Negative / Null Result ReportSocial Sciences
Xueqin Qian, Renáta Tichá, Roger J. Stancliffe · 2017 · Journal of Policy and Practice in Intellectual Disabilities
Abstract Although numerous studies in the U.K. and Australia have shown that Active Support (AS) is an effective intervention in increasing staff assistance and engagement for people with intellectual and developmental disabilities (IDD)…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Dooruj Rambaccussing, Murat Mazibaş · 2020 · Journal of risk and financial management
We test whether the selected cryptocurrencies exhibit long memory behavior in returns and volatility. We use data on five most traded cryptocurrencies: Bitcoin, Litecoin, Ethereum, Bitcoin Cash, and XRP. Using recent tests of long memory developed against persistent and nonlinear alternatives, this paper finds that long memory is mostly rejected in returns. The tests fail to reject the null hypothesis of long memory in most cases across different volatility proxies and cryptocurrencies. The estimated memory parameters show that volatility is persistent, and when volatility is measured by log r
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Animamalar Mayavannan, Emily Shantz, Ian D. Haidl et al. · 2023 · Frontiers in Immunology
Introduction Chlamydia trachomatis ( C. trachomatis ) is a Gram-negative obligate intracellular bacterium that causes reproductive tract complications in women, including ectopic pregnancies and tubal factor infertility. We hypothesized that mast cells, which are common at mucosal barriers, may contribute to responses to Chlamydia infection and aimed to define human mast cell responses to C. trachomatis . Methods Human cord blood-derived mast cells (CBMCs) were exposed to C. trachomatis to assess bacterial uptake, mast cell degranulation, gene expression, and production of inflammatory mediato
View details →Negative / Null Result ReportOpen accessMedicine
Nasrine Bendjilali, Helen Kim, Shantel Weinsheimer et al. · 2013 · PLoS ONE
BACKGROUND: Brain arteriovenous malformations (BAVM) are clusters of abnormal blood vessels, with shunting of blood from the arterial to venous circulation and a high risk of rupture and intracranial hemorrhage. Most BAVMs are sporadic, but also occur in patients with Hereditary Hemorrhagic Telangiectasia, a Mendelian disorder caused by mutations in genes in the transforming growth factor beta (TGFβ) signaling pathway. METHODS: To investigate whether copy number variations (CNVs) contribute to risk of sporadic BAVM, we performed a genome-wide association study in 371 sporadic BAVM cases and 56
View details →Negative / Null Result ReportOpen accessMedicine
Helen M Collins, Susan A. Greenfield · 2024 · International Journal of Molecular Sciences
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no effective treatments, not least due to the lack of authentic animal models. Typically, rodent models recapitulate the effects but not causes of AD, such as cholinergic neuron loss: lesioning of cholinergic neurons mimics the cognitive decline reminiscent of AD but not its neuropathology. Alternative models rely on the overexpression of genes associated with familial AD, such as amyloid precursor protein, or have genetically amplified expression of mutant tau. Yet transgenic rodent models poorly replicate the neuropatho
View details →Negative / Null Result ReportOpen accessNeuroscience
Nuno Gomes, Bettina M. Pause, Monique A. M. Smeets et al. · 2023 · Chemical Senses
Fear and anxiety are the most frequently studied emotional states in chemosignal research. Despite differences between these two emotional states, findings from research using fear and anxiety body odors (BOs) are often treated as part of…
View details →Negative / Null Result ReportOpen accessPsychology
Julia Holzer, Luisa Grützmacher, Marko Lüftenegger et al. · 2024 · Learning and Instruction
Despite broad theoretical consensus on the direct and indirect relevance of teacher emotions for instructional behavior and student outcomes, empirical evidence is inconclusive. Moreover, there is limited research in this area involving disadvantaged and younger student populations, and addressing students’ school well-being as an outcome explicitly. This study investigates associations between teacher emotions (joy, anger, anxiety), teacher-reports of instructional behavior (cognitive and motivational stimulation, classroom management, and social support), and students' reported school well-b
