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403 real negative results, null findings, and replication failures · Replication Failure. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Replication Failure

Pyruvate and α-ketoglutarate precursor feeding combined with methyl jasmonate elicitation increases anthraquinone accumulation in hairy root cultures of Rubia tinctorum

Kalapuj Y, Perassolo M, Rodrïguez JM et al. · 2026 · Preprint

Abstract Anthraquinones (AQs) are specialized metabolites produced by Rubia tinctorum that have traditionally been used as dyes, but also have important biological activities. The present research studied the effects of the addition of…

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Replication FailureOpen accessComputer Science

Spin Transfer Torque Driven Coupled Oscillators for Self-Oscillating RF Mixers

Supriyo Maji · 2017 · arXiv

Spin transfer torque oscillators (STOs) based on magnetic tunnel junction (MTJ) devices are emerging as a possible replacement for complementary metal-oxide semiconductors for radio-frequency (RF) signal generation. Advantages include low power consumption, small device area, and large frequency tunability. But such a single device cannot achieve the necessary noise performance for RF applications. It has been reported lately that a network of globally coupled STOs achieves significant improvement in phase noise. The study here is to propose use of such coupled STOs as self-oscillating RF mixe

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Replication FailureOpen accessComputer Science

Chains That See, Answers That Don't: A Multi-Aspect Evaluation Recipe for Forced Chain-of-Thought on Video-MME

Zhichao Fan, Yanhang Li, Zexin Zhuang · 2026 · arXiv

Forced chain-of-thought (CoT) is widely assumed to make vision-language models more reliable on video question answering. We propose a small three-probe evaluation recipe to test that assumption: paired accuracy across direct, CoT, answer-first, and no-video conditions; a counterfactual video-swap diagnostic over the CoT chains; and a four-rung visual-degradation ladder. Each probe is reported under both a strict and a permissive regex scorer, with multiplicity correction over a manuscript-declared primary family. Applied to Qwen2.5-VL on Video-MME subsets, the recipe returns a two-part findin

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Replication FailureOpen accessComputer Science

Not All Flips Are Conformity: Decomposing Stance Convergence in Multi-Agent LLM Debate

Xiqi Hao, Zengqing Wu, Yu-Xuan Qiu et al. · 2026 · arXiv

Multi-agent debate (MAD) is a promising strategy for improving LLM reasoning, but when agents converge on a shared answer, it is unclear whether that convergence reflects genuine deliberation or social compliance. We show that the conventional answer flip rate conflates three distinct mechanisms: spontaneous instability, stance-induced conformity, and reasoning-induced persuasion. Our three-source decomposition framework isolates each through controlled counterfactual conditions. In the primary MMLU-Pro setting, 37% of agent-question observations change under self-reflection alone, while robus

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Replication FailureOpen accessComputer Science

Contrastive Predictive Coding Done Right for Mutual Information Estimation

J. Jon Ryu, Pavan Yeddanapudi, Xiangxiang Xu et al. · 2025 · arXiv

The InfoNCE objective, originally introduced for contrastive representation learning, has become a popular choice for mutual information (MI) estimation, despite its indirect connection to MI. In this paper, we demonstrate why InfoNCE should not be regarded as a valid MI estimator, and we introduce a simple modification, which we refer to as InfoNCE-anchor, for accurate MI estimation. Our modification introduces an auxiliary anchor class, enabling consistent density ratio estimation and yielding a plug-in MI estimator with significantly reduced bias. Beyond this, we generalize our framework us

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Replication FailureOpen accessMathematics

Mixing on $k$ Columns of the Transvection Walk

Natesh Pillai, Aaron Smith · 2026 · arXiv

In Diaconis and Saloff-Coste (1996), the authors introduced the simple ``transvection" walk on $\mathrm{GL}_n(\mathbb F_2)$: at each step, choose two distinct rows and add one to the other. In Ben-Hamou (2025), the author recently proved that this walk has mixing time $O(n^2\log n)$. Inspired by applications in cryptography (see Sotiraki (2016)), Ben-Hamou and Peres (2018) conjectured that the first $k$ columns of this walk mixed in $O(nk \log(n))$ steps. Our main result is a proof of this conjecture uniformly in $n$ and $k.$ Our proof is based on a local-to-global entropy estimate, in the spi

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Replication FailureOpen accessGynecology and obstetrics

Association of cytotoxic T-lymphocyte-associated protein 4 polymorphisms with recurrent pregnancy loss: A case-control study

Fereshteh Vaziri Nezamdoust, Hossein Hadinedoushan, Nasrin Ghasemi · 2023 · International Journal of Reproductive BioMedicine

Abstract Background: A large proportion of cases of recurrent pregnancy loss (RPL) are associated with immunological factors. Objective: This study investigated the association between single nucleotide polymorphisms of cytotoxic T-lymphocyte-associated protein (CTLA)-4 gene in women with a history of RPL compared to healthy women. Materials and Methods: A case-control study was performed on 2 groups consisting of 120 healthy women with no history of abortion and at least one delivery (control) and 120 women with a history of 2 or more primary RPLs (case). In addition, 5 mL of peripheral blood

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Replication FailureOpen access

Heritability of the Carabelli Cusp in Twins

Robert H. Biggerstaff · 1973

The study of the Carabelli trait among 199 monozygotic and dizygotic twin pairs failed to demonstrate a high degree of heritability. Analyses of antimere differences in individuals indicated a lack of mirroring and no sexual dimorphism.…

