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Browse the failure-mode index

19,843 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

High-dose metoclopramide versus placebo for gastroduodenal visualization during endoscopy in patients with acute upper gastrointestinal bleeding. A triple-blind, randomized clinical trial.

Herrera-Elizondo JL, Jiménez-Castillo RA, García-Compeán D et al. · 2026 · Revista de gastroenterologia de Mexico (English)

Introduction and aims The usefulness of metoclopramide for improving endoscopic visualization in upper gastrointestinal bleeding (UGIB) is controversial. Our primary aim was to evaluate the utility of metoclopramide 20 mg/IV for endoscopic…

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Negative / Null Result ReportMedicine

Platelet-rich plasma versus plasma gel for fat graft survival under cigarette smoke exposure: An experimental study.

Naghizade B, Özyazgan İ, Bozkurt F et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Background Autologous fat grafting is widely used in plastic surgery, but graft survival remains unpredictable, particularly under compromised conditions such as cigarette smoking. Smoking impairs microcirculation and tissue oxygenation,…

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Negative / Null Result ReportMedicine

Clinical Features Outperform MRI Radiomics for Predicting Intra-Articular Hyaluronic Acid Response in Knee Osteoarthritis.

Alkhatatbeh T, Alkhatatbeh A, Liao Y et al. · 2026 · Annals of the New York Academy of Sciences

Intra-articular hyaluronic acid (IAHA) injections are used for knee osteoarthritis, but clinical response is highly variable. This study evaluated whether quantitative magnetic resonance imaging (MRI) radiomics provides incremental…

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Negative / Null Result ReportMedicine

Survival Trends of People With Spina Bifida From 1950-2020.

Schlaepfer CH, Lange SM, Lau GA et al. · 2026 · JAMA pediatrics

Importance People with spina bifida historically have worse survival. Despite health care improvements, survival improvement data are mixed. Objectives To compare survival for people with spina bifida to an unaffected cohort and to…

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Negative / Null Result ReportMedicine

Endoscopic Ultrasound-guided Transluminal Drainage of Walled-off Necrosis using Naso-cystic Drain with Metal Stent versus Metal Stent Alone: A Randomized Controlled Pilot Study.

Kar N, Rana SS, Gupta R et al. · 2026 · Pancreas

Background and aims Endoscopic ultrasound (EUS)-guided drainage using a lumen-apposing metal stent (LAMS) has become the standard of care in managing symptomatic walled-off necrosis (WON). However, the role of nasocystic drainage (NCD) in…

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Negative / Null Result ReportMedicine

Enhancing the accuracy of high-sensitivity troponin for diagnosing acute myocardial infarction in emergency department patients with kidney dysfunction: a scoping review.

Morningstar M, Edwards M, Yang L et al. · 2026 · CJEM

Objectives To systematically identify and describe optimal methodology used to improve the diagnostic accuracy of high-sensitivity cardiac troponin for diagnosis of myocardial infarction in patients with kidney dysfunction. Methods…

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Negative / Null Result ReportMedicine

Dietary folate education versus once-weekly iron folic acid supplementation for improving folate status in reproductive-aged women: a quasi-experimental study.

Sroypechr K, Hutchinson C, Satheannoppakao W et al. · 2026 · BMC nutrition

Background The folate status of women of reproductive age (WRA) in Thailand is suboptimal for reducing risk of neural tube defects (NTD). This research aimed to compare the effect of dietary folate education based on the health belief…

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Negative / Null Result ReportOpen accessMedicine

Incremental Value of Adding S100B to NSE for High-Specificity Rule-in of Poor Neurological Outcome After Out-of-Hospital Cardiac Arrest.

Hong S, Lee S, Park JS et al. · 2026 · Journal of clinical medicine

Background : We evaluated whether adding S100B to NSE improved discrimination or high-specificity rule-in of poor neurological outcome after out-of-hospital cardiac arrest (OHCA). Methods : In this single-center retrospective cohort study,…

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Negative / Null Result Report

Effects of Cognitive Demand Reduction on Choice Overload

Seo S, Lee S, Lee N et al. · 2026 · Preprint

Choice overload occurs when an ever-growing number of options impairs decision quality, because evaluating options taxes cognitive resources. We investigated whether reducing cognitive demand could mitigate overload by encouraging greater…

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Negative / Null Result ReportMedicine

Effect of prolonged interval between neoadjuvant chemoradiotherapy and surgery on pathological and oncological outcomes in locally advanced rectal cancer: a randomized controlled trial.

Sileika E, Cerkauskaite D, Bausys A et al. · 2026 · International journal of colorectal disease

Background The optimal interval between neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME) in locally advanced rectal cancer (LARC) remains controversial. This randomized controlled trial evaluated whether prolonging…

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Negative / Null Result ReportMedicine

Digital Phenotyping and Lifestyle Intervention in Patients With Myasthenia Gravis (DIG-MG): A Randomized Controlled Trial of Feasibility, Adherence, and Effects on Fatigue.

Norling M, Eriksson N, Westerberg E et al. · 2026 · Muscle & nerve

Introduction/aims Physical activity and sleep influence fatigue in myasthenia gravis (MG), and digital health technologies (DHT) enable objective monitoring of these behaviors in daily life. Using this approach, we evaluated whether a…

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Negative / Null Result ReportMedicine

Do Laser and Light Activation Improve In-Office Dental Bleaching Outcomes? An Umbrella Review of Efficacy, Tooth Sensitivity, and Biological Safety.

Allende JB, Campos-Bijit V, Morales-Gómez C et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To synthesize umbrella-level evidence on laser or light activation and photobiomodulation in in-office dental bleaching, including whitening efficacy, tooth sensitivity, and biological safety. Systematic reviews were searched in…

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Negative / Null Result ReportMedicine

To Drain or Not to Drain? The Manchester Buckle Study.

Kiraly P, Lippera M, Ally N et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To assess whether external drainage of subretinal fluid (SRF) improves anatomical or visual outcomes in scleral buckle surgery for rhegmatogenous retinal detachment (RRD). Methods Retrospective review of 609 primary scleral buckles…

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Negative / Null Result ReportMedicine

Exploring hemodynamic measurements from the Tromsø Study for prediction of cardiovascular disease using traditional statistical models and machine learning approaches.

Azulay N, Singstad BJ, Schirmer H et al. · 2026 · Scientific reports

In Norway, NORRISK2 is the government-recommended risk model for predicting an individual's 10-year probability of getting cardiovascular disease (CVD). This study aims to investigate the potential for improvement of CVD prediction by…

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