Negative / Null Result ReportOpen accessSocial Sciences
Jo Pearson, Itiel E. Dror, Emma Jayes et al. · 2026 · Scientific Reports
The use of Artificial Intelligence (AI) to effectively support human decision making depends on whether humans are willing to trust in, and thus rely on, AI. Understanding human reliance on AI is critical given controversial reports of AI inaccuracy and bias. Furthermore, the erroneous belief that using technology removes biases may lead to overreliance on AI. To examine humans’ reliance on AI, human participants (N = 295, Mage = 33.79) judged the authenticity of 80 faces (40 real, 40 AI-synthesized) presented alongside guidance supposedly from humans or from AI. This guidance was correct only
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Joss Bland‐Hawthorn, Thor Tepper-García, Oscar Agertz et al. · 2025 · The Astrophysical Journal
Abstract In response to recent observations from JWST and Atacama Large Millimeter Array, we explore a new class of dynamically self-consistent models that mimics a plausible progenitor of the Milky Way over a wide range of disk gas fractions, f gas . The high gas surface densities encourage vigorous star formation, which in turn couples with the gas to drive turbulence. We show that this coupling through momentum recoil drives a random walk of the baryonic potential minimum with respect to total gravitational potential, Φ tot ( R , ϕ , z ). The amplitude of the bulk motion depends on the feed
View details →Negative / Null Result ReportOpen accessMedicine
Hyunmin Yu, Jacqueline Margo Brooks Carthon, Linda H. Aiken et al. · 2026 · Research in Nursing & Health
The Pathway to Excellence (Pathway) program administered by the American Nurses Credentialing Center, recognizes organizations that foster positive nursing practice environments. However, evidence linking Pathway designation to nurse-reported outcomes remains limited. This cross-sectional study integrated data from the Penn 2024 Nurses4All Study and the American Hospital Association Annual Survey. The sample included 16,979 direct care nurses from 1672 hospitals in 10 US states (866 nurses in 63 Pathway hospitals and 16,113 nurses in 1609 non-Pathway, non-Magnet hospitals). The independent var
View details →Negative / Null Result ReportOpen accessMedicine
Vanda Haralović, Mislav Mokos, Sanja Špoljar et al. · 2025 · Biomedicines
Background: Hypochlorous acid (HOCl) is an integral component of the human innate immune system. It possesses antimicrobial properties and is available in solution, dermal spray, and scar gel forms. Objectives/Methods: This review presents data from studies on the clinical use of HOCl in various specialties, including dermatology, surgery, dentistry, ophthalmology, and rhinology. Results: Due to its anti-inflammatory/antimicrobial/immunomodulatory and healing properties, HOCl is advantageous in treating various skin disorders: ulcus cruris (and wound care), diabetic ulcers, atopic dermatitis,
View details →Negative / Null Result ReportOpen accessSocial Sciences
Matt Lowe, Madeline McKelway · 2026 · Journal of the European Economic Association
Abstract Joint household decision-making becomes more common as economies develop. Can external intervention advance this transition? We study this question in the context of female employment in India. We randomized which spouse was given…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Guangxiang Liu, Md Kamal Hossain · 2026 · Journal of Computer Assisted Learning
ABSTRACT Background Amid Bangladesh's national efforts to enhance digital inclusion, rural university students continue to face persistent infrastructural and educational inequalities that limit their access to quality English learning…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Niti Sureka, Rashi Maheshwari, Amit H Agravat et al. · 2026 · Frontiers in Oncology
Hypoxia, a defining hallmark of solid tumors, arises from structurally and functionally abnormal vasculature, rapid cellular proliferation, and impaired perfusion, resulting in chronic and cycling oxygen deprivation within the tumor massThe hypoxic tumor microenvironment orchestrates extensive molecular reprogramming primarily through stabilization and activation of hypoxia-inducible factors (HIF-1α and HIF-2α), which regulate broad transcriptional networks governing metabolism, angiogenesis, stemness, invasion, and immune modulation. Under low oxygen tension, tumor cells shift toward aerobic
View details →Negative / Null Result ReportOpen accessComputer Science
Prabha M. Kumarage, Mirka Saarela · 2026 · AI
