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750 real negative results, null findings, and replication failures · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessMedicine

Preoperative Intravenous Desmopressin and Perioperative Blood Loss in Patients Undergoing Major Spine Surgery : Preoperative Intravenous Desmopressin and Perioperative Blood Loss in Spine Surgery Patients.

Alizadeh A, Moradi M, Vafaeimastanabad M et al. · 2025 · Galen medical journal

Background Major spine surgeries often involve significant blood loss, increasing transfusion risks and postoperative complications. Desmopressin, a synthetic vasopressin analog, may reduce bleeding by enhancing clotting factor release,…

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Failed Experiment ReportOpen accessMedicine

Variation of rabbit serum IgA in relation to RHDV vaccination and infection: implications for serological diagnosis and epidemiological investigations.

Capucci L, Di Giovanni V, Schiavitto M et al. · 2026 · Veterinary research

Rabbit haemorrhagic disease (RHD) is a highly pathogenic and contagious disease caused by RHD virus (RHDV) and RHDV type 2 (RHDV2), two distinct Lagovirus europaeus belonging to the Caliciviridae family. Serological investigations have…

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Failed Experiment ReportMedicine

Diagnostic challenges in cardiac amyloidosis: a case report of negative initial endomyocardial biopsy.

Mojahedi A, Goldschmidt M, Skopicki H et al. · 2025 · International journal of physiology, pathophysiology and pharmacology

Cardiac amyloidosis (CA) is a challenging acquired heart disease caused by the deposition of β-pleated amyloid proteins, often leading to nonspecific symptoms that complicate the diagnosis. This case report describes an 83-year-old male…

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Failed Experiment ReportOpen accessMedicine

Persistent cognitive deficits in ACL-injured athletes despite of rehabilitation: an observational longitudinal study.

Jiménez-Martínez J, Alarcón-López F, Chirosa-Ríos LJ et al. · 2025 · Frontiers in sports and active living

Background Rehabilitation programs following an anterior cruciate ligament (ACL) injury tend to focus on improving conditional aspects such as biomechanics. Recently, some studies have analyzed the relationship between cognition and ACL…

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Failed Experiment ReportOpen accessMedicine

Cytogenomics and optical genome mapping approaches characterize a derivative interstitial monosomy 18p due to a maternal complex intrachromosomal rearrangement.

Graziani L, Genovese S, Genovesi ML et al. · 2025 · Molecular cytogenetics

Background Monosomy 18p (MIM: 146390) is a well-known chromosomal disorder associated with intellectual disability, short stature, and non-specific craniofacial features resulting from partial or total deletion of the short arm of…

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Failed Experiment ReportMedicine

Evaluation of leukocyte depletion filters for the removal of EpCAM-positive tumor cells during oncologic intraoperative blood salvage using CATUVAB<sup>®</sup>: an exploratory feasibility study.

Mathis S, Putzer G, Schnegg L et al. · 2026 · BMC anesthesiology

Background Intraoperative blood salvage (IBS) reduces exposure to allogeneic blood but is accompanied by concerns in oncologic surgery regarding the potential reinfusion of residual tumor cells and subsequent metastatic dissemination. The…

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Failed Experiment ReportOpen accessMedicine

Dynamic monitoring of antibody drug conjugates targeting TROP2 or HER2 in breast cancer using circulating tumor cells.

Mishra A, Abelman RO, Cunneely Q et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America

Antibody-drug conjugates (ADCs) target surface proteins on cancer cells, leading to internalization and delivery of a drug payload, thereby enhancing selectivity and minimizing toxicity. ADCs against TROP2 (Sacituzumab govitecan) or HER2…

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Failed Experiment ReportMedicine

Comparative assessment of behavioral and systemic effects of small (10 nm) and large (100 nm) tellurium nanoparticles in a chronic mouse model.

Rogachev VV, Goltyaev MV, Varlamova EG et al. · 2026 · Biochemical and biophysical research communications

This study presents a comparative evaluation of the behavioral and systemic effects of small (10 nm) and large (100 nm) tellurium nanoparticles (TeNPs) obtained by laser ablation in a chronic in vivo experiment on male BALB/c mice. TeNPs…

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Failed Experiment ReportMedicine

Comparative analysis of the toxicity of fragmented and fibrous microplastics versus natural particles in the sea squirt Ciona intestinalis type A (Ciona robusta).

Saad R, Sekiguchi T, Takai Y et al. · 2026 · Marine environmental research

Microplastics (MPs) are ubiquitous in marine environments and readily ingested by filter-feeding organisms, yet the ecotoxicological effects of irregularly shaped MPs remain poorly understood. This study assessed the accumulation and…

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Failed Experiment ReportMedicine

Gestational timing and vaccine platform shape maternally derived neutralizing immunity and vaccine RNA detection in piglets following maternal vaccination with C-strain or FlagT4G against classical swine fever.

Coronado L, Muñoz-Aguilera A, Puente-Marin S et al. · 2026 · Frontiers in veterinary science

Control of classical swine fever (CSF) in endemic regions relies heavily on vaccination of breeding herds. Optimizing vaccination strategies is essential for sustainable disease control covering pigs belonging to different categories. Data…

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Failed Experiment Report

Semaglutide promotes intramuscular fat formation after injury

Noble C, Geller D, Urs N et al. · 2026 · Preprint

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become defining therapies in the management of type 2 diabetes and obesity. Despite recent interest in the effects of GLP-1RA therapy on skeletal muscle, their influence on muscle…

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Failed Experiment ReportOpen accessMedicine

Semaglutide

· 2006

Semaglutide was not detectable in the milk of mothers taking the drug subcutaneously. Their breastfed infants experienced no adverse effects. Some brands of oral semaglutide, such as Rybelsus, contain the absorption enhancer salcaprozate…

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Failed Experiment ReportOpen accessMedicine

The Effects of Conservative Fluid Management and Active Deresuscitation on Markers of Tissue Perfusion, Kidney Injury, and Vascular Injury in Critically Ill Adults: A Secondary Analysis of the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) Trial.

McMullan RR, McGrath C, Cody N et al. · 2026 · Critical care explorations

Objectives Test the hypothesis that conservative fluid management with active deresuscitation would not adversely affect tissue perfusion or kidney injury and would be associated with reduced vascular injury compared with usual care.…

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Failed Experiment ReportMedicine

Dentin Bond Strength of Resin Cements Under Simulated Intraoral Humidity Conditions.

Washino T, Nikaido T, Burrow MF et al. · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Background/aims Adhesive procedures performed after dental trauma are often carried out in emergency settings with compromised isolation due to bleeding, limited access, and patient cooperation. This study evaluated how variation in…

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Failed Experiment ReportOpen accessMedicine

Dried Black Soldier Fly (<i>Hermetia illucens</i>) Larvae in a Sustainable Diet for Laying Hens: Effects on Welfare and Behavior.

Znazen Y, Gaddes M, Janssens GPJ et al. · 2026 · Animals : an open access journal from MDPI

This study evaluated the effects of locally sourced ingredient dietary, with or without supplementation of black soldier fly ( Hermetia illucens ; BSF) larvae, on laying hen welfare. A total of 150 Lohman White hens aged 30 weeks were…

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