e-ISSN: Pending

Browse the failure-mode index

19,735 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessPsychology

Parent Engagement and School Readiness: Effects of the Getting Ready Intervention on Preschool Children's Social–Emotional Competencies

Susan M. Sheridan, Lisa L. Knoche, Carolyn Pope Edwards et al. · 2010 · Early Education and Development

RESEARCH FINDINGS: Parental engagement with children has been linked to a number of adaptive characteristics in preschool children, and relationships between families and professionals are an important contributor to school readiness.…

View details →
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

Mark C. Lloyd, Jessica J. Cunningham, Marilyn M. Bui et al. · 2016 · Cancer Research

Spatial heterogeneity in tumors is generally thought to result from branching clonal evolution driven by random mutations that accumulate during tumor development. However, this concept rests on the implicit assumption that cancer cells…

View details →
Negative / Null Result ReportOpen accessMedicine

Effects of Tamoxifen and Exemestane on Cognitive Functioning of Postmenopausal Patients With Breast Cancer: Results From the Neuropsychological Side Study of the Tamoxifen and Exemestane Adjuvant Multinational Trial

C. Schilder, Caroline Seynaeve, L.V.A.M. Beex et al. · 2010 · Journal of Clinical Oncology

PURPOSE: To evaluate the influence of adjuvant tamoxifen and exemestane on cognitive functioning in postmenopausal patients with breast cancer (BC). PATIENTS AND METHODS: Neuropsychological assessments were performed before the start (T1)…

View details →
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Endogeneity in CEO power: A survey and experiment

Zhichuan Li · 2016 · Investment Analysts Journal

The endogeneity problem has always been one, if not the only, obstacle to understanding the true relationship between different aspects of empirical corporate finance. Variables are typically endogenous, instruments are scarce, and…

View details →
Negative / Null Result ReportEnvironmental Science

Experimental tests of the bacterial distance–decay relationship

Thomas Bell · 2010 · The ISME Journal

Community similarity declines with increasing geographic distance if species tend to be locally adapted or if they are dispersal limited. The distance-decay of similarity has been shown for bacteria previously, but distinguishing between…

View details →
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice

Jacob M. Allen, Margret E. Berg Miller, Brandt D. Pence et al. · 2015 · Journal of Applied Physiology

We have previously shown that voluntary wheel running (VWR) attenuates, whereas forced treadmill running (FTR) exacerbates, intestinal inflammation and clinical outcomes in a mouse model of colitis. As the gut microbiome is implicated in…

View details →
Negative / Null Result ReportOpen accessComputer Science

Multiple comparison test by Tukey’s honestly significant difference (HSD): Do the confident level control type I error

Anita Nanda, Bibhuti Bhusan Mohapatra, Abikesh Prasada Kumar Mahapatra et al. · 2021 · International Journal of Statistics and Applied Mathematics

Examining a huge amount of data is a typical issue in any research process. However, different statistical processes and techniques play essential role to derive a meaningful conclusion from the presented enormous data. Control of type I…

View details →
Negative / Null Result ReportOpen accessPhysics and Astronomy

Radiation reaction effects on radiation pressure acceleration

Matteo Tamburini, Ф. Пегораро, A. Di Piazza et al. · 2010 · New Journal of Physics

Radiation reaction (RR) effects on the acceleration of a thin plasma foil by a superintense laser pulse in the radiation pressure dominated regime are investigated theoretically. A simple suitable approximation of the Landau-Lifshitz equation for the RR force and a novel leapfrog pusher for its inclusion in particle-in-cell simulations are provided. Simulations for both linear and circular polarization of the laser pulse are performed and compared. It is found that at intensities exceeding $10^{23} \Wcm$ the radiation reaction force strongly affects the dynamics for a linearly polarized laser

View details →
Negative / Null Result ReportEconomics, Econometrics and Finance

Do Weather-Induced Moods Affect the Processing of Earnings News?

ED DEHAAN, Joshua Madsen, Joseph D. Piotroski · 2016 · Journal of Accounting Research

We investigate whether unpleasant environmental conditions affect stock market participants’ responses to information events. We draw from psychology research to develop a new prediction that weather-induced negative moods reduce market…

View details →
Negative / Null Result ReportBusiness, Management and Accounting

Corporate Boards, Audit Committees, and Earnings Management: Pre‐ and Post‐SOX Evidence

Aloke Ghosh, Antonio Marra, Doocheol Moon · 2010 · Journal of Business Finance &amp Accounting

Abstract: Primarily motivated by the claims that the recent regulatory initiatives empowering boards and audit committees restrain earnings management, we examine whether board characteristics (composition, size, and structure) and audit…

