Negative / Null Result ReportOpen accessMedicine
Caterina Peraldo‐Neia, Giuliana Cavalloni, Elisabetta Fenocchio et al. · 2018 · PLoS ONE
The association of anti-EGFR to gemcitabine and oxaliplatin (GEMOX) chemotherapy did not improve survival in biliary tract carcinoma (BTC) patients. Multiple mechanisms might be involved in the resistance to anti-EGFR. Here, we explored the mutation profile of EGFR extracellular domain (ECD), of tyrosine kinase domain (TKD), and its amplification status. EGFR mutational status of exons 12, 18-21 was analyzed in 57 tumors by Sanger sequencing. EGFR amplification was evaluated in 37 tumors by Fluorescent In Situ Hybridization (FISH). Kaplan-Meier curves were calculated using the log-rank test. S
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Joop Schaye, Evgenii Chaikin, Matthieu Schaller et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT We present the COLIBRE galaxy formation model and the COLIBRE suite of cosmological hydrodynamical simulations. COLIBRE includes new models for radiative cooling, dust grains, star formation, stellar mass loss, turbulent diffusion, pre-supernova stellar feedback, supernova feedback, supermassive black holes, and active galactic nucleus (AGN) feedback. The multiphase interstellar medium is explicitly modelled without a pressure floor. Hydrogen and helium are tracked in non-equilibrium, with their contributions to the free electron density included in metal-line cooling calculations. Th
View details →Negative / Null Result ReportOpen accessPsychology
Joyce S. Pang, Hiram Ring, Kate Y Huang et al. · 2026 · Journal of Personality Assessment
Implicit motives have a clear relation to observed behavior but are time-consuming to measure. Automating the content coding of implicit motives has been a pursuit since the 1960s, but has not been widely adopted due to limitations with…
View details →Negative / Null Result ReportOpen accessPsychology
Terence J. Lyons, Merle Spriggs, Leevi Kerkelä et al. · 2026 · Nature Communications
Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is largely unknown. In an exploratory, placebo-controlled, within-subjects, electroencephalography (EEG), and magnetic resonance imaging (MRI) study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain changes are detected from one-hour to one-month after a single high-dose (25 mg) of psilocybin. Increases in cognitive flexibility, psychological insight, and well-being are seen at one-month. Diffusion ten
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ihsen Abid · 2025 · Engineering Technology & Applied Science Research
Saudi Arabia, as one of the world’s leading oil producers, faces critical challenges in transitioning to sustainable economic growth. The heavy reliance on oil exports, coupled with rapid urbanization and environmental degradation, underscores the urgent need for green growth strategies tailored to the Kingdom’s unique socioeconomic and environmental context. This study aims to investigate the factors influencing the Green Growth Index (GGI), which measures sustainable economic growth, and analyze the short-term and long-term relationships between key variables such as environmental technology
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Soumik Barman, Francesco Borriello, Byron Brook et al. · 2022 · ACS Chemical Biology
) cells, and germinal center (GC) B cells along with the IgG2c-skewed humoral response in vivo. Dual-loaded cGAMP/CL075-PSs did not outperform admixed cGAMP-PS and CL075-PS in vivo. These data validate an optimally designed adjuvantation…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Sara Vitoria-Estruch, Ángel Romero‐Martínez, Marisol Lila et al. · 2018 · International Journal of Environmental Research and Public Health
Proactively aggressive individuals have been shown to present a different pattern of autonomic nervous system (ANS) dysregulation from that of individuals characterized by reactive violence. Although attempts have been made to classify intimate partner violence (IPV) perpetrators based on ANS reactivity to acute stress, subsequent studies have failed to replicate this classification. Notably, the proposed classification neglected the role of chronic alcohol abuse in ANS dysregulation and the fact that this dysregulation entails an abnormal stress response. The aim of the present study was to a
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
M. Bernert, T.O.S.J. Bosman, T. Lunt et al. · 2025 · Nuclear Materials and Energy
Power exhaust is a crucial issue for future fusion reactors. Divertor detachment and the required power dissipation fractions of about 95% are foreseen to be achieved by impurity seeding. In a tokamak, at high seeding levels the radiation often concentrates in a small region inside the confined plasma near the X-point. In early observations the so-called X-point radiator (XPR) often led to back-transitions to L-mode or disruptions. In metal tokamaks or with higher available heating power, these regimes can be stabilized and are now established on AUG, JET, TCV, KSTAR and WEST. The XPR is a col
View details →Negative / Null Result ReportOpen accessPsychology
Emilou Noser, Jessica Schoch, Ulrike Ehlert · 2018 · PLoS ONE
