19,815 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Joao Gabriel Ostrowski, József Menyhárt · 2020 · Acta Polytechnica Hungarica
Based particularly on data technologies, information is rapidly evolving in engineering. In mechanical engineering, maintenance is benefiting the most from data innovations, the reduction of maintenance costs, and the improvement of system…
View details →Magdalena Sabat, Bartosz Haładus, Michał Klincewicz et al. · 2022 · Scientific Reports
The perceived duration of an interval depends on numerous aspects of the passed event both endogenous, including physiological arousal, level of wakefulness, attention, and surprise, as well as exogenous such as valence, salience, or context in the environment. There is some evidence that "time-giving" cues from the environment (zeitgebers) are coupled with time perception. The movement of the sun on the horizon was demonstrated to affect interval perception in a study conducted by Schatzschneider et al. (2016) claiming that the sun's motion is a zeitgeber that influences time perception. In t
View details →Pooja Advani, Kathryn J. Ruddy, Joerg Herrmann et al. · 2023 · Frontiers in Oncology
Background The cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer agents are well known, but molecular genetic testing is lacking for the early identification of patients at risk for therapy-related cardiac toxicity. Methods Using the Agena Bioscience MassARRAY system, we genotyped TRPC6 rs77679196, BRINP1 rs62568637, LDB2 rs55756123, RAB22A rs707557, intergenic rs4305714, LINC01060 rs7698718, and CBR3 rs1056892 (V244M) (previously associated with either doxorubicin or trastuzumab-related cardiotoxicity in the NCCTG N9831 trial of anthracycline-based chemotherapy ± trastuzum
View details →Chunyuan Zhang, Xu Wu, Yanfang Xian et al. · 2019 · Evidence-Based Complementary and Alternative Medicine
Isorhynchophylline (IRN) and rhynchophylline (RN), a pair of stereoisomers, are tetracyclic oxindole alkaloids isolated from Uncaria rhynchophylla , a commonly used Chinese medicinal herb. These two compounds have drawn extensive attention…
View details →Kawthar Al-Salmi, Farook S Wali, Ahmed Sameer Nadeem et al. · 2019 · Journal of Neurology & Stroke
Background: nerve conduction study (NCS) is a neurophysiologic medical diagnostic test used commonly to evaluate the function of the peripheral nerves. It is an extension to the clinical examination and extremely useful to diagnose and…
View details →Yi-Lun Ge, Pu-Zhi Wang, Jia-Hui Yan et al. · 2022 · Advanced Neurology
Hyposmia is one of the cardinal symptoms of Parkinson’s disease (PD), with a considerably high prevalence rate in PD individuals. However, some individuals still retain normal olfactory function. Recent studies have shown that genetic factors may play a role in such a phenomenon. This study aimed to explore the potential genetic factors underlying the variation of olfactory function among PD individuals. Two hundred and three Han Chinese individuals with PD were recruited into this study. All the individuals underwent detailed clinical assessment conducted by experienced neurologists
View details →Andreea Geambașu, Sybren Spit, Daan van Renswoude et al. · 2022 · Developmental Science
We conducted a close replication of the seminal work by Marcus and colleagues from 1999, which showed that after a brief auditory exposure phase, 7-month-old infants were able to learn and generalize a rule to novel syllables not previously present in the exposure phase. This work became the foundation for the theoretical framework by which we assume that infants are able to learn abstract representations and generalize linguistic rules. While some extensions on the original work have shown evidence of rule learning, the outcomes are mixed, and an exact replication of Marcus et al.'s study has
View details →Mattias Ekre, Jakob Tytor, Mogens Bove et al. · 2020 · Diseases of the Esophagus
Summary Eosinophilic esophagitis (EoE) is a chronic inflammatory condition with eosinophilic infiltration of the esophageal mucosa. The most prominent symptom is dysphagia, which may result in esophageal bolus impaction in need of surgical…
View details →Simon Holmbacka, Robert Müller · 2017