View details →Negative / Null Result ReportOpen accessDecision Sciences
Yusuf Wanjala Musi, Elegwa Mukulu, Margaret Oloko · 2018 · Journal of Management and Sustainability
Strategic planning is a very crucial phenomenon in all organisations. It is the tool that determines the destiny of the firm. The objective of this study was to investigate the influence of financial resource strategic planning on firm performance, to determine influence of human capital strategic planning on firm performance, to analyze the influence of material resource strategic planning on firm performance and to determine influence of information resource strategic planning on firm performance in agriculture research based institutions of Kenya. Although there had been previous internatio
View details →Negative / Null Result ReportOpen accessPsychology
Sandra Godinho, Margarida V. Garrido, Michael Zürn et al. · 2018 · Cognition & Emotion
Previous research has revealed a stable preference for words with inward consonantal-articulation patterns (from the front to the back of the mouth; e.g. BENOKA), over outward-words (from the back to the front; e.g. KENOBA). Following the…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Rajrani Ruhel, Mohit Mazumder, Prabu Gnanasekaran et al. · 2021 · FEBS Journal
Geminivirus replication initiator protein (Rep) is a multifunctional viral protein required for replication. During the process of viral replication, Rep acts as a site- and strand-specific endonuclease, ligase, ATPase, and helicase. B'…
View details →Negative / Null Result ReportOpen accessPsychology
Annika Gunst, Marlene Werner, Lourens Waldorp et al. · 2018 · Scientific Reports
Problems related to low sexual desire in women are common clinical complaints, and the aetiology is poorly understood. We investigated predictors of change in levels of sexual desire using a novel network approach, which assumes that mental disorders arise from direct interactions between symptoms. Using population-based data from 1,449 Finnish women, we compared between-subject networks of women whose sexual desire decreased, increased, or remained stable over time. Networks were estimated and analyzed at T1 (2006) and replicated at T2 (2013) using R. Domains included were, among others, sexu
View details →Negative / Null Result ReportNeuroscience
Jessica Nicosia, David A. Balota · 2020 · Psychology and Aging
Recent evidence indicates that older adults' decreased ability to inhibit irrelevant information may lead to increased processing and greater memory for distractor information compared with younger adults. The present experiments examine…
View details →Negative / Null Result ReportOpen accessMedicine
Maija K. Pietilä, Irina C. Albulescu, Martijn J. van Hemert et al. · 2017 · Viruses
Semliki Forest virus (SFV) is an arthropod-borne alphavirus that induces membrane invaginations (spherules) in host cells. These harbor the viral replication complexes (RC) that synthesize viral RNA. Alphaviruses have four replicase or nonstructural proteins (nsPs), nsP1-4, expressed as polyprotein P1234. An early RC, which synthesizes minus-strand RNA, is formed by the polyprotein P123 and the polymerase nsP4. Further proteolytic cleavage results in a late RC consisting of nsP1-4 and synthesizing plus strands. Here, we show that only the late RCs are highly active in RNA synthesis in vitro. F
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miruna C. Barbu, Carmen Amador, Alex S. F. Kwong et al. · 2022 · EBioMedicine
BACKGROUND: DNA methylation (DNAm) is associated with time-varying environmental factors that contribute to major depressive disorder (MDD) risk. We sought to test whether DNAm signatures of lifestyle and biochemical factors were associated with MDD to reveal dynamic biomarkers of MDD risk that may be amenable to lifestyle interventions. METHODS: , N=565), using CpG sites reported in previous well-powered methylome-wide association studies. We also compared their predictive accuracy for MDD to a MDD MS in an independent GS sub-sample (N=4,432). FINDINGS: =-0.069-0.083) remained significantly a
View details →Negative / Null Result ReportOpen accessEnergy
Jingwen Shi, Ning Li, Yan Liang et al. · 2025 · Angewandte Chemie International Edition
