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20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Entrepreneurial Skills, Significant Differences between Serbian and German Entrepreneurs

Carlos Morales, Percy Marquina Feldman · 2013 · Journal of CENTRUM Cathedra (JCC) The Business and Economics Research Journal

An extensive literature review reveals various authors acknowledge skills have an impact on entrepreneurial success. However, a lack of consensus regarding the main skills an entrepreneur needs is apparent. In this study, a contribution is made to the debate with empirical data and analysis, in two steps: by testing mean differences and reducing data with a principal components analysis. A sample of 394 potential entrepreneurs was administered the SAT-ECENT questionnaire, testing four skills: readiness to change, learning capacity, impact on people, and stress tolerance. The questionnaires wer

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Negative / Null Result ReportOpen accessMedicine

Is There Significant Difference between Digital and Glass Mercury Thermometer?

Hadgu Gerensea, Rajalakshmi Murugan · 2016 · Advances in Nursing

Background . Children’s decisions concerning investigation and treatment may be based on the results of temperature alone. Although the accuracy of axillary temperature measurement is affected by a number of factors, device dwell time and device type are common. Objective . Compare body temperature between glass mercury thermometer (GMT) and digital thermometer (DT). Method . Comparative descriptive study was used. A total of 101 samples were taken with convenient sampling technique, but 98 were analyzed. Statistical significance (p<0.01) and clinical significance (MD≥0.2°C) were used in th

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Negative / Null Result ReportPsychology

Hybrid Strategy—Interference or Integration? How Corporate Communication Impacts Consumers’ Memory and Company Evaluation

Zifei Fay Chen, Weiting Tao · 2020 · International Journal of Strategic Communication

This study investigates whether hybrid strategy would be more effective than corporate social responsibility (CSR) strategy in boosting CSR information recall and company evaluation. Informed by the corporate ability (CA)-CSR-hybrid…

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Negative / Null Result ReportOpen accessEnergy

Microalgae-mediated green synthesis of silver nanoparticles: a sustainable approach using extracellular polymeric substances from Graesiella emersonii KNUA204

Jeong‐Mi Do, Ji Won Hong, Ho‐Sung Yoon · 2025 · Frontiers in Microbiology

Traditional nanoparticle synthesis relies on chemical and physical methods that often involve hazardous reagents, high energy consumption, and environmental toxicity. As a sustainable alternative, biological synthesis utilizes biomolecules in an eco-friendly manner to form nanoparticles. This study explores the green synthesis of silver nanoparticles (AgNPs) using extracellular polymeric substances (EPS) secreted by the microalga Graesiella emersonii KNUA204, highlighting the potential of microalgal biomolecules in nanotechnology. EPS-rich supernatant from G. emersonii enabled AgNP formation u

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Negative / Null Result ReportOpen accessPsychology

Effectiveness and moderators of individual cognitive behavioral therapy versus treatment as usual in clinically depressed adolescents: a randomized controlled trial

Yvonne Stikkelbroek, Gerko Vink, Maaike H. Nauta et al. · 2020 · Scientific Reports

We examined if manualized cognitive behavioral therapy (CBT) was more effective than Treatment As Usual (TAU) for clinically depressed adolescents within routine care. This multisite Randomized controlled trail included 88 clinically depressed adolescents (aged 12-21 years) randomly assigned to CBT or TAU. Multiple assessments (pre-, post treatment and six-month follow-up) were done using semi-structured interviews, questionnaires and ratings and multiple informants. The primary outcome was depressive or dysthymic disorder based on the KSADS. Completers, CBT (n = 19) and TAU (n = 26), showed a

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Negative / Null Result ReportEnvironmental Science

Effects of competition with Bromus tectorum on early establishment of Poa secunda accessions: can seed source impact restoration success?

Mollie E. Herget, Kristina M. Hufford, Daniel L. Mummey et al. · 2015 · Restoration Ecology

When landscapes are heavily impacted by biological invasion, local populations of native plant species may no longer be adapted to altered environmental conditions. In these cases, it is useful to investigate alternative sources of…

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Negative / Null Result ReportMedicine

Is the Short Form of the Mini-Mental State Examination (MMSE) a better screening instrument for dementia in older primary care patients than the original MMSE? Results of the German study on ageing, cognition, and dementia in primary care patients (AgeCoDe).

Janine Stein, Melanie Luppa, Hanna Kaduszkiewicz et al. · 2015 · Psychological Assessment

The aim of the study was to investigate the psychometric properties of a Short Form of the Mini-Mental State Examination (SMMSE) for the screening of dementia in older primary care patients. Data were obtained from a large longitudinal…

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Negative / Null Result ReportOpen accessPsychology

A Cognitive Approach to the Instruction of Phrasal Verbs: Rudzka-Ostyn’s Model

Ghuzayyil Mohammed Al-Otaibi · 2019 · Journal of language and Education

English as a Foreign Language (EFL) learners find some phrasal verbs problematic because of their idiomatic and polysemous nature. They are frequently used in spoken English and textbooks suggest an arbitrary way in teaching them. Cognitive linguists proposed that the particle plays a major role in determining the meaning of such phrasal verbs. This study investigated the effectiveness of a cognitive approach (i.e., Rudzka-Ostyn’s Model) in teaching taught and new phrasal verbs including metaphorical ones. Using a list of frequent phrasal verbs, a quasi-experimental design was used in which an

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Negative / Null Result ReportMedicine

A Combination of Impulsivity Subdomains Predict Alcohol Intoxication Frequency

Laura O’Halloran, Brian Pennie, Lee Jollans et al. · 2018 · Alcoholism Clinical and Experimental Research

