Negative / Null Result ReportOpen accessPhysics and Astronomy
Francesco D’Eugenio, Ignas Juodžbalis, Xihan Ji et al. · 2025 · Monthly Notices of the Royal Astronomical Society
ABSTRACT We present a ‘Little Red Dot’ (LRD) broad-line active galactic nucleus (AGN) at $z=5.077 $, observed with NIRSpec/MSA (micro-shutter assembly) and NIRSpec/IFU (integral-field unit) by the JADES (JWST Advanced Deep Extragalactic Survey) and BlackTHUNDER (Black holes in THe early Universe aNd their DensE surRoundings) surveys. Combining spatially resolved and high-resolution spectroscopy, we characterize its central engine, host, and environment. H$\alpha $ has multiple components, including two broad Gaussians, yielding a black-hole mass $\log (M_{\bullet }/{\rm M}_\odot) = 7.65 $, whi
View details →Negative / Null Result ReportOpen accessMedicine
Yuting Tan, Rui Xue, Yuwei Pan et al. · 2026 · Signal Transduction and Targeted Therapy
The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis of cancer cachexia, a syndrome affecting ~50-80% of cancer patients with various incidences of different types of malignancies. Despite its prevalence, a comprehensive understanding of cancer cachexia progression, with a holistic view at the cross-organismal, cellular and molecular levels, remains elusive. In this review, we undertake an in-depth exploration of the relevant target organs and their regulatory roles in cancer cachexia, with a particular focus on m
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Rickard Strandberg, Fredrik Åberg, Juho Asteljoki et al. · 2025 · BMJ
OBJECTIVE: To develop and validate a novel risk prediction model for incident major adverse liver outcomes (MALO) in a primary care setting. DESIGN: Population based cohort study. SETTING: Sweden, with validation in Finland and the UK.…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jiayi Liu, Weichen Hong, Zhendong Sun et al. · 2026 · Frontiers in Immunology
The proposal of the gut-lung axis has profoundly reshaped our understanding of the mechanisms underlying respiratory diseases. As a crucial component of this axis, the gut microbiota plays a central role in pulmonary immune regulation through inter-organ communication mediated by metabolic products. However, a systematic integration of mechanisms explaining how gut microbes achieve precise cross-organ immune regulation remains elusive. Existing research predominantly focuses on descriptive observations, such as the association between early-life microbiota dysbiosis and an increased risk of as
View details →Negative / Null Result ReportOpen accessEngineering
Denis A. Zadkov, Nikita MARTYUSHEV, Boris V. Malozyomov et al. · 2026 · Mathematics
In this study, a comprehensive mathematical method for modeling the operational reliability of mine hoisting equipment under conditions of incomplete and heavily censored data is developed. The analyzed dataset includes 259 observations collected over a five-year period for six critical components, with the overall level of censoring reaching 62% and exceeding 70% for long life mechanical subsystems. Considering right, left, and interval censoring, the paper proposes a unified statistical procedure that combines empirical estimation of failure rates with parametric identification using Weibull
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Aras Fahrettin Korkmaz, Fatih Ekinci, Şehmus Altaş et al. · 2025 · Biology
This study presents a novel approach for classifying Discomycetes species using deep learning and explainable artificial intelligence (XAI) techniques. The EfficientNet-B0 model achieved the highest performance, reaching 97% accuracy, a 97% F1-score, and a 99% AUC, making it the most effective model. MobileNetV3-L followed closely, with 96% accuracy, a 96% F1-score, and a 99% AUC, while ShuffleNet also showed strong results, reaching 95% accuracy and a 95% F1-score. In contrast, the EfficientNet-B4 model exhibited lower performance, achieving 89% accuracy, an 89% F1-score, and a 93% AUC. These
View details →Negative / Null Result ReportOpen accessMedicine
Dominika Szalewska, Renata Główczyńska, Ryszard Piotrowicz et al. · 2021 · ESC Heart Failure
AIMS: The aim of our study was to analyse the benefits of a 9 week hybrid comprehensive telerehabilitation (HCTR) programme in heart failure (HF) patients according to aetiology, as a subanalysis of the Telerehabilitation in Heart Failure…
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Lionel Perrier, Frédéric Balusson, Magali Morelle et al. · 2024 · Radiotherapy and Oncology
BACKGROUND AND PURPOSE: We performed a cost-effectiveness analysis (CEA) comparing an adaptive radiotherapy (ART) strategy, based on weekly replanning, aiming to correct the parotid gland overdose during treatment and expecting therefore…
View details →Negative / Null Result ReportOpen accessMedicine
Harold E. Lebovitz, Bernhard Ludvik, Jarosław Kozakowski et al. · 2015 · Physiological Reports
