Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Katsiaryna Salavei Bardos, Dev R. Mishra, Hyacinthe Somé · 2025 · Journal of Corporate Finance
In a sample of U.S. firms, we find strong evidence that firms' implied cost of equity is decreasing in a novel proxy of firm-level climate change sentiments of earnings call participants, supporting prior literature that shows investors demand higher returns from their investments in brown firms and lower returns from that in green firms. This effect, however, is particularly pronounced for the firm-years headquartered in the states experiencing higher than median per-capita energy related CO2 emissions, those headquartered in climate related disaster intensive counties and those headquartered
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lidia Bakota, Kerli Tulva, Nataliya I. Trushina et al. · 2026 · Translational Psychiatry
The neuronal microtubule-associated protein tau is involved in several neurodegenerative diseases, collectively referred to as tauopathies. In these diseases, it aggregates and plays a central role in triggering cell death. Tau was…
View details →Negative / Null Result ReportOpen accessMedicine
Gerti Dajti, Maria Chiara Vaccaro, Giuliana Germinario et al. · 2025 · Clinical Transplantation
BACKGROUND: The role of machine perfusion after kidney transplantation (KT) in extended criteria donors (ECD) is unclear, and the current evidence in the literature remains controversial. METHODS: We present an open-label single center…
View details →Negative / Null Result ReportOpen accessMedicine
Shangkai Gao, Léa Décarie-Spain, Cindy Gu et al. · 2026 · Comprehensive physiology
Glucagon-like peptide-1 (GLP-1) is a nutrient-responsive hormone classically associated with glucose homeostasis and food intake control, yet its receptor is broadly expressed throughout the central nervous system (CNS) in circuits governing complex cognitive processes. Here, we synthesize emerging evidence from preclinical models and human studies demonstrating that GLP-1 receptor (GLP-1R) signaling modulates multiple cognitive domains, including reward and motivational processes relevant to obesity and substance use disorder, affective-related behaviors, and learning and memory. We propose a
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Kamel Mouloudj, Tiziana Amoriello, Eeman Almokdad et al. · 2026 · Sustainability
Product waste in grocery supply chains remains a major concern for multiple stakeholders, particularly retailers, due to the direct financial losses it generates and the potential risks it poses to customer health and safety. In this context, digital technologies—especially artificial intelligence (AI)—offer promising opportunities to improve retail performance and reduce waste. Accordingly, this study aims to investigate the factors influencing retailers’ intentions to adopt AI-based solutions for product waste reduction. To achieve this objective, the Technology Acceptance Model (TAM) was ex
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ruairidh Macleod, Frederik Valeur Seersholm, Bianca De Sanctis et al. · 2026 · Nature
Abstract Plague is among the most devastating diseases in human history 1 . However, early strains of the plague-causing bacterium Yersinia pestis lacked virulence factors that are required for the bubonic form until around 3,800 years ago 2,3 . Consequently, the morbidity and mortality of early plague strains remain unclear. Here we describe early plague strains that are associated with two phases of outbreaks among mid-Holocene hunter-gatherers near Lake Baikal in southeast Siberia, beginning from about 5,500 years ago. These outbreaks occur across four hunter-gatherer cemeteries, with a 39%
View details →Negative / Null Result ReportOpen accessPsychology
Kimmo Sorjonen, Gustav Nilsonne, Ata Ghaderi et al. · 2026 · PLoS ONE
The random-intercept cross-lagged panel model (RI-CLPM) is an extension of the traditional cross-lagged panel model. The RI-CPLM specifically addresses prospective effects within individuals. In the present simulations, we found that the RI-CLPM is susceptible to spurious findings when observed scores on the two variables are affected by common auto-correlated state factors. In reanalyses of empirical data, we found contradictory decreasing, increasing, and null prospective effects between within-individual levels of self-esteem and problematic eating behaviors among Dutch teenagers (N = 1856)
View details →Negative / Null Result ReportOpen accessMedicine
Yüksel Erkin, Erkan Özduran, İlhan Celil Özbek et al. · 2026 · PLoS ONE
Patients seeking information about Myofascial Pain Syndrome (MPS), which affects a large segment of the population, are increasingly turning to AI-based chatbots as an alternative to traditional methods. However, the medical accuracy of the content offered by these digital platforms, as well as its suitability to the "grade 6 reading level" standard, which determines its comprehensibility by patients, is a critical point of uncertainty. This study aims to fill this significant gap in the literature by systematically comparing MPS content generated by different AI models using readability indic
