e-ISSN: Pending

Browse the failure-mode index

19,830 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Real-World Outcomes of Barbed Versus Interrupted Sutures for Laparoscopic Choledochotomy: A 12-Month Follow-Up in Patients With Choledocholithiasis.

Zhao P, Zhou Y, Zhang C et al. · 2026 · Surgical laparoscopy, endoscopy & percutaneous techniques

Background The optimal suture technique for primary closure after laparoscopic choledochotomy remains uncertain. We compared real-world outcomes of barbed continuous and conventional interrupted sutures in patients with…

View details →
Negative / Null Result ReportMedicine

Do anaerobic bottles add value? A comparative study of blood culture bottle combinations in a tertiary care centre.

Benedict Vinothini A, Mythilipraba S, Punnen SA et al. · 2026 · Indian journal of medical microbiology

Background Bloodstream infections (BSIs) require rapid identification and susceptibility testing to guide timely antimicrobial therapy. Although paired aerobic and anaerobic blood culture bottles are routinely used, the incremental benefit…

View details →
Negative / Null Result ReportMedicine

Sphincter-sparing pre-closure technique-assisted endoscopic papillectomy versus conventional endoscopic papillectomy for duodenal papilla adenomas: a multicenter retrospective cohort study.

Liu FQ, Ren LN, Zhou XR et al. · 2026 · Gastrointestinal endoscopy

Background and aims This multicenter retrospective cohort study aims to evaluate the efficacy and safety of sphincter-sparing pre-closure technique-assisted endoscopic papillectomy (EP) versus conventional EP for duodenal papilla adenomas.…

View details →
Negative / Null Result ReportOpen accessMedicine

Perceived leg length discrepancy after total hip arthroplasty is associated with global spinopelvic coronal flexibility.

Minoji S, Ishikura H, Kudo M et al. · 2026 · Archives of orthopaedic and trauma surgery

Background Perceived leg length discrepancy (pLLD) is a common source of dissatisfaction after total hip arthroplasty (THA), even in the absence of significant radiographic discrepancies. While spinopelvic factors have been increasingly…

View details →
Negative / Null Result ReportOpen accessMedicine

Interfascial Plane Blocks for Perioperative Analgesia in Dogs Undergoing Laparoscopic Ovariectomy: A Retrospective Study (2020-2025).

Paolini A, Serpieri M, Bonaffini G et al. · 2026 · Animals : an open access journal from MDPI

This retrospective study compared three ultrasound-guided locoregional techniques-transversus abdominis plane (TAP), quadratus lumborum (QL), and caudal thoracic paravertebral (C-TPV) blocks-in dogs undergoing laparoscopic ovariectomy.…

View details →
Negative / Null Result ReportOpen accessMedicine

Influence of sport mouth-formed type mouthguards on saliva secretion and composition during jaw activity: a pilot study.

van Vliet KE, Lobbezoo F, van Splunter AP et al. · 2026 · BMC oral health

BACKGROUND: We hypothesized that wearing a mouthguard may affect salivary flow and composition. Therefore, we investigated the impact of mouthguard use on saliva secretion rate and some salivary constituents under different jaw activities.…

View details →
Negative / Null Result Report

Investigating Gendered Implicit Bias Among Healthcare Workers in South Africa: Development and Piloting of an Implicit Association Test in a High Tuberculosis and HIV Setting

Medina-Marino A, Shrader C, Axt J et al. · 2026 · Preprint

Abstract Background In sub-Saharan Africa, men with HIV and/or tuberculosis (TB) report negative experiences within health services and demonstrate poorer engagement and treatment outcomes compared to women. We developed and piloted an…

View details →
Negative / Null Result ReportMedicine

Sacral positioning and interface pressure in the beach-chair position during shoulder surgery: a retrospective, observational study.

Takatori N, Uchiyama Y, Ito H et al. · 2026 · Journal of tissue viability

Background Intraoperative pressure-related skin injuries remain a concern during surgery under general anaesthesia. Although interface pressures have been evaluated in various surgical positions, sacral pressure in the beach-chair position…

View details →
Negative / Null Result Report

Impact of co-administration of proton pump inhibitors on efficacy and safety of oral semaglutide in patients with type 2 diabetes: a single-center retrospective study

Yokoyama T, Uchino T, Yazawa Y et al. · 2026 · Preprint

Abstract Background Oral semaglutide, a glucagon-like peptide-1 receptor agonist, improves glycemic control and reduces body weight in patients with type 2 diabetes. Although proton pump inhibitors (PPIs) have been reported to slightly…

View details →
Negative / Null Result ReportMedicine

Migraine is Associated With Altered Preoperative Endodontic Pain Perception and Mechanical Sensory Function but Not Short-Term Postoperative Pain: A Prospective Clinical Study.

