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Browse the failure-mode index

20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Thyroid hormones and thyroid hormone sensitivity indices correlate with volumetric bone mineral density and vertebral fracture risk among the osteoporotic population in northern China.

Meicen, Wei, Yanai et al. · 2026 · Frontiers in endocrinology

Thyroid hormones play critical roles in regulating bone turnover and maintaining bone mass. However, the relationship among thyroid hormones, their sensitivity indices, bone mineral density (BMD) and fracture risk remained unclear in the…

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Negative / Null Result ReportMedicine

Timing for green prescription: comparing the immediate and cumulative effects of different duration horticultural therapy programs on college students' mental health.

Liu, Chen, Sun et al. · 2026 · Frontiers in psychology

Although the mental health benefits of horticultural therapy (HT) are well-established, the influence of intervention duration and the temporal dynamics of effects remain insufficiently explored, lacking evidence for optimal protocol…

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Negative / Null Result ReportMedicine

Risk Factors and Survival Analysis of Epstein-Barr Virus Infection After Pediatric Liver Transplantation.

Li, Li, Xie et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

To explore the risk factors affecting Epstein-Barr virus (EBV) infection after pediatric liver transplantation (PLT) and analyze the survival outcomes of EBV infection in PLT. A retrospective analysis was conducted on clinical data from…

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Negative / Null Result ReportMedicine

[Targeted muscle reinnervation for treatment of painful stump neuroma].

Xiong, Shali, Kadier et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To investigate the effectiveness of incorporating small gap anastomosis (SGA) and epineurial sheath tube (EST) sleeve coaptation into conventional targeted muscle reinnervation (TMR) for the treatment of post-amputation painful stump…

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Negative / Null Result ReportMedicine

[Comparative study on effectiveness of bioinductive patch-augmented arthroscopic rotator cuff repair].

Sun, Yao, Gu et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To evaluate the effectiveness of using a bioinductive patch on tendon healing, functional recovery, and safety in arthroscopic rotator cuff repair. A non-concurrent controlled study with prospective enrollment of the intervention group and…

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Negative / Null Result ReportMedicine

[Effectiveness analysis of single-incision treatment for adjacent two-segmental lumbar disc herniation using uni-portal non-coaxial spinal endoscopic surgery].

He, Li, Xiao et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To investigate the feasibility and effectiveness of uni-portal non-coaxial spinal endoscopic surgery (UNSES) via a single incision for the treatment of adjacent two-segmental lumbar disc herniation (LDH). A retrospective analysis was…

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Negative / Null Result ReportMedicine

Effect of ammonia-free silver fluoride and silver diammine fluoride on immediate microshear bond strength of resin-modified glass ionomer to demineralised primary tooth dentine.

Abedinzade Zare, Vafadar, Behroozibakhsh et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

This study aimed to compare the effect of water-based ammonia-free silver fluoride (SF) and silver diammine fluoride (SDF) on the microshear bond strength (MSBS) of resin-modified glass ionomer (RMGIC) to artificially demineralised primary…

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Negative / Null Result ReportMedicine

Biologically enhanced anterior cruciate ligament reconstruction: Platelet-rich plasma or bone marrow aspirate concentrate does not lead to better clinical or radiological outcomes-A randomized controlled trial of 175 cases with 2 years of follow-up.

Mokhtar, Gawish, Abdelgawad et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

To compare the clinical and radiological outcomes of anterior cruciate ligament reconstruction (ACLR) augmented with platelet-rich plasma (PRP) (1) or bone marrow aspirate concentrate (BMAC) (2) against a control group undergoing standard…

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Negative / Null Result ReportMedicine

Impact of central adiposity on the heart rate and calorie estimation accuracy of diverse smartwatches and the resulting subjective exercise experience.

Lertyongphati, Udomkhwamsuk, Amornrungrojanakul et al. · 2026 · Frontiers in sports and active living

In light of the growing global trend toward health awareness, wearable technologies like smartwatches have become essential for monitoring physiological indicators such as heart rate (HR). However, their utility faces two critical…

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Negative / Null Result ReportMedicine

Transcervical carotid artery stenting compared to transfemoral carotid artery stenting and carotid endarterectomy: perioperative and short-term results from a single center.

Jin, Ni, Huang et al. · 2026 · Frontiers in cardiovascular medicine

Carotid artery stenosis is a major cause of ischemic stroke. Various revascularization strategies exist, including Carotid Endarterectomy (CEA), Transfemoral Carotid Artery Stenting (TF-CAS), and Transcervical Carotid Artery Stenting…

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Negative / Null Result ReportMedicine

Accuracy of Visual Inspection of Thickened Liquids: Implications for Multidisciplinary Dysphagia Management and Clinical Nutrition.

