19,840 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Chan A, Freschi L, de-Pinna GFAM · 2026 · Preprint
Abstract Leaf sheaths in monocotyledons may be open or closed, yet the developmental regulation of sheath margins remains unclear in Commelinaceae, a family with closed sheaths. This study investigated the morphogenesis of leaf sheaths in…
View details →Lanham BS, Morris RL · 2026 · Marine environmental research
The strength of biotic stressors (i.e., predation) can determine the success of shellfish reef restoration projects. In recruitment limited systems where seeding is a common restoration strategy, ensuring the survival of seeded individuals…
View details →Turner KM, Svegborn A, Robbins TW · 2026 · Psychopharmacology
Rationale Recent research on habits and skills has produced a wave of new theories regarding the shift in control from medial to lateral regions of the dorsal striatum, and how these regions are implicated in the selected and executed of…
View details →Uenishi R, Kawata R, Manabe T et al. · 2026 · Preprint
Neuroinflammation is a central driver of tauopathy, yet the precise chemokines that orchestrate the inflammatory microenvironment remain elusive. Here, we report C-X-C motif chemokine ligand 10 (CXCL10) is markedly upregulated in the…
View details →Dachille GP, Zuanna AD, Paiella M et al. · 2026 · Preprint
Abstract We quantify how the employment expansion accompanying Italy’s post-pandemic recovery mitigated the distributional consequences of the contemporaneous surge in prices, which disproportionately affected households at the bottom of…
View details →Cárdenas SA · 2026 · Preprint
Objective(s): Strategic overcharging involves threatening disproportionately harsh punishment to widen the differential between the potential sentence if convicted at trial (PTS) and the plea sentence. Though larger discounts increase plea…
View details →Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayon F · 2026 · Psychopharmacology
Rationale Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive avoidance (no…
View details →Ben-Chetrit E, Zilberstein Z, Levin PD · 2026 · Preprint
Abstract Background Obtaining blood cultures at IV insertion is common practice, but is probably associated with greater contamination. Whether use of first-aliquot-diversion (diversion) reduces contamination in this context is not clear.…
View details →DiLeone R, Trinko JR, Atangana E et al. · 2026 · Preprint
Binge eating disorder (BED) is characterized by episodic overconsumption of palatable food and involves dysregulated motivational and arousal processes. The orexin (hypocretin) system, through its widespread projections to mesolimbic…
View details →Plouhinec L, Maresca M, Saget J et al. · 2026 · Applied microbiology and biotechnology
As demand for sustainable and welfare-conscious food production increases, reducing the environmental and health impacts of animal feed has become a key challenge. Soybean meal (SBM) is widely used in poultry diets for its high protein…
View details →Pearson AL, Tomaszewska MA, Brown CD et al. · 2026 · Preprint
Abstract Exposure to heat in urban settings is a significant and growing public health concern. Yet, few studies have longitudinally measured everyday heat exposure using GPS-derived activity space data, paired with fine resolution…
View details →Ki SY, Jeong YT · 2026 · Biochemical and biophysical research communications
Peripheral sensory nerve injury triggers Wallerian degeneration, a process characterized by axonal fragmentation, myelin breakdown, and robust macrophage infiltration. While macrophages are widely implicated in debris clearance and repair…
View details →Schmid JA, Hogue M, Aguilar-Cardoza J et al. · 2026 · Environmental toxicology and chemistry
Agricultural run-off is one of the leading sources of environmental pollution in the United States. Insecticides and neonicotinoids have become the most used insecticide class across the world and act as an agonist on the nicotinic…
View details →Riviere JC, Marty V, Cavaillé J et al. · 2026 · Preprint
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the loss of paternally expressed genes within the imprinted 15q11-q13 locus, which includes clusters of box C/D small nucleolar RNAs (SNORDs), notably the SNORD115 and…
View details →Alshammari AK, Maina M, Alsuwat MA et al. · 2026 · Preprint
Respiratory viral-bacterial co-infections cause severe disease across species, yet the molecular mechanisms underlying enhanced pathogenesis remain poorly understood. This study characterised H3N8 equine influenza A virus (IAV) and…
