20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Bonilla AM, Garrido G, Consolini AE et al. · 2025 · Preprint
Gomphrena perennis L. possesses a rich phenolic profile and has demonstrated cardiovascular and anti-inflammatory activities; however, its neuropharmacological properties re-main unexplored. The behavioral effects, underlying mechanisms,…
View details →Marcotte-Chénard A, Sandilands RE, Teixeira AA et al. · 2026 · American journal of physiology. Cell physiology
Beta-hydroxybutyrate (BHB) exerts anti-inflammatory effects in cell and animal models, but translational work in humans remains limited. We investigated how exogenous ketone monoester (KME) ingestion in vivo and BHB treatment of human…
View details →Effinger D, Hirschberger S, Arntjen T et al. · 2026 · Nutrients
Background/Objectives : The ketogenic diet (KD) has been shown to exert beneficial effects on human immunity by enhancing cytotoxic T lymphocyte function through metabolic reprogramming. However, strict dietary restrictions limit adherence…
View details →Bos MD, Ho CSL, Meyer NH et al. · 2026 · The Journal of surgical research
Introduction Epidemiological studies indicate that physical activity reduces cancer risk and mortality, while sedentary behavior exerts opposite effects. However, their impact on tumor metastasis remains unclear. This study investigated…
View details →Sogawa K, Funada M · 2026 · Toxicology letters
Cannabidiol (CBD) is a non-psychoactive cannabinoid with increasing global use, yet safety data during pregnancy remain limited. Preclinical studies suggest possible developmental neurotoxicity. Here, we examined the effects of CBD…
View details →Takata M, Nishikawa M, Hayashi H et al. · 2025 · Cureus
Background It remains unclear whether omecamtiv mecarbil, a cardiac myosin direct activator, enhances vascular smooth muscle myosin function at clinical and supra-clinical doses. Aims The current study evaluated the effect of omecamtiv…
View details →Day AS, Ballard TM, Benetti M et al. · 2026 · Journal of the Academy of Nutrition and Dietetics
Background The "gold standard" for successful blinding in controlled food-based dietary interventional trials includes a sham diet. Objective This study aimed to develop and evaluate a sham diet intended for use as a comparator in…
View details →Hancock G, Batterby E, Dovers E et al. · 2026 · Emergency medicine Australasia : EMA
Background Point-of-care ultrasound (POCUS) is widely used in emergency departments (ED) and has potential value during cardiac arrest for identifying reversible causes (e.g., pericardial effusion, pneumothorax and pulmonary embolism) and…
View details →Sun Q, Miao Z, Bian L et al. · 2026 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Methionine oxidation in monoclonal antibodies (mAbs) could critically compromise drug stability and efficacy. This investigation comprehensively evaluated the structural and functional impacts of oxidation on a mAb An under long-term…
View details →Messanh KV, Muhie Ddine M, Ambrosini V et al. · 2026 · Journal of photochemistry and photobiology. B, Biology
Botrytis cinerea (B. cinerea) is a fungus with a high mutation rate and infects more than 200 plant species, causing significant yield losses. Therefore, new strategies to fight against this ubiquitous phytopathogen are highly sought…
View details →Palner M, Kolesnik E, Baun C et al. · 2026 · Neuropharmacology
Mammalian brain may contain an endogenous pool of the psychedelic substance N,N-dimethyltryptamine (DMT), which may act as a co-transmitter with serotonin (5-HT). We tested the joint hypotheses that endogenous DMT would accumulate in rat…
View details →Navez M, Gilbo N, Vandermeulen M et al. · 2026 · Preprint
Abstract Background Kidney transplantation from donation after circulatory death (DCD) donors is increasingly used but remains associated with warm ischemic injury. Normothermic machine perfusion (NMP) enables functional assessment and…
View details →Baltin ME, Shulman AA, Nikulina MI et al. · 2025 · Preprint
Immersive virtual reality (VR) technologies are being increasingly applied in clinical settings, physiotherapy, and neurorehabilitation due to their potential to modulate neurophysiological functions. However, the mechanistic basis of VR’s…
View details →de Lima Cruz GF, Pereira OG, Alves WS et al. · 2025 · Tropical animal health and production
Tropical grasses are widely used for silage, but their high fiber content and variable quality often limit ruminal degradation and animal performance. Strategies such as optimizing regrowth age (RA) and applying fibrolytic enzymes may help…
View details →Sadeghi M, Shahrooz S, Aghamohammadi M et al. · 2025 · BMC research notes
Objective Asthma is a common multifactorial inflammatory disease affecting both children and adults. Various cells and cytokines contribute to this inflammatory process. Smooth muscle contraction, vascular congestion, and airway edema lead…
