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Browse the failure-mode index

20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

A medication-wide association study to identify medications associated with incident clinically significant diabetic retinopathy

Ruilin Xiong, Wei Wang, Xianwen Shang et al. · 2023 · Therapeutic Advances in Ophthalmology

Background: Diabetic retinopathy, a common microvascular complication of diabetes mellitus, is one of the leading causes of vision loss worldwide. Although some oral drugs have been suggested to affect the risk of diabetic retinopathy,…

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Negative / Null Result Report

No Significant Association Between Vitamin C Supplements and Frailty in Korean Older Adults: A Cross-Sectional Analysis of the 2018–2019 Korea National Health and Nutrition Examination Survey

Seung Guk Park, Hyoeun Kim · 2025 · Nutrients

Background/Objectives: The association between vitamin C intake and frailty among older adults remains unclear, and evidence from Asian populations is limited. Using nationally representative data, we aimed to examine whether vitamin C…

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Negative / Null Result Report

Conventional machine learning-based prediction models did not outperform the International IgA Nephropathy Prediction Tool

Sehoon Park, Yisak Kim, Chung Hee Baek et al. · 2025 · Kidney Research and Clinical Practice

Background: Immunoglobulin A nephropathy (IgAN) is a major cause of end-stage kidney disease (ESKD). The International IgA Nephropathy Prediction Tool (IIgAN-PT) predicts IgAN prognosis, but improvement in the prediction performance using…

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Negative / Null Result Report

Significant association between IL-18 and OCT4 gene polymorphisms in susceptibility and clinical characteristics of prostate cancer*

Shaojun Nong, Yangbo Guan, Zhiwei Wang et al. · 2019 · Oncology and Translational Medicine

Abstract Objective Recent studies have shown abnormal expression of octamer-binding transcription factor 4 (OCT4) and interleukin-18 (IL-18) to be related to cancer. However, the molecular mechanisms by which the IL-18 and OCT4 gene…

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Negative / Null Result Report

Where did they come from, where did they go? Niche conservatism in woody and herbaceous plants and implications for plant‐based paleoclimatic reconstructions

Zack J. Quirk, Selena Y. Smith, R. Paul Acosta et al. · 2024 · American Journal of Botany

Abstract Premise The ecological conditions that constrain plants to an environmental niche are assumed to be constant through time. While the fossil record has been used previously to test for niche conservatism of woody flowering plants,…

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Negative / Null Result Report

Humans outperform Merlin Sound ID in field-based point-count surveys

Brooke D Goodman, Kyle A Lima, Seth Benz et al. · 2025 · Ornithological Applications

Abstract Point counts are integral to bird population monitoring, and multiple methods have been developed to improve their reliability. These methods include multiple-observer protocols, double-sampling, and surveys using autonomous…

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Negative / Null Result Report

Identification of Most Significant Parameter of Impact of Climate Change and Urbanization on Operational Efficiency of Hydropower Plant

Priyanka Majumder, Apu Kumar Saha · 2019 · International Journal of Energy Optimization and Engineering

The operational performance of hydropower plants (HPPs) is largely affected as the output from the plant entirely depends on the rainfall and demand from consumers both of which are compromised due to the vulnerability in climatic patterns…

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Negative / Null Result Report

Did the Inclusion of China’s A‐Shares in the MSCI Index Improve the Information Content of Listed Firms? Analysis Based on Stock Price Synchronisation and Environmental Social Governance

Jing Wu · 2022 · Wireless Communications and Mobile Computing

Chinese A‐shares were officially included in the Morgan Stanley Capital International (MSCI) Emerging Markets Index from June 2018. The inclusion of the A‐share market into the MSCI Index is one of the most influential events in the…

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Negative / Null Result Report

Threshold definitions for significant change on the timed 25‐foot walk and nine‐hole peg test in primary progressive multiple sclerosis

Marcus W. Koch, Pavle Repovic, Jop Mostert et al. · 2023 · European Journal of Neurology

Abstract Background and purpose The timed 25‐foot walk (T25FW) and nine‐hole peg test (NHPT) exhibit random variability in the short term. A threshold of ≥20% change from baseline has been used to indicate true disability change, but other…

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Negative / Null Result Report

Association of Diuretic Dosage With Outcomes in Patients With Hemodynamically Significant Isolated Tricuspid Valve Regurgitation

Vidhu Anand, Christopher G. Scott, Khaled Ali et al. · 2025 · Journal of the American Heart Association

Background Tricuspid valve surgery is recommended for severe isolated tricuspid regurgitation (TR) if symptoms persist despite optimal medical therapy. The definition of optimal therapy for TR is unclear beyond managing underlying…

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Negative / Null Result Report

Analysis of Pediatric Pulpotomy, Pulpectomy, and Extractions in Primary Teeth Revealed No Significant Association with Subsequent Root Canal Therapy and Extractions in Permanent Teeth: A Retrospective Study

Arash Farhadian, Mayce Arreem Issa, Karl Kingsley et al. · 2024 · Pediatric Reports

Recent evidence suggests that an ever-growing number of pediatric patients require invasive treatments such as root canal therapy (RCT) in their permanent dentition, albeit with little information about risk factors such as prior invasive…

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Negative / Null Result Report

Applying portfolio theory to benefit endangered amphibians in coastal wetlands threatened by climate change, high uncertainty, and significant investment risk

Mitchell J. Eaton, Adam J. Terando, Jaime A. Collazo · 2024 · Frontiers in Conservation Science

The challenge of selecting strategies to adapt to climate change is complicated by the presence of irreducible uncertainties regarding future conditions. Decisions regarding long-term investments in conservation actions contain significant…

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Negative / Null Result Report

How does servant leadership work in times of uncertainty? Examining servant leadership and perceived job insecurity during significant organizational change

Armin Pircher Verdorfer, Xuan Feng, Claudia Peus et al. · 2025 · Journal of Managerial Psychology

Purpose While the benefits of servant leadership are well established, its effectiveness during major organizational change remains unclear. Grounded in conservation of resources theory, this study examines how servant leadership functions…

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Negative / Null Result Report

Exploring effectiveness of CBT in obese patients with binge eating disorder: personality functioning is associated with clinically significant change

Laura van Riel, Elske van den Berg, Marike Polak et al. · 2023 · BMC Psychiatry

Abstract Background Binge eating disorder (BED), as the most prevalent eating disorder, is strongly related to obesity and other somatic and psychiatric morbidity. Despite evidence-based treatments a considerable number of BED patients…

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Negative / Null Result Report

When Do Single‐Species Occupancy Models Outperform Multispecies Models?

Gavin G. Cotterill, Douglas A. Keinath, Tabitha A. Graves · 2025 · Ecology and Evolution

ABSTRACT Occupancy models have become increasingly popular for species monitoring and assessment, in part, because detection/non‐detection data are readily obtained using a variety of methods. Multispecies occupancy models (MSOMs) can…

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Negative / Null Result Report

Patients Undergoing Elective Inpatient Major Therapeutic Procedures in Florida Had No Significant Change in Hospital Mortality or Mortality-Related Comorbidities Between 2007 and 2019

Richard H. Epstein, Franklin Dexter, Brenda G. Fahy · 2023 · Anesthesia & Analgesia

BACKGROUND: In a recent study, rapid response team implementation at 1 hospital was associated with only a 0.1% reduction in inpatient mortality from 2005 to 2018, characterized in the accompanying editorial as a “tepid” improvement. The…

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