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129 real negative results, null findings, and replication failures · Methods Dead-End. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Methods Dead-EndOpen accessComputer Science

Another Facet of LIG Parsing

Pierre Boullier · 1996 · arXiv

In this paper we present a new parsing algorithm for linear indexed grammars (LIGs) in the same spirit as the one described in (Vijay-Shanker and Weir, 1993) for tree adjoining grammars. For a LIG $L$ and an input string $x$ of length $n$, we build a non ambiguous context-free grammar whose sentences are all (and exclusively) valid derivation sequences in $L$ which lead to $x$. We show that this grammar can be built in ${\cal O}(n^6)$ time and that individual parses can be extracted in linear time with the size of the extracted parse tree. Though this ${\cal O}(n^6)$ upper bound does not impro

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Methods Dead-EndOpen accessDairy processing. Dairy products

Effect of nicotinic acid supplementation on digestion, metabolism, microbiome, and production in late-lactation Holstein cows

R.B. Standish, A.D. Wright, N.L. Whitehouse et al. · 2024 · Journal of Dairy Science

ABSTRACT: The purpose of this experiment was to determine if nicotinic acid (NA) effects on dairy cows and rumen microbial characteristics are forage-type dependent (corn silage, CS; grass silage, GS). Four late-lactation (DIM = 225 ± 12 d) Holstein cows were used in a 4 × 4 Latin square design with a 2 × 2 factorial arrangement of treatments. The main effects were a CS (66.10% CS) based diet or a GS (79.59%) based diet with or without 12 g/d NA. Each experimental period lasted for 28 d. Milk production and milk components, blood metabolites, apparent total-tract nutrient digestibilities, minu

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Methods Dead-EndOpen accessMedicine (General)

A one-step NIST traceable HPLC method for quantitation of vitamin B6 and 4-pyridoxic acid in human plasma

Xiaochun Zhang, Xiaoying Tang, Thomas M. Daly · 2020 · Practical Laboratory Medicine

Objectives: Vitamin B6 deficiency is associated with a wide spectrum of clinical syndromes. While vitamin B6 status is primarily assessed by measuring the biologically active form of the vitamin, pyridoxal 5-phosphate (PLP), concurrent measurement of the final metabolite 4-pyridoxic acid (PA) can provide additional information regarding supplement intake and hypophosphatasia. The aim of this study is to develop a simple method traceable to the NIST standard reference material 3950 for simultaneous detection of PLP and PA. Design & methods: A one-step reverse phase HPLC method with fluorescence

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Methods Dead-EndOpen accessSocial sciences (General)

Metacognitive Strategy Training Improves Decision-Making Abilities in Amnestic Mild Cognitive Impairment

Foteini Aikaterini Pikouli, Despina Moraitou, Georgia Papantoniou et al. · 2023 · Journal of Intelligence

Mild cognitive impairment (MCI) is associated with deficits in decision-making, which is of utmost importance for daily functioning. Despite evidence of declined decision-making abilities, research on decision-making interventions for MCI is scarce. As metacognition seems to play an important role in decision-making, the present study’s aim was to examine whether a metacognitive strategy training can improve MCI patients’ decision-making abilities. Older adults—patients of a day care center, diagnosed with amnestic MCI (n = 55) were randomly allocated in two groups, which were matched in gende

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Methods Dead-EndMedicine

Exploratory Analysis of the Convergence Between Acoustic Measures and Qualitative Spectrographic Analysis Following Expressiveness Training in Journalism Students.

Batista DJ, da Conceição AS · 2026 · Journal of voice : official journal of the Voice Foundation

Objectives This study aims to explore the convergence between objective acoustic measures and qualitative spectrographic analysis in the evaluation of the effects of an expressiveness-oriented training program in journalism students.…

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Methods Dead-EndOpen accessFinance

Predictive Power of ESG Factors for DAX ESG 50 Index Forecasting Using Multivariate LSTM

Manuel Rosinus, Jan Lansky · 2025 · International Journal of Financial Studies

As investors increasingly use Environmental, Social, and Governance (ESG) criteria, a key challenge remains: ESG data is typically reported annually, while financial markets move much faster. This study investigates whether incorporating annual ESG scores can improve monthly stock return forecasts for German DAX-listed firms. We employ a multivariate long short-term memory (LSTM) network, a machine learning model ideal for time series data, to test this hypothesis over two periods: an 8-year analysis with a full set of ESG scores and a 16-year analysis with a single disclosure score. The evalu

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Methods Dead-EndOpen accessMedicine

Whole exome sequencing and single-cell DNA sequencing for assessment of clonal heterogeneity and evolution in acute myeloid leukemia.

