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20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Subjective well-being mediates the longitudinal effect of insomnia symptoms on internalizing symptoms in community-dwelling older adults.

Ying Y, Meng R, Xu J et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives The associations between insomnia symptoms and internalizing symptoms are well-established, particularly in older adults; however, the mediating factors remain inconsistent. This study seeks to explore the longitudinal…

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Negative / Null Result Report

Attention-Deficit/Hyperactivity Disorder across the Menstrual Cycle: Late-Luteal Symptom Exacerbation, Medication Use, and the Role of Sleep Quality and Perceived Stress

Nayman S, Del Din J, Ríos MB et al. · 2025 · Preprint

BackgroundEmerging evidence indicates perimenstrual exacerbation of Attention-Deficit/Hyperactivity Disorder (ADHD) in females and reduced perceived stimulant responsiveness during the luteal phase. Prospective clinical studies jointly…

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Negative / Null Result ReportMedicine

Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.

Zhou DD, Lord SJ, Lin FP et al. · 2026 · Lung cancer (Amsterdam, Netherlands)

Background In NSCLC, TP53 mutations are heterogeneous with varied effects on protein synthesis, function and clinical outcomes. We hypothesize that a refined classification of TP53 mutations, beyond binary categorization, could improve…

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Negative / Null Result ReportMedicine

Computed Tomography Measurement of Optic Nerve Sheath Diameter in Thrombolysis-Treated Ischemic Stroke: Association with Post-Thrombolytic Intracranial Hemorrhage.

Coşkun Yaş S, Üçöz Kocaşaban D, Güler S et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Optic nerve sheath diameter (ONSD) measurement is a non-invasive marker of intracranial pressure. Its role in predicting post-thrombolytic intracranial hemorrhage in acute ischemic stroke patients remains unclear. This study aimed to…

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Negative / Null Result ReportMedicine

Survival implications of computed tomography-derived muscle mass changes in patients with epithelial ovarian cancer undergoing bowel surgery.

Kim J, Lee YY, Kim TJ et al. · 2026 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Objective Sarcopenia is a known adverse prognostic factor in gastrointestinal cancers undergoing bowel resection; however, its prognostic relevance in epithelial ovarian cancer remains unclear. This study aimed to evaluate the prognostic…

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Negative / Null Result Report

Sleep Benefits to Spatial Source Memory in Older Adults

Kuhlmann BG, Shakoor S, Schicker LA et al. · 2025 · Preprint

While it is well-established that sleep benefits episodic memory, most evidence is on younger adults. The current study examined sleep benefits in older adults and chose spatial source memory as a target measure for which a recent study in…

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Negative / Null Result ReportMedicine

Cranioplasty after surgical site infection in brain tumor patients: insights from a 15-year Swedish multicenter study.

Holmgren K, Fletcher-Sandersjöö A, Sæmundsson B et al. · 2026 · Journal of neurosurgery

Objective Postoperative surgical site infections (SSIs) following brain tumor surgery frequently necessitate wound revision and bone flap removal. However, data on subsequent cranial reconstruction in this context remain limited. The aim…

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Negative / Null Result ReportMedicine

When the Lights Go Out: Studying Sex Differences in Sleep Latency, Sleep Quality, and Social Behavior in Captive Rhesus Macaques (Macaca mulatta) Over a 24-h Period.

Roach A, Furman S, Hadeed J et al. · 2025 · American journal of primatology

Assessments of nonhuman primate (NHP) affiliation are typically restricted to daytime behavior. There is, however, a growing interest in understanding NHP behavior and welfare over the 24-h period. To assess the sleep quality and sociality…

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Negative / Null Result ReportMedicine

The MEniscal TeaR Outcome (METRO) study : a prospective cohort study exploring the factors that affect outcomes in patients undergoing treatment for a meniscal tear.

Ahmed I, Dhaif F, Bowes MA et al. · 2025 · The bone & joint journal

Aims The aim of this study was to describe the baseline characteristics of patients with a meniscal tear and explore associations with 12-month outcomes. Methods This prospective, national multicentre cohort study recruited patients aged…

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Negative / Null Result ReportMedicine

Longitudinal associations between maternal depression, problematic media use, and parenting efficacy as a time-varying mediator.

Holmgren HG, Densley RL, Coyne SM et al. · 2026 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

Prior research suggests a link between maternal depression and mothers' problematic media use (PMU), defined as compulsive or dysregulated media use that interferes with daily functioning. This study examined whether parenting…

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Negative / Null Result ReportMedicine

Associations between physical literacy and physical activity in adults. A cross-sectional study with self-report and device-based physical activity assessments.

Naylor A, Keegan R, Martin K et al. · 2025 · Journal of sports sciences

Physical literacy has been shown to relate to children's engagement in physical activity. However, it is unclear whether this relationship extends to adults. A two-phase cross-sectional study was conducted to examine whether physical…

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Negative / Null Result ReportMedicine

Impaired Goal-Directed Planning in Transdiagnostic Compulsivity Is Explained by Uncertainty About Learned Task Structure.

Sookud S, Martin I, Gillan CM et al. · 2026 · Biological psychiatry. Cognitive neuroscience and neuroimaging

Background Diminished use of goal-directed (model-based) decision making is a hallmark of transdiagnostic compulsivity, promoting an overreliance on inflexible and habitual behaviors. However, the origin of this impairment remains unclear.…

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Negative / Null Result Report

Consolidating Climate Anxiety Scales Using Rasch Modelling

Gago T, Sargisson RJ, Milfont TL · 2025 · Preprint

Despite being an important mental health consequence of climate change, climate anxiety assessment has been fragmented. Reviews of measures of climate anxiety raise concerns about content and convergent validity. We aimed to select the…

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Negative / Null Result ReportMedicine

Predictors and Outcomes Associated with Clinically Significant Improvements in Anxiety and Depression Symptoms Following Cardiac Rehabilitation.

Hernández L, Williamson TM, Campbell T et al. · 2025 · The Canadian journal of cardiology

Background Cardiac rehabilitation (CR) participation improves depressive and anxious symptoms post-coronary catheterization, yet it is unclear to what extent improvements are clinically significant. This study characterized the proportion…

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Negative / Null Result ReportMedicine

Water deficit induced by polyethylene glycol leads to the depletion of phenolic compounds but did not alter lignification in roots of Scots pine (Pinus sylvestris).

Ivanov YV, Kartashov AV, Ivanova AI et al. · 2026 · Functional plant biology : FPB

Global climate change is accompanied by an increase in the frequency and severity of droughts, which negatively impact plant growth. One of the protective mechanisms that allows plants to withstand the negative drought effects is the…

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Negative / Null Result Report

Cereal grafting in rice and pearl millet preserves photosynthetic performance and stomatal dynamics, establishing a platform for root-shoot communication studies

Mbaluto CM, Martinez-Goni XS, Tripathi A et al. · 2026 · Preprint

Cereal grafting using embryonic tissues has recently become technically feasible; however, the physiological consequences of cereal grafting remain uncharacterized. We systematically evaluate photosynthetic performance and stomatal…

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