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20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Eight Days of L-Citrulline or L-Arginine Supplementation Did Not Improve 200-m and 100-m Swimming Time Trials

Ozcan Esen, Mustafa Can Eser, Mekki Abdioglu et al. · 2022 · International Journal of Environmental Research and Public Health

The effects of L-citrulline or L-arginine supplementation on exercise performance are equivocal, and the effects on swimming performance are unclear. We aimed to assess whether 8-day supplementation with L-arginine or L-citrulline…

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Negative / Null Result Report

Physical activity and prenatal depression: going beyond statistical significance by assessing the impact of reliable and clinical significant change

Marina Vargas-Terrones, Taniya S. Nagpal, Maria Perales et al. · 2020 · Psychological Medicine

Abstract Background Previous literature supports exercise as a preventative agent for prenatal depression; however, treatment effects for women at risk for prenatal depression remain unexplored. The purpose of the study was to examine…

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Negative / Null Result ReportOpen accessMedicine

Evaluating deep learning methods in detecting and segmenting different sizes of brain metastases on 3D post-contrast T1-weighted images

Youngjin Yoo, Pascal Ceccaldi, Siqi Liu et al. · 2021 · Journal of Medical Imaging

Purpose: We investigate the impact of various deep-learning-based methods for detecting and segmenting metastases with different lesion volume sizes on 3D brain MR images. Approach: A 2.5D U-Net and a 3D U-Net were selected. We also…

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Negative / Null Result Report

Mid‐term results show no significant difference in postoperative clinical outcome, pain and range of motion between a well‐established total knee arthroplasty design and its successor: a prospective, randomized, controlled trial

Georg Hauer, Nina Hörlesberger, Sebastian Klim et al. · 2020 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose The purpose of this study was to compare the clinical and functional outcome scores following total knee arthroplasty (TKA) with two different systems. The hypothesis was that there is a difference between patients…

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Negative / Null Result Report

Saline versus Saline with Blood as a Contrast Agent for Right‐to‐left Shunt Diagnosis by Transcranial Doppler: Is There a Significant Difference?

Marcos Christiano Lange, Viviane Flumignan Zétola, Élcio J Piovesan et al. · 2010 · Journal of Neuroimaging

ABSTRACT BACKGROUND AND PURPOSE Agitated saline solution (AS) is the contrast agent (CA) of choice for the diagnosis of right‐to‐left shunt (RLS). The aim of this study was to compare AS to AS with blood (ASb) in the diagnosis and…

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Negative / Null Result ReportAgricultural and Biological Sciences

Stay cool, travel far: cold‐acclimated oriental fruit moth females have enhanced flight performance but lay fewer eggs

Aurélie Ferrer, Dominique Mazzi, Silvia Dorn · 2014 · Entomologia Experimentalis et Applicata

Abstract Acclimation to a particular environment may provide organisms with advantages in that environment. In species with multiple generations per year, acclimation may cause life‐history traits to vary with season and between…

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Negative / Null Result Report

Home-based intervention for non-Hispanic black families finds no significant difference in infant size or growth: results from the Mothers & Others randomized controlled trial

Heather M. Wasser, Amanda L. Thompson, Chirayath M. Suchindran et al. · 2020 · BMC Pediatrics

Abstract Background Non-Hispanic black (NHB) infants are twice as likely as non-Hispanic white infants to experience rapid weight gain in the first 6 months, yet few trials have targeted this population. The current study tests the…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis

Guadalupe Nibeyro, Verónica M. Baronetto, Juan I. Folco et al. · 2023 · Frontiers in Immunology

Introduction: Identification of tumor specific neoantigen (TSN) immunogenicity is crucial to develop peptide/mRNA based anti-tumoral vaccines and/or adoptive T-cell immunotherapies; thus, accurate in-silico classification/prioritization proves critical for cost-effective clinical applications. Several methods were proposed as TSNs immunogenicity predictors; however, comprehensive performance comparison is still lacking due to the absence of well documented and adequate TSN databases. Methods: Here, by developing a new curated database having 199 TSNs with experimentally-validated MHC-I present

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Skill-relatedness and employment growth of firms in times of prosperity and crisis in an oil-dependent region

John-Erik Rørheim, Ron Boschma · 2021 · Environment and Planning A Economy and Space

Many studies have shed light on the positive side of relatedness, but little attention has yet been devoted to possible downsides of relatedness for firm performance in regions. We found in a case study of the oil-dependent Stavanger region in Norway that plants in industries that are skill-related to the dominant oil and gas industry showed lower employment growth than plants in other industries. This was the case both in the boom and the crisis periods, even when controlling for supply linkages to the oil and gas sector. However, we also found that plants skill-related to the oil and gas ind