View details →Pan X, Sarker S, Yu JJ et al. · 2026 · Insects
High rates of pest infestations are frequently reported in low-income homes in the U.S. However, even with access to effective insecticides, most residents are unaware of how to properly control indoor pests. We designed and evaluated the…
View details →Kass C, Katz-Greenberg G, Bodner J et al. · 2025 · Transplant immunology
Purpose Belatacept has been associated with less de novo specific antibody (dnDSA) development, but few publications have compared the incidence of dnDSA development between tacrolimus and belatacept-based immunosuppression regimens. The…
View details →Ferreira RD, Faleiros Ferreira CH, Gonçalves-Ferri WA · 2025 · Preprint
Background Inhaled nitric oxide (iNO) is a standard treatment for neonatal pulmonary hypertension in high-resource settings. Yet, its efficacy and cost-effectiveness in low- and middle-income countries (LMICs) remain underexplored. This…
View details →Zhang Y, Pan J, Hou J et al. · 2025 · Medicine
Rationale Asthenozoospermia (AZS), a leading cause of male infertility, frequently results from genetic defects that disrupt flagellar assembly. Mutations in the DNAH11 gene can cause abnormal dynein arm structures, leading to AZS and…
View details →Masri A, Tully TN, Como K et al. · 2025 · Journal of avian medicine and surgery
Euthanasia is a common veterinary medical procedure performed on terminally ill backyard chickens ( Gallus gallus domesticus ). To reduce stress for these animals, it is important to develop a euthanasia protocol that provides a rapid and…
View details →Lee JH, Hwang K, Jeong WK · 2026 · Clinics in orthopedic surgery
Background Arthroscopic rotator cuff repair is widely performed; yet tendon healing failure still occurs in some cases and remains a challenge. To address this issue, several studies have investigated intraoperative injection or patch…
View details →Cuadrado C, Breedlove C, Toro H · 2025 · Avian diseases
Vaccination with a recombinant Newcastle disease virus (NDV) LaSota (LS) strain expressing Arkansas (Ark) -type infectious bronchitis virus (IBV) spike ectodomain (Se) protein and granulocyte-macrophage colony-stimulating factor (GMCSF)…
View details →Daudi S, Zampelis V, Belfrage O et al. · 2025 · The bone & joint journal
Aims Short, uncemented hip stems might provide a favourable alternative in total hip arthroplasty (THA) by preserving proximal bone mass through reduced strain-adaptive remodelling. We evaluated and compared the migration and…
View details →Gates RS, McCoy K, Stewart J et al. · 2026 · Surgery
Background Timely diagnosis and treatment of primary hyperparathyroidism requires a high index of suspicion and collaboration across specialties. The diagnosis often is overlooked. This study aimed to determine whether the introduction of…
View details →Busanello A, Koller OG, Menezes VM et al. · 2025 · The British journal of nutrition
The objective of this study was to evaluate the impact of incorporating group-based nutritional education into usual care on adherence to nutritional counselling among outpatients with type 2 diabetes (T2DM). This parallel-group,…
View details →Williams KG, Constantine EP, Whitney KE et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose To determine whether patients undergoing arthroscopic partial meniscectomy (APM) with synovitis treated by synovectomy exhibit similar outcomes to those without synovitis after 24-month follow-up. Methods A total of 181 patients…
View details →Lopresti AL, Smith SJ · 2025 · Clinical drug investigation
Background and objectives Bacopa monnieri is a plant used in Ayurvedic medicine with traditional uses for memory and cognitive function. The objective of this study was to examine the effects of supplementation with a Bacopa monnieri…
View details →Timmermans J, Van Goethem B, Stock E et al. · 2026 · Veterinary surgery : VS
Objective To evaluate the soft palate thickness in brachycephalic dogs 3 months after performing folded flap palatoplasty (FFP) or standard staphylectomy (STS). Study design Prospective, observational study. Animals Twenty client-owned…
View details →Foddai M, Carter CG, Wood AT et al. · 2025 · Comparative Biochemistry and Physiology, Part A
Sustained aerobic training is suggested to enhance cardiac performance and growth in farmed salmonids, but its effects under suboptimum elevated temperatures remain unclear. This study examined whether continuous training at different…
View details →Modica V, Glávits R, Clewell A et al. · 2025 · Preprint
Anaerostipes caccae CLB101 (CLB101) is an obligate, anaerobic bacteria that was isolated from the stool of a healthy infant. Due to its ability to produce butyrate and its potential promotion of microbiome health through multiple…
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