Abstract The transfer path of photogenerated charges greatly affects the final photocatalytic performance, but this important fact has not been clearly demonstrated experimentally. Here, we construct an ultrastable crystalline catalytic…
View details →Negative / Null Result ReportNeuroscience
Laurent Grégoire, Pierre Perruchet, Bénédicte Poulin-Charronnat · 2014 · Journal of Experimental Psychology Learning Memory and Cognition
Most earlier studies investigating the evolution of the Stroop effect with the amount of reading practice have reported data consistent with an inverted U-shaped curve, whereby the Stroop effect appears early during reading acquisition,…
View details →Negative / Null Result ReportOpen accessMaterials Science
Suriati Paiman, T. Hui Ling, M. Husham et al. · 2020 · Results in Physics
This paper focused on the growth of zinc oxide nanowires on unannealed and annealed indium tin oxide-coated-coated glass substrates on the structural, optical, and electrical properties towards surface acoustic wave (SAW) piezoelectric…
View details →Negative / Null Result ReportOpen accessMedicine
Aditya Kumar Gudimella Tirumala, Shubham Mishra, Nritya Trivedi et al. · 2023 · Telematics and Informatics Reports
This article presents a study comparing the responses of two AI chatbots, ChatGPT and ChatSonic, regarding inquiries about epilepsy. Overall, ChatGPT and ChatSonic are very similar in terms of their capabilities and limitations and they…
View details →Negative / Null Result ReportOpen accessMedicine
Ruijuan Liu, Xia Li, Jingyao Wei et al. · 2019 · Frontiers in Pharmacology
Despite its narrow therapeutic window and large inter-individual variability, cyclosporine A (CsA) is the first-line therapy following organ transplantation. Metabolized mainly by CYP3A and being a substrate of P-glycoprotein (P-gp), CsA is susceptible to drug-drug interactions. Baicalin (BG) is a drug used for adjuvant therapy of hepatitis in traditional Chinese medicine. Since its aglycone Baicalein (B) inhibits CYP3A and P-gP, co-administration might affect CsA pharmacokinetics. This study investigated the effect of BG on CsA pharmacokinetics. In a two-period study, 16 healthy volunteers re
View details →Negative / Null Result ReportMedicine
Kun Man, Jiafeng Liu, Cindy Liang et al. · 2023 · ACS Applied Materials & Interfaces
Determining the mechanistic causes of lung diseases, developing new treatments thereof, and assessing toxicity whether from chemical exposures or engineered nanomaterials would benefit significantly from a preclinical human lung alveolar…
View details →Negative / Null Result ReportOpen accessEngineering
Amlan Jyoti Kalita, Maibam Pooya Chanu, Nayan M. Kakoty et al. · 2025 · Wearable Technologies
Electromyogram (EMG)-controlled prosthetic hands have advanced significantly during the past two decades. However, most of the currently available prosthetic hands fail to replicate human hand functionality and controllability. To measure the emulation of the human hand by a prosthetic hand, it is important to evaluate the functional characteristics. Moreover, incorporating feedback from end users during clinical testing is crucial for the precise assessment of a prosthetic hand. The work reported in this manuscript unfolds the functional characteristics of an EMG-CoNtrolled PRosthetIC Hand ca
View details →Negative / Null Result ReportOpen accessPsychology
Simone Di Plinio · 2022 · Frontiers in Psychology
Correlation coefficients are often compared to investigate data across multiple research fields, as they allow investigators to determine different degrees of correlation to independent variables. Even with adequate sample size, such differences may be minor but still scientifically relevant. To date, although much effort has gone into developing methods for estimating differences across correlation coefficients, adequate tools for variable sample sizes and correlational strengths have yet to be tested. The present study evaluated four different methods for detecting the difference between two
View details →Negative / Null Result ReportOpen accessMedicine
Fabrizio Ricci, Franz–Josef Neumann, Nicole Rübsamen et al. · 2022 · Frontiers in Cardiovascular Medicine
