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Browse the failure-mode index

19,820 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Lack of association between cytomegalovirus infection and liver fibrosis in patients with biliary atresia after the Kasai procedure.

Lucas A, Novebri NA, Heros PAI et al. · 2026 · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

Background Biliary atresia (BA) is a serious condition and the leading cause for liver transplantation in children. The exact cause for BA is currently unknown, with one suggested mechanism being a viral infection. Cytomegalovirus (CMV) is…

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Negative / Null Result ReportMedicine

The role of IgM anti-acetylated protein antibodies and B cells in the origin of anti-modified protein autoimmunity in rheumatoid arthritis.

Athanasiadou A, Kroos S, van de Wetering R et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)

Objective Rheumatoid arthritis (RA) is characterized by anti-modified protein antibodies (AMPAs), including anti-citrullinated (ACPA), anti-carbamylated (anti-CarP), and anti-acetylated (AAPA) protein antibodies. In contrast to other…

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Negative / Null Result ReportMedicine

Circulating GPER-1, 8-Iso-Prostaglandin F<sub>2</sub>α, and Raftlin-1 in Hypertensive Women During the Menopausal Transition: Associations with BMI and Diagnostic Performance.

Öztürk Ü, Üremiş MM, Kurutaş EB · 2026 · Journal of clinical medicine

Background: Hypertension (HTN) is a multifactorial condition involving alterations in vascular signaling, inflammation, and oxidative stress. Women during the menopausal transition may experience increased cardiovascular risk due to…

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Negative / Null Result ReportOpen accessMedicine

Optimal duration of neoadjuvant chemotherapy prior to CRS ± HIPEC for colorectal cancer: An assessment of survival and postoperative outcomes.

Bennett FJ, Oppat KM, Zaidi MY et al. · 2026 · Surgical oncology insight

Background Cytoreductive surgery (CRS) with or without heated intraperitoneal chemotherapy (HIPEC) represents a viable therapy for select patients with colorectal cancer (CRC) peritoneal metastases. Given recurrence rates, challenges…

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Negative / Null Result ReportOpen accessMedicine

Weight and sleep health in OSA: exploring their link.

Beatty CJ, Landry SA, Mann DL et al. · 2026 · Frontiers in sleep

Objectives Weight loss is often recommended for individuals with obesity and OSA, however, weight loss is particularly hard for this population. This study investigates how weight and weight change are associated with sleep health in…

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Negative / Null Result ReportMedicine

Unveiling connections: bisphenol A and vitamin D dynamics in breast milk among healthy lactating mothers.

Cinkilli Aktağ E, Yalçin SS, Yіrün A et al. · 2025 · International journal of environmental health research

Bisphenol A (BPA) has negative impact on human health. This study aims to explore the association between the levels of BPA and 25(OH) vitamin D in breastmilk. BPA exposure and vitamin D sources were recorded on the study form. Breastmilk…

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Negative / Null Result ReportOpen accessMedicine

Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population: the Swedish CArdioPulmonary BioImage Study.

Emilsson ÖI, Malinovschi A, Johnsson Å et al. · 2025 · Thorax

Background Nocturnal gastro-oesophageal reflux (nGER) is common in people with respiratory diseases, but its association with pulmonary abnormalities is not known. Aim Investigate the association between nGER and pulmonary abnormalities on…

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Negative / Null Result ReportOpen accessMedicine

Association between neutrophil extracellular traps, the Von Willebrand factor axis, and clinical outcome in stable coronary artery disease.

Bratseth V, Kindberg KM, Warlo EMK et al. · 2026 · Frontiers in cardiovascular medicine

Introduction Coronary artery disease (CAD) is the clinical manifestation of atherosclerosis, an inflammatory disorder of the coronary arteries, characterized by endothelial dysfunction, lipid accumulation, immune activation, and formation…

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Negative / Null Result ReportMedicine

The Relationships Between Cochlear Nerve Health and AzBio Sentence Scores in Quiet and Noise in Postlingually Deafened Adult Cochlear Implant Users.

Gao Z, Yuan Y, Oleson JJ et al. · 2026 · Ear and hearing

Objectives This study investigated the relationships between the cochlear nerve (CN) health and sentence-level speech perception outcomes measured in quiet and noise in postlingually deafened adult cochlear implant (CI) users. Design Study…

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Negative / Null Result ReportMedicine

Lack of association between chronological age and fisher group and poor outcomes in older patients with severe-grade aneurysmal subarachnoid hemorrhage: a nationwide registry study in Japan.

Suzuki K, Sato H, Sorimachi T et al. · 2025 · Neurosurgical review

Older age and Fisher group scores predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, among aging societies, treatment indications and decisions in older patients with severe-grade aSAH (World…

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Negative / Null Result ReportMedicine

Gestational weight gain and postpartum depressive symptoms in high-income women with low and late fertility.

Zanardo V, Polver S, Zanardo B et al. · 2025 · European journal of obstetrics, gynecology, and reproductive biology

Objective This study aimed to investigate the relationship between GWG and postpartum depressive symptoms among high income women with 'low and late fertility', combined into a single category. Methods We examined the impact of low and…

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Negative / Null Result ReportMedicine

The Value of Anti-Drug Antibody Detection in Discriminating Patients from Healthy Controls and Predicting the Gross Motor Functional State in Patients with Pompe Disease.

Aziz-Ahari S, Aminian M, Rahimian A et al. · 2026 · Iranian journal of allergy, asthma, and immunology

Anti-recombinant human acid α-glucosidase (anti-rhGAA) antibody formation is a major challenge in patients with Pompe disease receiving enzyme replacement therapy (ERT). The clinical significance of these antibodies and their detection…

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Negative / Null Result ReportOpen accessMedicine

Radiolucent lines after robotic-assisted surface-matching kinematically aligned UKA: short-term incidence and lack of association with tibial alignment.

Itou J, Kuwasawa A, Nihei K et al. · 2026 · Archives of orthopaedic and trauma surgery

Purpose This study investigated the clinical outcomes of robotic-assisted unicompartmental knee arthroplasty (UKA) performed using a surface-matching kinematic technique that restores native joint morphology without alignment constraints.…

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Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Middle Cerebral Artery Diastolic Deceleration Area and Gestational Diabetes Mellitus: A Prospective Case-Control Study.

Emiralioglu Cakır Z, Ankara Aktaş H, Gercik Arzık I et al. · 2026 · Medicina (Kaunas, Lithuania)

Backgroud and Objectives : To evaluate conventional Doppler indices and the novel middle cerebral artery (MCA) diastolic deceleration area (DDA) in pregnancies complicated by gestational diabetes mellitus (GDM), and to explore their…

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Negative / Null Result ReportMedicine

Lack of Association of Emotional Distress With Insulin Initiation in the GRADE Randomized Diabetes Comparative Effectiveness Trial.

Presley CA, Butera NM, Krause-Steinrauf H et al. · 2025 · The science of diabetes self-management and care

PurposeThe purpose of this study is to evaluate whether higher emotional distress (depressive symptoms or diabetes distress) was associated with a lower likelihood of basal or rapid-acting insulin initiation among participants enrolled in…

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