Negative / Null Result ReportOpen accessMedicine
Xiaodong Wang, Jing He, Gouping Ding et al. · 2025 · Frontiers in Immunology
Immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 have achieved groundbreaking clinical success in multiple cancers; however, a large proportion of patients experience primary or acquired resistance. This review synthesizes the complex mechanisms underlying resistance to PD-1/CTLA-4 blockade and surveys emerging strategies to overcome them. Resistance arises from multifaceted interactions among tumor-intrinsic alterations (e.g., epigenetic silencing of antigen presentation machinery via EZH2/PRC2, oncogenic pathway-driven upregulation of PD-L1, genetic loss of IFNγ pathway componen
View details →Negative / Null Result ReportOpen accessMedicine
Osama Sobhi Moaket, Sarah Eyad Obaid, Fawaz Eyad Obaid et al. · 2025 · International Journal of Molecular Sciences
Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and depression, are marked by progressive neuronal dysfunction and loss, yet current treatments remain largely symptomatic with limited disease-modifying efficacy. Glucagon-like peptide-1 (GLP-1), an incretin hormone traditionally associated with metabolic regulation, has emerged as a promising neuroprotective agent. Its receptor, GLP-1R, is expressed in key brain regions implicated in cognition, emotion, and motor control, including the hippocampus, frontal cortex, and substantia nigra. GLP-1R a
View details →Negative / Null Result ReportOpen accessEngineering
Jianghui Zheng, Guoliang Wang, Leiping Duan et al. · 2025 · Nature Nanotechnology
Abstract Triple‐junction solar cells theoretically outperform their double-junction and single‐junction counterparts in power conversion efficiency, yet practical perovskite–perovskite–silicon devices have fallen short of both theoretical limits and commercial targets. To address surface defects in the top perovskite junction, we introduce a piperazine-1,4-diium chloride treatment, which replaces less stable lithium fluoride. For interfacing the top and middle perovskite junctions, we optimize the size of gold nanoparticles deposited on atomic layer-deposited tin oxide for best ohmic contactin
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chiara H. Moretti, E. Grasset, Jiaying Zhu et al. · 2025 · Cell Reports
The gut microbiota regulates host intestinal serotonin synthesis, thereby promoting the development and maintenance of the enteric nervous system, which controls bowel motility. Functional bowel disorders, including irritable bowel syndrome, are associated with altered serotonin levels and gut microbiota composition. However, it is unclear if the gut microbiota can synthesize bioactive serotonin, which may affect enteric nervous system development. Here, we identify a consortium of the human gut bacteria Limosilactobacillus mucosae and Ligilactobacillus ruminis that synthesizes serotonin in vi
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Monica E. Mesecar, Megan F. Duffy, Dominic J. Acri et al. · 2026 · npj Aging
As age is a significant risk factor for multiple neurodegenerative diseases, investigating normal brain aging may help identify molecular events contributing to increased disease risk over time. Single-nucleus RNA sequencing (snRNA-seq) enables analysis of gene expression changes within specific cell-types, offering insights into the molecular mechanisms underlying aging. However, most brain aging snRNA-seq datasets use age-matched controls from studies focused on pathology and sample cortical regions. Therefore, there is a need to investigate non-pathological aging within brain regions vulner
View details →Negative / Null Result ReportOpen accessMedicine
Natalia Spasova, Desislava Somleva, Bozhidar Krastev et al. · 2024 · Folia Medica
Introduction : Trimethylamine-N-oxide (TMAO) is a metabolite produced by intestinal microbiota. It is well recognized as an independent risk marker for cardiovascular and renal diseases and mortality. Aim : The aim of the present study was…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ahmet Jeyhunov, Jong Dae Kim, Seong Mi Bae · 2025 · Sustainability
This paper explores the effect of board diversity on environmental, social, and governance (ESG) performance in Korean-listed firms using regression analysis. Our findings reveal that an increased board size significantly correlates with higher ESG scores when combined with other board diversity dimensions. The presence of female directors on boards was found to have a significant effect on environmental and social components of ESG performance. Age diversity exhibits a negative association with ESG scores, emphasizing potential disruptions from intergenerational differences. Foreign directors