Background The instant, single-sampling rule-out of acute myocardial infarction (AMI) is still an unmet clinical need. We aimed at testing and comparing diagnostic performance and prognostic value of two different single-sampling biomarker strategies for the instant rule-out of AMI. Methods From the Biomarkers in Acute Cardiac Care (BACC) cohort, we recruited consecutive patients with acute chest pain and suspected AMI presenting to the Emergency Department of the University Medical Center Hamburg-Eppendorf, Hamburg, Germany. We compared safety, effectiveness and 12-month incidence of the comp
View details →Negative / Null Result Report
Teng Liu, Jian‐She Wang · 2023 · Liver International
Abstract Background and Aims A recent study suggested that administration of ursodeoxycholic acid (UDCA) at dosages usually employed clinically may reduce rates of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. A…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Valeriy Timofeyev, C. A. Porter, Dipika Tuteja et al. · 2010 · American Journal of Physiology-Heart and Circulatory Physiology
Adenylyl cyclase (AC) is the principal effector molecule in the β-adrenergic receptor pathway. AC(V) and AC(VI) are the two predominant isoforms in mammalian cardiac myocytes. The disparate roles among AC isoforms in cardiac hypertrophy…
View details →Negative / Null Result ReportOpen accessMedicine
Xi Luo, Xiaodong Huang, Jingwei Luo et al. · 2022 · BMC Cancer
PURPOSE: Concurrent chemoradiotherapy (CCRT) is a standard treatment choice for locally advanced hypopharyngeal carcinoma. The aim of this study was to investigate whether induction chemotherapy (IC) followed by CCRT is superior to CCRT alone to treat locally advanced hypopharyngeal carcinoma. METHODS AND MATERIALS: Patients (n = 142) were randomized to receive two cycles of paclitaxel/cisplatin/5-fluorouracil (TPF) IC followed by CCRT or CCRT alone. The primary end point was overall survival (OS). The secondary end points included the larynx-preservation rate, progression-free survival (PFS),
View details →Negative / Null Result ReportOpen accessMedicine
Tongtian Ni, Ying Chen, Bing Zhao et al. · 2021 · Scientific Reports
Severe acute pancreatitis (SAP) is a life-threatening disease. Fluid Resuscitation Via Colon (FRVC) may be a complementary therapy for early controlled fluid resuscitation. But its clinical application has not been reported. This study aims to explore the impact of FRVC on SAP. All SAP patients with the first onset within 72 h admitted to the hospital were included from January 2014 to December 2018 through electronic databases of Ruijin hospital and were divided into FRVC group (n = 103) and non-FRVC group (n = 78). The clinical differences before and after the therapy between the two groups
View details →Negative / Null Result ReportImmunology and Microbiology
Duan S. Loy, Bradley J. Blitvich, John Dustin Loy et al. · 2015 · Journal of General Virology
Infectious myonecrosis virus (IMNV) causes significant economic losses in farmed shrimp, where associated mortality in ponds can reach 70 %. To explore host/pathogen interactions, a next-generation sequencing approach using lymphoid organ…
View details →Negative / Null Result ReportOpen accessMedicine
Magnus Lindskog, Anna Laurell, Anders Kjellman et al. · 2022 · European Urology Open Science
Background: The prognosis of patients with synchronous metastatic renal cell carcinoma (mRCC) is poor. Whereas single-agent tyrosine kinase inhibition (TKI) is clearly insufficient, the effects can be enhanced by combinations with immune checkpoint inhibitors. Innovative treatment options combining TKI and other immune-stimulating agents could prove beneficial. Objective: To evaluate the clinical effects on metastatic disease when two doses of allogeneic monocyte-derived dendritic cells (ilixadencel) are administrated intratumorally followed by nephrectomy and treatment with sunitinib compared
View details →Negative / Null Result ReportOpen accessMedicine
Ethan S. Lindgren, Onur Çil, A. S. Verkman et al. · 2022 · Current Ophthalmology Reports
Purpose of Review: To review the role of ocular surface epithelial (corneal and conjunctival) ion transporters in the pathogenesis and treatment of dry eye disease (DED). Recent Findings: Currently, anti-inflammatory agents are the mainstay of DED treatment, though there are several agents in development that target ion transport proteins on the ocular surface, acting by pro-secretory or anti-absorptive mechanisms to increase the tear fluid Film volume. Activation or inhibition of selected ion transporters can alter tear fluid osmolality, driving water transport onto the ocular surface via osm
View details →