Generative Artificial Intelligence (GenAI) models produce increasingly sophisticated outputs, yet their underlying mechanisms remain opaque. To clarify how explainability is conceptualized and implemented in GenAI research, this two-stage review systematically examined 261 articles retrieved from six major databases. After removing duplicates and applying predefined inclusion criteria, 63 articles were retained for full analysis. In the first stage, an umbrella review synthesized insights from 18 review papers to identify prevailing frameworks, strategies, and conceptual challenges surrounding
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh et al. · 2026 · Nature
Abstract Identifying transcriptional enhancers and their target genes is essential for understanding gene regulation and the effect of human genetic variation on disease 1–6 . Here we create and evaluate a resource of more than 92 million enhancer–gene regulatory interactions across 1,458 biosamples covering 369 cell types and tissues, by integrating predictive models, chromatin states, three-dimensional contacts and large-scale genetic perturbations generated by the ENCODE Consortium 7 . We first create a systematic benchmarking pipeline to compare predictive models, assembling a dataset of 1
View details →Negative / Null Result ReportOpen accessMedicine
Xiaofeng Dai, Chongxiang Wang, Ping Jiang et al. · 2026 · MedComm
Chronic pain is a globally prevalent and complex condition, encompassing three primary subtypes, that is, nociceptive, neuropathic, and nociplastic, each with distinct biopsychosocial mechanisms. Chronic pain was historically viewed as a monolithic symptom and managed with opioid-centric models, causing widespread therapeutic failure. While recognition of its heterogeneity has driven a paradigm shift toward precision medicine, tailoring multimodal strategies to the dominant pain mechanism, critical challenges persist. These include difficulty in identifying treatable root causes, limited long-
View details →Negative / Null Result ReportOpen accessPsychology
Kağan Kırcaburun, Pınar Özdemir · 2026 · Behavioral Sciences
The rapid integration of generative artificial intelligence (GAI) tools into academic and professional contexts has raised concerns regarding unethical use and the potential development of problematic usage patterns. Drawing on personality and moral psychology frameworks, the present study examined the associations between antagonistic personality traits (narcissism, Machiavellianism, and psychopathy) and problematic (i.e., addictive) GAI use (PGAIU), as well as the chain mediating effect of moral disengagement and unethical GAI use (UGAIU). Data were collected from an adult sample (N = 491; 5
View details →Negative / Null Result ReportOpen accessMedicine
Wenjing Chen, Heng Tian, Ran Wei et al. · 2026 · International Journal of Molecular Medicine
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, are characterized by progressive loss of neurons. Although the precise pathogenesis of such diseases is complex and…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Mehdi Solhi, Majid Elahi Shirvan, Tahereh Taherian · 2026 · Asian-Pacific Journal of Second and Foreign Language Education
Abstract The dynamic and reciprocal nature of boredom and motivation in L2 classrooms remains underexplored and little is known about how L2 teachers’ perceived boredom (PTB), foreign language learning boredom (FLB), and L2 writing motivation (WM) evolve within and across individuals over time, particularly from a dynamic systems perspective. A total of 264 English as a foreign language (EFL) learners and 21 teachers participated, and data were collected using a 10-day experience sampling approach. We specifically examined three feedback loops—PTB-FLB, FLB-WM, and PTB-WM. Dynamic structural eq
View details →Negative / Null Result ReportOpen accessPsychology
E. G. J. M. Arts, Bram Orobio de Castro, Ellen Luteijn et al. · 2024 · Social Development
Abstract This study investigated whether interactive virtual reality (VR) training of social and emotional abilities (InterAction) improves socio‐emotional functioning of youth with developmental language disorders (DLD). To this end we conducted a multiple baseline intervention study, comparing participants’ social abilities during a baseline phase with their changes in abilities during the intervention and posttest phase. The training group consisted of 29 adolescents ( 20 boys, 9 girls ) with DLD from the Netherlands. The training consisted of nine, weekly (45–50 min) individual sessions wi
View details →Negative / Null Result ReportOpen accessMedicine
Daniel R. Richardson, Ying Wang, Marie Anne Flannery et al. · 2026 · JAMA Oncology