BACKGROUND: Impulsivity, broadly characterized as the tendency to act prematurely without foresight, is linked to alcohol misuse in college students. However, impulsivity is a multidimensional construct and different subdomains likely…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Directed Evolution Pipeline for the Improvement of Orthogonal Translation Machinery for Genetic Code Expansion at Sense Codons

Wil Biddle, David G. Schwark, Margaret A. Schmitt et al. · 2022 · Frontiers in Chemistry

The expansion of the genetic code beyond a single type of noncanonical amino acid (ncAA) is hindered by inefficient machinery for reassigning the meaning of sense codons. A major obstacle to using directed evolution to improve the efficiency of sense codon reassignment is that fractional sense codon reassignments lead to heterogeneous mixtures of full-length proteins with either a ncAA or a natural amino acid incorporated in response to the targeted codon. In stop codon suppression systems, missed incorporations lead to truncated proteins; improvements in activity may be inferred from increase

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Negative / Null Result Report

From Cytokine Storm to Cytokine Breeze: Did Lessons Learned from Immunopathogenesis Improve Immunomodulatory Treatment of Moderate-to-Severe COVID-19?

Goran Rondovic, Dragan Djordjevic, Ivo Udovicic et al. · 2022 · Biomedicines

Complex immune response to infection has been highlighted, more than ever, during the COVID-19 pandemic. This review explores the immunomodulatory treatment of moderate-to-severe forms of this viral sepsis in the context of specific…

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Negative / Null Result Report

Evaluation and Applications of the Clinically Significant Change Method with the Violence Risk Scale‐Sexual Offender Version: Implications for Risk‐Change Communication

Mark E. Olver, Sarah M. Beggs Christofferson, Stephen C. P. Wong · 2015 · Behavioral Sciences & the Law

We examined the use of the clinically significant change (CSC) method with the Violence Risk Scale‐Sexual Offender version (VRS‐SO), and its implications for risk communication, in a combined sample of 945 treated sexual offenders from…

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Negative / Null Result Report

Do robots outperform humans in human-centered domains?

Robert Riener, Luca Rabezzana, Yves Zimmermann · 2023 · Frontiers in Robotics and AI

The incessant progress of robotic technology and rationalization of human manpower induces high expectations in society, but also resentment and even fear. In this paper, we present a quantitative normalized comparison of performance, to…

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Negative / Null Result Report

Innate Immunity and CKD: Is There a Significant Association?

Moran Plonsky-Toder, Daniella Magen, Shirley Pollack · 2023 · Cells

Chronic kidney disease (CKD) constitutes a worldwide epidemic, affecting approximately 10% of the global population, and imposes significant medical, psychological, and financial burdens on society. Individuals with CKD often face elevated…

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Negative / Null Result Report

A case series: Association of anaphylaxis with a significant decrease in platelet levels and possible secondary risk of thrombosis

Brian P. Peppers, Anant Vatsayan, Jignesh Dalal et al. · 2018 · Immunity, Inflammation and Disease

Abstract Introduction Anaphylaxis is a life threatening systemic inflammatory process that share mediators involved in the coagulation cascade. Platelet activating factor, known to increase platelet aggregation, has also been implicated as…

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Negative / Null Result ReportOpen accessNeuroscience

Psychological mechanisms of offset analgesia: The effect of expectancy manipulation

Tibor M. Szikszay, Wacław M. Adamczyk, Janina Panskus et al. · 2023 · PLoS ONE

A frequently used paradigm to quantify endogenous pain modulation is offset analgesia, which is defined as a disproportionate large reduction in pain following a small decrease in a heat stimulus. The aim of this study was to determine whether suggestion influences the magnitude of offset analgesia in healthy participants. A total of 97 participants were randomized into three groups (hypoalgesic group, hyperalgesic group, control group). All participants received four heat stimuli (two constant trials and two offset trials) to the ventral, non-dominant forearm while they were asked to rate the

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Negative / Null Result ReportOpen accessMedicine

Replication of H9 influenza viruses in the human ex vivo respiratory tract, and the influence of neuraminidase on virus release

Renee W. Y. Chan, Louisa Chan, Chris Ka Pun Mok et al. · 2017 · Scientific Reports

H9N2 viruses are the most widespread influenza viruses in poultry in Asia. We evaluated the infection and tropism of human and avian H9 influenza virus in the human respiratory tract using ex vivo respiratory organ culture. H9 viruses infected the upper and lower respiratory tract and the majority of H9 viruses had a decreased ability to release virus from the bronchus rather than the lung. This may be attributed to a weak neuraminidase (NA) cleavage of carbon-6-linked sialic acid (Sia) rather than carbon-3-linked Sia. The modified cleavage of N-acetlylneuraminic acid (Neu5Ac) and N-glycolylne

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Negative / Null Result ReportOpen accessMedicine

Rescue of Infectious Rotavirus Reassortants by a Reverse Genetics System Is Restricted by the Receptor-Binding Region of VP4

Alexander Falkenhagen, Marno Huyzers, Alberdina A. van Dijk et al. · 2021 · Viruses

The rotavirus species A (RVA) capsid contains the spike protein VP4, which interacts with VP6 and VP7 and is involved in cellular receptor binding. The capsid encloses the genome consisting of eleven dsRNA segments. Reassortment events can result in novel strains with changed properties. Using a plasmid-based reverse genetics system based on simian RVA strain SA11, we previously showed that the rescue of viable reassortants containing a heterologous VP4-encoding genome segment was strain-dependent. In order to unravel the reasons for the reassortment restrictions, we designed here a series of

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