Negative / Null Result ReportOpen accessHealth Professions
Nasser Lubega, Abigail Anderson, Nicole Nelson · 2023 · PLoS ONE
High rates of irreproducibility and of poor mental health in graduate students have been reported in the biomedical sciences in the past ten years, but to date, little research has investigated whether these two trends interact. In this study, we ask whether the experience of failing to replicate an expected finding impacts graduate students' mental health. Using an online survey paired with semi-structured qualitative interviews, we examined how often biomedical science doctoral students at a large American public university experienced events that could be interpreted as failures to replicat
View details →Negative / Null Result ReportOpen accessHealth Professions
Ann‐Marie Towers, Stacey Rand, Stephen Allan et al. · 2025 · BMJ Open
OBJECTIVES: To assess the feasibility of capturing older care home residents' quality of life (QoL) in digital social care records and the construct validity (hypothesis testing) and internal consistency (Cronbach's alpha) of four QoL measures. DESIGN: doption) study, a mixed-methods pilot of a prototype minimum dataset (MDS). SETTING: Care homes (with or without nursing) registered to provide care for older adults (>65 years) and/or those living with dementia. All homes used a digital record system from one of two suppliers. PARTICIPANTS: Data were extracted from 748 residents. All permanent
View details →Negative / Null Result ReportOpen accessSocial Sciences
Giovanna M. Invernizzi, Ahmed Ezzeldin Mohamed · 2022 · Journal of Experimental Political Science
Abstract How does exposure to conspiracy theories affects voters’ political attitudes? Using an online experiment among US subjects, we show that exposure to conspiracy theories decreases voters’ trust in the domestic informational…
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Goodness C. Aye, Olorato Gadinabokao, Rangan Gupta · 2016 · Energy Sources Part B Economics Planning and Policy
Causality testing procedures in the frequency domain and the time domain are employed to analyses the relationship between oil prices and interest rate in South Africa, covering the time period January 1936–November 2013 . Results show…
View details →Negative / Null Result ReportOpen accessComputer Science
Fabrice Djatsa · 2019 · Journal of Information Security
As the economy increases its dependence on the internet to increase efficiency and productivity in all aspects of society, close attention has been directed to solve the challenges related to internet security. Despite the large amount of…
View details →Negative / Null Result ReportOpen accessPsychology
R. Constance Wiener, Alcinda Trickett Shockey, D. Leann Long · 2014 · Journal of Dental Education
Geriatric education is an important component of the dental hygiene curriculum because, in it, students acquire skills and attitudes to help provide quality care to older adults. The purpose of this study was to determine if off-site…
View details →Negative / Null Result ReportOpen accessHealth Professions
Paul Kwame Essandoh, Frederick Ato Armah, Ernest K. A. Afrifa et al. · 2011 · Environment and Natural Resources Research
Environmental noise pollution generated from industrial and transport activities in Ghana have received considerable attention from regulators and policy makers unlike rising noise levels in residential settings. This study measured ambient noise levels in four halls of residence in the University of Cape Coast (UCC), Ghana to ascertain compliance with permissible limits. Questionnaires were also used to evaluate the possible non-auditory noise effects. The results indicate that the same sex halls (Adeyhe and Casford) were within the day and night permissible noise limit of the Ghana Environme
View details →Negative / Null Result ReportOpen accessPsychology
Savannah Kelly · 2017 · Evidence Based Library and Information Practice
Abstract Objective – The purpose of this quantitative study was to measure the impact of providing research struggle videos on first-year students’ research self-efficacy. The three-part video series explicated and briefly addressed common…
View details →Negative / Null Result ReportOpen accessMedicine
Muhammad Junaid Tahir, Komal Tehzeeb, Farah Javaid et al. · 2023
Background: Parkinson's disease, is a degenerative neurological disorder, may have an adverse effect on movement, balance, and coordination. Physical therapy, a frequent Parkinson's disease treatment, tries to improve the patient's…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jeanne M. McCaffery, George D. Papandonatos, Lucy F. Faulconbridge et al. · 2015 · Psychosomatic Medicine
OBJECTIVES: Numerous studies have found elevated depressive symptoms among individuals with Type 2 diabetes, yet the mechanisms remain unclear. We examined whether genetic loci previously associated with depressive symptoms predict…
View details →Negative / Null Result ReportOpen accessNeuroscience
Christopher J. Wertz, Faith M Hanlon, Nicholas A. Shaff et al. · 2018 · Schizophrenia Bulletin