View details →Negative / Null Result ReportOpen accessMedicine
Michael J. Corley, Varun B. Dwaraka, Alina P.S. Pang et al. · 2026 · Nature Communications
Glucagon-like peptide-1 (GLP-1) receptor agonists have attracted interest as gerotherapeutics, yet clinical-trial evidence for their effects on biological aging is lacking. We report a post hoc exploratory epigenetic age analysis of a 32-week, randomized, double-blind, placebo-controlled phase 2b trial (NCT04019197) of semaglutide in adults with human immunodeficiency virus (HIV)-associated lipohypertrophy (semaglutide n = 45; placebo n = 39). The parent trial's primary endpoint was change in visceral adipose tissue, with secondary cardiometabolic and body-composition endpoints; epigenetic agi
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Eva S. M. van der Heijden, Karin Näsvall, Fernando Seixas et al. · 2025 · Proceedings of the National Academy of Sciences
A central question in evolutionary biology is what drives the diversification of lineages. Rapid, recent radiations are ideal systems for this question because they still show key morphological and ecological adaptations associated with speciation. While most research on recent radiations focuses on those occurring in insular environments, less attention has been given to continental radiations with complex species interactions. Here, we study the drivers of continental radiations of Melinaea and Mechanitis butterflies (Nymphalidae: Ithomiini), which have rapidly radiated in the continental Ne
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Da Cui · 2025 · Frontiers in Sustainable Food Systems
Under the dual challenges of intensifying global food security crises and pressing demands for sustainable agricultural development, investigating the mechanisms through which large-scale agricultural operations affect the grain production resilience carries significant strategic importance. Using a quasi-natural experiment based on land transfer policy, this study assesses these mechanisms. The findings indicate that large-scale agricultural operations significantly enhances grain production resilience. This positive effect is mediated by increased income levels among rural residents and grea
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Zhuoming Zhang, Tengpeng Xu, Yun Chen · 2026 · The Astrophysical Journal
Abstract We present a Bayesian comparative analysis of five cosmological models: ΛCDM, w CDM, w 0 w a CDM, ϕ CDM (with scalar-field dark energy), and an interacting dark energy scenario (the ξ -index model), to investigate dark energy evolution and the Hubble tension. Utilizing the latest data from the second data release of the Dark Energy Spectroscopic Instrument (Baryon Acoustic Oscillations, BAO), Pantheon+ (type Ia supernovae, SNIa), and cosmic microwave background (CMB) data (including lensing) from Planck and the Atacama Cosmology Telescope, we report three key findings. First, the Hubb
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Joss Bland‐Hawthorn, Thor Tepper-García, Oscar Agertz et al. · 2025 · The Astrophysical Journal
Abstract In response to recent observations from JWST and Atacama Large Millimeter Array, we explore a new class of dynamically self-consistent models that mimics a plausible progenitor of the Milky Way over a wide range of disk gas fractions, f gas . The high gas surface densities encourage vigorous star formation, which in turn couples with the gas to drive turbulence. We show that this coupling through momentum recoil drives a random walk of the baryonic potential minimum with respect to total gravitational potential, Φ tot ( R , ϕ , z ). The amplitude of the bulk motion depends on the feed
View details →Negative / Null Result ReportOpen accessMedicine
Hyunmin Yu, Jacqueline Margo Brooks Carthon, Linda H. Aiken et al. · 2026 · Research in Nursing & Health
The Pathway to Excellence (Pathway) program administered by the American Nurses Credentialing Center, recognizes organizations that foster positive nursing practice environments. However, evidence linking Pathway designation to nurse-reported outcomes remains limited. This cross-sectional study integrated data from the Penn 2024 Nurses4All Study and the American Hospital Association Annual Survey. The sample included 16,979 direct care nurses from 1672 hospitals in 10 US states (866 nurses in 63 Pathway hospitals and 16,113 nurses in 1609 non-Pathway, non-Magnet hospitals). The independent var
View details →Negative / Null Result ReportOpen accessMedicine
Vanda Haralović, Mislav Mokos, Sanja Špoljar et al. · 2025 · Biomedicines
