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Browse the failure-mode index

20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Deuterium-depletion has no significant impact on the mutation rate of Escherichia coli, deuterium abundance therefore has a probabilistic, not deterministic effect on spontaneous mutagenesis

Walliyulahi Ajibola, Ildikó Karcagi, Gábor Somlyai et al. · 2021 · PLOS ONE

Deuterium (D), the second most abundant isotope of hydrogen is present in natural waters at an approximate concentration of 145–155 ppm (ca. 1.5E-4 atom/atom). D is known to influence various biological processes due to its physical and…

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Negative / Null Result Report

Host Bloodmeal Source Has No Significant Effect on the Fecundity and Subsequent Larval Development Traits of the Progeny in Culicoides furens Poey (Diptera: Ceratopogonidae)

Dinesh Erram, Theodore Vincent Black, Nathan Burkett-Cadena · 2021 · Journal of Medical Entomology

Abstract Culicoides Latreille species (Diptera: Ceratopogonidae) are insects of significant medical and veterinary importance worldwide because their bites can cause major annoyance, allergic reactions, and/or pathogen transmission to…

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Negative / Null Result Report

Thalassemia and assisted reproduction: non-transfusion-dependent thalassemia shows no significant effect on live birth rates after embryo transfer

Li Fan, Liuyan Wei, Ni Tang et al. · 2025 · Frontiers in Cell and Developmental Biology

Background Thalassemia is a hereditary blood disorder that can impact fertility due to various factors such as iron overload and endocrine disruption. While the effects of iron overload on fertility outcomes in transfusion-dependent…

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Negative / Null Result Report

Man vs. machine: can AI outperform ESL student translations?

Anas Alkhofi · 2025 · Frontiers in Artificial Intelligence

This study compares the quality of English-to-Arabic translations produced by Google Translate (GT) with those generated by student translators. Despite advancements in neural machine translation technology, educators often remain…

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Negative / Null Result Report

Implementation of significant mental health service change: perceptions and concerns of a mental health workforce in the context of transformation

Margaret Glogowska, Melissa Stepney, Stephen Rocks et al. · 2022 · Journal of Health Organization and Management

Purpose As part of an evaluation of the nationally mandated Child and Adolescent Mental Health Services (CAMHS) “transformation” in one foundation NHS trust, the authors explored the experiences of mental health staff involved in the…

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Negative / Null Result Report

Virtual Reality-Assisted, Single-Session Exposure for Public Speaking Anxiety: Improved Self-Reports and Heart Rate but No Significant Change in Heart Rate Variability

Tonia-Flery Artemi, Thekla Konstantinou, Stephany Naziri et al. · 2025 · Virtual Worlds

Introduction: This study examines the combined use of objective physiological measures (heart rate [HR], heart rate variability [HRV]) and subjective self-reports to gain a comprehensive understanding of anxiety reduction…

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Negative / Null Result Report

Climate change - mediated atmospheric 210Po and 210Pb distribution: How significant can it be for the inhalation dose to humans?

Saif Uddin, Aysun U. Gorgun, Scott W. Fowler et al. · 2023 · Journal of Environmental Exposure Assessment

The concentration of 210Po and 210Pb in vegetation, and their transfer from soil to vegetation and via aerosol deposited on foliage are well established. The available data show significantly higher levels of these radionuclides in ash…

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Negative / Null Result Report

Did the accuracy of oral amoxicillin dosing of children improve after British National Formulary dose revisions in 2014? National cross-sectional survey in England

Olivia Rann, Mike Sharland, Paul Long et al. · 2017 · BMJ Open

Objectives Inaccurate antibiotic dosing can lead to treatment failure, fuel antimicrobial resistance and increase side effects. The British National Formulary for Children (BNFC) guidance recommends oral antibiotic dosing according to age…

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Negative / Null Result Report

Evaluating a peer-led wellbeing programme for doctors-in-training during the COVID-19 pandemic in Victoria, Australia, using the Most Significant Change technique

Karen Crinall, Madeleine Ward, Rebecca McDonald et al. · 2022 · Evaluation Journal of Australasia

This article discusses the use of the Most Significant Change (MSC) technique in a mixed-methods evaluation of a pilot wellbeing programme for obstetrics and gynaecology doctors-in-training introduced at a large public hospital during…

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Negative / Null Result Report

Do Fractals Confirm the General Theory of Relativity?

Irina Rozgacheva · 2019 · Symmetry

The relatively high abundance of fractal properties of complex systems on Earth and in space is considered an argument in support of the general relativity of the geometric theory of gravity. The fractality may be called the fractal…

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Negative / Null Result Report

Investigation of association between clinically significant prostate cancer, obesity and platelet to-lymphocyte ratio and neutrophil -to-lymphocyte ratio

Johanna Dahan, Jehonathan Pinthus, Guila Delouya et al. · 2024 · BMC Urology

Abstract Introduction Several blood markers of inflammation are elevated in prostate cancer (PCa) and have prognostic value. Little is known about the relationship between these markers, PCa, and other factors associated with chronic…

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Negative / Null Result Report

The Identification of Significant Single Nucleotide Polymorphisms for Shoot Sulfur Accumulation and Sulfur Concentration Using a Genome-Wide Association Analysis in Wild Soybean Seedlings

Hui Wang, Yu’e Zhang, Yudan Chen et al. · 2024 · Agronomy

To understand the genetic basis of soybean sulfur utilization, a genome-wide association study (GWAS) and transcriptome analysis were used to discover new sulfur utilization genes in 121 wild soybeans. The shoot sulfur accumulation (SA)…

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Negative / Null Result Report

Deriving significant factors for managing change in UN

James Wan, Raafat Saade, Ling Wang · 2019 · Journal of Organizational Change Management

Purpose A consequence of the UN general assembly resolution calling for increased efficiency and better utilization of resources in all its agencies, is a mandate for change. As a response to this resolution, the purpose of this paper is…

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Negative / Null Result Report

Significant association of hyperandrogenism and insulin resistance with the epigenetic alterations in PPARG1 gene in granulosa cells of PCOS females

Zahra Dashti, Vahid Razban, Jafar Fallahi et al. · 2025 · Egyptian Journal of Medical Human Genetics

Abstract Background Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine and metabolic disorders, affecting approximately 15% of females. This syndrome is characterized by its remarkable heterogeneity, and epigenetic…

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Negative / Null Result Report

Addition of an online, validated family history questionnaire to the Dutch FIT-based screening programme did not improve its diagnostic yield

Victorine H. Roos, Frank G. J. Kallenberg, Manon van der Vlugt et al. · 2020 · British Journal of Cancer

Abstract Background Faecal immunochemical testing (FIT) is suboptimal in detecting advanced neoplasia (AN). To increase the sensitivity and yield of a FIT-based screening programme, FIT could be combined with risk factors for AN. We…

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Negative / Null Result Report

Where Did the Y Chromosome in the Spiny Rat Go, and How Did It Get There?

Miki Okuno, Kentaro Matsuoka, Yuta Mochimaru et al. · 2025 · Molecular Biology and Evolution

Abstract The XX/XY sex chromosome system is highly conserved across mammals, with rare exceptions where males lack a Y chromosome. Among these is the genus Tokudaia, a group of spiny rats comprising three species with unique sex chromosome…

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