Research has indicated that men's facial width-to-height ratio (fWHR) is part of an evolved system of social dominance, aggression, and power. fWHR has been linked to antisocial behavior, measured by self-reported aggression, but recent studies have failed to replicate this finding. To overcome these inconsistencies, influencing factors such as social status have to be taken into account in order to explain the relationship between fWHR and aggression. In particular, income has been shown to be an important influencing factor in this relationship. Furthermore, previous findings suggested that
View details →Negative / Null Result ReportOpen accessSocial Sciences
Richard Fendler, Craig Ruff, Milind Shrikhande · 2018 · Online Learning
Much of the e-education literature suggests that there is no significant difference in aggregate student learning outcomes between online and face-to-face instruction. In this study, we develop a model that forecasts the grade that individual students would have most likely earned in the alternate class setting. Students for whom the difference between the actual grade received in one class format (for example, online) and the forecasted grade in the other class setting (for example, face-to-face) is one full letter grade or higher are called “jumpers.” Our findings indicate that jumpers are n
View details →Negative / Null Result ReportOpen accessMedicine
Stefano Fiorucci, Ginevra Urbani, Eleonora Distrutti et al. · 2025 · Pharmaceuticals
The Farnesoid-X-receptor (FXR) is a bile sensor involved in the regulation of bile acid homeostasis, fibrosis, inflammation, and metabolism. Obeticholic acid (OCA), a semisynthetic derivative of chenodeoxycholic acid (CDCA), initially named 6-ethyl-CDCA or INT-747, is the first in a class of FXR ligands that have been approved for clinical use for the treatment of patients with primary biliary cholangitis (PBC) who are unresponsive or intolerant to ursodeoxycholic acid. In this narrative review, we will examine the current status and future perspective of clinical use of OCA. Based on results
View details →Negative / Null Result ReportSocial Sciences
Kitae Sohn, Illoong Kwon · 2016 · The Singapore Economic Review
Trust was found to promote entrepreneurship in the US. We investigated whether this was true in a developing country, Indonesia. We failed to replicate this; this failure was true whether trust was estimated at the individual or community…
View details →Negative / Null Result ReportOpen accessNeuroscience
Hye-Won Yang, Danyeong Kim, YoungSoon Yang et al. · 2025 · International Journal of Molecular Sciences
TREM2 (triggering receptor expressed on myeloid cells 2) is a membrane-bound receptor primarily expressed on microglia in the central nervous system (CNS). TREM2 plays a crucial role in regulating immune responses, phagocytosis, lipid metabolism, and inflammation. Mutations in the TREM2 gene have been linked to various neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s disease (PD), and Nasu–Hakola disease (NHD). These mutations are suggested to impair microglial activation and reduce the ability to clear amyloid aggregates, leading to ex
View details →Negative / Null Result ReportOpen accessMedicine
Ömer Aydın, Enis Karaarslan, Fatih Safa Erenay et al. · 2026 · Turkish Journal of Engineering
DeepSeek v3, developed in China, was released in December 2024, followed by Alibaba’s Qwen 2.5 Max in January 2025 and Qwen3 235B in April 2025. These free and open-source models offer significant potential for academic writing and content…
View details →Negative / Null Result ReportOpen accessComputer Science
Shervin Malmasi · 2016 · Figshare
The prediction of an author's native language using only their second language writing -- a task called Native Language Identification (NLI) -- is usually tackled using supervised classification. This is underpinned by the presupposition…
View details →Negative / Null Result ReportOpen accessNeuroscience
Amit Walia, Matthew Shew, Jordan Varghese et al. · 2023 · JAMA Otolaryngology–Head & Neck Surgery
Importance: Cochlear implantation produces remarkable results in postlingual deafness, although auditory outcomes vary. Electrocochleography (ECochG) has emerged as a valuable tool for assessing the cochlear-neural substrate and evaluating…
View details →Negative / Null Result Report
Jamal T. Maalouf, James Combs, William E. Gillis et al. · 2020 · Journal of Knowledge Management
Purpose The purpose of this paper is to introduce strategy as a factor that explains when franchisors – through the franchisees they select – seek to replicate routines exactly versus allow local adaptation of routines.…
View details →Negative / Null Result ReportMedicine
Haruo Ohtani, Hiroyasu Ishida, Yuka Ito et al. · 2011 · Pathology International
Autoimmune pancreatitis (AIP) (also called IgG4-related sclerosing pancreatitis (IgG4-SP)) and IgG4-related sclerosing cholangitis (IgG4-SC) are frequently associated with each other. It is generally believed that association of these…
View details →Negative / Null Result ReportMedicine
Wen-Jyi Lo, Wen Shin Chang, Han-Fang Hsu et al. · 2017 · PubMed
