Negative / Null Result Report
A.R.J.V. Vossen, H.H. van der Zee, N. Davelaar et al. · 2018 · Journal of the European Academy of Dermatology and Venereology
Abstract Background Treatment with apremilast has recently demonstrated clinically meaningful improvement in moderate hidradenitis suppurativa ( HS ). Objective To evaluate the change in expression of inflammatory markers in lesional skin…
View details →Negative / Null Result Report
Yoshitaka Shimada, Yoshihito Takahashi, Hiroyoshi Iguchi et al. · 2013 · Journal of Medical Case Reports
Abstract Introduction Liver cavernous hemangioma is the most common noncystic hepatic lesion, and a hemangioma that undergoes degeneration and fibrous replacement is called a hepatic sclerosed hemangioma. Case presentation A 63-year-old…
View details →Negative / Null Result Report
Shan Ren, Wenjing Wang, Junfeng Lu et al. · 2022 · Frontiers in Immunology
Objective In clinical practice, a substantial proportion of chronic hepatitis B virus (HBV) infections that do not fit into any of the usual immune states are considered to be in the “grey zone (GZ)”. This study aimed to investigate the…
View details →Negative / Null Result Report
Juliana Chen, Harpreet Kaur, Joanna Jaques et al. · 2022 · Clinical Obesity
Summary Despite the obesity epidemic, there are relatively few multidisciplinary obesity services in Australia, and only limited data on the effectiveness of these services. The aim of this study was to evaluate the effectiveness of a…
View details →Negative / Null Result Report
Jorge G. Ruiz, Allen D. Andrade, Ramanakumar Anam et al. · 2013 · The Diabetes Educator
Purpose The purpose of this study was to investigate whether computer-based programmed instruction (CPI) with a dynamic avatar (DA) improves retention of medication information better than text (controls) or better than CPI with text…
View details →Negative / Null Result Report
Johan P. Mackenbach, Marina Karanikolos, Jamie Lopez Bernal et al. · 2015 · Scandinavian Journal of Public Health
Background: The upturn of life expectancy in Central and Eastern Europe in the 1990s, after a period of stagnation or even decline, is one of the main events in European population history of the late 20th century, but has not been…
View details →Negative / Null Result Report
Winston A. Haynes, Kathy Kamath, Rebecca Waitz et al. · 2021 · Frontiers in Immunology
Identification of the antigens associated with antibodies is vital to understanding immune responses in the context of infection, autoimmunity, and cancer. Discovering antigens at a proteome scale could enable broader identification of…
View details →Negative / Null Result Report
Melissa A. Snyder, Kieran McCann, Maryline J. Lalande et al. · 2016 · Journal of Neurochemistry
Abstract The sigma‐1 receptor (σ‐1R) is a chaperone protein located at the endoplasmic reticulum ( ER ) mitochondrial interface with roles in neuroprotection and cognition. Increasing evidence suggests that loss of σ‐1R function could…
View details →Negative / Null Result Report
Lauren N. Forrest, Ross C. Jacobucci, Carlos M. Grilo · 2020 · Psychological Medicine
Abstract Background Eating-disorder severity indicators should theoretically index symptom intensity, impairment, and level of needed treatment. Two severity indicators for binge-eating disorder (BED) have been proposed (categories of…
View details →Negative / Null Result Report
Hao Huang, Wei Song, Xue‐Yan Liu · 2021 · Global Change Biology
Abstract Anthropogenic nitrogen (N) emissions and deposition have been increasing over past decades. However, spatiotemporal variations of N deposition levels and major sources remain unclear in many regions, which hinders making…
View details →Negative / Null Result Report
Volodymyr Dvornyk, Irina Ponomarenko, Oksana Minyaylo et al. · 2021 · PLOS ONE
Background and purpose The study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases ( MMPs ) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia. Methods The 781…
View details →Negative / Null Result Report
Anne M Rowat, Catriona Graham, Martin Dennis · 2018 · BMJ Open Gastroenterology
Objective To establish the likely accuracy of pH testing to identify gastric aspirates at different pH cut-offs to confirm nasogastric tube placement. Methods This prospective observational study included a convenience sample of adult…
View details →Negative / Null Result Report
Aydin Demircioğlu · 2023 · Diagnostics
In radiomics, utilizing features extracted from pretrained deep networks could result in models with a higher predictive performance than those relying on hand-crafted features. This study compared the predictive performance of models…
