19,830 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Seco-Cervera M, Gisbert-Ferrándiz L, Macias-Ceja DC et al. · 2025 · PloS one
Epigenetics has emerged as a modulator of inflammation-related diseases and changes in miRNA expression have been associated with regional location, inflamed mucosa and disease activity in Crohn´s disease (CD). We analyse here the…
View details →Casadevall A · 2025 · The Journal of clinical investigation
Invasive fungal infections carry high morbidity and mortality, but there are no fungal vaccines. In this issue of the JCI, Okaa et al. report that endonuclease 2 (Eng2), an antigen shared by the Blastomyces, Histoplasma, and Coccidioides…
View details →Cao L, Hu J, Mao X et al. · 2026 · Frontiers in oncology
Background Malignant phyllodes tumors (MPTs) of the breast are rare fibroepithelial neoplasms characterized by aggressive clinical behavior and limited evidence guiding systemic therapy in the metastatic setting. Immune checkpoint…
View details →Castro LA, Chen DE, O'Scannlain A et al. · 2026 · Journal of the mechanical behavior of biomedical materials
Elastic fibers are critical for proper mechanical function of large arteries such as the aorta. Fragmentation, degradation, or reduced amounts of elastic fibers are associated with aortic diseases such as stiffening-induced hypertension…
View details →Fage C, Loison S, Zwygart AC et al. · 2025 · Antiviral research
Influenza viruses pose a significant threat due to annual epidemics and pandemic potential. Resistance to current antivirals underscores the need for new drugs and strategies to prevent its emergence. We previously developed two novel…
View details →Jacob A, Mahmoud A, Eldweik L et al. · 2025 · BMJ neurology open
Background Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing autoimmune disease of the central nervous system (CNS). Management during pregnancy is challenging due to limited safety data for disease-modifying therapies.…
View details →Tekin-Taş Z, Özger HS, Sultanova F et al. · 2025 · Infectious diseases & clinical microbiology
Objective Real-time multiplex polymerase chain reaction (PCR) test increases the detection of viral respiratory tract infections. This study aimed to evaluate the effect of real-time multiplex PCR on antibiotic use in viral respiratory…
View details →Cajado AG, Lopes MH, Rangel GFP et al. · 2025 · European journal of pharmacology
Irinotecan-based anticancer therapy induces intestinal mucositis, increasing the risk of sepsis and patient death. The phosphoinositide 3-kinases (PI3K) are involved in cancer and inflammatory diseases, but their role in intestinal…
View details →Etemadi R, Mansouri A, Salehidoost R et al. · 2025 · International journal of endocrinology
Objective Hungry bone syndrome (HBS), marked by severe and persistent hypocalcemia, frequently occurs after parathyroidectomy for primary hyperparathyroidism (PHPT). Despite its prevalence, there is limited research on this complication.…
View details →Delibasi IB, Gumusburun N, Bulut S et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
Citalopram is a selective serotonin reuptake inhibitor (SSRI) and has been associated with reproductive dysfunction in women. In this study, the effects of citalopram on reproductive health in female rats were investigated. Albino Wistar…
View details →Lodefalk M, Nilsson O · 2025 · Hormone research in paediatrics
Introduction Vitamin D-dependent rickets type 2A (VDDR2A) is a rare, autosomal recessive disorder caused by pathogenic variants of the VDR gene encoding the vitamin D receptor. It has been proposed to be a form of parathyroid hormone…
View details →Mann K, Potluri P, Paul EE et al. · 2026 · Journal of cosmetic dermatology
Introduction Chemotherapy-induced alopecia (CIA) is known to have a significant psychological and quality of life impact. Although cold caps have been shown to prevent CIA, expense and extension of treatment durations are barriers for…
View details →Shakhidzhanov S, Filippova A, Bovt E et al. · 2025 · Preprint
Introduction: Critically ill COVID-19 patients receiving prophylactic-dose antico-agulation exhibit high rates of thrombosis and mortality. Escalation of anticoagu-lation also does not reduce mortality and has an uncertain impact on the…
View details →Pereira GF, Sanches MC, De-Paula OC et al. · 2025 · Scientific reports
Classifying seed dormancy is an essential task for plant propagation; however, several plant species lack information about the kind of dormancy the seeds have or inaccurate reports are passed on without an in-depth investigation. We…
View details →He Y, Ding Y, Gong C et al. · 2024 · Behavioural brain research