Current benchmark suites for evaluating energy efficiency of modern computer systems fail to replicate real-world streaming applications accurately enough because of indeterministic load pattern which depends heavily on the input data of…
View details →Sara R. Rashkin, Mario A. Cleves, Gary M. Shaw et al. · 2022 · American Journal of Medical Genetics Part A
Abstract Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures,…
View details →Mariela E. Jaffé, Rainer Greifeneder · 2019 · Journal of Language and Social Psychology
This article investigates the negativity bias in truth judgments, which holds that negatively (vs. positively) framed statements are more likely to be judged true. Throughout four studies we find that expectations moderate the negativity…
View details →Peter Doshi · 2024 · BMJ
A top selling antiplatelet drug has never quite shaken off doubts about its advantage over cheaper rivals. With generic versions of ticagrelor about to launch, Peter Doshi takes a fresh look at the evidence
View details →Aliea M. Jalali, Brent M. Peterson, Thushara Galbadage · 2020 · Frontiers in Public Health
The Coronavirus disease 2019 (COVID-19) pandemic has elicited an abrupt pause in the United States in multiple sectors of commerce and social activity. As the US faces this health crisis, the magnitude and rigor of their initial public health response was unprecedented. As a response, the entire nation shutdown at the state-level for the duration of a ~1-3 months. These public health interventions, however, were not arbitrarily decided, but rather, implemented as a result of evidence-based practices. These practices were a result of lessons learned during the 1918 influenza pandemic and the ci
View details →Mohammad R. Jahan‐Parvar, Filip Žikeš · 2023 · Review of Financial Studies
Abstract We present evidence that several popular low-frequency measures of effective spread suffer from a volatility-induced bias and that volatility is the primary driver of the variation of these liquidity proxies. Using data for U.S. equities and major foreign exchange rates, we show that the bias arises when the effective spread is small relative to volatility. We document that the bias has become more acute over time and show that volatility-biased measures fail to replicate some well-known results in empirical finance. We conclude by providing guidance on the choice of low-frequency mea
View details →Zengyou He, Hao Liang, Zheng Chen et al. · 2020 · IEEE Transactions on Knowledge and Data Engineering
Community detection is a key data analysis problem across different fields. During the past decades, numerous algorithms have been proposed to address this issue. However, most work on community detection does not address the issue of…
View details →Bijay Kumar Jha, Sanjay Varikuti, Chaitenya Verma et al. · 2023 · npj Vaccines
Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a secreted cis-trans peptidyl isomerase expressed in all life stages of Trypanosoma cruzi. This protein in the insect stage leads to the inactivation of insect anti-parasitic peptides and parasite transformation whereas in the intracellular amastigotes it participates in generating ROS promoting the growth of parasites. We have generated a parasite mutant with depleted expression of Cyp19 by removal of 2 of 3 genes encoding this protein using doubl
View details →Elizabeth Bartlett, Ashley Yttredahl, Maura Boldrini et al. · 2023 · European Psychiatry
Abstract Background Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT 1A R) binding potential, especially…
View details →Sherry Towers, Anuj Mubayi, Carlos Castillo‐Chávez · 2018 · PLoS ONE
BACKGROUND: When attempting to statistically distinguish between a null and an alternative hypothesis, many researchers in the life and social sciences turn to binned statistical analysis methods, or methods that are simply based on the moments of a distribution (such as the mean, and variance). These methods have the advantage of simplicity of implementation, and simplicity of explanation. However, when null and alternative hypotheses manifest themselves in subtle differences in patterns in the data, binned analysis methods may be insensitive to these differences, and researchers may erroneou
View details →Gautam Das, Malayendu Saha, Abhijit Kundu · 2016 · Vision The Journal of Business Perspective