Gastric electrical stimulation with the implanted DIAMOND device has been shown to improve glycemic control and decrease weight and systolic blood pressure in patients with type 2 diabetes inadequately controlled with oral antidiabetic agents. The objective of this study was to determine if device implantation alone (placebo effect) contributes to the long-term metabolic benefits of DIAMOND(®) meal-mediated gastric electrical stimulation in patients with type 2 diabetes. The study was a 48 week randomized, blinded, cross-over trial in university centers comparing glycemic improvement of DIAMON
View details →Negative / Null Result ReportOpen accessMedicine
В. Т. Ивашкин, М. V. Maevskaya, Е. Н. Широкова et al. · 2021 · Drugs - Real World Outcomes
While no “gold-standard” pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) is yet established, essential phospholipids (EPLs) are reported to decrease steatosis and improve laboratory parameters. This analysis evaluated…
View details →Negative / Null Result ReportOpen accessMedicine
James M. Heun, Axel Grothey, Megan E. Branda et al. · 2011 · The Oncologist
Abstract Learning Objectives After completing this course, the reader will be able to: Explain the difference in survival prediction between response criteria (WHO) when used as a two-level variable (CR/PR vs. other) and as a three-level…
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Maheswari Senthil, Farshid Dayyani · 2023 · BMC Cancer
BACKGROUND: Studies from Asia indicate that normothermic intraperitoneal chemotherapy (NIPEC) may confer survival benefit in patients with gastric peritoneal carcinomatosis (PC). However, data regarding this approach is lacking in western population. The current STOPGAP trial is intended to assess 1-year progression-free survival benefit of sequential systemic chemotherapy and paclitaxel NIPEC in patients with gastric/ gastroesophageal junction (GEJ) adenocarcinoma PC. METHODS: This is a prospective, single center, single arm, phase II investigator-initiated clinical trial. Patients with histo
View details →Negative / Null Result ReportOpen accessMedicine
Michelli Marcela Dadam, Aline Braz Pereira, Mariane R. Cardoso et al. · 2024 · Respiratory Care
BACKGROUND: Re-intubation is necessary in 2% to 30% of cases of patients receiving a planned extubation. This procedure is associated with prolonged mechanical ventilation, a greater need for tracheostomy, a higher incidence of…
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Bjoern Zante, Katja Erne, Marie-Madlen Jeitziner · 2022 · Scientific Reports
Abstract To help reduce the spread of the SARS-CoV-2 virus during the COVID-19 pandemic, ICU visits were banned or restricted. Therefore, family-centered care as usually practiced was not feasible Video calls were recommended to meet…
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Kumi Orita, Yukihide Minoda, Ryo Sugama et al. · 2020 · The Bone & Joint Journal
Aims Vitamin E-infused highly cross-linked polyethylene (E1) has recently been introduced in total knee arthroplasty (TKA). An in vitro wear simulator study showed that E1 reduced polyethylene wear. However there is no published…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miki Takemura, Rio Nakamura, Merime Ota et al. · 2023 · Antimicrobial Agents and Chemotherapy
ABSTRACT Achromobacter spp. and Burkholderia cepacia complex (Bcc) are rare but diverse opportunistic pathogens associated with serious infections, which are often multidrug resistant. This study compared the in vitro antibacterial activity of the siderophore antibiotic cefiderocol against Achromobacter spp. and Bcc isolates with that of other approved antibacterial drugs, including ceftazidime-avibactam, ciprofloxacin, colistin, imipenem-relebactam, and meropenem-vaborbactam. Isolates were collected in the SIDERO multinational surveillance program. Among 334 Achromobacter spp. isolates [76.6%
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Marina da Costa Rosa, Alex Shimura Yamashita, Gregory J. Riggins · 2021 · Neuro-Oncology
BACKGROUND: Isocitrate Dehydrogenase 1/2 (IDH1/2) mutations are diagnostic for Astrocytoma or Oligodendroglioma, IDH-mutant. In these IDH-mutant gliomas, retinoic acid-related gene expression is commonly silenced by DNA hypermethylation.…
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Anna Larsson, Johanna Berg, Mikael Gellerfors et al. · 2021 · BMC Medical Informatics and Decision Making
Abstract Background Accurate prehospital trauma triage is crucial for identifying critically injured patients and determining the level of care. In the prehospital setting, time and data are often scarce, limiting the complexity of triage…
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Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata et al. · 2020 · International Journal of Cancer
Oral mucositis is a common and distressing complication in patients receiving high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single-center retrospective analysis that…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Xuan Xu, Penghao Zhen, Fuchao Yu et al. · 2022 · Frontiers in Cardiovascular Medicine