Harun AS, Shikder AHMZH, Moni SD et al. · 2026 · Journal of oral rehabilitation

Background Migraine has been associated with altered nociceptive processing and may influence the clinical presentation of odontogenic pain. This study evaluated whether migraine is associated with preoperative endodontic pain,…

View details →
Negative / Null Result ReportMedicine

Source- and land-use-dependent controls on black carbon accumulation in urban soils: A comparison between an industrial city and a megacity in central China.

Zhan C, Liu S, Kang W et al. · 2026 · Environmental pollution (Barking, Essex : 1987)

Black carbon (BC) is an important component of soil organic carbon (SOC), with implications for carbon sequestration and environmental quality, yet its variability across contrasting urban systems remains insufficiently understood. This…

View details →
Negative / Null Result ReportMedicine

Clinical and radiographic outcomes of cannulated cancellous screw osteosynthesis with and without side-plate for nondisplaced femoral neck fractures: a multicenter propensity score-matched study.

Maeda K, Funahashi H, Tokutake K et al. · 2026 · International orthopaedics

Purpose This study aimed to evaluate postoperative outcomes, including clinical results, radiological assessments, and complications, in patients over 50 years old with nondisplaced femoral neck fractures (Garden classification I-II)…

View details →
Negative / Null Result ReportMedicine

Efficacy and Safety of Denosumab versus Zoledronic Acid in the Treatment of Hypercalcemia in Primary Hyperparathyroidism: A Retrospective Comparative Study.

Liu Y, Liu L, Wang J et al. · 2026 · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Objective Nephrotoxicity of bisphosphonates limits their utility in the management of severe hypercalcemia among patients with primary hyperparathyroidism (PHPT) and impaired renal function. It remains unclear whether denosumab is an…

View details →
Negative / Null Result ReportMedicine

Clinical outcomes of a Locator-bilateral segmental bar concept versus a conventional rigid bar concept for maxillary implant-supported overdentures: a retrospective cohort study.

Zheng J, Chen M, Fu J · 2026 · BMC oral health

Background This retrospective cohort study evaluated a Locator-bilateral segmental bar concept (LBSB) for maxillary implant-supported overdentures and compared it with a conventional rigid bar concept (CRB) in terms of implant survival,…

View details →
Negative / Null Result ReportMedicine

Effectiveness of Audiovisual Distraction During Dental Treatment Under Nitrous Oxide/Oxygen Conscious Sedation in Paediatric Patients: A Randomized Crossover Clinical Trial.

Gentile T, Vanacore S, Caputo M et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Dental anxiety represents a major challenge in paediatric dentistry and is a frequent cause of non-cooperative behaviour during dental treatment. Nitrous oxide/oxygen inhalation conscious sedation is widely used to…

View details →
Negative / Null Result ReportMedicine

The trajectories of relative concentrations of antirhodococcal immunoglobulin A differ from those of immunoglobulin G subisotypes in bronchoalveolar lavage fluid but not serum of foals.

Aucoin AA, Zhidkov V, Legere RM et al. · 2026 · American journal of veterinary research

Objective To characterize age-related trajectories of the relative concentrations of anti-virulence-associated protein A (VapA) immunoglobulin (Ig)-G1, IgG3/5, IgG4/7, and IgA in serum and bronchoalveolar lavage fluid (BALF) as indicators…

View details →
Negative / Null Result ReportMedicine

Combined Pain Neuroscience Education and Progressive Muscle Relaxation for Post-Thoracoscopic Pain.

Wang X, Li W, Wang F et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Purpose The objective of this study was to evaluate whether combining pain neuroscience education (PNE) with progressive muscle relaxation (PMR) could reduce acute pain after thoracoscopic lung resection, alleviate psychological distress,…

View details →
Negative / Null Result ReportMedicine

Comparing Spinal and General Anesthesia for Prone Percutaneous Nephrolithotomy: A Propensity Score-Matched Study.

Chen L, Xu D, Hou L · 2026 · Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Background/objective Prone percutaneous nephrolithotomy (PCNL) is commonly performed under general anesthesia (GA); however, increasing evidence supports the feasibility of PCNL under spinal anesthesia (SA). This study presents our…

View details →
Negative / Null Result ReportMedicine

Development and Preliminary Clinical Evaluation of a Multifunctional Operative Support Arm in Reproductive Laparoscopic Surgery: A Randomized Controlled Study.

Mao W, Lu N · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research

Objective To evaluate short-term clinical outcomes, surgeon-reported fatigue, and staff user experience associated with a multifunctional operative support arm in reproductive laparoscopic surgery. Design Single-center, parallel-group…

View details →