19,823 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
saboul H, Lesage V, Beernaert L et al. · 2025 · Preprint
Abstract Methods: A prospective randomized trial was conducted from October 26, 2022, to September 15, 2023, involving 101 patients randomized into two groups: the interventional group received POCUS (pulmonary and inferior vena cava…
View details →Davila-Piñón P, Díez Martín AI, Nogueira-Rodríguez A et al. · 2025 · Preprint
Background: /Objectives: Computer-aided detection (CADe) systems are increasingly used in endoscopy to enhance lesion recognition. PolyDeep is a CADe/x tool previously assessed in an observational study. The aim of our study is to…
View details →Bouman Z, De Vries F, De Ruiter M et al. · 2026 · Endoscopy international open
Background and study aims Esophagogastroduodenoscopy is a widely used medical examination. Despite the short duration of this procedure, many patients experience anxiety, pain, and discomfort. The aim of this study was to examine effects…
View details →García-García M, Mosqueda J, Escobar-Cabrera JE et al. · 2025 · Toxicon : official journal of the International Society on Toxinology
A recent clinical case involving a Poecilotheria regalis bite was treated with Mexican L. mactans antivenom (Aracmyn Plus, Silanes, Mexico), resulting in the improvement of some of the symptoms. This could be attributed to cross-reactivity…
View details →Belak L, James K, Auguste L et al. · 2026 · Preprint
ABSTRACT Background Hypertension is a leading modifiable cardiovascular risk factor prominently influenced by health-related social needs (HRSN). Whether detailed information on HRSN can improve identification of hypertension among…
View details →Baumann AN, Chatzis K, Son E et al. · 2026 · Spine
Study design Retrospective single-center study. Objective We aim to compare the prognostic capacity of postoperative T4-L1PA mismatch versus T4PA and L1PA alone. Summary of background data The assessment of T4-L1PA mismatch, the difference…
View details →Li YH, Cheng YC, Chang CY et al. · 2026 · Diagnostics (Basel, Switzerland)
Objectives: Multimodal large language models (MLLMs) have shown potential for medical image classification. We evaluated four optimization strategies in two MLLMs-GPT-4o (gpt-4o-2024-08-06) and Gemini 2.5 Flash-Lite-for ultrasound-based…
View details →Kishimoto T, Nakashima R, Kawano K et al. · 2026 · Preprint
Alveolar capillary endothelial cells are positioned adjacent to the alveolar epithelium and contribute to lung homeostasis and injury responses. Single-cell studies have identified aerocyte capillary endothelial cells (aCap), which are…
View details →Klaps S, Verbrugghe J, Goossens N et al. · 2026 · BMC sports science, medicine & rehabilitation
Background To compare the effects of a multimodal whole-body high-intensity training (HIT) program versus a moderate-intensity training (MIT) program on inspiratory muscle function in persons with chronic nonspecific low back pain…
View details →Biccirè FG, Arbustini E, Ozaki Y et al. · 2026 · Atherosclerosis
Background and aims Atherosclerotic plaque rupture is largely acknowledged as the main mechanism of acute coronary syndrome. However, the prognostic significance of plaque rupture detected in nonculprit coronary sites remains largely…
View details →Wisetmongkolchai T, Somboonchai P, Piromlertamorn W et al. · 2026 · JBRA assisted reproduction
Objective To investigate the effects of quercetin supplementation in aging mice on the oocyte number and in vitro fertilization outcomes. Methods Thirty-two to forty-week-old aging female mice were randomly assigned into two groups, with…
View details →Straumann S, Heidt T, Uhor F et al. · 2026 · Preprint
Abstract Background: High-altitude rescue operations expose Emergency Medical Services (EMS) teams to hypobaric hypoxia, which may impair cognition and team performance. However, its effect on the overall quality of prehospital emergency…
View details →Virhammar J, Fasth O, Ekblom M et al. · 2026 · The Lancet. Neurology
Background Idiopathic normal pressure hydrocephalus is a potentially reversible cause of gait disturbance, cognitive impairment, and urinary incontinence, typically in adults aged 60 years or older. Ventriculoperitoneal shunt surgery…
View details →Vasileiou D, Tsironi K, Konstantonis D et al. · 2026 · European journal of orthodontics
Objectives To evaluate the validity of digital manual and automated structural superimposition on the anterior cranial base using Björk's two-dimensional (2D) cephalometric method. Secondary aims included assessing repeatability and…
View details →Gilbert DL, Aschbacher-Smith LE, Migneault KY et al. · 2026 · Pediatric neurology
Background Children and youth with neurofibromatosis type 1 (NF1) commonly experience motor, behavioral, and cognitive problems. Promising findings from an NF1 mouse model suggested that the antioxidant N-acetylcysteine (NAC) might address…
