescence in ovarian aging. Targeting cellular senescence has been proposed as a potential strategy to improve ovarian aging. p16 and p21 are classical molecules…
View details →de Boer N, Vučko Z, Koster DI et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Antipsychotic-induced weight gain (AiWG) is a common, burdensome adverse effect. Switching to antipsychotics with lower metabolic risks, such as aripiprazole, is recommended, but long-term data is limited. Long-acting injectables (LAIs)…
View details →Sholikah TA, Septyaningtrias DE, Sumiwi YAA et al. · 2025 · Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
Background this study aimed to examine the impact of a TNF-α antagonist on markers of neuronal death, the total number of myenteric neurons, and the volume of each colonic layer in diabetic rats. Methods thirty male rats were divided into…
View details →Carmon L, Nassar M, Idan D et al. · 2026 · Journal of clinical medicine
Background/Objectives : Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterized by impaired glycosaminoglycan degradation, leading to multisystem involvement and progressive growth impairment. Longitudinal growth data in…
View details →Cedeno Escobar AM, Walstrom KM · 2025 · microPublication biology
Imbalances between pathogenic and commensal bacteria cause microbial dysbiosis that disrupts host development. Streptococcus mutans ' virulence factors promote human oral cell colonization, leading to dysbiosis if unchecked. When grown…
View details →Goldberg TS, Shalem Y, Fujinaga D et al. · 2025 · Journal of insect physiology
Juvenile hormones (JHs) are key insect endocrine signals regulating pre-adult development and adult life history strategies, physiology, and behavior. The importance of this endocrine signal has led to the development of insecticides…
View details →Kitaoka Y, Tsukahara C, Fujita N et al. · 2025 · International ophthalmology
Purpose Intravitreal injections of some drugs such as anti-VEGF antibodies are available for certain human ocular diseases. Meanwhile, inhibition of SARM1 has been reported to exert neuroprotection in several neurodegenerative disease…
View details →Garofolo IC, Santos PF, Silva MF et al. · 2026 · Nutrition and health
Background: Type 2 Diabetes Mellitus is a metabolic disease characterized by hyperglycemia and hyperinsulinemia, closely linked to obesity. According to the International Diabetes Federation, in 2021, almost 6.7 million adults aged 20-79…
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