19,820 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Manca, Paulus, Almeida et al. · 2026 · Neuroscience
Social connectedness strongly influences health and longevity, and adult pair bonds provide psychological benefits distinct from other social relationships. Oxytocin (OT), corticotropin-releasing hormone (CRH), and opioids play an…
View details →Ertürkmen Aru, Büke, Saat et al. · 2026 · Familial cancer
Biallelic loss-of-function variants in NTHL1 are associated with an autosomal recessive cancer predisposition syndrome, whereas the cancer risk associated with monoallelic NTHL1 variants remains uncertain. The recurrent truncating variant…
View details →Fiorenza, Millot, Lecomte et al. · 2026 · The Journal of antimicrobial chemotherapy
Prosthetic joint infections (PJI) of the hip and knee are most often caused by Staphylococcus spp. and require long-term treatment with rifampicin and fluoroquinolone as first-line treatment. However, resistance, contraindications or…
View details →Kobayashi, Yabuki, Sugiyama et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectiveNo studies have examined the effectiveness of platelet-rich plasma (PRP) alone and platelet-rich fibrin (PRF) without alveolar bone grafting or other bone substitutes for alveolar cleft repair during infancy. This study evaluated…
View details →Sulciner, Wang, Fairweather et al. · 2026 · Cureus
ON-Q pumps, or surgically placed wound catheters, provide analgesia without the side effects of epidural catheters. This study aimed to evaluate perioperative outcomes, including total postoperative oral morphine milligram equivalents…
View details →Sæther, Butt, Eubank et al. · 2026 · Frontiers in psychology
Psychological stressors have become a natural part of the process of developing skills in talent development environments of youth athletes. However, there is little research on psychological stressors among talented female athletes and…
View details →Jamei-Martel, Garibaldi, Castroviejo Fernández et al. · 2026 · JSES international
The optimal management of high-grade acromioclavicular (AC) joint dislocations remains controversial. While surgical treatment improves radiographic alignment, its impact on functional outcomes remains debated. This study prospectively…
View details →Huang, Yin, Lin · 2026 · Transplantation proceedings
The utilization of hepatitis B surface antigen-positive (HBsAg+) living kidney donors is a strategy to expand the donor pool. However, concerns regarding their renal safety after nephrectomy persist due to the potential impact of chronic…
View details →Foster, Millist, Germaine et al. · 2026 · Epilepsia open
ES-481 is a novel potent and selective antagonist of TARP-y8-dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES-481 as an add-on anti-seizure…
View details →Ucan Gunduz, Nizam Tekcan, Erdem et al. · 2026 · Journal of pediatric ophthalmology and strabismus
To investigate microstructural alterations in the retina, choroid, and optic nerve head in children with spina bifida using optical coherence tomography. Thirty-eight children with spina bifida and 32 children without spina bifida were…
View details →Zamaniyan, Abbasi, Habibpour et al. · 2026 · International journal of reproductive biomedicine
Diminished ovarian reserve is one of the most important issues in in vitro fertilization cycles. Some authors have reported beneficial effects of dual triggering in women with poor ovarian response, whereas other investigators have…
View details →Alencar, Teles, Cunha et al. · 2026 · Revista brasileira de ortopedia
Artificial intelligence (AI) tools based on natural language, such as ChatGPT 4.1 mini (OpenAI Group PBC) and Gemini 2.5 Flash (Alphabet Inc.), are used by patients as sources of medical information. The current study aimed to evaluate and…
View details →Alencar, Teles, Cunha et al. · 2026 · Revista brasileira de ortopedia
Artificial intelligence (AI) tools based on natural language, such as ChatGPT 4.1 mini (OpenAI Group PBC) and Gemini 2.5 Flash (Alphabet Inc.), are used by patients as sources of medical information. The current study aimed to evaluate and…
View details →Petrina, Dong, Beamer et al. · 2026 · Open forum infectious diseases
Vaginal dysbiosis is associated with HIV acquisition and preterm delivery. Our objective was to evaluate prevalent vaginal infections, and changes in microbiota and cytokines among pregnant and breastfeeding women from 4 African countries…
View details →Hardika, Kurniawan, Laksmi et al. · 2026 · Journal of the ASEAN Federation of Endocrine Societies
Leukocyte telomere length (LTL) is considered a biomarker of cellular senescence. Previous studies have reported the associations between shortened telomere length and type 2 diabetes mellitus (T2DM). However, the role of underlying…