View details →
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

pH and exchangeable aluminum are major regulators of microbial energy flow and carbon use efficiency in soil microbial communities

Davey L. Jones, Emily C. Cooledge, Frances C. Hoyle et al. · 2019 · Soil Biology and Biochemistry

The microbial partitioning of organic carbon (C) into either anabolic (i.e. growth) or catabolic (i.e. respiration) metabolic pathways represents a key process regulating the amount of added C that is retained in soil. The factors regulating C use efficiency (CUE) in agricultural soils, however, remain poorly understood. The aim of this study was to investigate substrate CUE from a wide range of soils (n = 970) and geographical area (200,000 km2) to determine which soil properties most influenced C retention within the microbial community. Using a 14C-labeling approach, we showed that the aver

View details →
Negative / Null Result ReportOpen accessMedicine

Phase III Multinational, Randomized, Double-Blind, Placebo-Controlled Study of Tivantinib (ARQ 197) Plus Erlotinib Versus Erlotinib Alone in Previously Treated Patients With Locally Advanced or Metastatic Nonsquamous Non–Small-Cell Lung Cancer

Giorgio V. Scagliotti, Joachim von Pawel, Silvia Novello et al. · 2015 · Journal of Clinical Oncology

PURPOSE: Tivantinib, a MET receptor tyrosine kinase inhibitor, demonstrated increased anticancer activity in preclinical and early clinical studies when combined with erlotinib. Our study aimed to confirm efficacy and safety of the…

View details →
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

International Shocks, Variable Markups, and Domestic Prices

Mary Amiti, Oleg Itskhoki, Jozef Konings · 2019 · The Review of Economic Studies

Abstract How strong are strategic complementarities in price setting across firms? In this article, we provide a direct empirical estimate of firms’ price responses to changes in competitor prices. We develop a general theoretical…

View details →
Negative / Null Result ReportOpen accessMedicine

Screening for Preeclampsia

US Preventive Services Task Force, Kirsten Bibbins‐Domingo, David C. Grossman et al. · 2017 · JAMA

IMPORTANCE: Preeclampsia affects approximately 4% of pregnancies in the United States. It is the second leading cause of maternal mortality worldwide and may lead to serious maternal complications, including stroke, eclampsia, and organ…

View details →
Negative / Null Result ReportOpen accessPsychology

Reasons for Testing Mediation in the Absence of an Intervention Effect: A Research Imperative in Prevention and Intervention Research

Holly P. O’Rourke, David P. MacKinnon · 2018 · Journal of Studies on Alcohol and Drugs

OBJECTIVE: Mediation models are used in prevention and intervention research to assess the mechanisms by which interventions influence outcomes. However, researchers may not investigate mediators in the absence of intervention effects on…

View details →
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Social Transfer of Pathogenic Fungus Promotes Active Immunisation in Ant Colonies

Matthias Konrad, Meghan L. Vyleta, Fabian J. Theis et al. · 2012 · PLoS Biology

Due to the omnipresent risk of epidemics, insect societies have evolved sophisticated disease defences at the individual and colony level. An intriguing yet little understood phenomenon is that social contact to pathogen-exposed individuals reduces susceptibility of previously naive nestmates to this pathogen. We tested whether such social immunisation in Lasius ants against the entomopathogenic fungus Metarhizium anisopliae is based on active upregulation of the immune system of nestmates following contact to an infectious individual or passive protection via transfer of immune effectors amon

View details →
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

The Impact of Medicaid on Labor Market Activity and Program Participation: Evidence from the Oregon Health Insurance Experiment

Katherine Baicker, Amy Finkelstein, Jae Song et al. · 2014 · American Economic Review

In 2008, a group of uninsured low-income adults in Oregon was selected by lottery for the chance to apply for Medicaid. Using this randomized design and 2009 administrative data, we find no significant effect of Medicaid on employment or…

View details →
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Identifying significant edges in graphical models of molecular networks

Marco Scutari, Radhakrishnan Nagarajan · 2013 · Artificial Intelligence in Medicine

OBJECTIVE: Modelling the associations from high-throughput experimental molecular data has provided unprecedented insights into biological pathways and signalling mechanisms. Graphical models and networks have especially proven to be useful abstractions in this regard. Ad hoc thresholds are often used in conjunction with structure learning algorithms to determine significant associations. The present study overcomes this limitation by proposing a statistically motivated approach for identifying significant associations in a network. METHODS AND MATERIALS: A new method that identifies significa

View details →
Negative / Null Result ReportOpen accessMedicine

Emergency Department–Initiated Palliative Care in Advanced Cancer

Corita R. Grudzen, Lynne D. Richardson, Pauline N. Johnson et al. · 2016 · JAMA Oncology