Importance: Health care systems should strive to achieve outcomes that matter to patients. Limited data exist on the outcomes achieved by patients with cancer with different treatment outcome preferences. Objective: To describe treatment…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michael Korenjak, Nuri A. Temiz, Stéphane Keïta et al. · 2026 · Genome Medicine
BACKGROUND: Tobacco use is linked to multiple cancer types and a quarter of cancer deaths. Tobacco smoke contains numerous mutagenic chemicals such as polycyclic aromatic hydrocarbons (PAH), however, the mutagenicity of many chemicals in…
View details →Negative / Null Result ReportOpen accessChemistry
Weida Wang, Chunqi Wang, Baocheng Zhao et al. · 2026 · Foods
Soybean protein content is a key indicator of nutritional value and quality grade, and its determination is important for quality evaluation and cultivar selection. To overcome the time-consuming and costly limitations of conventional chemical assays, this study proposed a multiple linear learner ensemble importance-score wavelength selection (MLLEISWS) method to identify informative wavelengths from soybean near-infrared spectra and establish a partial least squares (PLS) model. MLLEISWS was compared with competitive adaptive reweighted sampling, successive projections algorithm, and uninform
View details →Negative / Null Result ReportOpen accessMedicine
Brenda M O'Neill, Judy Martina Bradley, Bronwen A. Connolly et al. · 2026 · JAMA
Importance: Evidence for remote multicomponent rehabilitation among critical care survivors is sparse. Objective: To investigate the effects of a 6-week, remote, multicomponent rehabilitation intervention in survivors of critical illness following discharge from the hospital after an intensive care unit (ICU) admission compared with standard care on health-related quality of life at 8 weeks. Design, Setting, and Participants: Pragmatic, multicenter, assessor-blinded, randomized clinical trial conducted from December 2022 to November 2025 at 52 National Health Service hospitals in the UK. Parti
View details →Negative / Null Result ReportOpen accessEngineering
E. Maartensson, N. Welch, M. Scarpari et al. · 2026 · Nuclear Fusion
Abstract ST-E1 is Tokamak Energy’s commercially competitive fusion power plant design featuring a lifetime high-temperature superconducting (HTS) magnet cage, which has completed its pre-concept design stage. A central challenge at the pre-concept stage is the need to iteratively and consistently integrate the development of the magnet cage, core plasma physics, and power-exhaust systems, while avoiding serial design loops and late discovery of infeasible operating scenarios. Accurate representation of inductive current drive is particularly critical, as it tightly couples magnetic equilibria,
View details →Negative / Null Result ReportOpen accessMedicine
Guiomar Mendieta, Paul M. Ridker, Barry A. Borlaug et al. · 2026 · European Journal of Heart Failure
AIMS: We hypothesized that targeting interleukin-6-a cytokine central to NOD-like receptor protein 3 (NLRP3) inflammasome activation that is associated with both the onset and progression of heart failure (HF)-may be beneficial in patients with HF and circulating evidence of cardiovascular inflammation but without overtly reduced ejection fraction (EF). We describe the rationale and design of two clinical trials (ATHENA and HERMES) investigating ziltivekimab, a human monoclonal antibody directed against the interleukin-6 ligand, in patients with HF and mildly reduced or preserved EF (HFmrEF/HF
View details →Negative / Null Result ReportOpen accessMedicine
Lama Alfehaid, Nada Alsuhebany, Yahya M K Tawfik et al. · 2026 · Frontiers in Cardiovascular Medicine
Venous thromboembolism (VTE) is a leading cause of preventable hospital-acquired morbidity and mortality. Despite the availability of effective prophylaxis, its application in clinical practice remains inconsistent, often due to uncertainty in risk stratification. This review evaluates the validity and implementation of VTE risk assessment models (RAMs) in medical inpatients. Seven widely used RAMs, Caprini, Padua, IMPROVE, IMPROVEDD, Wells, Geneva, and Kucher e-alert, are critically examined alongside emerging digital and biomarker-enhanced tools. The Padua and IMPROVE scores show consistent
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Wolfgang Wüster · 2025 · Vertebrate Zoology
The advent of molecular methods has revolutionised the field of species delimitation and description, one of the key tasks of systematic biology. In animal taxonomy, one marker, the mitochondrial DNA (mtDNA) molecule, has acquired and retained disproportionate influence. This is despite its uniparental, clonal mode of inheritance, as a result of which the entire molecule acts as a single locus, and that precludes its use as a test for admixture between putative lineages, a key consideration in species delimitation. To establish the extent to which the limitations of mtDNA affect present-day ta
