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20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Analysis of Genome-Wide Association Study (GWAS) data looking for replicating signals in Alzheimer's disease (AD).

Hui Shi, Christopher Medway, James M. Bullock et al. · 2010 · PubMed

We have performed cross-platform comparisons of output from 4 GWAS in late-onset Alzheimer's disease (LOAD) - Reiman et al., 2007; Li et al., 2008; Beecham et al., 2008 and Carrasquillo et al., 2009 to search for new association signals.…

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Negative / Null Result ReportOpen accessMedicine

Effects of Changes in the Levels of Damage-Associated Molecular Patterns Following Continuous Veno–Venous Hemofiltration Therapy on Outcomes in Acute Kidney Injury Patients With Sepsis

Jie Wu, Jianan Ren, Qinjie Liu et al. · 2019 · Frontiers in Immunology

Background: Continuous veno–venous hemofiltration (CVVH) could influence immunomodulation by cytokine removal. Damage-associated molecular patterns (DAMPs) are released by injured cells and have roles in sepsis. We investigated if the magnitude of DAMPs removal was associated with mortality in patients with sepsis undergoing CVVH. Methods: We conducted a prospective, observational study on patients acquiring CVVH at department of surgery, Jinling Hospital. Circulating levels of DAMPs (mitochondrial DNA [mtDNA]; nuclear DNA [nDNA]; heat shock protein [HSP]70) and cytokines were measured at the

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Negative / Null Result ReportOpen accessMedicine

Outcome is unchanged by adding vincristine upfront to the Malawi 28‐day protocol for endemic Burkitt lymphoma

Sarita Depani, Kondwani Joseph Banda, Simon Bailey et al. · 2015 · Pediatric Blood & Cancer

BACKGROUND: We previously reported a 28-day treatment protocol for children with endemic Burkitt lymphoma (BL) which included four doses of cyclophosphamide (CPM), intrathecal methotrexate and hydrocortisone (IT MTX/HC) at Queen Elizabeth…

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Negative / Null Result ReportOpen accessMedicine

Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study

Shao-rui Hao, Yan Ren, Shan-yan Zhang et al. · 2020 · Journal of Zhejiang University SCIENCE B

BACKGROUND: Currently, there are no drugs that have been proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because of its broad antiviral activity, interferon (IFN) should be evaluated as a…

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Negative / Null Result ReportOpen accessMedicine

Nebulized heparin and salbutamol versus salbutamol alone in acute exacerbations of chronic obstructive pulmonary disease requiring mechanical ventilation: a double-blind randomized controlled trial

Tarek Mohamed Ashoor, Ahmad Mahmoud Hasseb, Ibrahim M. Esmat · 2020 · Korean journal of anesthesiology

Background: Nebulized heparin has been effectively used in the management of many pulmonary diseases. However, its effect on mechanically ventilated patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) has never…

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Negative / Null Result ReportOpen accessMedicine

A comparison of different vitrification devices and the effect of blastocoele collapse on the cryosurvival of <i>in vitro</i> produced porcine embryos

Louise Katherine Bartolac, Jenna Lowe, George Koustas et al. · 2015 · Journal of Reproduction and Development

The aim of this study was to determine the optimum conditions for vitrifying in vitro produced day 7 porcine embryos using different vitrification devices and blastocoele collapse methods. Firstly embryos were collapsed by micro-pipetting,…

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Negative / Null Result ReportOpen accessMedicine

Effect of high-volume hemofiltration on children with sepsis

Botao Ning, Sheng Ye, Yi Lyu et al. · 2020 · Translational Pediatrics

BACKGROUND: Sepsis has always been a challenge in pediatric intensive care unit (PICU) with poor prognosis. In order to evaluate the effect between routine continuous renal replacement therapy (CRRT) and high-volume hemofiltration (HVHF)…

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Negative / Null Result Report

Did an Ultra-Low Emissions Policy on Coal-Fueled Thermal Power Reduce the Harmful Emissions? Evidence from Three Typical Air Pollutants Abatement in China

Penghao Ye, Senmao Xia, Yu Xiong et al. · 2020 · International Journal of Environmental Research and Public Health

Thermal power generation based on coal-fired power plants has the advantages of stability and controllability and has been the largest source of electricity supply in China. Coal-fired power plants, however, are also accompanied by high…

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Negative / Null Result ReportOpen accessMedicine

The effects of midazolam or propofol plus fentanyl on ICU mortality: a retrospective study based on the MIMIC-IV database

Wen Sun, Yan Yang, Shidong Hu et al. · 2022 · Annals of Translational Medicine

Background: Patients in the intensive care unit (ICU) are often under stress and fail to cooperate well with invasive treatments. Analgesia and sedation are of great significance for reducing the suffering of patients and ensuring the…

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Negative / Null Result Report

Can we find the right balance in cause‐related marketing? Analyzing the boundaries of balance theory in evaluating brand‐cause partnerships

Joseph T. Yun, Brittany R. L. Duff, Patrick Vargas et al. · 2019 · Psychology & Marketing

Abstract Cause‐related marketing (CRM) refers to the phenomenon where brands partner with causes, such as nonprofit organizations. Consumers may see some CRM partnerships as less compatible than others, however the level of perceived…

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Negative / Null Result Report

Skin‐to‐skin contact during eye examination did not reduce pain compared to standard care with parental support in preterm infants

Laila Kristoffersen, Ragnhild Støen, Håkon Bergseng et al. · 2019 · Acta Paediatrica

