Negative / Null Result ReportMedicine
Bonthrone AF, Cromb D, Javed SA et al. · 2026 · Placenta
Objectives To assess if maternal stress is higher in pregnancies with congenital heart disease (CHD) compared to low-risk pregnancies and if maternal stress is associated with placental microstructure and function. To explore if CHD alters…
View details →Negative / Null Result Report
Pagano R, Kruashvili L, Puchalska M et al. · 2026 · Preprint
ABSTRACT Alcohol craving and consumption fluctuate across the reproductive cycle in females with alcohol use disorder (AUD), suggesting that estrogen signaling contributes to disease vulnerability. Here, we investigated the role of…
View details →Negative / Null Result ReportMedicine
Li J, de Vries HD, Ustyantsev K et al. · 2026 · Journal of lipid research
Farnesoid-x-receptor (FXR), a bile acid (BA)-activated nuclear receptor, is a therapeutic target for cholestatic and metabolic liver diseases. However, species differences in BA metabolism and FXR signaling hamper translation from mice to…
View details →Negative / Null Result ReportMedicine
Kirk C, Smith E, Wozniak A et al. · 2026 · Cutaneous and ocular toxicology
Purpose Emerging evidence supports a protective role of statins at preventing the progression of early-intermediate stage non-neovascular (dry) AMD. Clinical findings, however, remain equivocal as to the beneficial effects of statin use…
View details →Negative / Null Result ReportMedicine
Mattke AC, Schlapbach LJ, Takashima M et al. · 2026 · ASAIO journal (American Society for Artificial Internal Organs : 1992)
Extracorporeal membrane oxygenation (ECMO) can trigger a systemic inflammatory response syndrome (SIRS) with activation of inflammatory, endothelial, and coagulation system pathways. We assessed in a randomized trial whether a) sweep flow…
View details →Negative / Null Result ReportMedicine
Gu C, Xu R, Yin B et al. · 2025 · Integrative zoology
Predator cues have profound impacts on the behavior and physiology of prey animals. However, the mechanisms underlying stress responses induced by chronic exposure to predator cues in mammals, particularly the role of the gut microbiota,…
View details →Negative / Null Result ReportMedicine
Luo Y, Wei K · 2026 · Experimental brain research
Motor adaptation arises from multiple learning mechanisms, including use-dependent learning (UDL) driven by repetition and implicit error-based learning (EBL) driven by motor prediction errors. Although both mechanisms contribute…
View details →Negative / Null Result Report
Both A, Chevalier C, Connor MG et al. · 2026 · Preprint
Crosstalk between respiratory bacteria and human airway epithelial cells initiates cellular immunity, yet the molecular determinants of asymptomatic carriage versus inflammation remain incompletely understood. A key regulator of airway…
View details →Negative / Null Result ReportMedicine
Souza VKB, Ferreira DA, Arantes APR et al. · 2026 · Cell biochemistry and biophysics
Chronic neuroinflammation contributes to neuronal damage through oxidative stress and inflammatory mediators, highlighting the need for novel therapeutic strategies. This study evaluated the cytotoxicity and neuroprotective effects of…
View details →Negative / Null Result Report
Litif C, Libster AM, Desfor S et al. · 2026 · Preprint
The Reln gene encodes the extracellular glycoprotein Reelin that regulates synaptic plasticity and activity-dependent gene expression with implications in several neuropsychiatric disorders, including substance use disorder. While reduced…
View details →Negative / Null Result Report
Anwar S, Ebrahimi-Iranpour S, Huq S et al. · 2025 · Preprint
Lysosomes are organelles responsible for degrading unwanted extracellular material that cells internalize, or intracellular material targeted for disposal. Typically, lysosomes are globular in morphology. However, in activated macrophages…
View details →Negative / Null Result ReportMedicine
Shim HG, Fanning AS, Raymond JL · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
It is increasingly recognized that learning and memory depend not only on changes in synaptic strength but also on experience-dependent modifications of intrinsic neuronal excitability. However, how these two forms of plasticity interact…
View details →Negative / Null Result ReportMedicine
Acton JP, Alsharif NS, Bond JW et al. · 2026 · European journal of applied physiology
Coenzyme Q10 (CoQ 10 ) is an integral component of the mitochondrial electron transfer system. Most studies have administered the oxidised form of CoQ 10 (ubiquinone) and observed no effects on mitochondrial respiratory function or…
View details →Negative / Null Result ReportMedicine
Su Y, Hu Q, Dou Z et al. · 2026 · Food research international (Ottawa, Ont.)
