Negative / Null Result ReportOpen accessMedicine
Ciara Conduit, Ian D. Davis, Jeffrey C. Goh et al. · 2023 · British Journal of Urology
OBJECTIVE: To evaluate the efficacy of sequential treatment with ipilimumab and nivolumab following progression on nivolumab monotherapy in individuals with advanced, non-clear-cell renal cell carcinoma (nccRCC). MATERIALS AND METHODS:…
View details →Negative / Null Result ReportOpen accessMedicine
Silvia Park, Emma Langley, Jong‐Mu Sun et al. · 2015 · Oncotarget
// Silvia Park 1, * , Emma Langley 2, * , Jong-Mu Sun 1 , Steve Lockton 2 , Jin Seok Ahn 1 , Anjali Jain 2 , Keunchil Park 1 , Sharat Singh 2 , Phillip Kim 2 , Myung-Ju Ahn 1 1 Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Prometheus Laboratories Inc, A Nestlé Health Science Company, Department of Research and Development, San Diego, CA, USA * These authors have contributed equally to this work Correspondence to: Myung-Ju Ahn, e-mail: silkahn@skku.edu Phillip Kim, e-mail: pkim@prometheuslabs.co
View details →Negative / Null Result Report
Christopher A. Tait, Abtin Parnia, Nishan Zewge-Abubaker et al. · 2020 · BMC Public Health
Abstract Background Child mortality has been reduced by more than 50 % over the past 30 years. A range of secular economic and social developments have been considered to explain this phenomenon. In this paper, we examine the association…
View details →Negative / Null Result Report
Naicheng Wu, Guohao Liu, Min Zhang et al. · 2022 · Animals
One of the key targets of community ecology and biogeography concerns revealing the variability and underlying drivers of biodiversity. Most current studies understand biodiversity based on taxonomic information alone, but few studies have…
View details →Negative / Null Result Report
Gamze Durhan, Ahmet Gürkan Erdemir, Sezin Yuce Sari et al. · 2020 · Breast Care
Objective: Lymphatic irradiation in breast cancer improves locoregional control and has been shown to decrease distant metastasis. However, irradiation also accelerates the formation of atherosclerosis and can cause stenosis,…
View details →Negative / Null Result Report
B. WIELSTRA, J. W. ARNTZEN · 2014 · Zootaxa
We collected nuclear DNA data (52 markers) with next-generation sequencing for nine Triturus newt specimens, including the holotype and two of the paratypes of T. arntzeni, from the type locality at Vrtovać in eastern Serbia. We compare…
View details →Negative / Null Result Report
Marlies Oostendorp, Christine H. ten Hove, Miranda van Berkel et al. · 2023 · Archives of Pathology & Laboratory Medicine
Context.— Total serum bilirubin (TSB) analysis is pivotal for diagnosing neonatal hyperbilirubinemia. Because of a routine change in laboratory equipment, our TSB assay changed from a diazo to a vanadate oxidase method. Upon…
View details →Negative / Null Result Report
Huanhuan Chang, Jiao Li · 2022 · Journal of Clinical Laboratory Analysis
Abstract Background At present, there is a new variant Omicron BA.2 of SARS‐CoV‐2. In some previous studies, it was found that CBC, NLR, CRP, SAA, etc. in patients with SARS‐CoV‐2 had a series of changes, which were significantly…
View details →Negative / Null Result Report
Ping Yue, Xiaoan Zuo, Kaihui Li et al. · 2021 · Land Degradation & Development
Abstract As the third most important greenhouse gas, nitrous oxide (N 2 O) poses a significant threat to global warming and the ozone layer. However, the effects of precipitation changes on N 2 O emissions in arid areas remain unclear,…
View details →Negative / Null Result Report
Barton J. Mann, Taco Gosens, Stephen Lyman · 2012 · The American Journal of Sports Medicine
Treatment outcome researchers in orthopaedics frequently report only tests of statistical significance between group means to evaluate the effectiveness of a given intervention. Although important in establishing that mean differences are…
View details →Negative / Null Result Report
Haoran Zhou, Jung-Min Ji, Min Kim et al. · 2018 · Nanomaterials
The rational design of porphyrin sensitizers is always crucial for dye-sensitized solar cells (DSSCs), since the change of only a single atom can have a significant influence on the photovoltaic performance. We incorporated the…
View details →Negative / Null Result Report
Joshua Fisher, Poonam Arora, Sophia Rhee · 2018 · Sustainability
The viability of conservation efforts, including protected areas and buffer zones, depends on finding ways to make those strategies more attractive and viable for local populations. This paper presents a pilot study utilizing a rapid rural…
View details →Negative / Null Result Report
Geoffrey L. Dickens, Laura E. O'Shea · 2017 · International Journal of Forensic Mental Health
Outcomes measures are commonly derived from post-discharge recidivism, readmission, and mortality rates but information about common outcomes across admission is scant. We determined whether reliable and clinically significant change in…
View details →Negative / Null Result Report
Seo-Ha Jeong, Yeon Gyo Nam · 2024 · Healthcare