Obstructive sleep apnea (OSA) accelerates the progression of chronic heart failure (CHF). OSA is characterized by chronic intermittent hypoxia (CIH), and CIH exposure accelerates cardiac systolic dysfunction and cardiac remodeling in a cardiac afterload stress mouse model. Mechanistic experiments showed that long-term CIH exposure activated hypoxia-inducible factor 1α (HIF-1α) expression in the mouse heart and upregulated miR-29c expression and that both HIF-1α and miR-29c simultaneously inhibited sarco-/endoplasmic reticulum calcium ATPase 2a (SERCA2a) expression in the mouse heart. Cardiac H
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Stephen J. Tomasetti, Jeffrey R. Kraemer, Christopher J. Gobler · 2021 · Frontiers in Marine Science
Many shallow coastal systems experience diel fluctuations in dissolved oxygen (DO) and pH that can intensify throughout the summer season and expose estuarine organisms to repeated episodes of coastal hypoxia and acidification. In temperate regions, larval release of the economically important blue crab Callinectes sapidus occurs in the summer, and while the earliest stage (zoea I) larvae are susceptible to persistent low DO and low pH conditions, their sensitivity to diel fluctuations is unknown. Here, a series of short-term (≤96 h) experiments were conducted to investigate the survival of C.
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Vanja Vaccaro · 2013 · World Journal of Gastroenterology
AIM: To investigate activity, toxicity, and prognostic factors for survival of erlotinib and fixed dose-rate gemcitabine (FDR-Gem) in advanced pancreatic cancer. METHODS: We designed a single-arm prospective, multicentre, open-label phase…
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Markus Karlsson, Tino Kurz · 2016 · Acta Ophthalmologica
PURPOSE: Oxidative stress-related damage to retinal pigment epithelial (RPE) cells is an important feature in the development of age-related macular degeneration. Iron-catalysed intralysosomal production of hydroxyl radicals is considered…
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Jittawadee Murphy, Walter R. Weiss, David J. Fryauff et al. · 2014 · Malaria Journal
BACKGROUND: When rhesus monkeys (Macaca mulatta) are used to test malaria vaccines, animals are often challenged by the intravenous injection of sporozoites. However, natural exposure to malaria comes via mosquito bite, and antibodies can neutralize sporozoites as they traverse the skin. Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed. METHODS: Several species and strains of mosquitoes were tested for their ability
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Masahiro Kikuchi, Hiroyuki Harada, Ryo Asato et al. · 2021 · Medicina
Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. Materials and Methods: In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analy
View details →Negative / Null Result ReportEnvironmental Science
Christopher J. Kotalik, William H. Clements · 2019 · Environmental Science & Technology
Evaluations of aquatic insect responses to contaminants typically use larval life stages to characterize taxa sensitivity, but the effects of contaminants to emerging terrestrial adults have received less attention. We present the results…
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Helena Lam, Nakul Katyal, Catherine D. Parker et al. · 2018 · Cureus
Thromboelastography with platelet mapping (TEG-PM) is a modality to measure platelet function, especially in patients taking antiplatelet medications. It consists of two components: arachidonic acid (AA), which is sensitive to aspirin, and adenosine diphosphate (ADP), which is sensitive to clopidogrel. In patients with spontaneous intracerebral hemorrhages (sICH), the clinical interpretation of platelet mapping is unclear. The objective of this study was to evaluate TEG-PM in patients with sICH on aspirin and/or clopidogrel who receive platelet transfusions. This study was an IRB-approved, ret
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Youngjin Yoo, Pascal Ceccaldi, Siqi Liu et al. · 2021 · Journal of Medical Imaging
Purpose: We investigate the impact of various deep-learning-based methods for detecting and segmenting metastases with different lesion volume sizes on 3D brain MR images. Approach: A 2.5D U-Net and a 3D U-Net were selected. We also…
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Georg Hauer, Nina Hörlesberger, Sebastian Klim et al. · 2020 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract Purpose The purpose of this study was to compare the clinical and functional outcome scores following total knee arthroplasty (TKA) with two different systems. The hypothesis was that there is a difference between patients…
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Marcos Christiano Lange, Viviane Flumignan Zétola, Élcio J Piovesan et al. · 2010 · Journal of Neuroimaging
ABSTRACT BACKGROUND AND PURPOSE Agitated saline solution (AS) is the contrast agent (CA) of choice for the diagnosis of right‐to‐left shunt (RLS). The aim of this study was to compare AS to AS with blood (ASb) in the diagnosis and…
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