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Browse the failure-mode index

19,830 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Comprehensive assessment of hyperoside: cytotoxic, anti-cancer, genoprotective, radical scavenging and computational toxicity properties through <i>in vitro</i> and <i>in silico</i> approaches.

Burgazli AY, Avuloglu Yilmaz E, Mamur S et al. · 2026 · Toxicology mechanisms and methods

Hyperoside (HYP), a plant-derived flavonoid, was evaluated for its cytotoxic, anti-cancer, genotoxic, antigenotoxic, and antioxidant properties, and potential mechanisms of action using an integrated in vitro and in silico approach.…

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Negative / Null Result ReportMedicine

<i>SLC28A3 </i>expression and fludarabine-emergent autoimmune hemolytic anemia in chronic lymphocytic leukemia: A new player in an old equation.

Vukovic V, Karan-Djurasevic T, Antic D et al. · 2026 · Biomolecules & biomedicine

Fludarabine treatment in patients with chronic lymphocytic leukemia (CLL) has been associated with immune dysregulation and the development of autoimmune hemolytic anemia (AIHA). Prior research indicates a potential correlation between the…

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Negative / Null Result ReportMedicine

A pilot, randomized, placebo-controlled trial of rimegepant on visceral sensation and symptoms in nonconstipation IBS pain.

Halawi H, Matar A, Wang I et al. · 2026 · American journal of physiology. Gastrointestinal and liver physiology

Visceral hypersensitivity is a pivotal mechanism in pain associated with irritable bowel syndrome (IBS). Calcitonin gene-related peptide (CGRP) is expressed by visceral afferents. The aim of this study was to evaluate the efficacy of…

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Negative / Null Result ReportMedicine

Increasing Intrinsic Protein Disorder Improves CD8+ Immunogenicity for a SARS CoV2 Vaccine Candidate Antigen.

Wan L, Xie B, Shuda M et al. · 2026 · Molecular therapy : the journal of the American Society of Gene Therapy

CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI)…

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Negative / Null Result ReportMedicine

Initial static, pseudo-static, dynamic, and cognitive fit evaluation of three passive shoulder exoskeletons while performing simulated manufacturing tasks.

Abbasi D, Schall M, Acosta-Sojo Y et al. · 2026 · Applied ergonomics

Shoulder disorders have been associated with repetitive overhead work and manual lifting. Passive exoskeletons may reduce exposure to physical risk factors associated with shoulder injuries. This repeated-measures study evaluated the…

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Negative / Null Result ReportMedicine

Impact of an educational video on the quality of bowel preparation prior to colonoscopy: a randomized controlled study.

Vidon M, Wang X, Costes L et al. · 2026 · Clinics and research in hepatology and gastroenterology

Background and study aims Educational interventions have been proposed to improve adherence to bowel preparation instructions. We evaluated whether adding a short instructional video to standard written and oral information improves bowel…

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Negative / Null Result ReportMedicine

Mechanisms Linking Bonding and Bridging Social Capital and Self-Rated Health Among U.S. Refugees: A Structural Equation Modeling Approach.

Thapa K, R Iyer A, A Cruz-Gonzalez M et al. · 2026 · Journal of racial and ethnic health disparities

Background Refugees often experience disruptions in social networks after resettlement. This study examined associations between bonding (within-group) and bridging (across-group) social capital and self-rated health among resettled U.S.…

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Negative / Null Result ReportMedicine

Effects of xylazine on blood biochemical, oxidative, and haematological to responses to transport distance stress in day-old broiler chicks.

Abdulameer HS, Zarrinkavyani K, Fathi M et al. · 2026 · Poultry science

Transport of day-old chicks is a major concern in the poultry industry, as it induces stress that can impair performance and health. This study investigated whether xylazine, an alpha-2 adrenergic agonist that reduces metabolic rate, could…

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Negative / Null Result ReportMedicine

Accuracy of full-arch digital implant impression and bite registration: effect of different reference object strategies and intraoral scanners.

Rutkūnas V, Kubilius A, Akulauskas M et al. · 2026 · Journal of dentistry

Objectives This in vitro study evaluated the accuracy of digital impressions for full-arch implantsupported restorations by assessing scan body (SB) positional accuracy and inter-arch registration under different intraoral scanners (IOS)…

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Negative / Null Result ReportMedicine

Effects of Benzo[a]pyrene on Targeted Therapy Response and Platelet-Activating Factor-Receptor-Mediated Microvesicle Particle Release in Non-Small Cell Lung Cancer.

Rawal R, Thyagarajan A, Sahu RP · 2026 · Medical sciences (Basel, Switzerland)

Background/objectives Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality, driven by invasive behavior and frequent resistance to systemic therapies. Epidermal growth factor receptor tyrosine kinase inhibitors…

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