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19,814 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

CRISPR–Cas technologies in neurodegenerative disorders: mechanistic insights, therapeutic potential, and translational challenges

Raya Kh. Yashooa, Ari Q. Nabi, Shukur Wasman Smail et al. · 2026 · Frontiers in Neurology

CRISPR-Cas genome-editing technologies have emerged as powerful tools for precise DNA and RNA modulation, offering promising therapeutic strategies for neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). This review critically evaluates current CRISPR/Cas applications in neurodegeneration, with emphasis on mechanistic insights, therapeutic outcomes, and translational feasibility. Preclinical and early translational studies demonstrate that CRISPR-Cas platforms can correct pathogenic mutation

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Negative / Null Result ReportOpen accessMedicine

Anatomic Risk Factors for Initial and Secondary Noncontact Anterior Cruciate Ligament Injury: A Prospective Cohort Study in 880 Female Elite Handball and Soccer Players

Yusuke Kamatsuki, Marie Synnøve Qvale, Kathrin Steffen et al. · 2024 · The American Journal of Sports Medicine

Background: Anterior cruciate ligament (ACL) injury is one of the most severe injuries for athletes. It is important to identify risk factors because a better understanding of injury causation can help inform athletes about risk and increase their understanding of and motivation for injury prevention. Purpose: To investigate the relationship between anatomic factors and risk for future noncontact ACL injuries. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 870, excluding 9 players with a new contact ACL injury and a player with a new noncontact ACL injury just before the

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Microbial diversification is maintained in an experimentally evolved synthetic community

Zahraa S. Al-tameemi, Alejandra Rodríguez‐Verdugo · 2024 · mSystems

ABSTRACT Microbial communities are incredibly diverse. Yet, the eco-evolutionary processes originating and maintaining this diversity remain understudied. Here, we investigate the patterns of diversification for Pseudomonas putida evolving in isolation and with Acinetobacter johnsonii leaking resources used by P. putida . We experimentally evolved four experimental replicates in monoculture and co-culture for 200 generations. We observed that P. putida diversified into two distinct morphotypes that differed from their ancestor by single-point mutations. One of the most prominent mutations hit

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Negative / Null Result ReportOpen accessComputer Science

Does metaverse improve recommendations quality and customer trust? A user-centric evaluation framework based on the cognitive-affective-behavioural theory

Rabab Ali Abumalloh, Mehrbakhsh Nilashi, Osama Halabi et al. · 2024 · Journal of Innovation & Knowledge

Recommendation agents (RAs) have proven to be effective decision-making tools for customers, as they can boost trust and loyalty when customers shop online. They can analyse large amounts of data using machine learning algorithms and…

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Negative / Null Result ReportOpen accessMaterials Science

Solar methane pyrolysis in a liquid metal bubble column reactor: Effect of medium type and gas injection configuration

Malek Msheik, Sylvain Rodat, Stéphane Abanades · 2024 · Journal of Analytical and Applied Pyrolysis

Solar methane pyrolysis in different molten media and reactor configurations was experimented to improve hydrogen production . Pure Sn, Ni 0.18 Sn 0.82 , Cu 0.45 Bi 0.55 , and KCl melts were compared at three different temperatures…

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Negative / Null Result ReportOpen accessComputer Science

Rapid Integration of LLMs in Healthcare Raises Ethical Concerns: An Investigation into Deceptive Patterns in Social Robots

Robert Ranisch, Joschka Haltaufderheide · 2025 · Digital Society

Abstract Conversational agents are increasingly used in healthcare, with Large Language Models (LLMs) significantly enhancing their capabilities. When integrated into social robots, LLMs offer the potential for more natural interactions. However, while LLMs promise numerous benefits, they also raise critical ethical concerns, particularly regarding hallucinations and deceptive patterns. In this case study, we observed a critical pattern of deceptive behavior in commercially available LLM-based care software integrated into robots. The LLM-equipped robot falsely claimed to have medication remin

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Negative / Null Result ReportOpen accessPhysics and Astronomy

An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 4: Impact of Fitting Functions in Estimated Absorbed Doses

Sara Kurkowska, Julia Brosch-Lenz, Yuni K. Dewaraja et al. · 2025 · Journal of Nuclear Medicine