Inhibitory failure represents a core dysfunction in patients with schizophrenia (SP), which has predominantly been tested in the literature using reactive (ie, altering behavior after a stimulus) rather than proactive (ie, purposefully…
View details →Negative / Null Result ReportMedicine
Leon Veryard, Emma Jones, Gary Weaving et al. · 2013 · Current Alzheimer Research
Increased concentrations of pro-inflammatory blood cytokines and plasma homocysteine (Hcy) are frequently reported in Alzheimer's disease (AD). Hcy appears to have immunomodulating and pro-inflammatory activities. Further, emerging…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Shaoyuan Tan, Weixin Wu, Xinna Ge et al. · 2023 · One Health Advances
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for the global pork industry. Although modified live virus (MLV) vaccines are commonly used for PRRSV prevention and control, they still carry a risk of infecting the host and replicating in target cells, thereby increasing the likehood of virus recombination and reversion to virulence. In this study, we inserted the target sequence of miR-142 into the nsp2 hypervariable region of PRRSV to inhibit viral replication in its host cells of pigs, with the aim of achieving virus attenuation. The chimeri
View details →Negative / Null Result ReportPsychology
Jeannette Fuller, James Tapp, Simon Draycott · 2019 · Criminal Behaviour and Mental Health
BACKGROUND: Motivation and readiness to change are important drives for forensic patients accessing interventions. It is thought that guilt and shame influence these drives, but to date, their relationship has not been empirically tested.…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Gabriele Meyer, Jeffrey R. Leipprandt, Jianwei Xie et al. · 2012 · Endocrinology
Mammary organoids from adult mice produce tubules, analogous to mammary ducts in vivo, in response to hepatocyte growth factor (HGF) when cultured in collagen gels. The combination of HGF plus progestin (R5020) causes reduced tubule number…
View details →Negative / Null Result ReportOpen accessNeuroscience
Nicholas Murphy, Alison Killen, Rajnish Kumar Gupta et al. · 2021 · Frontiers in Neurology
Visual hallucinations (VH) are a common symptom of Parkinson's disease with dementia (PDD), affecting up to 65% of cases. Integrative models of their etiology posit that a decline in executive control of the visuo-perceptual system is a primary mechanism of VH generation. The role of bottom-up processing in the manifestation of VH in this condition is still not clear although visual evoked potential (VEP) differences have been associated with VH at an earlier stage of PD. Here we compared the amplitude and latency pattern reversal VEPs in healthy controls ( n = 21) and PDD patients ( n = 34) w
View details →Negative / Null Result ReportOpen accessMedicine
Marie Lefebvre, Michael P. Hengartner, Enrico Tronci et al. · 2022 · Physiology & Behavior
BACKGROUND: As eating behavior changes in relation to the menstrual cycle and weight changes with menopausal transition, ovarian hormones appear to be involved in regulating eating behavior. However, observations are contradictory and are difficult to compare, due to methodological problems related to nutritional epidemiology. To better understand the relationship between ovarian steroid hormones and eating behavior, our study evaluates women's responses to visual food cues at different points in the menstrual cycle with their specific serum estrogen/progesterone levels and women's responses i
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Kateryn Rochon, Rodney B. Baker, Glen W. Almond et al. · 2015 · Journal of Medical Entomology
We investigated the acquisition of porcine reproductive and respiratory syndrome (PRRS) virus by the stable fly (Diptera: Muscidae; Stomoxys calcitrans (L.)) through a bloodmeal, and virus persistence in the digestive organs of the fly…
View details →Negative / Null Result ReportMedicine
Maha N. Mian, Brianna R. Altman, Luna F. Ueno et al. · 2020 · Journal of Psychoactive Drugs
Savoring has covaried inversely with cannabis problems and moderated the association between cannabis use and negative consequences related to use. Research has not yet addressed the acceptability of savoring interventions for cannabis…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ivana Vranješ, Tinne Vander Elst, Yannick Griep et al. · 2022 · Group & Organization Management
In this study, we investigated whether and how perpetrators of bullying become targets themselves. Building on the notion of bullying as an escalation process and the Conservation of Resources Theory, we hypothesized that following enactment of bullying, people would experience increased relationship conflicts with colleagues, diminishing their sense of control and making them more likely to become exposed to bullying themselves. We tested this idea using longitudinal sequential mediated Structural Equation Modelling in a sample of 1420 Belgian workers. Our results confirmed that enactment of
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jessica A. Blayney, Matthew D. Scalco, Sharon Radomski et al. · 2019 · Psychology of Addictive Behaviors
