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Browse the failure-mode index

19,823 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

[Mandibular donor site healing after bone graft harvesting in cleft patients: a comparative study of rotary bur and piezoelectric osteotomy techniques].

Ivanov AL, Reshetnyak EI, Sukacheva SA · 2026 · Stomatologiia

Objective To evaluate mandibular donor site healing after cortical bone graft harvesting in cleft patients, comparing outcomes of osteotomies performed with rotary burs and piezosurgery. Material and methods Fifty-three patients (64 bone…

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Negative / Null Result ReportMedicine

Motivational Interviewing and Cognitive Behavioural Therapy in the Auckland Cardiac Rehabilitation Programme: A Propensity Score-Matched Study.

Marshall PW, Benatar JR, O'Halloran P et al. · 2026 · Heart, lung & circulation

Aim Suboptimal enrolment and engagement in cardiac rehabilitation remains a persistent issue worldwide. This study evaluated the impact of a nurse-specialist-delivered motivational interviewing (MI) and cognitive behavioural therapy (CBT)…

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Negative / Null Result ReportMedicine

Exploring iridotrabecular contact index and related factors in primary angle closure disease: a swept-source anterior segment OCT study.

Jeong Y, Park KH, Jeoung JW · 2026 · The British journal of ophthalmology

Background/aims This study evaluates the relationship between the iridotrabecular contact (ITC) index and various anterior segment parameters, with a particular focus on lens-related parameters, given their clinical relevance in primary…

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Negative / Null Result ReportOpen accessMedicine

Lamotrigine serum concentrations as longitudinal biomarkers for seizure risk prediction in pregnant women with epilepsy: a secondary analysis of the EMPiRE study.

Allotey J, Junaid F, Peréz T et al. · 2026 · BMJ neurology open

Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant…

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Negative / Null Result Report

Addressing Unanswered Questions About the Shift of Strategy Approach: A Multi-Study Investigation of Approach Variations, Repeated Interviews, and Innocent Versus Guilty Responses

Nyström L, Granhag A, Neofotistos E et al. · 2026 · Preprint

Introduction. The Shift-of-Strategy (SoS) approach aims to obtain concealed information from semi-cooperative suspects by prompting them to shift toward more forthcoming counter-interrogation strategies. While previous studies on the…

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Negative / Null Result ReportMedicine

IgA nephropathy occurrence, treatment, and prognosis in the last two decades in Denmark.

Ystrøm IK, Jensen SK, Andersen IT et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Background and hypothesis IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis; however, reported incidences and prevalences vary substantially across countries. This study assessed the epidemiology of IgAN including…

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Negative / Null Result ReportMedicine

Intravenous IRON supplementation in Heart Failure with Preserved Ejection Fraction and iron deficiency (IRON-HFpEF): a comprehensive phase II multicentre placebo-controlled randomised clinical trial.

van de Bovenkamp AA, Nassiri S, de Man FS et al. · 2026 · European journal of heart failure

Aims Iron deficiency (ID) is common in patients with heart failure with preserved ejection fraction (HFpEF). The IRON-HFpEF trial aimed to evaluate the mechanistic effects of intravenous iron supplementation on cardiovascular function and…

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Negative / Null Result ReportMedicine

Evaluation of a structured type 1 diabetes education program for adolescents and parents: Teens Empowered to Actively Manage Type 1 (TEAM T1).

Hagger V, Hendrieckx C, Cotterill A et al. · 2026 · Diabetic medicine : a journal of the British Diabetic Association

Aim To examine changes in psychological and clinical outcomes among adolescents and parents after structured type 1 diabetes education delivered in routine care. Methods Teens Empowered to Actively Manage Type 1 Diabetes (TEAM T1) is a…

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Negative / Null Result ReportMedicine

Prophylactic cavotricuspid isthmus ablation in addition to pulmonary vein isolation is associated with improved recurrence-free survival in patients aged > 70 years with paroxysmal atrial fibrillation.

Li JL, Wu JH, Zhao X et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

BACKGROUND: The role of prophylactic cavotricuspid isthmus (CTI) ablation remains controversial in atrial fibrillation (AF) patients without atrial flutter (AFL). Given the strong association between AF, AFL, and age, this study aimed to…

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Negative / Null Result ReportOpen accessMedicine

Effect of short-term supplemental oxygen therapy on 6-min walk distance in highlanders at risk for pulmonary hypertension: a randomised, crossover trial.