Background: Hypochlorous acid (HOCl) is an integral component of the human innate immune system. It possesses antimicrobial properties and is available in solution, dermal spray, and scar gel forms. Objectives/Methods: This review presents data from studies on the clinical use of HOCl in various specialties, including dermatology, surgery, dentistry, ophthalmology, and rhinology. Results: Due to its anti-inflammatory/antimicrobial/immunomodulatory and healing properties, HOCl is advantageous in treating various skin disorders: ulcus cruris (and wound care), diabetic ulcers, atopic dermatitis,
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Lambodhar Damodaran, Anna S. Jaeger, Louise H. Moncla · 2025 · Nature
Abstract Since late 2021, a panzootic of highly pathogenic H5N1 has devastated wild birds, agriculture and mammals. Here an analysis of 1,818 haemagglutinin sequences from wild birds, domestic birds and mammals reveals that the North American panzootic was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild, migratory birds. Transmission was primarily driven by Anseriformes, while non-canonical species acted as dead-end hosts. In contrast to the epizootic of 2015 (refs. 1,2 ), outbreaks in domestic birds were driven by around
View details →Negative / Null Result ReportOpen accessComputer Science
Prabha M. Kumarage, Mirka Saarela · 2026 · AI
Generative Artificial Intelligence (GenAI) models produce increasingly sophisticated outputs, yet their underlying mechanisms remain opaque. To clarify how explainability is conceptualized and implemented in GenAI research, this two-stage review systematically examined 261 articles retrieved from six major databases. After removing duplicates and applying predefined inclusion criteria, 63 articles were retained for full analysis. In the first stage, an umbrella review synthesized insights from 18 review papers to identify prevailing frameworks, strategies, and conceptual challenges surrounding
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Chi-Horng Liao · 2025 · Frontiers in Psychology
This study examines how media factors influence pro-environmental behavior (PEB) through an integration of Media System Dependency Theory (MSDT) and Norm Activation Theory (NAT). Using both Fuzzy Decision-Making Trial and Evaluation Laboratory (F-DEMATEL) and Structural Equation Modeling (SEM), it evaluates the effects of media factors on NAT components-awareness of consequences and ascription of responsibility-and their role in activating personal norms that drive PEB. The study also considers the moderating impact of self-efficacy on the link between personal norms and PEB. Findings from F-D
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Eliza Neights, Eric Burns, Chris L. Fryer et al. · 2025 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Gamma-ray bursts are the most luminous electromagnetic events in the Universe. Their prompt gamma-ray emission has typical durations between a fraction of a second and several minutes. A rare subset of these events have durations in excess of a thousand seconds, referred to as ultra-long gamma-ray bursts. Here, we report the discovery of the longest gamma-ray burst ever seen with a $\sim$25 000 s gamma-ray duration, GRB 250702B, and characterize this event using data from four instruments in the InterPlanetary Network and the Monitor of All-sky X-ray Image. We find a hard spectrum, su
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roxana-Maria Amărandi, Luminița Marin, Brînduşa Drăgoi et al. · 2024 · Molecular Pharmaceutics
High Resolution Image Download MS PowerPoint Slide Liposomes, small bilayer phospholipid-containing vesicles, are frequently used to ensure slow drug release for a prolonged and improved therapeutic effect. Nevertheless, current findings…
View details →Negative / Null Result ReportOpen accessMedicine
Carmella Evans‐Molina, Yasminye D. Pettway, Diane C. Saunders et al. · 2026 · Nature Communications
Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers…
View details →Negative / Null Result ReportOpen accessMedicine
Emmanouil Karampinis, Christina-Marina Zoumpourli, Aimilios Lallas et al. · 2026 · Medicina
Background and Objectives: Artificial intelligence (AI) has transitioned to an integral part of dermatology in only few years, yet perceptions of its use vary widely, reflecting diverse hopes, concerns, and perceived clinical utility. Materials and Methods: In this study, 300 dermatologists from 13 countries, representing a range of experience levels and AI usage statuses, were surveyed regarding the characteristics and applications of AI in dermatology. Results: Among respondents, 61.33% reported having used AI tools in clinical practice. Adoption of AI was observed across all age groups, cou
View details →Negative / Null Result ReportOpen accessMedicine
Xiaofeng Dai, Chongxiang Wang, Ping Jiang et al. · 2026 · MedComm