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Negative / Null Result Report

Writing as a Tool to Demonstrate Mathematical Understanding

Christie Lynn Martin · 2015 · School Science and Mathematics

In this study, I examine how using a writers' workshop model in mathematics creates a space for students to write about their mathematical thinking and problem solving and how their writing impacts instruction. This case study of one…

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Negative / Null Result ReportMedicine

Results of the Kigali Imbereheza Project: A 2-Arm Individually Randomized Trial of TI-CBT Enhanced to Address ART Adherence and Mental Health for Rwandan Youth Living With HIV

Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · JAIDS Journal of Acquired Immune Deficiency Syndromes

Background: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. Setting: Two urban clinics in Kigali, Rwanda. Methods: A 2-arm individual randomized controlled trial compared…

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Negative / Null Result ReportPsychology

Impact of a Student Success Course on Undergraduate Academic Outcomes

Leah D. Hoops, Shirley L. Yu, Andrea Burridge et al. · 2015 · Journal of College Reading and Learning

Both community colleges and four-year institutions offer Student Success Courses (SSCs) to promote student engagement (self-regulated learning, SRL) and performance (grades, retention, and graduation). However, little work has been done to…

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Negative / Null Result ReportOpen accessImmunology and Microbiology

Significant association of CD4+CD25+Foxp3+ regulatory T cells with clinical findings in patients with systemic lupus erythematosus

Xiaofan Yang, Weiwen Wang, Juan Xu et al. · 2019 · Annals of Translational Medicine

Background: Regulatory T (Treg) cells are one of the important mechanisms in maintaining self-tolerance and immune homeostasis. CD4+CD25+Foxp3+Treg is considered to have a role in the pathogenesis of systemic lupus erythematosus (SLE).…

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Negative / Null Result ReportAgricultural and Biological Sciences

A genome‐wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep

Allegra Niggeler, Jens Tetens, Anna Stäuble et al. · 2017 · Animal Genetics

Footrot is one of the most important causes of lameness in global sheep populations and is characterized by a bacterial infection of the interdigital skin. As a multifactorial disease, its clinical representation depends not only on…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing

Mohamad Saad, Ayman El‐Menyar, Khalid Kunji et al. · 2022 · Circulation Genomic and Precision Medicine

Background: Enthusiasm for using polygenic risk scores (PRSs) in clinical practice is tempered by concerns about their portability to diverse ancestry groups, thus motivating genome-wide association studies in non-European ancestry…

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Negative / Null Result ReportMedicine

Replication of a predictive model for youth ADHD in an independent sample from a developing country

Cezar H. Lorenzi, Douglas Teixeira Leffa, Rodrigo A. Bressan et al. · 2022 · Journal of Child Psychology and Psychiatry

BACKGROUND: Very few predictive models in Psychiatry had their performance validated in independent external samples. A previously developed multivariable demographic model for attention-deficit/hyperactivity disorder (ADHD) accurately…

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Negative / Null Result ReportOpen accessMedicine

Re-Sequencing of the <b><i>APOL1</i></b>-<b><i>APOL4</i></b> and <b><i>MYH9</i></b> Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression

Gregory A. Hawkins, David J. Friedman, Lingyi Lu et al. · 2015 · American Journal of Nephrology

<b><i>Background:</i></b> In African Americans (AAs), <i>APOL1</i> G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern.…

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Negative / Null Result ReportOpen accessSocial Sciences

Challenging Empathic Deficit Models of Autism Through Responses to Serious Literature

Melissa Chapple, Philip Davis, Josie Billington et al. · 2022 · Frontiers in Psychology

Dominant theoretical models of autism and resultant research enquiries have long centered upon an assumed autism-specific empathy deficit. Associated empirical research has largely relied upon cognitive tests that lack ecological validity and associate empathic skill with heuristic-based judgments from limited snapshots of social information. This artificial separation of thought and feeling fails to replicate the complexity of real-world empathy, and places socially tentative individuals at a relative disadvantage. The present study aimed to qualitatively explore how serious literary fiction,

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Negative / Null Result ReportMedicine

Dyslipidemia Is a Major Factor in Stem Cell Damage Induced by Uncontrolled Long-Term Type 2 Diabetes and Obesity in the Rat, as Suggested by the Effects on Stem Cell Culture

Maryam Masouminia, R. Gelfand, Istvan Kovanecz et al. · 2018 · The Journal of Sexual Medicine

BACKGROUND: Previous work showed that muscle-derived stem cells (MDSCs) exposed long-term to the milieu of uncontrolled type 2 diabetes (UC-T2D) in male obese Zucker (OZ) rats, were unable to correct the associated erectile dysfunction and…

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