Adhikari S, Eldfors S, Pitkänen E et al. · 2025 · Computational and structural biotechnology journal

Background Acute myeloid leukemia (AML) progresses by the accumulation of somatic mutations and clonal expansion of pre-leukemic cells. Patients may respond to initial therapy, but often relapse, underscoring an evolving disease. Next…

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Methods Dead-EndMedicine

Automation in the IVF laboratory in 2026: four technology domains, an asymmetric evidence base, and the case for parallel development with clinician-side automation.

Dirican EK · 2026 · Journal of assisted reproduction and genetics

Background Operator-dependent laboratory tasks-embryo selection, vitrification and warming, and intracytoplasmic sperm injection (ICSI)-have been the principal targets of IVF laboratory automation, and a fourth strand of work, integrated…

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Methods Dead-EndOpen accessMedicine (General)

Evaluating the psychometric properties of the attitudes towards depression and its treatments scale in an Australian sample

Di Benedetto M, Greenwood KM, Isaac F · 2012 · Patient Preference and Adherence

Fadia Isaac1, Kenneth Mark Greenwood2, Mirella Di Benedetto31Cairnmillar Institute School of Psychology Counselling and Psychotherapy, Camberwell, Victoria, Australia; 2School of Psychology and Social Science Faculty of Computing, Health and Science, Edith Cowan University, Joondalup, Western Australia, Australia; 3School of Health Sciences, Royal Melbourne Institute of Technology University, Bundoora, Victoria, AustraliaBackground: Individuals’ attitudes towards depression and its treatments may influence their likelihood of seeking professional help and adherence to treatment when depr

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Methods Dead-EndMedicine

Prognostic parameters for local control and survival after radiotherapy of stabilized bone metastases.

Potkrajcic V, Wahl D, Frantz S et al. · 2026 · Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

Background Postoperative radiotherapy following surgical stabilization in patients with bone metastases is commonly recommended. The aim of the study was to validate existing prognostic scores and parameters for local control and survival…

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Methods Dead-EndMedicine

Prospective evaluation of the CASST score to guide elective tracheostomy following oral cancer surgery: challenges and clinical misalignment.

Gulamani A, Shamim F, Khan S et al. · 2026 · International journal of oral and maxillofacial surgery

The Clinical Assessment Scoring System for Tracheostomy (CASST) was developed to predict the need for elective tracheostomy in head and neck cancer surgery, but evidence on its external performance remains limited. This prospective study…

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Methods Dead-EndOpen accessMathematics

The Constrained Maximum Likelihood Estimation For Parameters Arising From Partially Identified Models

Hao Luo, Alexandre Bouchard-Côté, Gabriela Cohen Freue et al. · 2016 · arXiv

We extend the constrained maximum likelihood estimation theory for parameters of a completely identified model, proposed by Aitchison and Silvey (1958), to parameters arising from a partially identified model. With a partially identified model, some parameters of the model may only be identified through constraints imposed by additional assumptions. We show that, under certain conditions, the constrained maximum likelihood estimator exists and locally maximize the likelihood function subject to constraints. We then study the asymptotic distribution of the estimator and propose a numerical algo

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Methods Dead-EndOpen accessComputer Science

LuMon: A Comprehensive Benchmark and Development Suite with Novel Datasets for Lunar Monocular Depth Estimation

Aytaç Sekmen, Fatih Emre Gunes, Furkan Horoz et al. · 2026 · arXiv

Monocular Depth Estimation (MDE) is crucial for autonomous lunar rover navigation using electro-optical cameras. However, deploying terrestrial MDE networks to the Moon brings a severe domain gap due to harsh shadows, textureless regolith, and zero atmospheric scattering. Existing evaluations rely on analogs that fail to replicate these conditions and lack actual metric ground truth. To address this, we present LuMon, a comprehensive benchmarking framework to evaluate MDE methods for lunar exploration. We introduce novel datasets featuring high-quality stereo ground truth depth from the real C

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