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Yashvee Dunneram, Jia Yi Lee, Cody Z. Watling et al. · 2026 · British Journal of Cancer
BACKGROUND: Vegetarian diets might influence cancer risk. METHODS: We studied 1,645,555 meat eaters, 57,016 poultry eaters, 42,910 pescatarians, 63,147 vegetarians and 8849 vegans in 9 cohorts (UK, US, Taiwan, India). After a median 16 years follow-up, incident cancers were: 4504 mouth and pharynx, 1308 oesophagus (squamous cell), 2105 oesophagus (adenocarcinoma), 3578 stomach, 30,528 colorectum, 2970 liver, 8030 pancreas, 3077 lung (never smokers), 61,368 breast, 11,220 endometrium, 8076 ovary, 45,946 prostate, 7193 kidney, 6869 bladder, 11,651 non-Hodgkin lymphoma, 4658 multiple myeloma and
View details →Negative / Null Result ReportOpen accessMedicine
Fedir Hladkykh, Tetiana Liadova, Mariia Matvieienko et al. · 2026 · Journal of Pain Research
Introduction: Central sensitization explains the mismatch between structural damage or inflammation and pain intensity in chronic musculoskeletal diseases. It defines the phenotype of fibromyalgia and contributes to persistent pain in…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Erlei Zhi, Haowei Bai, Chuan Ren et al. · 2025 · Nature Communications
Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its role in sperm function has remained unclear. Through whole-exome sequencing (WES) of 800 patients with asthenozoospermia, we…
View details →Negative / Null Result ReportOpen accessMedicine
Stosh Ozog, Elizabeth M. Krantz, Karyn Tindbaek et al. · 2026 · Nature Communications
Abstract Humoral immune-related adverse events, including hypogammaglobulinemia and B cell depletion, pose long-term infection risks after chimeric antigen receptor T cell therapy (CARTx) for hematologic malignancies. This prospective…
View details →Negative / Null Result ReportOpen accessPsychology
Chantal A. Miller, Keshun Zhang, Ronald Hübner · 2025 · Humanities and Social Sciences Communications
Abstract Aesthetic preferences vary widely among individuals and across cultures. These culture-specific aesthetic preferences are reflected in the environment, artistic behaviour, and consumer choices. People have the ability to infer the aesthetic preferences of others within their own culture through their Theory of Aesthetic Preferences , which is a subcategory of the Theory of Mind. An important question is whether people can also infer aesthetic preferences across different cultures. This study aimed to investigate aesthetic preference and aesthetic inference, as well as the underlying m
View details →Negative / Null Result ReportOpen accessMedicine
Cristina Migliore, Elisabetta Fenocchio, Silvia Giordano et al. · 2025 · Cancer Treatment Reviews
Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide, and is associated with a very poor prognosis, largely due to its aggressive nature and, typically, late-stage diagnosis. Molecular classifications proposed one decade ago have provided valuable insights into the disease's heterogeneity and paved the way for clinical trials of tailored treatments. However, most of these trials have failed, often due to inadequate patient selection, lack of reliable biomarkers of response/resistance, or for the high level of inter- and intra-tumor heterogeneity characterizing t
View details →Negative / Null Result ReportOpen accessMedicine
Steffen Tiedt, Alejandro Bustamante, Alan Cameron et al. · 2026 · The Lancet Neurology
The complexity and incomplete understanding of the pathophysiology of stroke poses substantial challenges to personalised medicine and the development of novel therapies, as reflected in the neutral results of many randomised trials. Current clinical algorithms lack the precision to diagnose stroke before hospital admission, predict disease progression and recovery, or assess recurrence risk. Biomarkers are urgently needed, yet the absence of a robust evidence base hinders their clinical translation. To lay the groundwork for addressing this knowledge gap, an international multidisciplinary pa
View details →Negative / Null Result ReportOpen accessMedicine
Bogang Wu, Win Thant, Elena Bitman et al. · 2026 · Journal for ImmunoTherapy of Cancer
ABSTRACT Background Immune exclusion inhibits anti-tumor immunity and response to immunotherapy, but its mechanisms remain poorly defined. In triple-negative breast cancer (TNBC), an aggressive and generally immune-rich subtype, an…
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