Individualized radiopharmaceutical therapies guided by patient-specific absorbed dose (AD) assessments using nuclear medicine imaging have the potential to improve both efficacy and safety. Understanding sources of variability in AD calculations is critical for standardization. The Society of Nuclear Medicine and Molecular Imaging Dosimetry Task Force launched the 177Lu Dosimetry Challenge to evaluate variability across steps within the dosimetry workflow. This work aimed to assess the variability in ADs due to different fitting and integration methods. Methods: Anonymized datasets from 2 pati

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Negative / Null Result Report

Significant effects on neonatal morbidity and mortality after regional change in management of post‐term pregnancy

CHARLOTTA GRUNEWALD, STELLAN HÅKANSSON, SISSEL SALTVEDT et al. · 2010 · Acta Obstetricia et Gynecologica Scandinavica

Abstract Objective. To evaluate the effects on neonatal morbidity of a regional change in induction policy for post‐term pregnancy from 43 +0 to 42 +0 gestational weeks (GWs). Design and setting. Nationwide retrospective register study…

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Negative / Null Result ReportImmunology and Microbiology

Characterization of newly revealed sequences in the infectious myonecrosis virus genome in Litopenaeus vannamei

Duan S. Loy, Bradley J. Blitvich, John Dustin Loy et al. · 2015 · Journal of General Virology

Infectious myonecrosis virus (IMNV) causes significant economic losses in farmed shrimp, where associated mortality in ponds can reach 70 %. To explore host/pathogen interactions, a next-generation sequencing approach using lymphoid organ…

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Negative / Null Result ReportOpen accessNursing

The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation

Shih‐Wei Huang, Horng‐Chyuan Lin, Yu-Feng Chou et al. · 2022 · Nutrients

Prolonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake and PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of protein intake on weaning from mechanical ventilation. Patients with the PMV (mechanical ventilation ≥6 h/day for ≥21 days) at our hospital between December 2020 and April 2022 were included in this study. Demographic data, nutrition records, laboratory data, weaning conditions, and survival data were retrieved from the patient’s electronic medical records.

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Negative / Null Result ReportOpen accessMedicine

Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease

Stefan Bräuer, Iñaki Schniewind, Elisabeth Dinter et al. · 2025 · Acta Neuropathologica Communications

Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with a wide range of clinical phenotypes. Pathologically, it is characterized by neuronal inclusions containing misfolded, fibrillar alpha-synuclein (aSyn). Prion-like properties of aSyn contribute to the spread of aSyn pathology throughout the nervous system as the disease progresses. Utilizing these properties, seed amplification assays (SAA) enable the detection of aSyn pathology in living patients. We hypothesized that structurally distinct aSyn aggregates, or strains, may underlie the clinical heterogeneity of PD. To t

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Gαqprotein-induced cardiomyopathy

Valeriy Timofeyev, C. A. Porter, Dipika Tuteja et al. · 2010 · American Journal of Physiology-Heart and Circulatory Physiology

Adenylyl cyclase (AC) is the principal effector molecule in the β-adrenergic receptor pathway. AC(V) and AC(VI) are the two predominant isoforms in mammalian cardiac myocytes. The disparate roles among AC isoforms in cardiac hypertrophy…

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Negative / Null Result ReportEarth and Planetary Sciences

Tornadic Supercell Environments Analyzed Using Surface and Reanalysis Data: A Spatiotemporal Relational Data-Mining Approach

David John Gagne, Amy McGovern, Jeffrey B. Basara et al. · 2012 · Journal of Applied Meteorology and Climatology

Abstract Oklahoma Mesonet surface data and North American Regional Reanalysis data were integrated with the tracks of over 900 tornadic and nontornadic supercell thunderstorms in Oklahoma from 1994 to 2003 to observe the evolution of…

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Negative / Null Result Report

Pro-inflammatory response ensured by LPS and Pam3CSK4 in RAW 264.7 cells did not improve a fungistatic effect on Cryptococcus gattii infection

Gabriela Yamazaki de Campos, Raquel Amorim Oliveira, Patrícia Kellen Martins Oliveira-Brito et al. · 2020 · PeerJ

Background The macrophage lineage is characterized by plasticity due to the acquisition of distinct functional phenotypes, and two major subsets are evaluated; classical M1 activation (strong microbicidal activity) and alternative M2…

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Negative / Null Result ReportOpen accessMedicine

Selective internal radiation therapy (SIRT) for hepatocellular carcinoma (HCC): informing clinical practice for multidisciplinary teams in England