The anomalies in respect to initial public offering (IPO) performance in literature have stimulated multitude of research works in explaining critical issues, such as under-pricing during short-run and underperformance phenomena in the…
View details →Zerrin Önder, İbrahim Çanak, Ümit Totur · 2017 · Open Mathematics
Abstract In this paper, we prove that a bounded double sequence of fuzzy numbers which is statistically convergent is also statistically ( C , 1, 1) summable to the same number. We construct an example that the converse of this statement…
View details →Amanda Zieselman, Jonathan Fisher, Ting Hu et al. · 2014 · BioData Mining
BACKGROUND: Alzheimer's disease is the most common form of progressive dementia and there is currently no known cure. The cause of onset is not fully understood but genetic factors are expected to play a significant role. We present here a bioinformatics approach to the genetic analysis of grey matter density as an endophenotype for late onset Alzheimer's disease. Our approach combines machine learning analysis of gene-gene interactions with large-scale functional genomics data for assessing biological relationships. RESULTS: We found a statistically significant synergistic interaction among t
View details →Mojun Zhu, Brian A. Costello, Jun Yin et al. · 2021 · Pancreas
OBJECTIVES: Systemic therapies for pancreatic neuroendocrine tumors (PNETs) are limited. The combination of bevacizumab and temsirolimus showed significant antitumor activity, but the single-agent activity of bevacizumab was unknown. We…
View details →Won Fy Lee, Clea McNeely, Janet E. Rosenbaum et al. · 2020 · Journal of Research on Educational Effectiveness
We examined the effect on attendance of a truancy court-diversion program for elementary students. Truancy court-diversion programs represent a shift from a law-and-order approach toward a public health model to address school absenteeism.…
View details →Pamela J. Kaisaki, Georg Otto, Karène Argoud et al. · 2016 · G3 Genes Genomes Genetics
Abstract To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown–Norway (BN) controls, which contain well-defined blocks (1–183 Mb) of genetic polymorphisms, and in 123 genetically heterogeneous rats of an (GK × BN)F2 offspring. Within each congenic we identified 73–1351 differentially expressed genes (DEGs), only 7.7% of which mapped within the congenic blocks, and which may be regulated in cis. The remai
View details →A. Archidona-Yuste, I. Clavero-Camacho, A. N. Ruiz-Cuenca et al. · 2024 · Zoological Letters
Abstract The ring nematode genus Xenocriconemella De Grisse and Loof, 1965 comprises only one nominal species, Xenocriconemella macrodora (Taylor, 1936) De Grisse and Loof, 1965. The initial objective of the present study was to…
View details →Kory Floyd, Nathan T. Woo · 2020 · Personal Relationships
Abstract Contrary to the claim that loneliness routinely impairs the decoding of social cues such as emotion displays, Knowles, Lucas, Baumeister, and Gardner (2015) proposed that lonely adults “choke under pressure,” experiencing…
View details →Andrew J. Steward, Daniel J. Kelly, Diane R. Wagner · 2016 · Tissue Engineering Part A
Although hydrostatic pressure (HP) is known to regulate chondrogenic differentiation of mesenchymal stromal/stem cells (MSCs), improved insight into the mechanotransduction of HP may form the basis for novel tissue engineering strategies.…
View details →Lewend Mayiwar, Linda Lai · 2019 · Social Psychology
Abstract. We performed an independent, direct, and better powered ( N = 295) replication of Study 1, an experiment ( N = 113) by Lammers, Stoker, and Stapel (2009) . Lammers and colleagues distinguished between social power (influence over…
View details →Hisayuki Katsuyama, Hidekatsu Yanai, Hiroki Adachi et al. · 2023 · Gastroenterology Research
Background: We previously reported that the selective peroxisome proliferator-activated receptor alpha modulator, pemafibrate, significantly reduced serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and…
View details →Shailesh D. Pawar, Sadhana S. Kode, Sachin S. Keng et al. · 2022 · The Indian Journal of Medical Research
Background & objectives Polio, measles, rubella, influenza and rotavirus surveillance programmes are of great public health importance globally. Virus isolation using cell culture is an integral part of such programmes. Possibility of…
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