κ-Carrageenase with alkaline resistance can promote the resource utilization of κ-carrageenan industrial residues. In this study, a rational design strategy integrating surface charge optimization and consensus sequence analysis was…
View details →Negative / Null Result ReportMedicine
Hosny R, Saad M, Shebl R et al. · 2026 · Emergency radiology
PURPOSE: To evaluate the necessity of computed tomography (CT) in open globe injuries after ophthalmological assessment in the emergency department (ED) prior to primary repair. METHODS: A review of the medical records of patients…
View details →Negative / Null Result ReportMedicine
Hofbauer LM, Rodriguez FS · 2026 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
PurposeThis study examined whether different types of help received influence subsequent levels of functional ability in older adults.MethodsLongitudinal data were drawn from the US Health and Retirement Study (HRS), the Survey of Health,…
View details →Negative / Null Result ReportMedicine
Rees M, Vieira F, Yarragudi SB et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)
Nasal high flow (NHF) with the asymmetrical cannula interface (AI) is increasingly used as respiratory support across a broad range of patients. By incorporating one unilaterally oversized prong, the AI enhances dead-space clearance and…
View details →Negative / Null Result ReportOpen accessMedicine
Okuizumi R, Maruyama S, Okamoto M et al. · 2026 · Journal of clinical biochemistry and nutrition
Coenzyme Q10 is a lipid-soluble antioxidant essential for the mitochondrial electron transport chain. Its concentration in the body decreases with age. The biosynthesis of coenzyme Q10 involves enzymes coq1 (PDSS1, PDSS2) through coq9,…
View details →Negative / Null Result ReportMedicine
Martin BI, Mirza SK, Ko H et al. · 2026 · The spine journal : official journal of the North American Spine Society
Background context Medicare's Transforming Episode Accountability Model (TEAM) holds hospitals accountable for 30-day postoperative complications across 18 categories of spinal fusion bundles, yet baseline differences in complication rates…
View details →Negative / Null Result ReportMedicine
Anijs RJS, Nguyen YN, Yanovska M et al. · 2025 · Thrombosis research
Background Colorectal cancer (CRC) patients are at increased risk of developing venous thromboembolism (VTE), leading to high morbidity and mortality. The exact mechanism remains unknown, which complicates risk prediction and treatment.…
View details →Negative / Null Result ReportMedicine
Yang S, Qin M, Wei J et al. · 2026 · Industrial Crops & Products.
Nicotinic acid (NIA) is known to function in heavy metal detoxification; however, the regulation and physiological significance of its endogenous secretion in metal tolerance remain unclear. In this study, NIA was identified as a…
View details →Negative / Null Result ReportMedicine
Jung J, Lutz KL, Dreager-Tougas KC et al. · 2025 · Journal of neurophysiology
Proctolin, an arthropod neuropeptide, is present in synaptic terminals innervating body wall muscles of Drosophila larvae. It acts as a cotransmitter with the excitatory neurotransmitter, l-glutamate (Glu). Previous work showed that…
View details →Negative / Null Result ReportMedicine
Vondrasek JD, Brown JE, Grosicki GJ et al. · 2026 · Journal of strength and conditioning research
Abstract Vondrasek, JD, Brown, JE, Grosicki, GJ, and Flatt, AA. Effects of short-duration cycling after resistance exercise on aortic stiffness and next-day recovery in strength-trained men. J Strength Cond Res 40(5): 536-544, 2026-We…
View details →Negative / Null Result Report
Bessonova Y, Clark I, Sumida R et al. · 2025 · Preprint
Neuromodulators play a key role in determining how an organism processes and responds to sensory cues. Often, different neuromodulators act on the same set of neural circuits to produce diverging behavioral outcomes. In this study, we…
View details →Negative / Null Result ReportMedicine
Scherer JS, Wu W, Wetmore JB et al. · 2026 · Kidney360
Background Legalization of cannabis across several US states may increase its use by individuals on hemodialysis, particularly among those with chronic pain. Contemporary data on frequency or factors associated with cannabis use by this…
View details →Negative / Null Result ReportMedicine
Men X, Taylor ZL, Marshe VS et al. · 2026 · Canadian journal of psychiatry. Revue canadienne de psychiatrie
BackgroundVenlafaxine is commonly prescribed for older adults with depression, yet the relationship between venlafaxine-related exposure and treatment outcomes remains unclear. We aimed to assess the association of exposure to venlafaxine,…
View details →Negative / Null Result ReportMedicine
Littmann J, Steiner N, Cabrejo-Jones K et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background A Moberg osteotomy is a dorsal closing wedge osteotomy of the base of the first proximal phalanx that is thought to augment the effect of cheilectomy by increasing dorsiflexion and ultimately improve patient outcomes in Hallux…
View details →Negative / Null Result Report
Al-Othman S, Wu Y, Fontanaud P et al. · 2026 · Preprint
SUMMARY Resident cardiac macrophages are understood to facilitate atrioventricular (AV) node conduction because they purportedly couple to AV node myocytes via connexin43 (Cx43) containing gap junctions. We tested this mechanism using…
View details →Negative / Null Result ReportMedicine
Vieira Y, Sobral M, Mateus V et al. · 2026 · International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Transcranial direct current stimulation (tDCS) has emerged as a promising tool to investigate and modulate emotional and social processes, including compassion. By targeting cortical regions implicated in empathy and prosocial behaviour…
View details →Negative / Null Result ReportMedicine
Jin Z, Li J, Thackray AE et al. · 2026 · Appetite
Oxyntomodulin (OXM) is a gut-derived peptide hormone with anorexigenic properties that reduce food intake and increase energy expenditure. This study investigated the effect of a single bout of moderate-intensity running on OXM…
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