Chronic pain is a globally prevalent and complex condition, encompassing three primary subtypes, that is, nociceptive, neuropathic, and nociplastic, each with distinct biopsychosocial mechanisms. Chronic pain was historically viewed as a monolithic symptom and managed with opioid-centric models, causing widespread therapeutic failure. While recognition of its heterogeneity has driven a paradigm shift toward precision medicine, tailoring multimodal strategies to the dominant pain mechanism, critical challenges persist. These include difficulty in identifying treatable root causes, limited long-
View details →Negative / Null Result ReportOpen accessPsychology
Kağan Kırcaburun, Pınar Özdemir · 2026 · Behavioral Sciences
The rapid integration of generative artificial intelligence (GAI) tools into academic and professional contexts has raised concerns regarding unethical use and the potential development of problematic usage patterns. Drawing on personality and moral psychology frameworks, the present study examined the associations between antagonistic personality traits (narcissism, Machiavellianism, and psychopathy) and problematic (i.e., addictive) GAI use (PGAIU), as well as the chain mediating effect of moral disengagement and unethical GAI use (UGAIU). Data were collected from an adult sample (N = 491; 5
View details →Negative / Null Result ReportOpen accessMedicine
Wenjing Chen, Heng Tian, Ran Wei et al. · 2026 · International Journal of Molecular Medicine
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, are characterized by progressive loss of neurons. Although the precise pathogenesis of such diseases is complex and…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Mehdi Solhi, Majid Elahi Shirvan, Tahereh Taherian · 2026 · Asian-Pacific Journal of Second and Foreign Language Education
Abstract The dynamic and reciprocal nature of boredom and motivation in L2 classrooms remains underexplored and little is known about how L2 teachers’ perceived boredom (PTB), foreign language learning boredom (FLB), and L2 writing motivation (WM) evolve within and across individuals over time, particularly from a dynamic systems perspective. A total of 264 English as a foreign language (EFL) learners and 21 teachers participated, and data were collected using a 10-day experience sampling approach. We specifically examined three feedback loops—PTB-FLB, FLB-WM, and PTB-WM. Dynamic structural eq
View details →Negative / Null Result ReportOpen accessMedicine
Daniel R. Richardson, Ying Wang, Marie Anne Flannery et al. · 2026 · JAMA Oncology
Importance: Health care systems should strive to achieve outcomes that matter to patients. Limited data exist on the outcomes achieved by patients with cancer with different treatment outcome preferences. Objective: To describe treatment…
View details →Negative / Null Result ReportOpen accessChemistry
Weida Wang, Chunqi Wang, Baocheng Zhao et al. · 2026 · Foods
Soybean protein content is a key indicator of nutritional value and quality grade, and its determination is important for quality evaluation and cultivar selection. To overcome the time-consuming and costly limitations of conventional chemical assays, this study proposed a multiple linear learner ensemble importance-score wavelength selection (MLLEISWS) method to identify informative wavelengths from soybean near-infrared spectra and establish a partial least squares (PLS) model. MLLEISWS was compared with competitive adaptive reweighted sampling, successive projections algorithm, and uninform
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Lucie E. Rowland, Mauro Stefanon, R. J. Bouwens et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Metallicity is a crucial tracer of galaxy evolution, providing insights into gas accretion, star formation, and feedback. At high redshift, these processes reveal how early galaxies assembled and enriched their interstellar medium. In this work, we present rest-frame optical spectroscopy of 12 massive ($\log (M_*/\mathrm{{\rm M}_{\odot }})>9$) galaxies at $z\sim 6$–8 from the Reionization Era Bright Emission Line Survey (REBELS) Atacama Large Millimetre/submillimetre Array (ALMA) large program, observed with the James Webb Space Telescope (JWST) NIRSpec integral field unit spec
View details →Negative / Null Result ReportOpen accessMedicine
Guiomar Mendieta, Paul M. Ridker, Barry A. Borlaug et al. · 2026 · European Journal of Heart Failure
AIMS: We hypothesized that targeting interleukin-6-a cytokine central to NOD-like receptor protein 3 (NLRP3) inflammasome activation that is associated with both the onset and progression of heart failure (HF)-may be beneficial in patients with HF and circulating evidence of cardiovascular inflammation but without overtly reduced ejection fraction (EF). We describe the rationale and design of two clinical trials (ATHENA and HERMES) investigating ziltivekimab, a human monoclonal antibody directed against the interleukin-6 ligand, in patients with HF and mildly reduced or preserved EF (HFmrEF/HF
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