Hertig D, Furian M, Müller J et al. · 2026 · ERJ open research

Background Little is known about the effects of portable supplemental oxygen therapy (SOT) to improve exercise performance in highlanders at risk for high-altitude pulmonary hypertension (HAPH). We aimed to investigate whether SOT improves…

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Negative / Null Result ReportMedicine

Effects of propionic acid inclusion and ensiling time on in situ ruminal starch degradability of high-moisture flint corn grain silage.

Martins BM, Vieira RAM, Bittencourt CS et al. · 2025 · Journal of dairy science

This study evaluated the effects of propionic acid inclusion (PAI; 0, 0.25, and 0.50% of fresh matter) and ensiling time (ENT; 30, 60, 90, 120, 150, and 180 d) on the chemical composition, fermentation profile, DM losses, and in situ…

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Negative / Null Result ReportMedicine

Postoperative Radiotherapy May Improve Survival in Certain Patients with pN2 Non-Small Cell Lung Cancer Who Do Not Have Extranodal Extension.

Jeon SH, Song C, Jeon JH et al. · 2026 · Cancer research and treatment

Purpose The aim of this study was to identify subgroups of patients with pathologic N2 (pN2) non-small cell lung cancer (NSCLC) who may benefit from postoperative radiotherapy (PORT). Particular attention was given to evaluating whether…

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Negative / Null Result ReportMedicine

Effects of guanidinoacetic acid and methionine supplementation in low-forage diets on ruminal fermentation and performance of feedlot-finished steers

Andriotti NM, Paris W, Maia FJ et al. · 2026 · Animal Feed Science and Technology.

Feed additives that improve energy metabolism efficiency can enhance cattle performance and nitrogen use. This study evaluated the effects of guanidinoacetic acid (GAA) and methionine (MET) supplementation, alone or combined, on…

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Negative / Null Result ReportMedicine

Circulating immune cell biomarkers in Psoriatic Arthritis: associations with clinical manifestations and treatment response in the TOFA-PREDICT trial.

Perton FT, Pouw JN, Spierings J et al. · 2026 · Arthritis research & therapy

Background To investigate the associations of circulating immune cell biomarkers with clinical manifestations and treatment response in Psoriatic Arthritis (PsA), and to evaluate whether these biomarkers improve prediction of individual…

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Negative / Null Result ReportMedicine

Stigma in functional neurological disorder; a longitudinal study.

Mcloughlin C, Ramsay N, Tak L et al. · 2026 · Journal of psychosomatic research

Background Stigma in Functional Neurological Disorder has been consistently reported by patient organisations as one of their biggest challenges. We aimed to longitudinally evaluate different components of stigma, namely perceived,…

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Negative / Null Result ReportMedicine

Effects of Acute Caffeine Supplementation on Integrated Biathlon Performance in Elite Male Athletes.

Engel H, Yilmaz C, Appelhans D et al. · 2026 · International journal of sport nutrition and exercise metabolism

Caffeine enhances endurance performance but may impair shooting accuracy, creating a potential trade-off for overall biathlon performance. In a randomized, placebo-controlled, crossover study, seven elite male biathletes consumed caffeine…

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Negative / Null Result ReportMedicine

Accuracy of thoracolumbar pedicle screw placement using intraoperative CT navigation versus 3D-printed patient-specific guides integrated with virtual surgical planning: a comparative study.

Pairojboriboon S, Charakorn K, Promoppatum P · 2026 · Expert review of medical devices

Background 3D-printed patient-specific pedicle screw guides (3DPSG) may provide accuracy comparable to intraoperative CT navigation (CTNav). Our 3DPSG workflow incorporates a virtual surgical planning (VSP) platform that uses deep-learning…

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Negative / Null Result ReportMedicine

Outcome after cardiac surgery in Jehovah's Witnesses.

Karlsson E, Dalén M, Svenarud P et al. · 2026 · Scandinavian cardiovascular journal : SCJ

Objectives Jehovah's Witnesses categorically refuse allogenic blood transfusions on religious grounds, a major challenge if intervention for heart disease is required. We retrospectively analyzed outcome after open-heart surgery in 26…

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