IMPORTANCE: The delivery of palliative care is not standard of care within most emergency departments (EDs). OBJECTIVE: To compare quality of life, depression, health care utilization, and survival in ED patients with advanced cancer…

View details →
Negative / Null Result ReportMedicine

Exploring Diseases/Traits and Blood Proteins Causally Related to Expression of ACE2, the Putative Receptor of SARS-CoV-2: A Mendelian Randomization Analysis Highlights Tentative Relevance of Diabetes-Related Traits

Shitao Rao, Alexandria Lau, Hon‐Cheong So · 2020 · Diabetes Care

OBJECTIVE COVID-19 has become a major public health problem. There is good evidence that ACE2 is a receptor for SARS-CoV-2, and high expression of ACE2 may increase susceptibility to infection. We aimed to explore risk factors affecting…

View details →
Negative / Null Result ReportOpen accessSocial Sciences

Secondary transfer effects of intergroup contact: Alternative accounts and underlying processes.

Nicole Tausch, Miles Hewstone, Jared B. Kenworthy et al. · 2010 · Journal of Personality and Social Psychology

Although intergroup contact is one of the most prominent interventions to reduce prejudice, the generalization of contact effects is still a contentious issue. This research further examined the rarely studied secondary transfer effect…

View details →
Negative / Null Result ReportOpen accessMedicine

Monitoring Cognitive Functioning

Margie E. Lachman, Stefan Agrigoroaei, Patricia A. Tun et al. · 2013 · Assessment

Assessment of cognitive functioning is an important component of telephone surveys of health. Previous cognitive telephone batteries have been limited in scope with a primary focus on dementia screening. The Brief Test of Adult Cognition…

View details →
Negative / Null Result ReportOpen accessSocial Sciences

Loneliness from young adulthood to old age: Explaining age differences in loneliness

Louise C. Hawkley, Susanne Buecker, Till Kaiser et al. · 2020 · International Journal of Behavioral Development

Prior research in non-U.S. samples has found a complex nonlinear relationship between loneliness and age. This research has shown that established predictors of loneliness - poor health, being unmarried, living alone, and having infrequent…

View details →
Negative / Null Result ReportOpen accessPhysics and Astronomy

Has NANOGrav Found First Evidence for Cosmic Strings?

Simone Blasi, Vedran Brdar, Kai Schmitz · 2021 · Physical Review Letters

The North American Nanohertz Observatory for Gravitational Waves has recently reported strong evidence for a stochastic common-spectrum process affecting the pulsar timing residuals in its 12.5-year data set. We demonstrate that this process admits an interpretation in terms of a stochastic gravitational-wave background emitted by a cosmic-string network in the early Universe. We study stable Nambu-Goto strings in dependence of their tension Gμ and loop size α and show that the entire viable parameter space will be probed by an array of future experiments.

View details →
Negative / Null Result ReportAgricultural and Biological Sciences

Agricultural Management and Soil Carbon Storage in Surface vs. Deep Layers

S.P. Syswerda, Andrew Corbin, D. L. Mokma et al. · 2010 · Soil Science Society of America Journal

Soil C sequestration research has historically focused on the top 0 to 30 cm of the soil profile, ignoring deeper portions that might also respond to management. In this study we sampled soils along a 10‐treatment management intensity…

View details →
Negative / Null Result ReportOpen accessSocial Sciences

Income Inequality and Class Divides in Parental Investments

Daniel Schneider, Orestes P Hastings, Joe LaBriola · 2018 · American Sociological Review

Historic increases in income inequality have coincided with widening class divides in parental investments of money and time in children. These widening class gaps are significant because parental investment is one pathway by which advantage is transmitted across generations. Using over three decades of micro-data from the Consumer Expenditure Survey and the American Heritage Time Use Survey linked to state-year measures of income inequality, we test the relationship between income inequality and class gaps in parental investment. We find robust evidence of wider class gaps in parental financi

View details →
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study

Su Hwan Lee, Yeojun Yun, Soo Jung Kim et al. · 2018 · Journal of Clinical Medicine

There have been few large-scale studies on the relationship between smoking and gut microbiota. We investigated the relationship between smoking status and the composition of gut microbiota. This was a population-based cross-sectional study using Healthcare Screening Center cohort data. A total of 758 men were selected and divided into three groups: never (n = 288), former (n = 267), and current smokers (n = 203). Among the three groups, there was no difference in alpha diversity, however, Jaccard-based beta diversity showed significant difference (p = 0.015). Pairwise permutational multivaria

View details →