View details →Saiz-Gonzalo G, Drouin G, Rao Y et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Non-nutritive sweeteners (NNS) are increasingly consumed during pregnancy, yet their distinct metabolic fates obscure a unified mechanism for developmental programming. We tested whether maternal NNS exposure acts upstream of metabolism by…
View details →Plouhinec L, Maresca M, Saget J et al. · 2026 · Preprint
Abstract As demand for sustainable and welfare-conscious food production increases, reducing the environmental and health impacts of animal feed has become a key challenge. Soybean meal (SBM) is widely used in poultry diets for its high…
View details →Magsi FH, Ullah A, Ma Y et al. · 2026 · Journal of chemical ecology
Fall armyworm (Spodoptera frugiperda) has emerged as a major pest of maize across the Americas, Africa and Asia. Current management relies heavily on synthetic insecticides, which are environmentally unsustainable. However, pheromone-based…
View details →Chen B, Wang Q, Xue X et al. · 2026 · NPJ biofilms and microbiomes
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition arising from interactions between genetic and environmental factors. The interplay between the microbiota-gut-brain axis and epigenetics has been implicated in ASD,…
View details →Takeuchi H, Akiba Y, Van Quang N et al. · 2026 · Journal of prosthodontic research
Purpose Osseointegration begins at the initial blood-implant contact; however, titanium-adhesive blood proteins remain incompletely defined. We used a structure-free, nano-smooth titanium substrate (Ra ≈ 0.6 nm) to identify…
View details →Riancho-Zarrabeitia L, Barrena OI, Santos-Gomez M et al. · 2026 · Reumatologia clinica
Background/objectives Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease marked by diverse autoantibodies. While serological clusters have been associated with distinct clinical phenotypes, most existing studies rely…
View details →Bonthrone AF, Cromb D, Javed SA et al. · 2026 · Placenta
Objectives To assess if maternal stress is higher in pregnancies with congenital heart disease (CHD) compared to low-risk pregnancies and if maternal stress is associated with placental microstructure and function. To explore if CHD alters…
View details →Pagano R, Kruashvili L, Puchalska M et al. · 2026 · Preprint
ABSTRACT Alcohol craving and consumption fluctuate across the reproductive cycle in females with alcohol use disorder (AUD), suggesting that estrogen signaling contributes to disease vulnerability. Here, we investigated the role of…
View details →Li J, de Vries HD, Ustyantsev K et al. · 2026 · Journal of lipid research
Farnesoid-x-receptor (FXR), a bile acid (BA)-activated nuclear receptor, is a therapeutic target for cholestatic and metabolic liver diseases. However, species differences in BA metabolism and FXR signaling hamper translation from mice to…
View details →Kirk C, Smith E, Wozniak A et al. · 2026 · Cutaneous and ocular toxicology
Purpose Emerging evidence supports a protective role of statins at preventing the progression of early-intermediate stage non-neovascular (dry) AMD. Clinical findings, however, remain equivocal as to the beneficial effects of statin use…
View details →Mattke AC, Schlapbach LJ, Takashima M et al. · 2026 · ASAIO journal (American Society for Artificial Internal Organs : 1992)
Extracorporeal membrane oxygenation (ECMO) can trigger a systemic inflammatory response syndrome (SIRS) with activation of inflammatory, endothelial, and coagulation system pathways. We assessed in a randomized trial whether a) sweep flow…
View details →Gu C, Xu R, Yin B et al. · 2025 · Integrative zoology
Predator cues have profound impacts on the behavior and physiology of prey animals. However, the mechanisms underlying stress responses induced by chronic exposure to predator cues in mammals, particularly the role of the gut microbiota,…
View details →Luo Y, Wei K · 2026 · Experimental brain research
Motor adaptation arises from multiple learning mechanisms, including use-dependent learning (UDL) driven by repetition and implicit error-based learning (EBL) driven by motor prediction errors. Although both mechanisms contribute…
View details →Giri S, Wang X · 2026 · American journal of physiology. Heart and circulatory physiology
Neointimal hyperplasia (NH) is a prominent pathological consequence following vascular injury and is driven in part by aberrant vascular smooth muscle cell (VSMC) proliferation. COP9 signalosome (CSN) subunit 5 (CSN5/JAB1/COPS5) is the…
View details →de Sousa Fernandes MS, Kanashiro A, da Silva Fidélis DE et al. · 2026 · Scientific reports
Environmental enrichment (EE), an experimental paradigm promoting cognitive, sensory, social, and motor stimulation, has been associated with neuroprotective effects. Although EE modulates immune function, its influence on the basal redox…
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