Fong, Kwan · 2026 · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

To evaluate the accuracy of visually estimating thickened liquid volume via video-observed conditions and to determine whether clinical experience or thickener composition influences judgement reliability. A cross-sectional online survey…

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Negative / Null Result ReportMedicine

The relationship between appetite hormones and body mass index in children with intoxication type metabolic diseases.

Koç, Konyalıgil, Özen Yeşil et al. · 2026 · Orphanet journal of rare diseases

The aim of this study is to comparatively examine the effects of appetite loss and insufficient energy intake, which trigger poor metabolic control parameters, on appetite hormones and body mass index in children with intoxication-type…

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Negative / Null Result ReportMedicine

The Effect of the Temporal Position of a Gap on Its Automatic Detection.

Omidvar, Campbell, Alain et al. · 2026 · The European journal of neuroscience

The presentation of a rarely occurring auditory stimulus that contains a silent interval (or gap) among a sequence of frequently occurring stimuli that do not contain a gap can elicit a negative-going event-related potential known as the…

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Negative / Null Result ReportMedicine

Prognosis of ER-positive, HER2-negative postmenopausal early breast cancer patients based on response to neoadjuvant endocrine therapy and multigene assay results: findings from the NEOS trial.

Iwata, Masuda, Yamamoto et al. · 2026 · Breast cancer (Tokyo, Japan)

We previously reported the 21-gene Oncotype DX® assay results from TransNEOS in patients enrolled in the phase 3 NEOS trial. However, the association between assay results and long-term prognosis has remained unclear. Of the 296…

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Negative / Null Result ReportMedicine

Clinically indicated versus routine replacement of peripheral intravenous cannulas in elderly patients: Secondary analysis of a multi-center randomized controlled trial in mainland China.

Jiang, Wang, Wei et al. · 2026 · Geriatric nursing (New York, N.Y.)

Peripheral Intravenous Cannulas (PIVCs) are extensively used for infusion therapy. Although current evidence suggests that adult patients may have PIVCs removed based on clinical indications, the indication in elderly patients remains…

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Negative / Null Result ReportMedicine

CT Perfusion Blood Flow Provides an Early Response Marker for Progression-free Survival in a Prospective Randomized Clinical Trial of Metastatic Renal Cell Carcinoma.

Ng, Chen, Wei et al. · 2026 · Technology in cancer research & treatment

IntroductionThere is currently no biomarker for progression-free survival (PFS) for patients undergoing treatment for metastatic renal cell carcinoma (RCC). The aim of our study was to evaluate computed tomography perfusion (CTp) blood…

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Negative / Null Result ReportMedicine

The Utility of Large Language Models to Assist With Emergency Triage Decisions Within Otolaryngology.

Hack, Attal, Steckbeck et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

To determine whether contemporary large language models can match clinician performance in evaluating the urgency of emergency otolaryngology referrals. Blinded cross-sectional diagnostic reasoning study. Simulated emergency referral…

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Negative / Null Result ReportMedicine

Relation between forearm flexor-pronator muscle elasticity and ulnar collateral ligament laxity of the elbow joint in high school pitchers with and without medial elbow tenderness: evaluation using shear wave elastography.

Tajika, Shitara, Hatori et al. · 2026 · JSES international

The forearm flexor-pronator muscle contributes to the dynamic stabilizer against valgus stress at the elbow during pitching motion. This study used shear wave ultrasonography to assess the relation between the elasticity of each forearm…

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Negative / Null Result ReportMedicine

Differences in gut microbiome of Hanwoo (Korean indigenous cattle) calves as driven by bovine rotavirus and bovine coronavirus infection.

Ku, Lee, Jung et al. · 2026 · Journal of animal science and technology

The gut microbiome of cattle suppresses pathogens and aids host immunity. However, the gut microbiome of newborn calves is still developing; therefore, diarrhea caused by pathogen infection is common. Rapid changes in the gut microbiome…

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Negative / Null Result ReportMedicine

External Validation of a Deep Learning-Based Artificial Intelligence System for Ultrasound Diagnosis of Thyroid Nodules: A Two-Center Retrospective Study.

Tang, Xu, Zhao et al. · 2026 · Journal of clinical ultrasound : JCU

To investigate the performance of an artificial intelligence (AI) diagnostic system for thyroid nodule sonography based on deep learning convolutional neural network (CNN). We retrospectively included 485 thyroid nodules with definite…

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