Abstract Aim We compared the pain relieving effect of skin‐to‐skin contact versus standard care in the incubator during screening for retinopathy of prematurity. Methods This randomised crossover study included 35 preterm infants of less…

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Negative / Null Result ReportOpen accessMedicine

No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population

Wanying Liang, Lihong Wang, Jian‐Hang Wei et al. · 2021 · Scientific Reports

Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid-femoral pulse wave velocity (cfPWV) in a Chinese population. We invited all inhabitants aged ≥ 18 years in two Dali communities for participation. The SphygmoCor system was used to record radial arterial waveforms. Aortic waveforms were derived using a generalized transfer function. The central BP was assessed by calibrating the brachial BP

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Negative / Null Result ReportOpen accessEngineering

A National and Regional Greenhouse Gas Breakeven Assessment of EVs across North America

Daniel Rasbash, Kevin Joseph Dillman, Jukka Heinonen et al. · 2023 · Sustainability

Electrification is considered key to decarbonizing the transport sector. While electric vehicles (EVs) lack tailpipe emissions, battery and electricity production can lead to significant emissions. This study analysed whether EVs can effectively mitigate GHG emissions in North America, by calculating two GHG breakeven indicators for EVs and comparing them to internal combustion engine vehicles (ICEVs). EV life cycle emissions were compared to those of ICEVs in Canada, Mexico, and the USA. In addition, this study considered potential national electricity grids evolutions and improvements in bat

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Negative / Null Result ReportOpen accessMedicine

Comparison of Systemic Immune-Inflammation Index and Naples Prognostic Score for Prediction Coronary Artery Severity Patients Undergoing Coronary Computed Tomographic Angiography

Eyüp Özkan, Aslan Erdoğan, Ali Karagöz et al. · 2023 · Angiology

This study compared the predictive power of the systemic immune-inflammation index (SII) and Naples prognostic score (NPS) in determining the severity of coronary artery disease (CAD). The study included 1138 patients who underwent…

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Negative / Null Result ReportOpen accessMedicine

Impact of age on thromboembolic events in patients with non‐valvular atrial fibrillation

Yun Gi Kim, Jong‐Il Choi, Ki Yung Boo et al. · 2019 · Clinical Cardiology

Abstract Background Age is a well‐established risk factor for thromboembolic events in patients with atrial fibrillation (AF). However, the mechanism underlying the association between age and thromboembolic events in AF remains unknown. Methods The prognostic value of age as a risk factor for thromboembolic events was analyzed using data from the Korean National Health Insurance Service (NHIS). In a large‐scale single‐center registry, cardiac hemodynamic parameters were examined to elucidate the cause of increased risk of thromboembolic events in older patients. Results NHIS sample cohort dat

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Negative / Null Result ReportOpen accessDentistry

Remineralization of Artificial Dentin Caries Using Dentin and Enamel Matrix Proteins

Katja Bächli, Patrick R. Schmidlin, Florian J. Wegehaupt et al. · 2019 · Materials

To assess the remineralizing potential of dentin matrix proteins and enamel matrix derivatives (DMPs and EMDs) after application on artificially induced dentin lesions, given the hypothesis that these materials increase the mineral uptake, binding, and mineralization. Forty-eight caries-free human premolars were used. Teeth were cut, polished, and embedded, leaving an open window on the root surface, of which one-third was covered with a flowable composite to preserve the healthy untreated dentin. Then, samples were demineralized in Buskes solution for 33 days. A micro-CT scan prior to treatme

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Negative / Null Result Report

Is There a Significant Difference in Accuracy of Four Intraoral Scanners for Short-Span Fixed Dental Prosthesis? A Comparative In Vitro Study

Anca Jivănescu, Adrian Bara, Andrei-Bogdan Faur et al. · 2021 · Applied Sciences

Is the accuracy of the older generation of IOSs an impediment for obtaining a quality intraoral digital impression? The aim of this study was to evaluate the differences in accuracy between four intraoral scanners (two of the latest IOSs…

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Negative / Null Result ReportMedicine

A prospective study on split-hand index as a biomarker for the diagnosis of amyotrophic lateral sclerosis

Zhili Wang, Mingsheng Liu, Zhengyi Cai et al. · 2020 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Objective To determine the practical diagnostic utility of split-hand index (SI) values calculated from F-wave persistence (SIFP) and the F/M amplitude ratio (SIF/M) for differentiating patients with amyotrophic lateral sclerosis (ALS)…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Clonal diploid and autopolyploid breeding strategies to harness heterosis: insights from stochastic simulation

Marlee R. Labroo, Jeffrey B. Endelman, Dorcus C. Gemenet et al. · 2023 · Theoretical and Applied Genetics

KEY MESSAGE: Reciprocal recurrent selection sometimes increases genetic gain per unit cost in clonal diploids with heterosis due to dominance, but it typically does not benefit autopolyploids. Breeding can change the dominance as well as additive genetic value of populations, thus utilizing heterosis. A common hybrid breeding strategy is reciprocal recurrent selection (RRS), in which parents of hybrids are typically recycled within pools based on general combining ability. However, the relative performances of RRS and other breeding strategies have not been thoroughly compared. RRS can have re

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Negative / Null Result ReportOpen accessEngineering

3D deformable registration of longitudinal abdominopelvic CT images using unsupervised deep learning

Maureen van Eijnatten, Leonardo Rundo, Batenburg, Joost et al. · 2021 · Data Archiving and Networked Services (DANS)

Background and Objectives: Deep learning is being increasingly used for deformable image registration and unsupervised approaches, in particular, have shown great potential. However, the registration of abdominopelvic Computed Tomography…

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