The tail plays important roles in locomotion control in many animals. But in animals with multiple body segments, the roles of the hind body segments and corresponding innervating neurons in locomotion control are not clear. Here, using…
View details →Bosnali E, Mutlu N, Cakmak K et al. · 2025 · Journal of pediatric surgery
Background Pediatric urolithiasis remains a significant health problem in certain regions worldwide. Extracorporeal shock wave lithotripsy (ESWL) is the preferred treatment for upper urinary tract stones smaller than 20 mm in children due…
View details →Roque-Torres JL, Woolcock AD, Santos A et al. · 2025 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
Objective To describe storage and oxidative lesions in canine packed red blood cells (pRBCs) during routine storage with additives, including saline, N-acetylcysteine (NAC), ascorbic acid (AA), and vitamin E analog (VE). Design…
View details →Battaglia-Vieni A, Marchant V, Tejedor-Santamaria L et al. · 2025 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives : Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality, and increased susceptibility to progression to chronic kidney disease (CKD), especially in the…
View details →Feldman S, Basra J, Lawani A et al. · 2025 · Ophthalmic surgery, lasers & imaging retina
Background and objective To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA). Patients and methods Prospective, single-masked,…
View details →Chen H, Huang X, Wang C et al. · 2025 · The Journal of infectious diseases
Assessing the time-varying effectiveness of coronavirus disease 2019 (COVID-19) vaccines is critical to guiding vaccine strategies and public health policies. We developed a Bayesian framework to estimate the waning vaccine effectiveness…
View details →Horizono J, Mizumoto K, Suico MA et al. · 2025 · Biological & pharmaceutical bulletin
Cyclodextrins (CDs) are cyclic oligosaccharides that encapsulate hydrophobic molecules such as cholesterol. Hydroxypropyl-β-cyclodextrin (HP-β-CD), a cyclic heptasaccharide, has gained attention as a protective agent for chronic kidney…
View details →Hojo FR, Martins TC, Vieira-Junior WF et al. · 2025 · Operative dentistry
This study evaluated the influence of six resin composite coating agents on color stability and surface roughness after toothbrushing abrasion. Discs (Ø6 mm x 2 mm) of nanofilled resin composite (Filtek Z350XT) were prepared for…
View details →Chen A, Chou TY, Chen Y et al. · 2024 · Preprint
Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is a major disease affecting banana production around the globe. To study the movement of Foc in planta and investigate potential physical mechanisms of deterrence, the roots…
View details →Giles C, Lee J · 2024 · Preprint
Abstract Nearly 90% of cancer deaths are due to metastasis. Conventional cancer therapeutics including chemotherapy, surgery, and radiotherapy, are effective in treating primary tumors, but may aggravate disseminated tumor cells (DTCs)…
View details →Beningaza AM, Di Benedetto IMD, Babino L et al. · 2025 · Acta tropica
Chagas disease, vectored by kissing bugs, poses a public health problem across the Americas. The best way for reducing disease transmission is through vector control, which is currently based on the use of insecticides. However,…
View details →Asadikorayem M, Weber P, Zhang S et al. · 2025 · Biomaterials advances
Osteoarthritis (OA) is one of the most common degenerative joint diseases, with no effective therapeutic options available. In this study, we aimed to develop an interpenetrating, in-situ-forming hydrogel based on biocompatible and…
View details →Baudat M, Joosten EAJ, Simons SHP · 2025 · Pediatric research
Background While the incidence of neonatal intensive care unit (NICU) admission steadily increases, neonatology lacks evidence of a safe, effective, and preventive analgesic for treating procedural pain. Given its role in nociception and…
View details →Moksi L, Sissala N, Ojala R et al. · 2026 · Journal of orthopaedic surgery and research
Background Avascular necrosis (AVN) of the femoral head is a progressive condition that leads to collapse of the femoral head in 85% of symptomatic patients when left untreated. As it is typically a disease that occurs among the younger…
View details →Wongkraisri C, Chusuwanrak K, Laocharoenkeat A et al. · 2024 · Preprint
Abstract Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
View details →Rajsiglova L, Babic M, Krausova K et al. · 2024 · Journal of immunotoxicology
Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles…
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