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422 real negative results, null findings, and replication failures · Replication Failure. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Replication FailureMedicine

UGT76B1 and 41 Additional Arabidopsis UDP-Glycosyltransferases Show No Detectable In Vitro Glycosylation Activity Toward <i>N</i>-Hydroxypipecolic Acid.

Bao J, Uchiyama T, Kusunoki K et al. · 2026 · Life (Basel, Switzerland)

N -hydroxypipecolic acid (NHP) is a key mobile signal in systemic acquired resistance in plants, and its glycosylation has been proposed to regulate immune signaling. Previous studies have demonstrated that the UDP-glycosyltransferase…

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Replication FailureOpen accessMedicine

Platelet desialylation, apoptosis, and T-lymphocyte-mediated immune dysregulation: unveiling the pathways of platelet clearance in platelet transfusion refractoriness.

Zhou Y, Zhong Z, Mo H et al. · 2026 · Research and practice in thrombosis and haemostasis

Background Platelet transfusion refractoriness (PTR) is a clinical challenge that can be classified into nonimmunologic and immunologic types, the latter resulting from both platelet alloimmunization and autoimmunity. Recent studies have…

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Replication FailureOpen accessMedicine

Searching for vertically transmitted endosymbionts in over 4,000 wild strains of three self-fertilizing <i>Caenorhabditis</i> species.

O'Connor LM, Singh A, Luallen RJ et al. · 2026 · microPublication biology

Vertically transmitted endosymbionts are microbes that live inside host cells and are transmitted between parent and offspring. Free-living nematodes interact with a wide variety of microbes but no vertically transmitted microbes have been…

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Replication FailureMedicine

Balancing the Game: The Relationship of Lower-Limb Asymmetry With Youth Soccer (Football) Performance - Laboratory vs. Field Insights.

Bartusevičius D, Stanislovaitienė J, Conte D · 2026 · Journal of strength and conditioning research

Abstract Bartusevičius, D, Stanislovaitienė, J, and Conte, D. Balancing the game: the relationship of lower-limb asymmetry with youth soccer (football) performance - laboratory vs. field insights. J Strength Cond Res XX(X): 000-000,…

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Replication FailureOpen accessNutritional diseases. Deficiency diseases

Sex-specific associations between type 2 diabetes and muscle health in middle-aged adults

Yijia Wang, Songting Gao, Qiang Xu et al. · 2025 · Diabetology & Metabolic Syndrome

Abstract Background Type 2 diabetes mellitus (T2DM) and sarcopenia have emerged as significant public health challenges that disproportionately affect middle-aged adults. However, the relationship between T2DM and muscle parameters in this critical age remains inadequately elucidated. Methods We conducted a comprehensive analysis of cross-sectional data derived from 2,446 middle-aged participants (aged 40–59 years; 1,230 men and 1,216 women) enrolled in the National Health and Nutrition Examination Survey (NHANES) 2011–2014. T2DM was defined by physician-confirmed diagnosis and/or glycohemoglo

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Replication FailureOpen accessInternal medicine

Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population

Bintang Y.M. Sinaga, Muhammad Amin, Yahwardiah Siregar et al. · 2014 · Acta Medica Indonesiana

Aim: to explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population. Methods: matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP. Results: the frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7%

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Replication FailureOpen access

Effect of feeding low protein diets supplemented with selected essential amino acids on growth performance and gut health in early weaned Large White Yorkshire piglets

N. Mohan, M. Dipu, K. Ally et al. · 2023 · Journal of Veterinary and Animal Sciences

A study was conducted to assess the effect of feeding low protein diets supplemented with selected amino acids on growth performance and gut health in early weaned Large White Yorkshire piglets. Thirty Large White Yorkshire female piglets…

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Replication Failure

Pyruvate and α-ketoglutarate precursor feeding combined with methyl jasmonate elicitation increases anthraquinone accumulation in hairy root cultures of Rubia tinctorum

Kalapuj Y, Perassolo M, Rodrïguez JM et al. · 2026 · Preprint

Abstract Anthraquinones (AQs) are specialized metabolites produced by Rubia tinctorum that have traditionally been used as dyes, but also have important biological activities. The present research studied the effects of the addition of…

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Replication FailureOpen accessComputer Science