Background/Objectives: Globally, life expectancy has been increasing with South Korea focusing on improving health to enhance quality of life. The COVID-19 pandemic further emphasized the need for digital transformation in healthcare,…
View details →Negative / Null Result Report
Wenhua Wan, Petra Döll, Hang Zheng · 2022 · Water Resources Research
Abstract To support the implementation of China's carbon neutrality target, this study assesses the impact of future climate change on hydroelectricity production (HP) in China. We developed a hydropower database for mainland China, which…
View details →Negative / Null Result Report
Joon Young Choi, Jeong Uk Lim, Ho Jung Jeong et al. · 2020 · BMC Pulmonary Medicine
Abstract Background We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Richard E. Pratley, Douglas Scott Denham, Rupal Trivedi et al. · 2026 · Nature Medicine
Abstract Loss of lean mass in proportion to total weight loss is observed with incretin mimetic therapies such as tirzepatide and has the potential to adversely affect health and function. Apitegromab is an investigational, fully human monoclonal antibody that selectively inhibits myostatin activation and is, thereby, capable of increasing muscle mass. In the randomized, double-blind, placebo-controlled phase 2 EMBRAZE study, adults with overweight or obesity ( n = 102) were randomized 1:1 to receive tirzepatide plus apitegromab (10 mg kg −1 ) or tirzepatide plus placebo. At week 24, apitegrom
View details →Negative / Null Result ReportOpen accessMedicine
Tara L. Alvarez, Mitchell Scheiman, Farzin Hajebrahimi et al. · 2025 · British Journal of Sports Medicine
OBJECTIVE: The CONCUSS randomised clinical trial compared the effectiveness of immediate office-based vergence/accommodative therapy with movement (OBVAM) to delayed therapy for the treatment of concussion-related convergence insufficiency…
View details →Negative / Null Result ReportOpen accessMedicine
Yu Jun Wong, Laurent Lam, Pierre‐Antoine Soret et al. · 2025 · Journal of Hepatology
BACKGROUND & AIMS: Both liver stiffness measurement (LSM) and biochemical response have prognostic significance in patients with primary biliary cholangitis (PBC). However, the frequency and clinical relevance of discordant biochemical and LSM changes remain unclear. We aim to determine the performance of the most recent or current LSM (LSMc) in predicting first hepatic decompensation (HD) in the setting of discordant biochemical and LSM responses. METHODS: In this international, multicenter study, we included patients with at least two reliable LSM performed at least 6 months apart. Patients
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sami Alobaidi · 2025 · Frontiers in Medicine
Chronic kidney disease (CKD) remains a major global health issue, affecting millions and presenting persistent diagnostic and therapeutic challenges. Conventional biomarkers such as serum creatinine and estimated glomerular filtration rate have well-recognized limitations, underscoring the need for novel diagnostic tools and interventions. Emerging evidence highlights the gut-kidney axis as a central contributor to CKD pathogenesis, shaped by microbial dysbiosis and altered metabolite production. Harmful metabolites such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide promote
View details →Negative / Null Result ReportOpen accessDentistry
Gilliana Rozenblum, Karima Ait‐Aissa, G. E. D. Zahran et al. · 2025 · Alzheimer s & Dementia
Oral dysbiosis contributes to Alzheimer's disease (AD) by promoting neuroinflammation. Pathobionts such as Porphyromonas gingivalis, Treponema denticola, and Fusobacterium nucleatum release virulence factors that induce amyloid beta aggregation and tau hyperphosphorylation, while the loss of commensals like Streptococcus salivarius and Neisseria spp. impairs anti-inflammatory protection, worsening neuronal damage. P. gingivalis is strongly linked to an increased risk of AD, especially in individuals with systemic conditions like diabetes, hypertension, and chronic kidney disease. Its presence
View details →Negative / Null Result ReportOpen accessMedicine
Mónika Fekete, Tamás Jarecsny, Andrea Ceglédi et al. · 2025 · Nutrients
Background: Neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are among the leading causes of disability and mortality worldwide. Dietary patterns have emerged as modifiable risk factors that may influence disease onset and progression. The Mediterranean diet (MedDiet), rich in fruits, vegetables, whole grains, legumes, fish, and extra virgin olive oil, has been consistently associated with better cognitive outcomes and reduced risk of neurodegeneration. Aim: This narrative review summarizes current evidence on the role of the MedDiet in slowing the progression
View details →Negative / Null Result ReportOpen accessMedicine
Fatemeh Mohammadyari, Amirreza Aflak, Mahta ZareDini et al. · 2025 · Frontiers in Medicine