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Replication FailureOpen accessVeterinary medicine

The effect of lasalocid sodium on growth performance and possible coccidiosis in weaned akkaraman lambs

Şakir Doğan TUNCER, Behiç COŞKUN, Rıfat CANTORAY et al. · Eurasian Journal of Veterinary Sciences

This experiment was carried out to investigate the effects of Na -lasalocid that was added into concentrate mixtures in 25, 50 and 75 g per ton on growth performance and against the possible coccidia infection of lambs. In the experiment, 40 Akkaraman male lambs with 3.5 - 4 months old were used. The research works were conducted as 4 groups for the period of 84 days. The ratian of the control group did not contain any Na-lasalocid. The average of final weights of lambs in the groups were 47.41; 48.91; 49.98 and 49.96 kg respectively, (P>0.05). Average daily weight gain was found to be 260 g i

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Replication FailureOpen accessInternal medicine

Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study

Kraemer Rachel, Claas Steven A, Devereux Richard B et al. · 2009 · BMC Medical Genetics

Abstract Background We conducted a genome-wide association study (GWAS) and validation study for left ventricular (LV) mass in the Family Blood Pressure Program – HyperGEN population. LV mass is a sensitive predictor of cardiovascular mortality and morbidity in all genders, races, and ages. Polymorphisms of candidate genes in diverse pathways have been associated with LV mass. However, subsequent studies have often failed to replicate these associations. Genome-wide association studies have unprecedented power to identify potential genes with modest effects on left LV mass. We describe here a

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Replication FailureMedicine

Chest wall injury surgeon, know thyself.

Pieracci FM, Doben A, Eriksson E et al. · 2026 · The journal of trauma and acute care surgery

Abstract The use of surgical stabilization of rib fractures (SSRF) for non-flail fracture patterns continues to rise. However, multiple, recent randomized controlled trials in this patient population have failed to show a clear benefit to…

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Replication FailureMedicine

A Phase II, Single-Arm, Open-Label, Bayesian Adaptive Efficacy and Safety Study of PBI-05204 in Patients with Stage IV Metastatic Pancreatic Adenocarcinoma.

Roth MT, Cardin DB, Borazanci EH et al. · 2020 · The oncologist

Lessons learned This trial evaluating a novel plant extract, PBI-05204, did not meet its primary endpoint of overall survival but did show signals of efficacy in heavily pretreated mPDA. PBI-05204 was generally well tolerated, with the…

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Replication FailureMedicine

Randomized, Double-Blind Phase III Study of Pazopanib Versus Placebo in Patients With Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease After Metastasectomy: ECOG-ACRIN E2810.

Appleman LJ, Kim SE, Harris WB et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose Patients with no evidence of disease (NED) after metastasectomy for renal cell carcinoma are at high risk of recurrence. Pazopanib is an inhibitor of vascular endothelial growth factor receptor and other kinases that improves…

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Replication FailureOpen accessMathematics

Fixed Point Theorem for Non-Self Maps of Regions in the Plane

Georg Ostrovski · 2011 · arXiv

Let X and Y be compact, simply connected and locally connected subsets of R^2, and let f : X -> Y be a homeomorphism isotopic to the identity on X. Generalizing Brouwer's plane translation theorem for self-maps of the plane, we prove that f has no recurrent (in particular, no periodic) points if it has no fixed points.

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Replication FailureOpen accessComputer Science

Quantum Corrections to Baryon Properties in Chiral Soliton Models

Frank Meier, Hans Walliser · 1996 · arXiv

We present a procedure to calculate 1-loop graphs in the soliton sector of chiral Lagrangians and use it to calculate quantum corrections to certain baryon observables in Skyrme-type models. Results generally show an improvement over the values obtained in tree approximation except for the case of the axial coupling g_A.

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Replication FailureMedicine

The Effect of a Mobile-Based Lymphedema Self-care Support Program in Women With Breast Cancer-Related Lymphedema: A Single-blind Randomized Controlled Study.

Deveci Koçbilek Z, Karayurt Ö, Bilik Ö et al. · 2026 · Computers, informatics, nursing : CIN

This single-blind, randomized controlled design study aims to examine the effect of a mobile-based Lymphedema Self-care Support Program on self-care, the quality of life, and lymphedema symptoms in women with breast cancer-related…

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Replication FailureOpen accessGeriatrics

Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease

Anum Zahra, Maarten van Smeden, Petra J. M. Elders et al. · 2025 · BMC Geriatrics

Abstract Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vulnerability in this frail population. However, the prognostic value of these cumulative comorbidity scores like the Charlson comorbidity index (CCI) remained unclear in this population. We evaluated the incremental predictive value of the CCI for predicting 28-day mortality in NH residents with COVID-19, compared to prediction using age and sex only. Methods

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Replication FailureOpen accessDiseases of the genitourinary system. Urology

Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients

Wanqing Huang, Jiuxu Bai, Yanping Zhang et al. · 2024 · Renal Failure

Background Elderly hemodialysis (HD) patients have a high risk of death. The effect of different types of HD membranes on survival is still controversial. The purpose of this study was to determine the relationship between the use of low-flux or high-flux membranes and all-cause and cardiovascular mortality in elderly hemodialysis patients.Methods This was a retrospective clinical study involving maintenance hemodialysis patients which were categorized into low-flux and high-flux groups according to the dialyzer they were using. Propensity score matching was used to balance the baseline data o

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