Spin Transfer Torque Driven Coupled Oscillators for Self-Oscillating RF Mixers

Supriyo Maji · 2017 · arXiv

Spin transfer torque oscillators (STOs) based on magnetic tunnel junction (MTJ) devices are emerging as a possible replacement for complementary metal-oxide semiconductors for radio-frequency (RF) signal generation. Advantages include low power consumption, small device area, and large frequency tunability. But such a single device cannot achieve the necessary noise performance for RF applications. It has been reported lately that a network of globally coupled STOs achieves significant improvement in phase noise. The study here is to propose use of such coupled STOs as self-oscillating RF mixe

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Replication FailureOpen accessComputer Science

Chains That See, Answers That Don't: A Multi-Aspect Evaluation Recipe for Forced Chain-of-Thought on Video-MME

Zhichao Fan, Yanhang Li, Zexin Zhuang · 2026 · arXiv

Forced chain-of-thought (CoT) is widely assumed to make vision-language models more reliable on video question answering. We propose a small three-probe evaluation recipe to test that assumption: paired accuracy across direct, CoT, answer-first, and no-video conditions; a counterfactual video-swap diagnostic over the CoT chains; and a four-rung visual-degradation ladder. Each probe is reported under both a strict and a permissive regex scorer, with multiplicity correction over a manuscript-declared primary family. Applied to Qwen2.5-VL on Video-MME subsets, the recipe returns a two-part findin

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Replication FailureOpen accessComputer Science

Not All Flips Are Conformity: Decomposing Stance Convergence in Multi-Agent LLM Debate

Xiqi Hao, Zengqing Wu, Yu-Xuan Qiu et al. · 2026 · arXiv

Multi-agent debate (MAD) is a promising strategy for improving LLM reasoning, but when agents converge on a shared answer, it is unclear whether that convergence reflects genuine deliberation or social compliance. We show that the conventional answer flip rate conflates three distinct mechanisms: spontaneous instability, stance-induced conformity, and reasoning-induced persuasion. Our three-source decomposition framework isolates each through controlled counterfactual conditions. In the primary MMLU-Pro setting, 37% of agent-question observations change under self-reflection alone, while robus

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Replication FailureOpen accessComputer Science

Contrastive Predictive Coding Done Right for Mutual Information Estimation

J. Jon Ryu, Pavan Yeddanapudi, Xiangxiang Xu et al. · 2025 · arXiv

The InfoNCE objective, originally introduced for contrastive representation learning, has become a popular choice for mutual information (MI) estimation, despite its indirect connection to MI. In this paper, we demonstrate why InfoNCE should not be regarded as a valid MI estimator, and we introduce a simple modification, which we refer to as InfoNCE-anchor, for accurate MI estimation. Our modification introduces an auxiliary anchor class, enabling consistent density ratio estimation and yielding a plug-in MI estimator with significantly reduced bias. Beyond this, we generalize our framework us

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Replication FailureOpen accessMathematics

Mixing on $k$ Columns of the Transvection Walk

Natesh Pillai, Aaron Smith · 2026 · arXiv

In Diaconis and Saloff-Coste (1996), the authors introduced the simple ``transvection" walk on $\mathrm{GL}_n(\mathbb F_2)$: at each step, choose two distinct rows and add one to the other. In Ben-Hamou (2025), the author recently proved that this walk has mixing time $O(n^2\log n)$. Inspired by applications in cryptography (see Sotiraki (2016)), Ben-Hamou and Peres (2018) conjectured that the first $k$ columns of this walk mixed in $O(nk \log(n))$ steps. Our main result is a proof of this conjecture uniformly in $n$ and $k.$ Our proof is based on a local-to-global entropy estimate, in the spi

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Replication FailureOpen accessGynecology and obstetrics

Association of cytotoxic T-lymphocyte-associated protein 4 polymorphisms with recurrent pregnancy loss: A case-control study

Fereshteh Vaziri Nezamdoust, Hossein Hadinedoushan, Nasrin Ghasemi · 2023 · International Journal of Reproductive BioMedicine

Abstract Background: A large proportion of cases of recurrent pregnancy loss (RPL) are associated with immunological factors. Objective: This study investigated the association between single nucleotide polymorphisms of cytotoxic T-lymphocyte-associated protein (CTLA)-4 gene in women with a history of RPL compared to healthy women. Materials and Methods: A case-control study was performed on 2 groups consisting of 120 healthy women with no history of abortion and at least one delivery (control) and 120 women with a history of 2 or more primary RPLs (case). In addition, 5 mL of peripheral blood

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