View details →Negative / Null Result ReportOpen accessMedicine
Juan He, Mi Chen, Jia Li et al. · 2025 · International Journal of Gynecological Cancer
Antibody-drug conjugates (ADCs) are an emerging class of targeted therapies that combine monoclonal antibodies with potent cytotoxic payloads, demonstrating significant potential in the treatment of gynecologic malignancies. By selectively targeting tumor-associated antigens, ADCs enable precise drug delivery while minimizing off-target toxicity. Currently, mirvetuximab soravtansine and tisotumab vedotin have been approved by the Food and Drug Administration for the treatment of folate receptor-alpha-positive, platinum-resistant ovarian cancer and recurrent cervical cancer, respectively, exhib
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Thomas L. Delworth, William F. Cooke, Vaishali Naik et al. · 2022 · Proceedings of the National Academy of Sciences
The Mediterranean region has been identified as a climate hot spot, with models projecting a robust warming and rainfall decline in response to increasing greenhouse gases. The projected rainfall decline would have impacts on agriculture…
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Vladimir Nikitović, Vesna Lukić · 2010 · International Migration
Abstract Serbia still hosts the largest number of forced migrants in Europe. The paper examines the impact of the refugee influx from newly formed states on the territory of the Socialist Federal Republic of Yugoslavia (SFRY) into Serbia…
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Shiekh Marifatul Haq, Muhammad Waheed, Riyaz Ahmad et al. · 2023 · Biology
The distribution of large ungulates is more often negatively impacted by the changing climate, especially global warming and species with limited distributional zones. While developing conservation action plans for the threatened species…
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Hunter Warwick, Carolyn Hutyra, Cary Politzer et al. · 2019 · Clinical Orthopaedics & Related Research
Abstract Background The generalizability of data derived from patient-reported outcome measures (PROMs) depends largely on the proportion of the relevant population that completes PROM surveys. However, PROM survey responses remain low,…
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Michael Hoppe, Alastair B. Ross, Cecilia Svelander et al. · 2018 · European Journal of Nutrition
Abstract Purpose To investigate the effects of eating wholegrain rye bread with high or low amounts of phytate on iron status in women under free-living conditions. Methods In this 12-week, randomized, parallel-design intervention study,…
View details →Negative / Null Result ReportOpen accessMedicine
Gabriëlle J. M. Tuijthof, M. M. de Vaal, I. N. Sierevelt et al. · 2011 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: During arthroscopies, bleeding episodes occur as a result of tissue damage. Irrigation systems assist in minimizing these disturbances. The performance of three arthroscopic irrigation systems in clearing bleeding episodes was…
View details →Negative / Null Result ReportOpen accessMedicine
Muna Canales, Terri Blackwell, Areef Ishani et al. · 2016 · American Journal of Nephrology
<b><i>Background:</i></b> Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was…
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R. G. Waruna Jinadasa, Bihong Li, Benjamin Schmitz et al. · 2016 · ChemSusChem
Abstract A series of monobenzoporphyrins ( WH1 – WH4 ) bearing different conjugated spacer groups were designed and synthesized as sensitizers for dye‐sensitized solar cells. Although a phenyl spacer only has a minimal impact on the…
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E. S. Skordas, N. V. Sarlis, P. A. Varotsos · 2010 · Chaos: An Interdisciplinary Journal of Nonlinear Science
Electric field variations that appear before rupture have been recently studied by employing the detrended fluctuation analysis (DFA) to quantify their long-range temporal correlations. These studies revealed that seismic electric signal…
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Xinyang Zhang, Alexander Palevski, Aharon Kapitulnik · 2022 · Proceedings of the National Academy of Sciences
Resistivity saturation is found on both superconducting and insulating sides of an “avoided” magnetic-field-tuned superconductor-to-insulator transition (H-SIT) in a two-dimensional In/InO x composite, where the anomalous metallic behavior…
View details →Negative / Null Result ReportOpen accessMedicine
