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Browse the failure-mode index

19,823 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Microfluidic sperm selection versus density gradient centrifugation in ICSI cycles with abnormal semen parameters: a randomized sibling-oocyte study.

Thanapongpibul C, Niransuk P, Sassanarakkit S et al. · 2026 · Scientific reports

Microfluidic sperm selection (MSS) is a centrifugation-free alternative to density gradient centrifugation (DGC) for sperm preparation in intracytoplasmic sperm injection (ICSI). This prospective, randomized sibling-oocyte study included…

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Negative / Null Result ReportMedicine

Association of the mitochondrial regulator PGC-1α with diabetes mellitus and myocardial ischemia-reperfusion injury in coronary artery bypass grafting.

Yildiz A, Yazici S, Yildiz Z · 2026 · BMC cardiovascular disorders

Objectives This study aimed to evaluate whether peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) could serve as a marker of myocardial ischemia by examining its association with cross-clamp time, which reflects…

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Negative / Null Result ReportOpen accessMedicine

Low-flow oxygen delivery in patients with disturbed consciousness.

Yamada SM · 2026 · Surgical neurology international

Background When low-flow oxygen (O2) delivery is required, a nasal cannula is commonly used. However, no reports have described arterial blood gas analysis in actual patients receiving O2 simultaneously through a mask and a nasal cannula.…

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Negative / Null Result ReportMedicine

Susceptibility of sorghum to infestation by Oryzaephilus surinamensis (Coleoptera: Silvanidae) and Trogoderma variabile (Coleoptera: Dermestidae): influence of variety and temperature.

Gourgouta M, Athanassiou CG, Arthur FH et al. · 2026 · Journal of economic entomology

This study evaluated the effects of sorghum variety and temperature on the population growth, frass production, kernel damage, and weight loss caused by Oryzaephilus surinamensis (L.) and Trogoderma variabile, Ballion, two common…

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Negative / Null Result Report

Perceptions of end-of-life care quality among bereaved closest contacts of community-dwelling older Australians: a cross-sectional survey of the ASPREE cohort

Keon-Cohen ZM, Tran C, Jones D et al. · 2026 · Preprint

Abstract Background High-quality end-of-life care (EOLC) is a recognised health and human-rights priority, yet Australian evidence largely derives from administrative data and cancer-specific, facility-based samples. Little is known about…

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Negative / Null Result ReportOpen accessMedicine

Influence of sport mouth-formed type mouthguards on saliva secretion and composition during jaw activity: a pilot study.

van Vliet KE, Lobbezoo F, van Splunter AP et al. · 2026 · BMC oral health

BACKGROUND: We hypothesized that wearing a mouthguard may affect salivary flow and composition. Therefore, we investigated the impact of mouthguard use on saliva secretion rate and some salivary constituents under different jaw activities.…

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Negative / Null Result Report

Investigating Gendered Implicit Bias Among Healthcare Workers in South Africa: Development and Piloting of an Implicit Association Test in a High Tuberculosis and HIV Setting

Medina-Marino A, Shrader C, Axt J et al. · 2026 · Preprint

Abstract Background In sub-Saharan Africa, men with HIV and/or tuberculosis (TB) report negative experiences within health services and demonstrate poorer engagement and treatment outcomes compared to women. We developed and piloted an…

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Negative / Null Result ReportMedicine

Sacral positioning and interface pressure in the beach-chair position during shoulder surgery: a retrospective, observational study.

Takatori N, Uchiyama Y, Ito H et al. · 2026 · Journal of tissue viability

Background Intraoperative pressure-related skin injuries remain a concern during surgery under general anaesthesia. Although interface pressures have been evaluated in various surgical positions, sacral pressure in the beach-chair position…

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Negative / Null Result Report

Impact of co-administration of proton pump inhibitors on efficacy and safety of oral semaglutide in patients with type 2 diabetes: a single-center retrospective study

Yokoyama T, Uchino T, Yazawa Y et al. · 2026 · Preprint

Abstract Background Oral semaglutide, a glucagon-like peptide-1 receptor agonist, improves glycemic control and reduces body weight in patients with type 2 diabetes. Although proton pump inhibitors (PPIs) have been reported to slightly…

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Negative / Null Result ReportMedicine

Migraine is Associated With Altered Preoperative Endodontic Pain Perception and Mechanical Sensory Function but Not Short-Term Postoperative Pain: A Prospective Clinical Study.

Harun AS, Shikder AHMZH, Moni SD et al. · 2026 · Journal of oral rehabilitation

Background Migraine has been associated with altered nociceptive processing and may influence the clinical presentation of odontogenic pain. This study evaluated whether migraine is associated with preoperative endodontic pain,…

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Negative / Null Result ReportMedicine

Source- and land-use-dependent controls on black carbon accumulation in urban soils: A comparison between an industrial city and a megacity in central China.

Zhan C, Liu S, Kang W et al. · 2026 · Environmental pollution (Barking, Essex : 1987)

Black carbon (BC) is an important component of soil organic carbon (SOC), with implications for carbon sequestration and environmental quality, yet its variability across contrasting urban systems remains insufficiently understood. This…

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Negative / Null Result ReportMedicine

Robotic versus laparoscopic rectal resection: impact on primary postoperative ileus and the role of intraoperative fluid balance: a propensity score-matched cohort study.

Urashima T, Yabuno T, Imanishi K et al. · 2026 · Surgical endoscopy

Background Few studies have directly compared the incidence of primary postoperative ileus (primary POI) between robotic surgery (RS) and laparoscopic surgery (LS) for rectal resection. Methods This retrospective cohort study included…

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Negative / Null Result ReportMedicine

Radial Versus Femoral Access for Diagnostic Coronary Angiography: Insights From a Tertiary Academic Center in Johannesburg.

Ntaka KL, Mpanya D, Adamu UG et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background The radial artery is the preferred access for performing diagnostic coronary angiograms (DCA). However, data on the safety and efficacy of radial compared to femoral access in low- and middle-income countries is limited. Aims…

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Negative / Null Result Report

Challenging the standard: Comparison of outcomes between Laparoscopically Assisted Anorectoplasty (LAARP) and Posterior Sagittal Anorectoplasty (PSARP) in the correction of rectobulbar fistula in Pediatric Patients

Sanchez MAC, Ruiz J, Siffredi J et al. · 2026 · Preprint

Abstract Background: Posterior sagittal anorectoplasty (PSARP) remains the standard surgical approach for rectobulbar fistula in patients with anorectal malformations (ARM). Laparoscopically assisted anorectoplasty (LAARP) has emerged as…

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Negative / Null Result ReportMedicine

Levels of acylated and deacylated ghrelin are elevated in unmedicated patients with major depressive disorder and obesity: a cross-sectional study.

Lis M, Miłuch T, Krupa R et al. · 2026 · Scientific reports

Major depressive disorder (MDD) frequently co-occurs with obesity, suggesting shared neuroendocrine mechanisms. Ghrelin, a hormone involved in appetite regulation, stress response, and reward processing, has been proposed as a biological…

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