Mounting evidence supports the notion that inflammatory processes play a role in carcinogenesis, and interleukin-10 (IL10) is an important inflammatory cytokine. This study aimed to evaluate the contribution of IL10 A-1082G (rs1800896),…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Caroline R. Amendola, William T. Cordell, Colin M. Kneucker et al. · 2023 · Metabolic Engineering
Pseudomonas putida KT2440 is a robust, aromatic catabolic bacterium that has been widely engineered to convert bio-based and waste-based feedstocks to target products. Towards industrial domestication of P. putida KT2440, rational genome…
View details →Negative / Null Result Report
Ian G Barr, Cleve Rynehart, Paul Whitney et al. · 2020 · Eurosurveillance
The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production…
View details →Negative / Null Result Report
Naiyue Hu, Chenghang Du, Wanqing Zhang et al. · 2022 · Agronomy
Grain yield and quality of wheat are both important components for food security. Great effort has been made in the genetic improvement of wheat grain yield in China. However, wheat grain quality (i.e., protein concentration and protein…
View details →Negative / Null Result Report
Christina Thunberg, Mari S. Messel, Liisa Raud et al. · 2020 · Scientific Reports
Abstract The ability to cancel an already initiated response is central to flexible behavior. While several different behavioral and neural markers have been suggested to quantify the latency of the stopping process, it remains unclear if…
View details →Negative / Null Result ReportOpen accessMedicine
Curtis J. Henry, Rebecca L. Sedjo, Andrii I. Rozhok et al. · 2015 · BMC Cancer
BACKGROUND: Inflammatory cytokines in the colonic microenvironment have been shown to increase with advance colorectal cancer disease state. However, the contribution of inflammatory cytokines to pre-malignant disease, such as the formation of adenomas, is unclear. METHODS: Using the Milliplex® MAP Human Cytokine/ Chemokine Magnetic Bead Panel Immunoassay, serum cytokine and chemokine profiles were assayed among participants without an adenoma (n = 97) and those with an adenoma (n = 97) enrolled in the NCI-funded Insulin Resistance Atherosclerosis Colon Study. The concentrations of interleukin
View details →Negative / Null Result ReportOpen accessMedicine
Manish A. Shah, Kohei Shitara, Florian Lordick et al. · 2022 · Clinical Cancer Research
PURPOSE: To compare napabucasin (generator of reactive oxygen species) plus paclitaxel with paclitaxel only in patients with second-line advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma. EXPERIMENTAL DESIGN: In the…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Patricia Burns, Gabriel Vinderola, Jorge Reinheimer et al. · 2011 · Journal of Dairy Research
The capacity of lactic acid bacteria to produce exopolysaccharides (EPS) conferring microorganisms a ropy phenotype could be an interesting feature from a technological point of view. Progressive adaptation to bile salts might render some…
View details →Negative / Null Result ReportOpen accessMedicine
Kota Ogawa, Akiko Noda, Jun Ueda et al. · 2020 · Cellular & Molecular Biology Letters
BACKGROUND: Animal model studies show that reductive stress is involved in cardiomyopathy and myopathy, but the exact physiological relevance remains unknown. In addition, the microRNAs miR-143 and miR-145 have been shown to be upregulated in cardiac diseases, but the underlying mechanisms associated with these regulators have yet to be explored. METHODS: We developed transgenic mouse lines expressing exogenous miR-143 and miR-145 under the control of the alpha-myosin heavy chain (αMHC) promoter/enhancer. RESULTS: The two transgenic lines showed dilated cardiomyopathy-like characteristics and
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Zuzana Sýkorová, Jana Rydlová, Renata Slavíková et al. · 2015 · Restoration Ecology
An extensive field trial was established on a fly ash deposit (1) to evaluate whether the inoculation with arbuscular mycorrhizal fungi ( AMF ) and/or ectomycorrhizal fungi ( EcMF ) improves growth and survival of 13 planted tree species…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Liza C. Villaruz, Grace Huang, Marjorie Romkes et al. · 2015 · Clinical Epigenetics
BACKGROUND: Carboplatin/paclitaxel (CP), with or without sorafenib, result in objective response rates of 18-20 % in unselected chemotherapy-naïve patients. Molecular predictors of survival and response to CP-based chemotherapy in metastatic melanoma (MM) are critical to improving the therapeutic index. Intergroup trial E2603 randomized MM patients to CP with or without sorafenib. Expression data were collected from pre-treatment formalin-fixed paraffin-embedded (FFPE) tumor tissues from 115 of 823 patients enrolled on E2603. The selected patients were balanced across treatment arms, BRAF stat
View details →Negative / Null Result ReportOpen accessMedicine
Bishwajit Bhowmik, Tasnima Siddiquee, Ibrahimu Mdala et al. · 2021 · Diabetes Research and Clinical Practice
AIM: To assess the efficacy of vitamin D3 or B12 supplementation during pregnancy. METHODS: Pregnant women at 6-14 weeks in the intervention arm received oral high dose intermittent vitamin D3 and/or low dose B12 supplementation if they…
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