Helen L. Reeves, John Reicher, Georgia Priona et al. · 2022 · Frontline Gastroenterology

Objective: Hepatocellular carcinoma (HCC) deaths are rising alarmingly. Many patients are unsuitable for available therapies. Poor response rates further hamper outcomes for those that are. Selective internal radiation therapy (SIRT) offers hope, although which patients benefit over standard approaches remains unclear. Design/method: As a quality/service improvement, we audited consecutive patients treated with SIRT (2015-2020) by the Newcastle upon Tyne Hospitals National Health Service Foundation Trust HCC multidisciplinary team. Indications, Barcelona clinic liver cancer (BCLC) stage, treat

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Negative / Null Result ReportOpen accessEnvironmental Science

Regional models do not outperform continental models for invasive species

Catherine S. Jarnevich, Helen R. Sofaer, Pairsa Belamaric et al. · 2022 · NeoBiota

Aim : Species distribution models can guide invasive species prevention and management by characterizing invasion risk across space. However, extrapolation and transferability issues pose challenges for developing useful models for invasive species. Previous work has emphasized the importance of including all available occurrences in model estimation, but managers attuned to local processes may be skeptical of models based on a broad spatial extent if they suspect the captured responses reflect those of other regions where data are more numerous. We asked whether species distribution models fo

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Negative / Null Result Report

OXIDIZED LIPIDS DID NOT REDUCE LIFESPAN IN THE FRUIT FLY, Drosophila melanogaster

Oleh V. Lushchak, Dmytro V. Gospodaryov, Ihor S. Yurkevych et al. · 2015 · Archives of Insect Biochemistry and Physiology

Aging is often associated with accumulation of oxidative damage in proteins and lipids. However, some studies do not support this view, raising the question of whether high levels of oxidative damage are associated with lifespan. In the…

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Negative / Null Result ReportOpen accessMedicine

Serum Albumin Level at Intensive Care Unit Admission and Delirium Duration and Severity in Critically Ill Adults

Rosalyn Chi, Anthony J. Perkins, Yara Khalifeh et al. · 2024 · American Journal of Critical Care

BACKGROUND: Hypoalbuminemia has been associated with an increased risk of in-hospital delirium. However, the relationship between serum albumin levels and the duration and severity of delirium is not well defined. OBJECTIVE: To investigate…

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Negative / Null Result ReportOpen accessSocial Sciences

Women’s environmental quality of life is key to their overall quality of life and health: Global evidence from the WHOQOL-100

Suzanne M. Skevington, Kara Schick‐Makaroff, Christine Rowland et al. · 2024 · PLoS ONE

Gender inequalities in health-related quality of life (QoL) are generally few and small, even in large surveys. Many generic measures limit assessment to QoL overall and its physical and psychological dimensions, while overlooking internationally important environmental, social, and spiritual QoL domains. Unique cross-cultural legacy data was collected using four WHOQOL-100 surveys of adults living in 43 cultures world-wide (17,608 adults; ages 15-101). It was first used to examined gender profiles of its five QoL international domains, and their component facets. Few significant gender differ

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

The Road to Remyelination in Multiple Sclerosis: Breakthroughs, Challenges, and Considerations for Future Trial Design

Leah Zuroff, Vista Farkhondeh, Riley Bove et al. · 2025 · Drugs

Despite major advances in multiple sclerosis (MS) treatment, disability accumulation independent of relapse activity remains a significant challenge. Chronic demyelination is a key driver of neurodegeneration and disease progression,…

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Negative / Null Result ReportOpen accessMedicine

Genetic predictors of GLP1 receptor agonist weight loss and side effects

Qiaojuan Jane Su, James R. Ashenhurst, Wanwan Xu et al. · 2026 · Nature

The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity. However, substantial inter-person variability exists in both…

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Negative / Null Result ReportOpen accessEngineering

Hybrid combinations of graphene nanoplatelet, carbon nanotube, and carbon black for tailored mechanical and triboelectric properties in polypropylene fibers

Yue Cheng, Jian Wang, Mingwang Shao et al. · 2025 · Advanced Composites and Hybrid Materials

Hybrid polymer composites with carbon fillers are of great interest for applications requiring specific mechanical, electrical, and thermal properties. However, studies on hybrid polymer composite fiber (HPCF) with multiple carbon fillers…

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