= 480; 61% female) reported on their alcohol and drug use behaviors across 5 time points spanning 1 calendar year. For many, this year included the transition out of college. Latent growth curve analysis was used to determine whether…
View details →Negative / Null Result ReportMedicine
James Foulds, Kim N. T. Ton, Martin A. Kennedy et al. · 2015 · Pharmacogenetics and Genomics
A functional polymorphism rs1799971 (A118G) in the μ-opioid receptor gene (OPRM1) produces an amino acid substitution Asn40Asp, which is believed to influence naltrexone response in nondepressed alcohol-dependent patients. In this study,…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Feride Acar · 2015 · Procedia - Social and Behavioral Sciences
Extant research shows that female managers face significant hurdles in the attainment of top level positions in IT organizations. Recently there have been some examples to women breaking through the glass ceiling to reach to higher…
View details →Negative / Null Result ReportSocial Sciences
Guy Assaker, Vincenzo Esposito Vinzi, Peter O’Connor · 2011 · Tourism and Hospitality Research
This study provides insights into a powerful statistical technique to test model invariance across multiple groups. In doing so, it provides insights for policymakers and contributes to the literature on tourism demand forecasting by…
View details →Negative / Null Result ReportOpen accessPsychology
Irene Trilla, Hanna Drimalla, Malek Bajbouj et al. · 2020 · Frontiers in Behavioral Neuroscience
Recent findings suggest a role of oxytocin on the tendency to spontaneously mimic the emotional facial expressions of others. Oxytocin-related increases of facial mimicry, however, seem to be dependent on contextual factors. Given previous literature showing that people preferentially mimic emotional expressions of individuals associated with high (vs. low) rewards, we examined whether the reward value of the mimicked agent is one factor influencing the oxytocin effects on facial mimicry. To test this hypothesis, 60 male adults received 24 IU of either intranasal oxytocin or placebo in a doubl
View details →Negative / Null Result ReportNeuroscience
Stefania Piscopo, Euan R. Brown · 2018 · Small
Abstract Membrane–nanoparticle interactions are important in determining the effects of manufactured nanomaterials on cell physiology and pathology. Here, silica, titanium, zinc, and magnesium oxide nanoparticles are screened against human…
View details →Negative / Null Result ReportOpen accessMedicine
Chang Yu, Ning Zhang, Weikang Zhu et al. · 2019 · Evidence-based Complementary and Alternative Medicine
Objectives . To evaluate the safety of moxa smoke, especially to provide quantitative information and details for the occupational prevention of acupuncturists. Methods . We combined the questionnaire-based cross-sectional survey and lung function testing-based historical retrospective cohort research to investigate the safety of moxa smoke exposure (MSE) among acupuncturists. A mathematical regression model was established to quantitatively evaluate the relationship between moxa smoke exposure and the respiratory health of the acupuncturist. The smoke exposure time of the acupuncturist and th
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jennifer Zou, Jinjing Zhou, Sarah Faller et al. · 2022 · G3 Genes Genomes Genetics
Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex human traits, but only a fraction of variants identified in discovery studies achieve significance in replication studies. Replication in genome-wide association studies has been well-studied in the context of Winner's Curse, which is the inflation of effect size estimates for significant variants due to statistical chance. However, Winner's Curse is often not sufficient to explain lack of replication. Another reason why studies fail to replicate is that there are fundamental difference
View details →Negative / Null Result ReportNeuroscience
Linda Liu, Zachary Burchill, Michael K. Tanenhaus et al. · 2017 · eScholarship (California Digital Library)
Sentence understanding is affected by recent experience. Animportant open question is whether this reflects adaptationto the statistics of the input. Support for this hypothesiscomes from the recent finding that listeners can…
View details →Negative / Null Result ReportOpen accessMedicine
Zofia Strojny, Rafał Rutkowski, Alina Kanikowska et al. · 2021 · Nutrients
Background: Chronotype is the pattern of the circadian rhythm that allows an individual to optimize times of sleep and activity. It has been observed that chronotypes may associate with some conditions and diseases, including obesity. It is not known, however, whether chronotypes determine the effectiveness of weight loss regimens. Therefore, in the present study, we compared the outcomes of a 3-week moderate calorie restriction undertaken by individuals with obesity under the same controlled hospital conditions. Methods: A total of 131 participants with obesity (median BMI 40.0) were studied.
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