Tomoaki Natsukawa, Norikazu Maeda, Shiro Fukuda et al. · 2017 · Journal of Atherosclerosis and Thrombosis
AIMS: Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact…
View details →Negative / Null Result ReportSocial Sciences
Holger Hopp, Teresa Kieseier, Jenny Jakisch et al. · 2021 · Multilingua
Abstract This paper reports findings of a project on pedagogical translanguaging (PTL) among 128 fourth-grade students learning English as a foreign language (EFL) in German primary schools. Over a period of six months, 20% of lesson time…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Shaharudin Jakpar, Michael Tinggi, Akmal Hisham Tak et al. · 2018 · UNIMAS Review of Accounting and Finance
This study is conducted to analyse the credibility of the fundamental analysis and technical analysis on predicting the stock return and compare both models to determine which model is more credible to be used as a good trading strategy by…
View details →Negative / Null Result ReportComputer Science
Anton Kotelyanskii, Gregory M. Kapfhammer · 2014
Although search-based test-data generators, like EvoSuite, efficiently and automatically create effective JUnit test suites for Java classes, these tools are often difficult to configure. Prior work by Arcuri and Fraser revealed that the…
View details →Negative / Null Result ReportOpen accessNeuroscience
Shan-Chuan Teng, Yunn-Wen Lien · 2022 · PLoS ONE
Mind wandering has been argued to be beneficial for breaking through mental impasses, which leads to better creative performance upon a second attempt (i.e., the incubation effect). However, the evidence is inconsistent. Different from the propensity for mind wandering that has been the focus of past studies, in this study we further examined the role of diversity (i.e., non-repetitiveness of mind wandering respective to its content) and types of mind wandering along the dimensions of intentionality and awareness during incubation when engaging in a 0-back task (a mind wandering-prone conditio
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Thomas Milic · 2015 · Swiss Political Science Review
Abstract After the vote of 9 February 2014, many attributed the surprising result to voter ignorance. The basic claim was that the majority of those voting in favour of the initiative possessed only a weak understanding of what the likely…
View details →Negative / Null Result ReportPsychology
Mark van Veen, Inge van Weeghel, Bauke Koekkoek et al. · 2014 · International Journal of Social Psychiatry
BACKGROUND: Risk of suicide is notoriously difficult to assess, and no gold standard is available, in terms of an instrument of first choice. Many different instruments are in use, among which are some that are not properly…
View details →Negative / Null Result ReportOpen accessMedicine
Axel Åkerblom, Lars Wallentin, Anders Larsson et al. · 2013 · Clinical Chemistry
BACKGROUND: The estimated glomerular filtration rate (eGFR) independently predicts cardiovascular death or myocardial infarction (MI) and can be estimated by creatinine and cystatin C concentrations. We evaluated 2 different cystatin C…
View details →Negative / Null Result ReportOpen accessMedicine
Sorena Keihani, Douglas Rogers, Bryn Putbrese et al. · 2019 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In 2018, the American Association for the Surgery of Trauma (AAST) published revisions to the renal injury grading system to reflect the increased reliance on computed tomography scans and non-operative management of high-grade…
View details →Negative / Null Result ReportOpen accessMedicine
Charlotte Lindblad Wollmann, Kyle D. Hart, Can Liu et al. · 2020 · Acta Obstetricia Et Gynecologica Scandinavica
INTRODUCTION: Predicting a woman's probability of vaginal birth after cesarean could facilitate the antenatal decision-making process. Having a previous vaginal birth strongly predicts vaginal birth after cesarean. Delivery outcome in…
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Clarin Collins · 2014 · Education Policy Analysis Archives
This study examined the SAS Education Value-Added Assessment System (EVAAS®) in practice, as perceived and experienced by teachers in the Southwest School District (SSD). To evaluate teacher effectiveness, SSD is using SAS EVAAS® for…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Daniel Lee, Gwendolyn Gardiner, Erica Baranski et al. · 2020 · Journal of Personality
OBJECTIVE: The current study seeks to replicate and extend principal findings reported in The World at 7:00, a project that examined the psychological experience of situations in 20 countries. METHOD: Data were collected from participants…
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