View details →Durgala, Horvath, Skrabanova et al. · 2026 · Frontiers in behavioral neuroscience
Traumatic brain injury (TBI) is a major health concern in the current population. Animal models are increasingly important for identifying early neurobehavioural changes associated with mild to severe as well as repetitive brain injuries.…
View details →Choi, Park, Song et al. · 2026 · Psychiatry investigation
Although its potential antidepressant effects have been suggested, evidence on long-term outcomes for post-delivery depression remains limited. We evaluated whether peripartum intravenous magnesium sulfate (MgSO₄) is associated with…
View details →Lamb, Akulian, Musani et al. · 2026 · Respiratory research
Single chain urokinase (LTI-01) intrapleural enzymatic therapy (IET) was safe and promising in a phase 1 clinical trial to overcome failed drainage in patients with pleural infection. The LTI-01-2001 phase 2a trial was a randomized,…
View details →Akdogan, Aydin · 2026 · BMC oral health
Data comparing the wear of 3D printed permanent resin (PR) and milled zirconia (Z) to that of primary tooth enamel are limited. This study aimed to investigate the wear behavior of two materials and their effect on antagonist primary…
View details →Güler, Kaplan, Şahan et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses
Pain during arteriovenous fistula (AVF) catheterization is a common discomfort faced by hemodialysis patients and can negatively affect treatment adherence, satisfaction, and overall quality of life. Effective pain management strategies…
View details →Russo, Comune, Di Nardo et al. · 2026 · International journal of cardiology
The shortened protocol of Nitroglycerin (NTG)-potentiated head-up tilt testing (HUTT), the so-called "fast Italian protocol," has been shown to significantly reduce test duration while maintaining diagnostic yield and safety in adults with…
View details →Yeh, Ahuja, Patel et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
We conducted a target trial emulation study to examine the effect of two glucagon-like peptide-1 receptor agonists (GLP1RAs) (semaglutide and tirzepatide) on clinical outcomes in patients with inflammatory bowel diseases (IBD) with obesity…
View details →Jyung, Sun, Li et al. · 2026 · Journal of pain and symptom management
Pain catastrophizing (PC) predicts worse pain outcomes in cancer survivors. However, little is known whether PC influences pain outcomes of non-pharmacological treatments such as acupuncture. This study aimed to assess the impact of PC on…
View details →Hurst, White, Ryu et al. · 2026 · Human pathology
Pulmonary venoocclusive disease (PVOD)/pulmonary capillary hemangiomatosis (PCH) belongs to the WHO group 1 pulmonary hypertension (PH), labeled as pulmonary arterial hypertension (PAH), though it mainly involves pulmonary veins, venules…
View details →Cai, Qu, Feng et al. · 2026 · Journal of thoracic disease
Lung squamous cell carcinoma (LUSC) is associated with poor prognosis and low 5-year survival rates, and effective targeted therapies remain unavailable in clinical practice. To investigate the expression levels and clinical significance…
View details →Mann, Sharma, Jhamb et al. · 2026 · Journal of conservative dentistry and endodontics
Esthetics are in high demand in modern dentistry; conservative dentistry offers tooth-colored restorative materials; however, drawbacks such as polymerization shrinkage can lead to microleakage. To minimize this problem, cavity liners are…
View details →Mahardika, Rakhmawati, Sulijaya et al. · 2026 · Frontiers in cellular and infection microbiology
To determine the differences in periodontal status-Probing Depth (PD), Clinical Attachment Loss (CAL), Bleeding on Probing (BOP); oral inflammatory biomarkers-Tumor Necrosis Factor Alpha (TNF-α), Interleukin 1 Beta (IL-1β),…
View details →Kato, Ngonzi, Byamukama et al. · 2026 · Cureus
The burden of pelvic organ prolapse (POP) is the highest among elderly women compared to their young and middle-aged counterparts. These women are also faced with various medical comorbidities. Surgery in these women presents a…
View details →Gupta, Madan, Dutta et al. · 2026 · Journal of clinical and experimental hepatology
Human epidermal growth factor receptor 2 (HER2) overexpression is a critical therapeutic target in gallbladder cancer (GBC), but detection requires invasive sampling. We developed a fully automated computed tomography (CT)-based framework…
View details →Reason, Rizvi, Chawla et al. · 2026 · Canada communicable disease report = Releve des maladies transmissibles au Canada
Language concordant care can influence patient outcomes. The level of language concordant care and its impact on adherence to infection prevention protocols has not been well described. To assess whether patients' preferred language…
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