View details →Negative / Null Result Report
Veeral Ajmera, Na Wang, Hanfei Xu et al. · 2023 · Alimentary Pharmacology & Therapeutics
Summary Background Adiposity amplifies the genetic risk of non‐alcoholic fatty liver disease (NAFLD). Aim We evaluated the association between overweight‐years, a cumulative exposure based on the product of the duration and severity of…
View details →Negative / Null Result ReportOpen accessEngineering
Shujun Hu, Xiaopeng Yin, Wen Liu et al. · 2025 · Structures
In prefabricated concrete structures, interfacial slip induced by shear at connection zones can critically undermine structural integrity, particularly when load transfer relies on reinforcing bar lap splices. To address this issue, this…
View details →Negative / Null Result ReportOpen accessNeuroscience
Nicholas Forelli, Trace Thome, Deborah Eaton et al. · 2026 · Science
Abstract Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant pharmacologic target of SGLT2i…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roberta Ottria, Susan Mirmajidi, Pierangela Ciuffreda · 2026 · International Journal of Molecular Sciences
This review delves into the complex relationship between short-chain fatty acids (SCFAs) produced by the gut microbiota and inflammatory bowel disease (IBD). IBD, which includes Crohn's disease and ulcerative colitis, is a group of chronic gastrointestinal disorders with an increasing global incidence. Despite extensive research, the exact etiopathogenesis remains elusive, although a complex interplay involving genetic predisposition, environmental influences, and abnormal immune responses against commensal gut microbes is widely recognized. SCFAs, primarily acetate and butyrate, emerge as key
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Claudia Monaco, Coleen A. McNamara, Bram Slütter et al. · 2025 · Physiological Reviews
Cardiovascular disease is the global number one cause of mortality and morbidity. The majority of cardiovascular diseases are caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roohi Chaudhary, Ralf Weiskirchen, Marcelo Ehrlich et al. · 2025 · Frontiers in Pharmacology
The transforming growth factor-β (TGF-β) superfamily (TGF-β-SF) comprises over 30 cytokines, including TGF-β, activins/inhibins, bone morphogenetic proteins (BMPs), and growth differentiation factors (GDFs). These cytokines play critical roles in liver function and disease progression. Here, we discuss Smad-dependent (canonical) and non-Smad pathways activated by these cytokines in a hepatocellular context. We highlight the connection between the deregulation of these pathways or the balance between them and key hepatocellular processes (e.g., proliferation, apoptosis, and epithelial-mesenchym
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Tingting Bai, Dong Xu, Muhammad Ali Nasir · 2026 · Technological Forecasting and Social Change
With the accelerating growth of the digital economy, digital technology—as a type of general-purpose technology—creates a more inclusive and open environment for innovation, thereby facilitating the shift toward a low-carbon economy by promoting green innovation. However, we know little about whether there are differences in the roles of various types of green innovation. Therefore, this study evaluates the impact of DE on low-carbon development (LCD) through heterogeneous green innovation. The results show that DE has a significant nonlinear effect on LCD, with an initial suppressing effect t
View details →Negative / Null Result ReportOpen accessEnergy
Yuqi Ren, Miao Cheng, Hongbin He et al. · 2025 · Nature Communications
CO2-to-hydrocarbon fuel conversion via artificial photosynthesis is limited by catalyst poisoning under high O2 partial pressures and sluggish C2-product formation. Herein, Ru0.6Cu1(Cu0–Cu1+)/CeO2 catalysts with adaptive O2 tolerance are…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Clare Balboni, Robin Burgess, Benjamin Olken · 2025 · The Review of Economic Studies
Abstract Environmental externalities—uncompensated damages imposed on others—lie at the root of climate change, pollution, deforestation and biodiversity loss. Empirical evidence is limited, however, as to how externalities drive private decision making. We study one such behaviour, illegal tropical forest fires, using 15 years of daily satellite data covering over 107,000 fires across Indonesia. Weather-induced variation in fire spread risk and variation in who owns surrounding land allow us to identify how far externalities influence the decision to use fire. Relative to when all spread risk