Background: Gastrointestinal bleeding (GIB), which includes both upper GIB (variceal and non-variceal) and lower GIB, represents a significant cause of emergency department referrals. Main body: Given the potential risks of blood transfusion, re-bleeding, and mortality in these patients, it is essential to establish a system for prioritizing critical patients. Several risk stratification scoring systems have been developed based on patients' clinical characteristics and/or endoscopic findings. However, the optimal scoring system for each clinical scenario remains uncertain. Conclusion: In this
View details →Negative / Null Result ReportOpen accessMedicine
Judith Charbit, Jean‐Sébastien Vidal, Olivier Hanon · 2025 · Nutrients
Cognitive aging is a complex, multifactorial process influenced by genetic, metabolic, and environmental factors. Among modifiable risk factors, nutrition has emerged as a promising target to preserve cognitive function. This review provides a comprehensive overview of the impact of dietary interventions-including specific nutrients and dietary patterns-on cognitive domains (memory, executive function, global cognition) and mental health. Recent findings: multinutrient supplementation, particularly combinations of B vitamins and omega-3 fatty acids, appears beneficial for episodic memory, espe
View details →Negative / Null Result ReportOpen accessEngineering
Angela Stefania Bergantino, Giulio Fusco, Mario Intini et al. · 2025 · The Annals of Regional Science
Abstract The digital economy can function either as a catalyst to stimulate economic growth or else as a driver of socioeconomic inequality when its benefits are unevenly distributed. This study investigates the effect of rural digital connectivity on income inequality in Italy. Utilizing NUTS 3 panel data spanning 2014–2022, we conduct a counterfactual Difference-in-Differences approach with continuous treatment intensity to estimate the impact of introducing rural broadband coverage at speeds of 30 and 100 Mbps on multiple measures of income distribution, including the Gini, Theil, and Atkin
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Borbála Turcsán, Dorottya Júlia Ujfalussy, Andrea Kerepesi et al. · 2025 · Scientific Reports
Most dog owners in Western countries regard their dogs as companions or family members, prompting extensive research on the human-animal bond. However, many studies rely on broad categories or single dimensions, such as satisfaction or attachment, which can oversimplify the complexity of these relationships. In contrast, our study employed a multifaceted approach, examining the dog-owner bond across 13 relationship scales and comparing these scales to four different types of human relationships to reveal the human-like roles of dogs within a family. Participants (N = 717) characterized their r
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Hartmut Jaeschke, Anup Ramachandran · 2025 · Exploration of Digestive Diseases
Acetaminophen (APAP)-induced liver injury and acute liver failure is a significant clinical problem worldwide; in addition, APAP overdoses in animals or in cell culture are used as popular models to study drug-induced liver injury mechanisms and test therapeutic interventions. Early assumptions that APAP toxicity is caused by a single mechanism resulting in a defined mode of cell death in hepatocytes had to be questioned when over the years many different mechanisms and modes of cell death were reported. Although many of the contradictory results and conclusions reported over the years can be
View details →Negative / Null Result ReportOpen accessMedicine
Şafak Kılıç · 2025 · PLoS ONE
BACKGROUND AND OBJECTIVE: Male fertility assessment through sperm morphology analysis remains a critical component of reproductive health evaluation, as abnormal sperm morphology is strongly correlated with reduced fertility rates and poor assisted reproductive technology outcomes. Traditional manual analysis performed by embryologists is time-intensive, subjective, and prone to significant inter-observer variability, with studies reporting up to 40% disagreement between expert evaluators. This research presents a novel deep learning framework combining Convolutional Block Attention Module (CB
View details →Negative / Null Result ReportOpen accessMaterials Science
Sonakshi Gupta, Akhlak Mahmood, Shivank Shukla et al. · 2025 · Macromolecular Rapid Communications
ABSTRACT Machine learning and artificial intelligence have revolutionized polymer science by enhancing the ability to rapidly predict key polymer properties and enabling generative design. The utilization of large language models (LLMs) in polymer informatics may offers additional opportunities for advancement. Unlike traditional methods that depend on large labeled datasets, hand‐crafted representations of the materials, and complex feature engineering, LLM‐based methods utilize natural language inputs via a transfer learning process and eliminate the need for complex representation and finge
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Jung Ho Choi, Brandon Gipper, Shawn Shi · 2025 · Review of Accounting Studies
Early empirical evidence showed a lack of relative performance evaluation (RPE) for executive pay, a surprise given its theoretical appeal. We hypothesize that executive pay transparency can enhance the monitoring of pay practices and…
View details →