View details →Fellers C, Storm BC · 2026 · Journal of experimental psychology. Learning, memory, and cognition
Across two experiments, we investigated the effects of cognitive offloading on prospective memory (PM). Participants performed two PM tasks, either relying on internal memory for both (Dual PM condition) or using an external reminder for…
View details →Benomar A, Fahed R, Omar AT et al. · 2026 · Journal of neurointerventional surgery
Background The Alberta Stroke Program Early CT Score (ASPECTS) and CT angiography (CTA) Collateral Score (CS) are routinely used to estimate ischemic core burden and collateral status in acute ischemic stroke due to large vessel occlusion,…
View details →Singhal M, Nidadavole K, Murphy DS et al. · 2026 · Journal of pharmaceutical sciences
Dissolution testing is performed to understand the rate and extent of drug release for assurance of in vivo bioavailability. In this case study, an immediate-release tablet of an investigational BCS Class II compound exhibited slow and…
View details →Smith HJ, Delf B, Rosi V et al. · 2026 · Preprint
Artificial voices are encountered frequently in modern life, including artificial “clones” of an individual’s voice. For natural voices, familiar talkers are more intelligible than unfamiliar talkers when competing speech is present, which…
View details →Dolak KD, Davila S, White PC · 2026 · BMC pediatrics
Background Procalcitonin is a useful screen for bacterial infection, but its utility in pediatric diabetic ketoacidosis (DKA) is unknown. Methods We conducted a retrospective study of DKA patients admitted to two pediatric hospitals in…
View details →Kobas B, Koth SC, Reitmayer A et al. · 2026 · Preprint
Abstract Continuous mechanical cooling is commonly used to maintain thermal comfort in office environments; however, its influence on human thermophysiological adaptation under sedentary conditions remains poorly understood. This study…
View details →Drake C, Buckman C, Brucker A et al. · 2026 · JAMA internal medicine
Importance Patients with diabetes and food insecurity are at greater risk of adverse health outcomes. Effective strategies to promote healthy food access are urgently needed. Objective To evaluate the effect of a produce prescription (PRx)…
View details →Tamás S, György H, András M et al. · 2026 · The international journal of lower extremity wounds
IntroductionThe treatment of chronic non-healing wounds represents a great challenge in healthcare, especially in rehabilitation medicine, as it contributes significantly to increased patient mortality and morbidity. Various types of laser…
View details →de Wasseige S, Mainguy-Seers S, Lavoie JP · 2026 · Equine veterinary journal
Background During clinical remission of severe equine asthma (SEA), affected animals can be challenging to distinguish from healthy horses. In humans, the degree of bronchodilation achieved with a β 2 -adrenergic bronchodilator is helpful…
View details →Untan I, Sabur V · 2026 · International journal of general medicine
Background Flank pain is a common emergency department (ED) presentation with a wide differential diagnosis. The albumin-to-globulin ratio (AGR) reflects both nutritional status and systemic inflammation, but its utility in…
View details →Lee-Miller CA, Kairalla JA, Hibbitts E et al. · 2026 · Blood advances
Abstract Patients with central nervous system (CNS) disease at diagnosis on Children's Oncology Group (COG) B-acute lymphoblastic leukemia (B-ALL) trials AALL0331 and AALL0232 had inferior outcomes, largely secondary to CNS relapse. In…
View details →Kong BH, Dillon K, Brady CM et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectiveTo determine whether the Centers for Disease Control and Prevention's Social Vulnerability Index (SVI) influences models of adherence to speech evaluations beyond individual demographic and clinical factors.DesignRetrospective…
View details →Matsuo A, Kanaya M · 2026 · Psychoneuroendocrinology
Stress contributes significantly to visceral pain hypersensitivity in irritable bowel syndrome (IBS). Although stress during critical developmental periods, such as chronic social defeat stress (CSDS) in adolescence or early-life…
View details →Wamsley EJ, Barron J, Livingston WH · 2026 · Journal of cognitive neuroscience
Memory is consolidated during "offline" states of reduced attention to the external stimulus environment, including sleep and resting wakefulness. While consolidation is usually studied on a timescale of hours to days, accumulating…
View details →Piazza FRG, Schuch JB, Ferreira DNSDS et al. · 2025 · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Objective N-acetylcysteine (NAC) is a medication known for its hepatoprotective properties and potential to reduce cravings and psychoactive substance use. Vitamin D is metabolized in the liver, and individuals with alcohol abuse often…
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