View details →Negative / Null Result ReportOpen accessPsychology
Kata Gellén, David Buttelmann · 2017 · Child Development Research
Rather than reenacting every action they observe, preverbal infants adapt their imitative behavior. Although previous studies have revealed the capability of preverbal infants to imitate selectively, the question about the adaptability of this behavior on an individual level did not attract considerable scientific attention until now. In the current study, we investigated whether 14-month-old infants flexibly alternate their imitative response in accordance with a model’s changing physical constraints in a body-part imitation paradigm. Participants were presented with two novel actions whereby
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Aris Katzourakis, Stéphane Hué, Paul Kellam et al. · 2011 · Journal of Virology
Xenotropic murine leukemia virus (MLV)-related virus (XMRV) has been amplified from human prostate cancer and chronic fatigue syndrome (CFS) patient samples. Other studies failed to replicate these findings and suggested PCR contamination…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Aliasghar Azma, Yakun Liu, Eden Tatek Alemu · 2026 · Scientific Reports
The aim of this study was to evaluate groundwater quality the Marvdasht aquifer using the Groundwater Quality Index (GWQI), which was determined using a conventional method and also predicted using three machine learning algorithms:…
View details →Negative / Null Result ReportOpen accessNeuroscience
Yi-Ting Chiu, Ariel Y. Deutch, Wei Wang et al. · 2026 · Nature Neuroscience
ABSTRACT Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety, post-traumatic stress disorder,…
View details →Negative / Null Result ReportOpen accessEngineering
Takahiro Ezaki, Kazumichi Ohtsuka, Mohcine Chraibi et al. · 2026 · Qucosa (Saxon State and University Library Dresden)
To better design safe and comfortable urban spaces, understanding the nature of human crowd movement is important. However, precise interactions among pedestrians are difficult to measure in the presence of their complex decision-making processes and many related factors. While extensive studies on pedestrian flow through bottlenecks and corridors have been conducted, the dominant mode of interaction in these scenarios may not be relevant in different scenarios. Here, we attempt to decipher the factors that affect human reactions to other individuals from a different perspective. We conducted
View details →Negative / Null Result ReportOpen accessMedicine
Katherine L. Ford, Michael B. Sawyer, Sunita Ghosh et al. · 2024 · ESMO Open
•Patients were able to increase and sustain dietary protein intake from preintervention levels.•Over one-half of patients in the 2.0 g/kg/day group maintained or gained MM with a 12-week targeted nutrition intervention.•This work…
View details →Negative / Null Result ReportOpen accessNeuroscience
Brian Premchand, Liyuan Liang, Kok Soon Phua et al. · 2024 · NeuroSci
Detecting stress is important for improving human health and potential, because moderate levels of stress may motivate people towards better performance at cognitive tasks, while chronic stress exposure causes impaired performance and health risks. We propose a Brain-Computer Interface (BCI) system to detect stress in the context of high-pressure work environments. The BCI system includes an electroencephalogram (EEG) headband with dry electrodes and an electrocardiogram (ECG) chest belt. We collected EEG and ECG data from 40 participants during two stressful cognitive tasks: the Cognitive Vig
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Chris Kent, Adam A. Scaife, Nick Dunstone et al. · 2025 · npj Climate and Atmospheric Science
Abstract Machine learning weather models trained on observed atmospheric conditions can outperform conventional physics-based models at short- to medium-range (1–14 day) forecast timescales. Here we take the machine learning model ACE2, trained to predict 6-hourly steps in atmospheric evolution and which can remain stable over long forecast periods, and assess it from a seasonal forecasting perspective (1–3 month lead time). Applying persisted sea surface temperature (SST) and sea-ice anomalies centred on 1 st November each year, we initialise a lagged ensemble of seasonal predictions covering
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